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Learn10783-1-AP
antibody from Proteintech Group
Targeting: BCL2L1
Bcl-X, bcl-xL, bcl-xS, BCL2L, BCLX, PPP1R52
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ELISAAntibody data
- Antibody Data
- Antigen structure
- References [178]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 10783-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10783-1-AP, RRID:AB_2064724
- Product name
- Bcl-XL antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Bcl-XL antibody (Cat. #10783-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Polymorphism rs2327430 in TCF21 predicts the risk and prognosis of gastric cancer by affecting the binding between TFAP2A and TCF21.
CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells.
GSK-126 Attenuates Cell Apoptosis in Ischemic Brain Injury by Modulating the EZH2-H3K27me3-Bcl2l1 Axis.
Fucoxanthin induces human melanoma cytotoxicity by thwarting the JAK2/STAT3/BCL-xL signaling axis.
LC-MS based metabonomics study on protective mechanism of ESWW in cerebral ischemia via CYTC/Apaf-1/NDRG4 pathway.
Chidamide enhances T-cell-mediated anti-tumor immune function by inhibiting NOTCH1/NFATC1 signaling pathway in ABC-type diffuse large B-cell lymphoma.
Suppression of the SLC7A11/glutathione axis causes ferroptosis and apoptosis and alters the mitogen-activated protein kinase pathway in nasopharyngeal carcinoma.
Endoplasmic reticulum stress exacerbates microplastics-induced toxicity in animal cells.
TMT-based proteomics analysis identifies the interventional mechanisms of Qijia Rougan decoction in improving hepatic fibrosis.
Proteomic analysis reveals that cigarette smoke exposure diminishes ovarian reserve in mice by disrupting the CREB1-mediated ovarian granulosa cell proliferation-apoptosis balance.
Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity.
Anti-hepatocellular carcinoma activity of Sorbaria sorbifolia by regulating VEGFR and c-Met/apoptotic pathway.
The MDM2-p53 Axis Represents a Therapeutic Vulnerability Unique to Glioma Stem Cells.
A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy.
A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3β/β-Catenin and TGF-β/Smad2/3 Signaling Pathways.
Exogenous Hydrogen Sulfide Induces A375 Melanoma Cell Apoptosis Through Overactivation of the Unfolded Protein Response.
Burn-Induced Apoptosis in the Livers of Aged Mice Is Associated With Caspase Cleavage of Bcl-xL.
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Platycodin D induces apoptotic cell death through PI3K/AKT and MAPK/ERK pathways and synergizes with venetoclax in acute myeloid leukemia.
Inhibition of endogenous hydrogen sulfide production suppresses the growth of nasopharyngeal carcinoma cells.
Venetoclax-Resistant T-ALL Cells Display Distinct Cancer Stem Cell Signatures and Enrichment of Cytokine Signaling.
Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway.
A multi-bioresponsive self-assembled nano drug delivery system based on hyaluronic acid and geraniol against liver cancer.
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8(+) T cell function and anti-tumor immunity.
Fenofibrate attenuates the cytotoxic effect of cisplatin on lung cancer cells by enhancing the antioxidant defense system in vitro.
Platycodin D induces proliferation inhibition and mitochondrial apoptosis in diffuse large B-cell lymphoma.
Photobiomodulation treatment inhibits neurotoxic astrocytic polarization and protects neurons in in vitro and in vivo stroke models.
A Mulberry Diels-Alder-Type Adduct, Kuwanon M, Triggers Apoptosis and Paraptosis of Lung Cancer Cells through Inducing Endoplasmic Reticulum Stress.
Integrated network pharmacology and experimental validation to explore the mechanisms underlying naringenin treatment of chronic wounds.
Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway.
Molecular mechanism of the miR-7/BCL2L1/P53 signaling axis regulating the progression of hepatocellular carcinoma.
Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia.
Navitoclax (ABT-263) Rejuvenates Human Skin by Eliminating Senescent Dermal Fibroblasts in a Mouse/Human Chimeric Model.
Protective effects of pentoxifylline against chlorine-induced acute lung injury in rats.
Dihydromyricetin Inhibits Pseudorabies Virus Multiplication In Vitro by Regulating NF-κB Signaling Pathway and Apoptosis.
Six first-line tyrosine kinase inhibitors reveal novel inhibition potential for the EGFR S768I mutation.
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
The STAT3 inhibitor stattic overcome bortezomib-resistance in multiple myeloma via decreasing PSMB6.
Overexpression of C9orf72 exacerbates Aβ25‑35‑induced oxidative stress and apoptosis in PC12 cells.
Cystathionine β-Synthase Regulates the Proliferation, Migration, and Invasion of Thyroid Carcinoma Cells.
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer.
Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway.
Combined treatment with dihydrotestosterone and lipopolysaccharide modulates prostate homeostasis by upregulating TNF-α from M1 macrophages and promotes proliferation of prostate stromal cells.
Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway.
Single-nucleus RNA Sequencing reveals the mechanism of cigarette smoke exposure on diminished ovarian reserve in mice.
HA-ADT suppresses esophageal squamous cell carcinoma progression via apoptosis promotion and autophagy inhibition.
BCL2L1 is identified as a target of naringenin in regulating ovarian cancer progression.
Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis.
Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer.
Exercise-induced neuroprotection against cerebral ischemia/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis.
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins.
Deduction of CDC42EP3 suppress development and progression of osteosarcoma.
Pharmacological Inhibition of Endogenous Hydrogen Sulfide Attenuates Breast Cancer Progression.
BNIP3 mediates the different adaptive responses of fibroblast-like synovial cells to hypoxia in patients with osteoarthritis and rheumatoid arthritis.
Gamma-oryzanol protects human liver cell (L02) from hydrogen peroxide-induced oxidative damage through regulation of the MAPK/Nrf2 signaling pathways.
Effect of alfalfa substituted with ramie on the expression of apoptotic genes in the gastrointestinal tracts of goats.
