ERBB3

gene product
HER3, LCCS2
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
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Novus Biologicals
120 antibodies
Invitrogen Antibodies
27 antibodies
GeneTex
24 antibodies
Abnova Corporation
23 antibodies
R&D Systems
23 antibodies
antibodies-online
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Aviva Systems Biology
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Acris Antibodies GmbH
41 antibodies
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Arigo
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Signalway Antibody LLC
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NSJ Bioreagents
5 antibodies
Bioworld Technology, Inc
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12 antibodies
ProSci
9 antibodies
St John's Laboratory
17 antibodies
Antibodies.com
1 antibody
Atlas Antibodies
1 antibody
Creative Biolabs
251 antibodies
Abbkine Scientific Co.Ltd.
9 antibodies
Boster Biological Technology
5 antibodies
Bethyl Laboratories
2 antibodies
Rockland Immunochemicals, Inc.
1 antibody
RabMAbs
13 antibodies
Everest Biotech
1 antibody
Proteintech Group
1 antibody
BioLegend
8 antibodies
Creative Diagnostics
20 antibodies
MyBioSource
18 antibodies
EMD Millipore
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GenWay
7 antibodies
United States Biological
107 antibodies
Miltenyi Biotec
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Spring Bioscience
12 antibodies
RayBiotech, Inc.
5 antibodies
Sino Biological Inc.
10 antibodies
Aldevron
1 antibody
Abbiotec
3 antibodies
Sigma-Aldrich
3 antibodies
eBioscience, An Affymetrix Company
2 antibodies