13449-1-AP

antibody from Proteintech Group

Targeting: PDGFRB CD140b, JTK12, PDGFR, PDGFR1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

13449-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#13449-1-AP, RRID:AB_2162644

Product name

PDGFRB antibody

Antibody type

Polyclonal

Description

PDGFRB antibody (Cat. #13449-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Proteomic profiling and molecular reclassification of high-grade serous ovarian cancer identifies prognostic subtypes and immunotherapy biomarkers.

Tu M, Tang S, Zhang Q, Guo T, Cen Y, Xu X, Wu S, Chen X, Lu W, Ding C, Xu J
EBioMedicine 2026 May;127:106248

---

AG1295 Attenuates High-Glucose-Induced Proliferation, Migration, Phenotype Transition, and Interleukin-6 Expression in Human Corneal Stromal Fibroblasts.

Zheng Y, Jiang H, Wang J, Zhang Q, Wan Q, Wang Y
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2026 Mar 18;:10807683261433333

---

Chelidonine overcomes P-gp-mediated adriamycin resistance in MCF-7/ADR cells by inhibiting PDGFRβ/PI3K/Akt pathway.

Zou X, Zhang Y, Liu K, Zhang L, Li J, Zhang Y, Zhang X, Yu L, Qu Z
Chinese herbal medicines 2026 Jan;18(1):167-177

---

PDGF-BB mitigates pericyte injury by activating the PHF19-PRC2 complex via the miR-221/BRCA1 signaling axis in Alzheimer's disease.

Yang H, Zhou H, Zhao K, Shi L, Li Y, Zhao Q, Ya J, Wu C
Brain research bulletin 2026 Apr;237:111819

---

Mettl3-Mediated m6A Methylation of Pdgfrb Regulates the Angiogenesis-Dependent Bone Formation.

Zhou S, Zhu Y, Yun L, Li M, Zhang T, Wumiti T, Zhou Q, Chen S, Hu Y, Han Z, Zhang C, Tong K, Zhang Y, Ma Y, Guo Y, Wang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71817

---

Cellular crosstalk mediated by Meteorin-like regulating hepatic stellate cell activation during hepatic fibrosis.

Zhou Y, Wang G, Liu L, Song L, Hu L, Liu L, Xu L, Wang T, Liu L, Wang Y, Zhang T, Guo B
Cell death & disease 2025 May 20;16(1):405

---

Mechanistic Insights into Maltol-Mediated Reversal of Postmenopausal Osteoporosis via Regulation of CDK14 Ubiquitination in Macrophages.

Jin Z, Wei Y, Zhou Z, Fan Z, Huang Y, Liu D
Journal of agricultural and food chemistry 2025 May 14;73(19):11730-11755

---

Edaravone dextranol alleviates ferroptosis, Cuproptosis, and blood-brain barrier damage after acute cerebral infarction.

Jin G, Han W, Duan T, Xue Z, Song C, Xu Y, Yu M
Metabolic brain disease 2025 Mar 3;40(3):134

---

(64)Cu Radiolabeled PDGFRβ-Targeting Affibody for PET Imaging in Pancreatic Cancer.

Li Z, Geng R, Zhan Y, Liu R, Li M, Ke N, Yang H, Lu X, Li L, Li S, Cai H
Molecular pharmaceutics 2025 Mar 3;22(3):1633-1640

---

Targeting CALR reduces energy metabolism of esophageal cancer cells and inhibits tumor‑associated fibroblast infiltration.

Miao Y, Wang X, He F, Zhang F, Huang Y, Lai Y, Wang Y, Zhang L, Yin H, Meng X, Liu H, Li W, Yang S
International journal of oncology 2025 Jun;66(6)

---

Effects of the regenerating gene family on DSS-induced ulcerative colitis in a mouse model.

Wang J, Chen W, Wang Y, Hayakawa E, Nishiura H, Ohmuraya M
Biochemical and biophysical research communications 2025 Jun 20;766:151894

---

Integrated proteogenomic characterization of ampullary adenocarcinoma.