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma.
The Photoperiod Regulates Granulosa Cell Apoptosis through the FSH-Nodal/ALK7 Signaling Pathway in Phodopus sungorus.
Epigallocatechin-3-Gallate Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via Inhibition of Apoptosis and Promotion of Autophagy through the ROS/MAPK Signaling Pathway.
Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells.
Selonsertib Alleviates the Progression of Rat Osteoarthritis: An in vitro and in vivo Study.
Reconstituting neurovascular unit with primary neural stem cells and brain microvascular endothelial cells in three-dimensional matrix.
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Anti-glioblastoma effects of nanomicelle-curcumin plus erlotinib.
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway.
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
p53 induces ARTS to promote mitochondrial apoptosis.
Total saponins from Rhizoma Panacis Majoris inhibit proliferation, induce cell cycle arrest and apoptosis and influence MAPK signalling pathways on the colorectal cancer cell.
Adipose-derived stem cells alleviate radiation-induced dermatitis by suppressing apoptosis and downregulating cathepsin F expression.
Dracomolphin A-E, new lignans from Dracocephalum moldavica.
Modulation of Wnt/β-catenin signaling in IL-17A-mediated macrophage polarization of RAW264.7 cells.
Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38/MAPK and Wnt/β-Catenin Signaling Pathways.
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
Activated STAT3 Could Reduce Survival in Patients with Esophageal Squamous Cell Carcinoma by Up-regulating VEGF and Cyclin D1 Expression.
Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms.
Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells.
Comparison of the Effects of Nonprotein and Protein Nitrogen on Apoptosis and Autophagy of Rumen Epithelial Cells in Goats.
Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells.
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
δ-Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β-catenin nuclear localization and activating its downstream target genes.
Blockade of HSP70 by VER-155008 synergistically enhances bortezomib-induced cytotoxicity in multiple myeloma.
Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway.
Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-κB and Nrf2 pathways.
PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.
MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway.
Tetrandrine enhances antitumor effects of the histone deacetylase inhibitor MS-275 in human cancer in a Bax- and p53-dependent manner.
Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux.
Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation.
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis.
Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways.
Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway.
Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4.
LncRNA HMMR-AS1 promotes proliferation and metastasis of lung adenocarcinoma by regulating MiR-138/sirt6 axis.
Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2α pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy.
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction.
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Soluble CXCL16 promotes TNF-α-induced apoptosis in DLBCL via the AMAD10-NF-κB regulatory feedback loop.
The long noncoding RNA TPTE2P1 promotes the viability of colorectal cancer cells.
Protective Effect of Extract of Bletilla Striata on Isoflurane Induced Neuronal Injury By Altering PI3K/Akt Pathway.
Glutaminolysis Mediated by MALT1 Protease Activity Facilitates PD-L1 Expression on ABC-DLBCL Cells and Contributes to Their Immune Evasion.
Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells.
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
Alisol B-23-acetate, a tetracyclic triterpenoid isolated from Alisma orientale, induces apoptosis in human lung cancer cells via the mitochondrial pathway.
Role of Daucosterol Linoleate on Breast Cancer: Studies on Apoptosis and Metastasis.
The role of the long non-coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR-93/RhoC pathway.
Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.
Silencing Lin28 promotes apoptosis in colorectal cancer cells by upregulating let‑7c targeting of antiapoptotic BCL2L1.
MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway.
Anticancer effect of PP31J isolated from Physalis pubescens L. in human cervical carcinoma cells.
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
The role of long non-coding RNA PCA3 in epithelial ovarian carcinoma tumorigenesis and progression.
DLEU1 contributes to ovarian carcinoma tumourigenesis and development by interacting with miR-490-3p and altering CDK1 expression.
Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma.
Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells.
SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways.
Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
Inhibition of store-operated Ca(2+) entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
MicroRNA-490 inhibits tumorigenesis and progression in breast cancer.
Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer.
Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats.
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction.
Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma.
Persistent Cytomegalovirus Infection in Amniotic Membranes of the Human Placenta.
MicroRNA-184 Modulates Doxorubicin Resistance in Osteosarcoma Cells by Targeting BCL2L1.
Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
HIF-1α inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute myeloid leukemia.
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer.
Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway.
β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.
Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells.
EGCG induces lung cancer A549 cell apoptosis by regulating Ku70 acetylation.
By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice.
Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.
An ESRG-interacting protein, COXII, is involved in pro-apoptosis of human embryonic stem cells.
Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling.
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Protective efficacy of carnosic acid against hydrogen peroxide induced oxidative injury in HepG2 cells through the SIRT1 pathway.
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Potent effects of dioscin against liver fibrosis.
Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells.
PNMA1 promotes cell growth in human pancreatic ductal adenocarcinoma.
Serine threonine kinase Pim-3 regulates STAT3 pathway to inhibit proliferation of human liver cancers.
Modulating the p66shc signaling pathway with protocatechuic acid protects the intestine from ischemia-reperfusion injury and alleviates secondary liver damage.
The mitochondrial thioredoxin is required for liver development in zebrafish.
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Pao Pereira Extract Suppresses Castration-Resistant Prostate Cancer Cell Growth, Survival, and Invasion Through Inhibition of NFκB Signaling.
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
KLF9, a transcription factor induced in flutamide-caused cell apoptosis, inhibits AKT activation and suppresses tumor growth of prostate cancer cells.
ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21((CIP1/WAF1)) in human cancer cells.
Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats.
Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo.
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Sine oculis homeobox homolog 1 promotes α5β1-mediated invasive migration and metastasis of cervical cancer cells.
Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway.
Synergistic anti-glioma effect of Hydroxygenkwanin and Apigenin in vitro.
Synergistic antitumour activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species (ROS)/Akt signaling.
Role of Ku70 and Bax in epigallocatechin-3-gallate-induced apoptosis of A549 cells in vivo.
