RA0231

antibody from Oursmab

Targeting: ERBB3 HER3, LCCS2

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0231

Provider

Oursmab

Product name

Elgemtumab (Biosimilar Reference Antibody) (ERBB3)

Antibody type

Monoclonal

Description

Elgemtumab (development code LJM716) is an investigational, fully human immunoglobulin G (IgG) monoclonal antibody developed as a targeted therapy for cancers driven by HER3 signaling. It functions as a potent and specific HER3 antagonist. Its mechanism of action is to bind with high affinity to the extracellular domain of HER3, thereby effectively blocking both ligand-dependent and ligand-independent HER3 signaling pathways. This dual blockade prevents the activation and subsequent dimerization of HER3 with other ErbB family receptors (like HER2 or EGFR), a critical step for downstream oncogenic signaling that promotes tumor cell survival, proliferation, and resistance to therapy.

Reactivity

Human

Isotype

IgG

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.