Zhang Q, Xu X, Jiang D, Wang Y, Wang H, Zhu J, Tang S, Wang R, Zhao S, Li K, Feng J, Xiang H, Yao Z, Xu N, Fang R, Guo W, Liu Y, Hou Y, Ding C
Cell discovery 2025 Jan 7;11(1):2

---

Single-cell and spatial atlas unveil tumor-specific microenvironment convergence and a prognosis-associated PLXDC1+ myofibroblast population in metastatic bladder cancer.

Wang Z, Miao J, Wang M, Ying Y, Zhang Z, Zeng S, Xu C
Journal of translational medicine 2025 Dec 15;24(1):88

---

pPB peptide-modified nanostructured lipid carriers loaded with astragaloside IV as a potential strategy for enhanced antifibrosis therapy.

Zhang S, Zhang X, Wang M, Guo L, Tan S
International journal of biological macromolecules 2025 Aug;319(Pt 3):145221

---

Eupatorium lindleyanum DC Ameliorates Carbon Tetrachloride-Induced Hepatic Inflammation and Fibrotic Response in Mice.

Yang J, Wang Y, Zhuo L, Lu G, Zhang M, Huang J, Li Y, Liu W, Qi J, Zhu A, Zhou Z
Pharmaceuticals (Basel, Switzerland) 2025 Aug 20;18(8)

---

Structural changes in cerebral microvasculature induced by ferroptosis contribute to blood-brain barrier disruption in Alzheimer's disease: an autopsy study.

Cao Y, Huang MY, Mao CH, Wang X, Xu YY, Qian XJ, Ma C, Qiu WY, Zhu YC
Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Apr;21(4):e70103

---

Promotion of mature angiogenesis in ischemic stroke by Taohong Siwu decoction through glycolysis activation.

Tang L, Liu Z, Ji Z, Zhang X, Zhao M, Peng D, Han L
Frontiers in pharmacology 2024;15:1395167

---

Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRβ/PI3K/AKT pathway.

Meng Q, Zhu H, Li Y, Peng X, Wang T, Huang H, Zhou H, Liu Y, Ru S, Wu J, Ma Y
Frontiers in pharmacology 2024;15:1341020

---

A switch in the pathway of TRPC3-mediated calcium influx into brain pericytes contributes to capillary spasms after subarachnoid hemorrhage.

Li Y, Zhou L, Deng H, Zhang Y, Li G, Yu H, Wu K, Wang F
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Sep;21(5):e00380

---

Low-intensity pulsed ultrasound modulates disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

Liu Z, Zhang H, Lu K, Chen L, Zhang Y, Xu Z, Zhou H, Sun J, Xu M, Ouyang Q, Thompson GJ, Yang Y, Su N, Cai X, Cao L, Zhao Y, Jiang L, Zheng Y, Zhang X
Cell reports 2024 Sep 24;43(9):114660

---

KIF1C facilitates retrograde transport of lysosomes through Hook3 and dynein.

Saji T, Endo M, Okada Y, Minami Y, Nishita M
Communications biology 2024 Oct 11;7(1):1305

---

Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2.

Lv D, Dixit D, Cruz AF, Kim LJY, Duan L, Xu X, Wu Q, Zhong C, Lu C, Gersey ZC, Gimple RC, Xie Q, Yang K, Liu X, Fang X, Wu X, Kidwell RL, Wang X, Bao S, He HH, Locasale JW, Agnihotri S, Rich JN
Cell metabolism 2024 Nov 5;36(11):2419-2436.e8

---

Oncogenic RTKs sensitize cancer cells to ferroptosis via c-Myc mediated upregulation of ACSL4.

Sun N, Wang J, Qin J, Ma S, Luan J, Hou G, Zhang W, Gao M
Cell death & disease 2024 Nov 27;15(11):861

---

Edaravone Dexborneol protects against blood-brain barrier disruption following cerebral ischemia/reperfusion by upregulating pericyte coverage via vitronectin-integrin and PDGFB/PDGFR-β signaling.

Sun Z, Zhao H, Yang S, Liu R, Yi L, Gao J, Liu S, Chen Y, Zhang Z
Free radical biology & medicine 2024 Nov 20;225:758-766

---

Cross-species single-cell analysis uncovers the immunopathological mechanisms associated with IgA nephropathy progression.