Chemical composition of total flavonoids from Salvia chinensia Benth and their pro-apoptotic effect on hepatocellular carcinoma cells: potential roles of suppressing cellular NF-κB signaling.
Suppression of the p66shc adapter protein by protocatechuic acid prevents the development of lung injury induced by intestinal ischemia reperfusion in mice.
CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.
Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma.
Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma.
Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.
Zhou X, Shen K, Cao S, Li P, Xiao J, Dong J, Cheng Q, Hu L, Xu Z, Yang L
Cancer cell international 2024 May 7;24(1):159
Cancer cell international 2024 May 7;24(1):159
CD74-ROS1 L2026M mutant enhances autophagy through the MEK/ERK pathway to promote invasion, metastasis and crizotinib resistance in non-small cell lung cancer cells.
Xu X, Li Y, Xu R, Meng Y, Li Z, Zuo D, Wu Y
The FEBS journal 2024 Mar;291(6):1199-1219
The FEBS journal 2024 Mar;291(6):1199-1219
GSK-126 Attenuates Cell Apoptosis in Ischemic Brain Injury by Modulating the EZH2-H3K27me3-Bcl2l1 Axis.
Zhou T, Zhang L, He L, Lan Y, Ding L, Li L, Wang Z
Molecular neurobiology 2024 Jun;61(6):3369-3383
Molecular neurobiology 2024 Jun;61(6):3369-3383
Fucoxanthin induces human melanoma cytotoxicity by thwarting the JAK2/STAT3/BCL-xL signaling axis.
Kuo MY, Dai WC, Chang JL, Chang JS, Lee TM, Chang CC
Environmental toxicology 2024 Jun;39(6):3356-3366
Environmental toxicology 2024 Jun;39(6):3356-3366
LC-MS based metabonomics study on protective mechanism of ESWW in cerebral ischemia via CYTC/Apaf-1/NDRG4 pathway.
Liang Y, Wang F, Song Y, Tang C, Wu R, Feng Q, Han M, Li Y, Chen W, Zhang J, Jiang M, Wang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155543
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155543
Chidamide enhances T-cell-mediated anti-tumor immune function by inhibiting NOTCH1/NFATC1 signaling pathway in ABC-type diffuse large B-cell lymphoma.
Li L, Yang W, Pan Y, Ye R, Wang Y, Li S, Jiang H, Zhang Q, Wang X, Yan J
Leukemia & lymphoma 2024 Jul;65(7):895-910
Leukemia & lymphoma 2024 Jul;65(7):895-910
Suppression of the SLC7A11/glutathione axis causes ferroptosis and apoptosis and alters the mitogen-activated protein kinase pathway in nasopharyngeal carcinoma.
Wang HH, Fan SQ, Zhan YT, Peng SP, Wang WY
International journal of biological macromolecules 2024 Jan;254(Pt 3):127976
International journal of biological macromolecules 2024 Jan;254(Pt 3):127976
Endoplasmic reticulum stress exacerbates microplastics-induced toxicity in animal cells.
Wang Z, Liu S, Cheng Z, Xu G, Li F, Bu Q, Zhang L, Song Y, An X
Food research international (Ottawa, Ont.) 2024 Jan;175:113818
Food research international (Ottawa, Ont.) 2024 Jan;175:113818
TMT-based proteomics analysis identifies the interventional mechanisms of Qijia Rougan decoction in improving hepatic fibrosis.
Chen X, Sun X, Ji S, Yu H, Wu P
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117334
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117334
Proteomic analysis reveals that cigarette smoke exposure diminishes ovarian reserve in mice by disrupting the CREB1-mediated ovarian granulosa cell proliferation-apoptosis balance.
Xu M, Li F, Xu X, Hu N, Miao J, Zhao Y, Ji S, Wang Y, Wang L
Ecotoxicology and environmental safety 2024 Feb;271:115989
Ecotoxicology and environmental safety 2024 Feb;271:115989
Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity.
Zhou Q, Shi D, Tang YD, Zhang L, Hu B, Zheng C, Huang L, Weng C
PLoS pathogens 2024 Apr;20(4):e1012146
PLoS pathogens 2024 Apr;20(4):e1012146
Anti-hepatocellular carcinoma activity of Sorbaria sorbifolia by regulating VEGFR and c-Met/apoptotic pathway.
Xu ZH, Dang Y, Dong Y, Dong CY, Liu Y, Chen X, Yao Z, Shi JP
Journal of ethnopharmacology 2024 Apr 24;324:117758
Journal of ethnopharmacology 2024 Apr 24;324:117758
The MDM2-p53 Axis Represents a Therapeutic Vulnerability Unique to Glioma Stem Cells.
Nakagawa-Saito Y, Mitobe Y, Togashi K, Suzuki S, Sugai A, Takenouchi S, Nakamura K, Sonoda Y, Kitanaka C, Okada M
International journal of molecular sciences 2024 Apr 2;25(7)
International journal of molecular sciences 2024 Apr 2;25(7)
A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy.
Wang N, Zhang Q, Wang Z, Liu Y, Yang S, Zhao X, Peng J
Carbohydrate polymers 2024 Apr 1;329:121795
Carbohydrate polymers 2024 Apr 1;329:121795
A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3β/β-Catenin and TGF-β/Smad2/3 Signaling Pathways.
Duan SF, Zhang MM, Dong Q, Yang B, Liu W, Zhang X, Yu HL, Zhang SH, Khan NH, Wu DD, Zhang XJ, Cen J
Journal of oncology 2023;2023:8456852
Journal of oncology 2023;2023:8456852
Exogenous Hydrogen Sulfide Induces A375 Melanoma Cell Apoptosis Through Overactivation of the Unfolded Protein Response.
Ma W, Zhang X, Zhuang L
Clinical, cosmetic and investigational dermatology 2023;16:1641-1651
Clinical, cosmetic and investigational dermatology 2023;16:1641-1651
Burn-Induced Apoptosis in the Livers of Aged Mice Is Associated With Caspase Cleavage of Bcl-xL.
