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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- PAB3375 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB3375, RRID:AB_1578550
- Product name
- PDGFRB polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of PDGFRB.
- Storage
- Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates.
YXXM motifs in the PDGF-beta receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals.
Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells.
Whiteman EL, Chen JJ, Birnbaum MJ
Endocrinology 2003 Sep;144(9):3811-20
Endocrinology 2003 Sep;144(9):3811-20
YXXM motifs in the PDGF-beta receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals.
Wu H, Windmiller DA, Wang L, Backer JM
The Journal of biological chemistry 2003 Oct 17;278(42):40425-8
The Journal of biological chemistry 2003 Oct 17;278(42):40425-8
Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells.
Uren A, Merchant MS, Sun CJ, Vitolo MI, Sun Y, Tsokos M, Illei PB, Ladanyi M, Passaniti A, Mackall C, Toretsky JA
Oncogene 2003 Apr 17;22(15):2334-42
Oncogene 2003 Apr 17;22(15):2334-42
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Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with PDGFRB polyclonal antibody (Cat # PAB3375) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. BC = breast carcinoma.
- Validation comment
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Flow cytometric analysis of SK-BR-3 cells using PDGFRB polyclonal antibody (Cat # PAB3375)(bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
- Validation comment
- Flow Cytometry