Chen X, Wang T, Chen L, Zhao Y, Deng Y, Shen W, Li L, Yin Z, Zhang C, Cai G, Zhang M, Chen X
JCI insight 2024 May 8;9(9)

---

Spatiotemporal ATF3 Expression Determines VSMC Fate in Abdominal Aortic Aneurysm.

Wen Y, Liu Y, Li Q, Tan J, Fu X, Liang Y, Tuo Y, Liu L, Zhou X, LiuFu D, Fan X, Chen C, Chen Z, Wang Z, Fan S, Liu R, Pan L, Zhang Y, Tang WH
Circulation research 2024 May 24;134(11):1495-1511

---

Artemisinin suppressed tumour growth and induced vascular normalisation in oral squamous cell carcinoma via inhibition of macrophage migration inhibitory factor.

Yu XH, Wu JB, Fan HY, Dai L, Xian HC, Chen BJ, Liao P, Huang MC, Pang X, Zhang M, Liang XH, Tang YL
Oral diseases 2024 Mar;30(2):363-375

---

In vitro modeling of recurrent Dermatofibrosarcoma Protuberans: Assessment of 5-aminolevulinic acid photodynamic therapy efficacy.

Jiang H, He K, Tan J, Zhu D, Yang N, Wang Y, Zhang J, Li X, Ren Y, Lu Y
Photodiagnosis and photodynamic therapy 2024 Jun;47:104093

---

[Aqueous extract of Chuan Xiong Rhizoma enhances inhibitory effect of temozolomide against brain metastasis of melanoma in mice].

Zhao Q, Zhang Z, Zhou X, Rong X, Liu X, Zhao X, Wang H, Pang J, Li S, Li X
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Jun 20;44(6):1088-1097

---

Fentanyl dysregulates neuroinflammation and disrupts blood-brain barrier integrity in HIV-1 Tat transgenic mice.

Rademeyer KM, R Nass S, Jones AM, Ohene-Nyako M, Hauser KF, McRae M
Journal of neurovirology 2024 Feb;30(1):1-21

---

Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells.

Tsujimoto H, Hoshina A, Mae SI, Araoka T, Changting W, Ijiri Y, Nakajima-Koyama M, Sakurai S, Okita K, Mizuta K, Niwa A, Saito MK, Saitou M, Yamamoto T, Graneli C, Woollard KJ, Osafune K
Cell reports 2024 Feb 27;43(2):113602

---

Comparison of preparation methods of rat kidney single-cell suspensions.

Wang T, Shen W, Li L, Wang H, Zhang M, Chen X
Scientific reports 2024 Feb 2;14(1):2785

---

IGF2BP2-modified circular RNA circCHD7 promotes endometrial cancer progression via stabilizing PDGFRB and activating JAK/STAT signaling pathway.

Shi R, Zhao R, Shen Y, Wei S, Zhang T, Zhang J, Shu W, Cheng S, Teng H, Wang H
Cancer gene therapy 2024 Aug;31(8):1221-1236

---

Targeting endothelial PDGFR-β facilitates angiogenesis-associated bone formation through the PAK1/NICD axis.

Lin H, Lin R, Hou J, Zhu C, Liu G, Lin Y, Su J, Yang M, Yang B, Ma Y, Cheng C, Deng M, Yu B, Xu T, Wu H, Cui Z
Journal of cellular physiology 2024 Aug;239(8):e31291

---

PKM2/Hif-1α signal suppression involved in therapeutics of pulmonary fibrosis with microcystin-RR but not with pirfenidone.

Ren Y, Wang J, Guo WW, Chen JW, Xu LZ, Wu ZW, Wang YP
Toxicon : official journal of the International Society on Toxinology 2024 Aug 28;247:107822

---

Predominant control of PDGF/PDGF receptor signaling in the migration and proliferation of human adipose‑derived stem cells under culture conditions with a combination of growth factors.

Sun Z, Fukui M, Taketani S, Kako A, Kunieda S, Kakudo N
Experimental and therapeutic medicine 2024 Apr;27(4):156

---

GIPC1 promotes tumor growth and migration in gastric cancer via activating PDGFR/PI3K/AKT signaling.

Li T, Zhong W, Yang L, Zhao Z, Wang LI, Liu C, Li W, Lv H, Wang S, Yan J, Wu T, Song G, Luo F
Oncology research 2023;32(2):361-371

---

Discovery of grey matter lesion-related immune genes for diagnostic prediction in multiple sclerosis.