Muro I, Qualman AC, Kovacs EJ, Idrovo JP
The Journal of surgical research 2023 Oct;290:147-155
The Journal of surgical research 2023 Oct;290:147-155
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ren M, Ma K, Pang X, Liu Y, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Platycodin D induces apoptotic cell death through PI3K/AKT and MAPK/ERK pathways and synergizes with venetoclax in acute myeloid leukemia.
Jiang X, Lin Y, Zhao M, Li Y, Ye P, Pei R, Lu Y, Jiang L
European journal of pharmacology 2023 Oct 5;956:175957
European journal of pharmacology 2023 Oct 5;956:175957
Inhibition of endogenous hydrogen sulfide production suppresses the growth of nasopharyngeal carcinoma cells.
Wang DY, Zhang J, Li HX, Zhang YX, Jing MR, Cai CB, Wang D, Qi HW, Wang YZ, Chen HJ, Li T, Zhai YK, Ji XY, Wu DD
Molecular carcinogenesis 2023 May;62(5):652-664
Molecular carcinogenesis 2023 May;62(5):652-664
Venetoclax-Resistant T-ALL Cells Display Distinct Cancer Stem Cell Signatures and Enrichment of Cytokine Signaling.
Shah K, Al Ashiri L, Nasimian A, Ahmed M, Kazi JU
International journal of molecular sciences 2023 Mar 5;24(5)
International journal of molecular sciences 2023 Mar 5;24(5)
Gastroprotective effects of ginsenoside Rh4 against ethanol-induced gastric mucosal injury by inhibiting the MAPK/NF-κB signaling pathway.
Wu Y, Duan Z, Qu L, Zhang Y, Zhu C, Fan D
Food & function 2023 Jun 6;14(11):5167-5181
Food & function 2023 Jun 6;14(11):5167-5181
A multi-bioresponsive self-assembled nano drug delivery system based on hyaluronic acid and geraniol against liver cancer.
Duan S, Xia Y, Tian X, Cui J, Zhang X, Yang Q, Zhao T, Lin Y, Zhang F, Zhang X, Cen J
Carbohydrate polymers 2023 Jun 15;310:120695
Carbohydrate polymers 2023 Jun 15;310:120695
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8(+) T cell function and anti-tumor immunity.
Zhao Y, Caron C, Chan YY, Lee CK, Xu X, Zhang J, Masubuchi T, Wu C, Bui JD, Hui E
Immunity 2023 Jun 13;56(6):1187-1203.e12
Immunity 2023 Jun 13;56(6):1187-1203.e12
Fenofibrate attenuates the cytotoxic effect of cisplatin on lung cancer cells by enhancing the antioxidant defense system in vitro.
Kogami M, Abe S, Nakamura H, Aoshiba K
Oncology letters 2023 Jul;26(1):313
Oncology letters 2023 Jul;26(1):313
Platycodin D induces proliferation inhibition and mitochondrial apoptosis in diffuse large B-cell lymphoma.
Liu P, Zhao M, Lin Y, Jiang X, Xia T, Li Y, Lu Y, Jiang L
Experimental hematology 2023 Jul;123:46-55.e1
Experimental hematology 2023 Jul;123:46-55.e1
Photobiomodulation treatment inhibits neurotoxic astrocytic polarization and protects neurons in in vitro and in vivo stroke models.
Feng Y, Yang L, Ma X, Huang Z, Zong X, Citadin CT, Lin HW, Zhang Q
Neurochemistry international 2023 Jan;162:105464
Neurochemistry international 2023 Jan;162:105464
A Mulberry Diels-Alder-Type Adduct, Kuwanon M, Triggers Apoptosis and Paraptosis of Lung Cancer Cells through Inducing Endoplasmic Reticulum Stress.
Ma M, Luan X, Zheng H, Wang X, Wang S, Shen T, Ren D
International journal of molecular sciences 2023 Jan 5;24(2)
International journal of molecular sciences 2023 Jan 5;24(2)
Integrated network pharmacology and experimental validation to explore the mechanisms underlying naringenin treatment of chronic wounds.
Sun R, Liu C, Liu J, Yin S, Song R, Ma J, Cao G, Lu Y, Zhang G, Wu Z, Chen A, Wang Y
Scientific reports 2023 Jan 4;13(1):132
Scientific reports 2023 Jan 4;13(1):132
Jinhua Qinggan granules attenuates acute lung injury by promotion of neutrophil apoptosis and inhibition of TLR4/MyD88/NF-κB pathway.
Zhu Y, Han Q, Wang L, Wang B, Chen J, Cai B, Wu C, Zhu X, Liu F, Han D, Dong H, Jia Y, Liu Y
Journal of ethnopharmacology 2023 Jan 30;301:115763
Journal of ethnopharmacology 2023 Jan 30;301:115763
Molecular mechanism of the miR-7/BCL2L1/P53 signaling axis regulating the progression of hepatocellular carcinoma.
Zhang N, Wang F, Zhu L, Chang R, Mok SRS, Peixoto RD, Tang W, Chen Z
Annals of translational medicine 2023 Jan 15;11(1):12
Annals of translational medicine 2023 Jan 15;11(1):12
Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia.
Kamachi K, Ureshino H, Watanabe T, Yoshida-Sakai N, Fukuda-Kurahashi Y, Kawasoe K, Hoshiko T, Yamamoto Y, Kurahashi Y, Kimura S
Cancer research communications 2023 Feb;3(2):297-308
Cancer research communications 2023 Feb;3(2):297-308
Navitoclax (ABT-263) Rejuvenates Human Skin by Eliminating Senescent Dermal Fibroblasts in a Mouse/Human Chimeric Model.
Takaya K, Ishii T, Asou T, Kishi K
Rejuvenation research 2023 Feb;26(1):9-20
Rejuvenation research 2023 Feb;26(1):9-20
Protective effects of pentoxifylline against chlorine-induced acute lung injury in rats.
Liu MM, Liu JZ, Zhao CQ, Guo P, Wang Z, Wu H, Yu W, Liu R, Hai CX, Zhang XD
BMC pharmacology & toxicology 2023 Feb 27;24(1):12
BMC pharmacology & toxicology 2023 Feb 27;24(1):12
Dihydromyricetin Inhibits Pseudorabies Virus Multiplication In Vitro by Regulating NF-κB Signaling Pathway and Apoptosis.
Zhao X, Chen Y, Zhang W, Zhang H, Hu Y, Yang F, Zhang Y, Song X
Veterinary sciences 2023 Feb 2;10(2)
Veterinary sciences 2023 Feb 2;10(2)
Six first-line tyrosine kinase inhibitors reveal novel inhibition potential for the EGFR S768I mutation.
Wang Y, Liu Q, Chu C, Li L, Wang Z, Liu Q, Wu G, Wei X, An L, Ma J
Toxicology and applied pharmacology 2023 Feb 15;461:116385
Toxicology and applied pharmacology 2023 Feb 15;461:116385
CUDC‑101 is a potential target inhibitor for the EGFR‑overexpression bladder cancer cells.
Wang Z, Li L, Chu C, Wei X, Liu Q, Wang R, Zhang G, Wu G, Wang Y, An L, Li X
International journal of oncology 2023 Dec;63(6)
International journal of oncology 2023 Dec;63(6)
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Wang HG, Wang D, Sarfraz M, Afzal A, Jing MR, Zhang YX, Cai CB, Qi HW, Chen HJ, Li T, Hu SJ, Liu HX, Ji XY, Wu DD
Translational oncology 2023 Dec;38:101770
Translational oncology 2023 Dec;38:101770
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Wang X, Zhou Y, Sun Q, Zhang Q, Zhou H, Zhang J, Du Y, Wang Y, Yuan K, Xu L, Zhang M, Yan D, Zeng L, Xu K, Sang W
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
The STAT3 inhibitor stattic overcome bortezomib-resistance in multiple myeloma via decreasing PSMB6.
Yuan C, Yuan M, Li W, Cheng H, Luo J, Zhang Q, Shi M, Niu M, Yang J, Sun Z, Yan Z, Xu K, Li Z, Yao Y
Experimental cell research 2023 Aug 1;429(1):113634
Experimental cell research 2023 Aug 1;429(1):113634
Overexpression of C9orf72 exacerbates Aβ25‑35‑induced oxidative stress and apoptosis in PC12 cells.
Chen J, Zhang M, Bai H, Shi P, Du M, Zhang S, Lou J
Acta neurobiologiae experimentalis 2022;82(1):77-87
Acta neurobiologiae experimentalis 2022;82(1):77-87
Cystathionine β-Synthase Regulates the Proliferation, Migration, and Invasion of Thyroid Carcinoma Cells.
Jiang QY, Li JM, Jing MR, Zhang YX, Zhang QQ, Cai CB, Wang D, Qi HW, Li T, Li YZ, Ji XY, Wu DD
Oxidative medicine and cellular longevity 2022;2022:8678363
Oxidative medicine and cellular longevity 2022;2022:8678363
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Chen J, Cui Z, Wang Y, Lyu L, Feng C, Feng D, Cheng Y, Li Z, Sun S
Oxidative medicine and cellular longevity 2022;2022:3182368
Oxidative medicine and cellular longevity 2022;2022:3182368
Smad7 Is Highly Expressed in Human Degenerative Discs and Participates in IL-1β-Induced Apoptosis of Rat AF Cells via the Mitochondria Pathway.
Li B, Lu ZY, Jiang SD, Jiang LS, Zheng XF
Oxidative medicine and cellular longevity 2022;2022:2912276
Oxidative medicine and cellular longevity 2022;2022:2912276
PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer.
Chen YG, Liu HX, Hong Y, Dong PZ, Liu SY, Gao YR, Lu D, Li T, Wang DY, Wu DD, Ji XY
International journal of biological sciences 2022;18(9):3605-3620
International journal of biological sciences 2022;18(9):3605-3620
Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway.
Bai Y, Chen J, Hu W, Wang L, Wu Y, Yu S
Frontiers in pharmacology 2022;13:847905
Frontiers in pharmacology 2022;13:847905
Combined treatment with dihydrotestosterone and lipopolysaccharide modulates prostate homeostasis by upregulating TNF-α from M1 macrophages and promotes proliferation of prostate stromal cells.
Tong Y, Guo YJ, Zhang Q, Bi HX, Kai K, Zhou RY
Asian journal of andrology 2022 Sep-Oct;24(5):513-520
Asian journal of andrology 2022 Sep-Oct;24(5):513-520
Chelerythrine-Induced Apoptotic Cell Death in HepG2 Cells Involves the Inhibition of Akt Pathway and the Activation of Oxidative Stress and Mitochondrial Apoptotic Pathway.
Lin Y, Zhang Q, Xie B, Jiang H, Shen J, Tang S, Dai C
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 18;11(9)
Single-nucleus RNA Sequencing reveals the mechanism of cigarette smoke exposure on diminished ovarian reserve in mice.
Li F, Wang Y, Xu M, Hu N, Miao J, Zhao Y, Wang L
Ecotoxicology and environmental safety 2022 Oct 15;245:114093
Ecotoxicology and environmental safety 2022 Oct 15;245:114093
HA-ADT suppresses esophageal squamous cell carcinoma progression via apoptosis promotion and autophagy inhibition.
Duan SF, Zhang MM, Zhang X, Liu W, Zhang SH, Yang B, Dong Q, Han JG, Yu HL, Li T, Ji XY, Wu DD, Zhang XJ
Experimental cell research 2022 Nov 1;420(1):113341
Experimental cell research 2022 Nov 1;420(1):113341
BCL2L1 is identified as a target of naringenin in regulating ovarian cancer progression.