Zhao P, Liu X, Wang Y, Zhang X, Wang H, Du X, Du Z, Yang L, Hou J
PeerJ 2023;11:e15299

---

Development of a contacting transwell co-culture system for the in vitro propagation of primary central nervous system lymphoma.

Nishi M, Tateishi K, Sundararaj JS, Ino Y, Nakai Y, Hatayama Y, Yamaoka Y, Mihana Y, Miyakawa K, Kimura H, Kimura Y, Yamamoto T, Ryo A
Frontiers in cell and developmental biology 2023;11:1275519

---

Rnf-213 Knockout Induces Pericyte Reduction and Blood-Brain Barrier Impairment in Mouse.

Li W, Niu X, Dai Y, Wu X, Li J, Sheng W
Molecular neurobiology 2023 Nov;60(11):6188-6200

---

Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting.

Gimple RC, Zhang G, Wang S, Huang T, Lee J, Taori S, Lv D, Dixit D, Halbert ME, Morton AR, Kidwell RL, Dong Z, Prager BC, Kim LJ, Qiu Z, Zhao L, Xie Q, Wu Q, Agnihotri S, Rich JN
JCI insight 2023 Mar 22;8(6)

---

Berbamine dihydrochloride suppresses the progression of colorectal cancer via RTKs/Akt axis.

Liu L, Liang D, Zheng Q, Zhao M, Lv R, Tang J, Chen N
Journal of ethnopharmacology 2023 Mar 1;303:116025

---

Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.

Jiang Q, Lei Z, Wang Z, Wang Q, Zhang Z, Liu X, Xing B, Li S, Guo X, Liu Y, Li X, Qi Y, Shu K, Zhang H, Huang Y, Lei T
Cancers 2023 Jun 27;15(13)

---

Supramolecular Hydrogel Microspheres of Platelet-Derived Growth Factor Mimetic Peptide Promote Recovery from Spinal Cord Injury.

Wu W, Jia S, Xu H, Gao Z, Wang Z, Lu B, Ai Y, Liu Y, Liu R, Yang T, Luo R, Hu C, Kong L, Huang D, Yan L, Yang Z, Zhu L, Hao D
ACS nano 2023 Feb 28;17(4):3818-3837

---

Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI-1-TGF-β-myoCAF-Dependent Mechanism.

Wu J, Jing X, Du Q, Sun X, Holgersson K, Gao J, He X, Hosaka K, Zhao C, Tao W, FitzGerald GA, Yang Y, Jensen LD, Cao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Aug;10(24):e2301505

---

Astragalus propinquus schischkin and Salvia miltiorrhiza bunge promote angiogenesis to treat myocardial ischemia via Ang-1/Tie-2/FAK pathway.

Zhang MX, Huang XY, Song Y, Xu WL, Li YL, Li C
Frontiers in pharmacology 2022;13:1103557

---

Halofuginone inhibits tumor migration and invasion by affecting cancer-associated fibroblasts in oral squamous cell carcinoma.

Wang D, Tian M, Fu Y, Sun Y, Ding L, Zhang X, Jing Y, Sun G, Ni Y, Song Y
Frontiers in pharmacology 2022;13:1056337

---

Inhibition of PFKFB3 in HER2-positive gastric cancer improves sensitivity to trastuzumab by inducing tumour vessel normalisation.

Yao X, He Z, Qin C, Zhang P, Sui C, Deng X, Fang Y, Li G, Shi J
British journal of cancer 2022 Sep;127(5):811-823

---

Patient-derived xenografts and in vitro model show rationale for imatinib mesylate repurposing in HEY1-NCoA2-driven mesenchymal chondrosarcoma.

Safaric Tepes P, Segovia D, Jevtic S, Ramirez D, Lyons SK, Sordella R
Laboratory investigation; a journal of technical methods and pathology 2022 Sep;102(9):1038-1049

---

PDGF signaling inhibits mitophagy in glioblastoma stem cells through N(6)-methyladenosine.