Xu J, Guo Z, Yuan S, Li H
Molecular and cellular biochemistry 2022 May;477(5):1541-1553
Molecular and cellular biochemistry 2022 May;477(5):1541-1553
Mitogen-activating protein kinase kinase kinase kinase-3, inhibited by Astragaloside IV through H3 lysine 4 monomethylation, promotes the progression of diabetic nephropathy by inducing apoptosis.
Fan Y, Fan H, Li P, Liu Q, Huang L, Zhou Y
Bioengineered 2022 May;13(5):11517-11529
Bioengineered 2022 May;13(5):11517-11529
Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer.
Sela Y, Li J, Maheswaran S, Norgard R, Yuan S, Hubbi M, Doepner M, Xu JP, Ho ES, Mesaros C, Sheehan C, Croley G, Muir A, Blair IA, Shalem O, Dang CV, Stanger BZ
Cancer research 2022 May 16;82(10):1890-1908
Cancer research 2022 May 16;82(10):1890-1908
Exercise-induced neuroprotection against cerebral ischemia/reperfusion injury is mediated via alleviating inflammasome-induced pyroptosis.
Liu MX, Luo L, Fu JH, He JY, Chen MY, He ZJ, Jia J
Experimental neurology 2022 Mar;349:113952
Experimental neurology 2022 Mar;349:113952
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
Tian H, Wang G, Wang Q, Zhang B, Jiang G, Li H, Chai D, Fang L, Wang M, Zheng J
Cancer science 2022 Mar;113(3):875-890
Cancer science 2022 Mar;113(3):875-890
Gemcitabine Cooperates with Everolimus to Inhibit the Growth of and Sensitize Malignant Meningioma Cells to Apoptosis Induced by Navitoclax, an Inhibitor of Anti-Apoptotic BCL-2 Family Proteins.
Yamamoto M, Suzuki S, Togashi K, Sugai A, Okada M, Kitanaka C
Cancers 2022 Mar 27;14(7)
Cancers 2022 Mar 27;14(7)
Deduction of CDC42EP3 suppress development and progression of osteosarcoma.
Xu P, Li X, Tang C, Wang T, Xu J
Experimental cell research 2022 Mar 1;412(1):113018
Experimental cell research 2022 Mar 1;412(1):113018
Pharmacological Inhibition of Endogenous Hydrogen Sulfide Attenuates Breast Cancer Progression.
Khan NH, Wang D, Wang W, Shahid M, Khattak S, Ngowi EE, Sarfraz M, Ji XY, Zhang CY, Wu DD
Molecules (Basel, Switzerland) 2022 Jun 23;27(13)
Molecules (Basel, Switzerland) 2022 Jun 23;27(13)
BNIP3 mediates the different adaptive responses of fibroblast-like synovial cells to hypoxia in patients with osteoarthritis and rheumatoid arthritis.
Deng R, Wang Y, Bu Y, Wu H
Molecular medicine (Cambridge, Mass.) 2022 Jun 11;28(1):64
Molecular medicine (Cambridge, Mass.) 2022 Jun 11;28(1):64
Gamma-oryzanol protects human liver cell (L02) from hydrogen peroxide-induced oxidative damage through regulation of the MAPK/Nrf2 signaling pathways.
Ma Y, Xiang S, Jiang W, Kong L, Tan Z, Liang Z, Yuan Z, Yi J, Zhu L
Journal of food biochemistry 2022 Jul;46(7):e14118
Journal of food biochemistry 2022 Jul;46(7):e14118
Effect of alfalfa substituted with ramie on the expression of apoptotic genes in the gastrointestinal tracts of goats.
Liu Q, Fu C, Yang H, Zhou C, Kang J, Chen L, Kong Z, Tan Z, Tang S
Food science & nutrition 2022 Jul;10(7):2400-2407
Food science & nutrition 2022 Jul;10(7):2400-2407
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15
Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma.
Zhang Q, Gao Y, Zhang Y, Jing M, Wang D, Wang Y, Khattak S, Qi H, Cai C, Zhang J, Ngowi EE, Khan NH, Li T, Ji A, Jiang Q, Ji X, Li Y, Wu D
Oncogene 2022 Dec;41(49):5238-5252
Oncogene 2022 Dec;41(49):5238-5252
The Photoperiod Regulates Granulosa Cell Apoptosis through the FSH-Nodal/ALK7 Signaling Pathway in Phodopus sungorus.
Qi Y, Xue HL, Zheng YJ, Yin YF, Xu WL, Xu JH, Wu M, Chen L, Xu LX
Animals : an open access journal from MDPI 2022 Dec 16;12(24)
Animals : an open access journal from MDPI 2022 Dec 16;12(24)
Epigallocatechin-3-Gallate Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease via Inhibition of Apoptosis and Promotion of Autophagy through the ROS/MAPK Signaling Pathway.
Wu D, Liu Z, Wang Y, Zhang Q, Li J, Zhong P, Xie Z, Ji A, Li Y
Oxidative medicine and cellular longevity 2021;2021:5599997
Oxidative medicine and cellular longevity 2021;2021:5599997
Thymoquinone Suppresses the Proliferation, Migration and Invasiveness through Regulating ROS, Autophagic Flux and miR-877-5p in Human Bladder Carcinoma Cells.
Zhou X, Wang F, Wu H, Chen X, Zhang Y, Lin J, Cai Y, Xiang J, He N, Hu Z, Jin X
International journal of biological sciences 2021;17(13):3456-3475
International journal of biological sciences 2021;17(13):3456-3475
Selonsertib Alleviates the Progression of Rat Osteoarthritis: An in vitro and in vivo Study.
Yan J, Zhang Y, Sheng G, Ni B, Xiao Y, Wang S, Wang T, Ma Y, Wang H, Wu H, Tu C
Frontiers in pharmacology 2021;12:687033
Frontiers in pharmacology 2021;12:687033
Reconstituting neurovascular unit with primary neural stem cells and brain microvascular endothelial cells in three-dimensional matrix.
Wang H, Yang H, Shi Y, Xiao Y, Yin Y, Jiang B, Ren H, Chen W, Xue Q, Xu X
Brain pathology (Zurich, Switzerland) 2021 Sep;31(5):e12940
Brain pathology (Zurich, Switzerland) 2021 Sep;31(5):e12940
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Wang J, Su Q, Wu Q, Chen K, Ullah A, Ghauri MA, Zhang Y
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Anti-glioblastoma effects of nanomicelle-curcumin plus erlotinib.
Bagherian A, Roudi B, Masoudian N, Mirzaei H
Food & function 2021 Nov 1;12(21):10926-10937
Food & function 2021 Nov 1;12(21):10926-10937
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Han B, Jiang P, Jiang L, Li X, Ye X
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway.
Li H, Dang C, Tai X, Xue L, Meng Y, Ma S, Zhang J
Scientific reports 2021 Jul 22;11(1):14985
Scientific reports 2021 Jul 22;11(1):14985
Hyperoside ameliorates the progression of osteoarthritis: An in vitro and in vivo study.
Sun K, Luo J, Jing X, Xiang W, Guo J, Yao X, Liang S, Guo F, Xu T
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153387
p53 induces ARTS to promote mitochondrial apoptosis.
Hao Q, Chen J, Liao J, Huang Y, Gan Y, Larisch S, Zeng SX, Lu H, Zhou X
Cell death & disease 2021 Feb 24;12(2):204
Cell death & disease 2021 Feb 24;12(2):204
Total saponins from Rhizoma Panacis Majoris inhibit proliferation, induce cell cycle arrest and apoptosis and influence MAPK signalling pathways on the colorectal cancer cell.
Chang L, Zhou R, He Y, Meng M, Hu J, Liu Y, Pan Y, Tang Z, Yue Z
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
Adipose-derived stem cells alleviate radiation-induced dermatitis by suppressing apoptosis and downregulating cathepsin F expression.
Yao C, Zhou Y, Wang H, Deng F, Chen Y, Zhu X, Kong Y, Pan L, Xue L, Zhou X, Shi C, Sheng X
Stem cell research & therapy 2021 Aug 9;12(1):447
Stem cell research & therapy 2021 Aug 9;12(1):447
Dracomolphin A-E, new lignans from Dracocephalum moldavica.
Zhang H, Wang S, Liu Q, Zheng H, Liu X, Wang X, Shen T, Ren D
Fitoterapia 2021 Apr;150:104841
Fitoterapia 2021 Apr;150:104841
Modulation of Wnt/β-catenin signaling in IL-17A-mediated macrophage polarization of RAW264.7 cells.
Yuan C, Yang D, Ma J, Yang J, Xue J, Song F, Liu X
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2020;53(8):e9488
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2020;53(8):e9488
Dihydroartemisinin Modulates Apoptosis and Autophagy in Multiple Myeloma through the P38/MAPK and Wnt/β-Catenin Signaling Pathways.
Wu X, Liu Y, Zhang E, Chen J, Huang X, Yan H, Cao W, Qu J, Gu H, Xu R, He J, Cai Z
Oxidative medicine and cellular longevity 2020;2020:6096391
Oxidative medicine and cellular longevity 2020;2020:6096391
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
Deng X, Liu J, Liu L, Sun X, Huang J, Dong J
International journal of biological sciences 2020;16(8):1403-1416
International journal of biological sciences 2020;16(8):1403-1416
Activated STAT3 Could Reduce Survival in Patients with Esophageal Squamous Cell Carcinoma by Up-regulating VEGF and Cyclin D1 Expression.
Zhang N, Zhang M, Wang Z, Gao W, Sun ZG
Journal of Cancer 2020;11(7):1859-1868
Journal of Cancer 2020;11(7):1859-1868
Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms.
Su W, Zhao J, Fan TJ
Frontiers in pharmacology 2020;11:202
Frontiers in pharmacology 2020;11:202
Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells.
Gao Y, Wen P, Chen B, Hu G, Wu L, Xu A, Zhao G
International journal of molecular sciences 2020 Sep 12;21(18)
International journal of molecular sciences 2020 Sep 12;21(18)
Comparison of the Effects of Nonprotein and Protein Nitrogen on Apoptosis and Autophagy of Rumen Epithelial Cells in Goats.
Kong Z, Zhou C, Kang J, Tan Z
Animals : an open access journal from MDPI 2020 Nov 9;10(11)
Animals : an open access journal from MDPI 2020 Nov 9;10(11)
Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells.
Wang J, Liu X, Zheng H, Liu Q, Zhang H, Wang X, Shen T, Wang S, Ren D
Chemico-biological interactions 2020 Nov 1;331:109279
Chemico-biological interactions 2020 Nov 1;331:109279
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
Zhang Y, Liu X, Yu M, Xu M, Xiao Y, Ma W, Huang L, Li X, Ye X
Life sciences 2020 Nov 1;260:118413
Life sciences 2020 Nov 1;260:118413
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, Li C, Li X, Ye X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 May 17;76:153216
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 May 17;76:153216
δ-Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β-catenin nuclear localization and activating its downstream target genes.
Ju L, Shan L, Yin B, Song Y
Cancer medicine 2020 Mar;9(6):2201-2212
Cancer medicine 2020 Mar;9(6):2201-2212
Blockade of HSP70 by VER-155008 synergistically enhances bortezomib-induced cytotoxicity in multiple myeloma.