Lv D, Gimple RC, Zhong C, Wu Q, Yang K, Prager BC, Godugu B, Qiu Z, Zhao L, Zhang G, Dixit D, Lee D, Shen JZ, Li X, Xie Q, Wang X, Agnihotri S, Rich JN
Developmental cell 2022 Jun 20;57(12):1466-1481.e6

---

Expanding tubular microvessels on stiff substrates with endothelial cells and pericytes from the same adult tissue.

Song X, Yu Y, Leng Y, Ma L, Mu J, Wang Z, Xu Y, Zhu H, Qiu X, Li P, Li J, Wang D
Journal of tissue engineering 2022 Jan-Dec;13:20417314221125310

---

Abi1 mediates airway smooth muscle cell proliferation and airway remodeling via Jak2/STAT3 signaling.

Wang R, Wang Y, Liao G, Chen B, Panettieri RA Jr, Penn RB, Tang DD
iScience 2022 Feb 18;25(2):103833

---

Artesunate Suppresses Choroidal Melanoma Vasculogenic Mimicry Formation and Angiogenesis via the Wnt/CaMKII Signaling Axis.

Geng B, Zhu Y, Yuan Y, Bai J, Dou Z, Sui A, Luo W
Frontiers in oncology 2021;11:714646

---

TMEM119 facilitates ovarian cancer cell proliferation, invasion, and migration via the PDGFRB/PI3K/AKT signaling pathway.

Sun T, Bi F, Liu Z, Yang Q
Journal of translational medicine 2021 Mar 17;19(1):111

---

A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas.

Yu S, Wei S, Savani M, Lin X, Du K, Mender I, Siteni S, Vasilopoulos T, Reitman ZJ, Ku Y, Wu D, Liu H, Tian M, Chen Y, Labrie M, Charbonneau CM, Sugarman E, Bowie M, Hariharan S, Waitkus M, Jiang W, McLendon RE, Pan E, Khasraw M, Walsh KM, Lu Y, Herlyn M, Mills G, Herbig U, Wei Z, Keir ST, Flaherty K, Liu L, Wu K, Shay JW, Abdullah K, Zhang G, Ashley DM
Clinical cancer research : an official journal of the American Association for Cancer Research 2021 Dec 15;27(24):6800-6814

---

PDGF-BB/SA/Dex injectable hydrogels accelerate BMSC-mediated functional full thickness skin wound repair by promoting angiogenesis.

Zhang Z, Li Z, Wang Y, Wang Q, Yao M, Zhao L, Shi J, Guan F, Ma S
Journal of materials chemistry. B 2021 Aug 21;9(31):6176-6189

---

Forkhead Box Q1 Is Critical to Angiogenesis and Macrophage Recruitment of Colorectal Cancer.

Tang H, Zheng J, Bai X, Yue KL, Liang JH, Li DY, Wang LP, Wang JL, Guo Q
Frontiers in oncology 2020;10:564298

---

Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.

Sun B, Luo X, Yang C, Liu P, Yang Y, Dong X, Yang Z, Xu J, Zhang Y, Li L
Stem cells international 2019;2019:8035076

---

Tissue plasminogen activator disrupts the blood-brain barrier through increasing the inflammatory response mediated by pericytes after cerebral ischemia.

Yang E, Cai Y, Yao X, Liu J, Wang Q, Jin W, Wu Q, Fan W, Qiu L, Kang C, Wu J
Aging 2019 Nov 18;11(22):10167-10182

---

Blocking CXCR3 with AMG487 ameliorates the blood-retinal barrier disruption in diabetic mice through anti-oxidative.

Wang H, Li J, Zhong P, Wang S, Zhang L, Yang R, Wu D, Chen M, Ji A, Li Y, Wang J
Life sciences 2019 Jul 1;228:198-207

---

BMP4 mediates the interplay between adipogenesis and angiogenesis during expansion of subcutaneous white adipose tissue.

Tang Y, Qian SW, Wu MY, Wang J, Lu P, Li X, Huang HY, Guo L, Sun X, Xu CJ, Tang QQ
Journal of molecular cell biology 2016 Aug;8(4):302-12

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The PDGFRB antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDGFRB. This antibody recognizes human, mouse, rat antigen. The PDGFRB antibody has been validated for the following applications: ELISA, WB analysis.

Appendix

13449-1-AP.pdf

Show more