Huang L, Wang Y, Bai J, Yang Y, Wang F, Feng Y, Zhang R, Li F, Zhang P, Lv N, Lei L, Hu J, He A
Cell stress & chaperones 2020 Mar;25(2):357-367
Cell stress & chaperones 2020 Mar;25(2):357-367
Synergetic inhibition of daidzein and regular exercise on breast cancer in bearing-4T1 mice by regulating NK cells and apoptosis pathway.
Wang B, Xu H, Hu X, Ma W, Zhang J, Li Y, Yu M, Zhang Y, Li X, Ye X
Life sciences 2020 Mar 15;245:117387
Life sciences 2020 Mar 15;245:117387
Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-κB and Nrf2 pathways.
Jin W, Xue Y, Xue Y, Han X, Song Q, Zhang J, Li Z, Cheng J, Guan S, Sun S, Chu L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110047
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jun;126:110047
PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.
Dong P, Fu H, Chen L, Zhang S, Zhang X, Li H, Wu D, Ji X
Journal of cellular and molecular medicine 2020 Jul;24(14):8221-8235
Journal of cellular and molecular medicine 2020 Jul;24(14):8221-8235
MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway.
Yang QY, Yang KP, Li ZZ
The Kaohsiung journal of medical sciences 2020 Jan;36(1):20-26
The Kaohsiung journal of medical sciences 2020 Jan;36(1):20-26
Tetrandrine enhances antitumor effects of the histone deacetylase inhibitor MS-275 in human cancer in a Bax- and p53-dependent manner.
Li H, Xu X, Zhang Y, Tang X, Li W
European journal of pharmacology 2020 Dec 5;888:173575
European journal of pharmacology 2020 Dec 5;888:173575
Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux.
Guan S, Tao S, Huang Y, Jin Y, Hu Y, Lu J
Ecotoxicology and environmental safety 2020 Dec 1;205:111062
Ecotoxicology and environmental safety 2020 Dec 1;205:111062
Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation.
Han J, Kan J, Wang X, Yuan Q, Song X, Huang M, Wu H
Translational cancer research 2020 Aug;9(8):4715-4725
Translational cancer research 2020 Aug;9(8):4715-4725
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
Yang T, Fan TJ, Xu B
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis.
Su Q, Wang J, Liu F, Zhang Y
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104840
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104840
Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways.
Xu B, Sui YL, Fan TJ
International journal of ophthalmology 2019;12(10):1524-1530
International journal of ophthalmology 2019;12(10):1524-1530
Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway.
Wu D, Li M, Gao Y, Tian W, Li J, Zhang Q, Liu Z, Zheng M, Wang H, Wang J, Teng T, Zhang L, Ji X, Xie Z, Ji A, Li Y
Journal of Cancer 2019;10(7):1693-1706
Journal of Cancer 2019;10(7):1693-1706
Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4.
Zhang X, Fang J, Chen S, Wang W, Meng S, Liu B
Cancer medicine 2019 Sep;8(12):5716-5734
Cancer medicine 2019 Sep;8(12):5716-5734
LncRNA HMMR-AS1 promotes proliferation and metastasis of lung adenocarcinoma by regulating MiR-138/sirt6 axis.
Cai Y, Sheng Z, Chen Y, Wang J
Aging 2019 May 25;11(10):3041-3054
Aging 2019 May 25;11(10):3041-3054
Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2α pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy.
Chen L, Liu L, Xie ZY, Wang F, Zhu L, Zhang C, Fan P, Sinkemani A, Hong X, Wu XT
Journal of cellular physiology 2019 Jul;234(7):11631-11645
Journal of cellular physiology 2019 Jul;234(7):11631-11645
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
Dong Q, Yang B, Han JG, Zhang MM, Liu W, Zhang X, Yu HL, Liu ZG, Zhang SH, Li T, Wu DD, Ji XY, Duan SF
Cancer letters 2019 Jul 28;455:60-72
Cancer letters 2019 Jul 28;455:60-72
Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction.
Zhang TY, Chen HY, Cao JL, Xiong HL, Mo XB, Li TL, Kang XZ, Zhao JH, Yin B, Zhao X, Huang CH, Yuan Q, Xue D, Xia NS, Yuan YA
Nature communications 2019 Jul 19;10(1):3192
Nature communications 2019 Jul 19;10(1):3192
Correlation between microbes and colorectal cancer: tumor apoptosis is induced by sitosterols through promoting gut microbiota to produce short-chain fatty acids.
Ma H, Yu Y, Wang M, Li Z, Xu H, Tian C, Zhang J, Ye X, Li X
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):168-183
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Zhang Y, Li Q, Yu S, Zhu C, Zhang Z, Cao H, Xu J
Biochemical and biophysical research communications 2019 Feb 12;509(3):753-762
Biochemical and biophysical research communications 2019 Feb 12;509(3):753-762
Soluble CXCL16 promotes TNF-α-induced apoptosis in DLBCL via the AMAD10-NF-κB regulatory feedback loop.
Yang H, Qiu B, Chen S, Xun Y, Pan Y, Chen M, Li WX, Liao W, El-Ashram S, Yang A, Liu F
Cell biology international 2019 Aug;43(8):863-874
Cell biology international 2019 Aug;43(8):863-874
The long noncoding RNA TPTE2P1 promotes the viability of colorectal cancer cells.
Dai X, Xie Y, Dong M, Zhao J, Yu H, Zhou B, Xu Y, Yu Y, Cao Y, Zhang Y
Journal of cellular biochemistry 2019 Apr;120(4):5268-5276
Journal of cellular biochemistry 2019 Apr;120(4):5268-5276
Protective Effect of Extract of Bletilla Striata on Isoflurane Induced Neuronal Injury By Altering PI3K/Akt Pathway.
Zhao G, Li K, Chen J, Li L
Translational neuroscience 2018;9:183-189
Translational neuroscience 2018;9:183-189
Glutaminolysis Mediated by MALT1 Protease Activity Facilitates PD-L1 Expression on ABC-DLBCL Cells and Contributes to Their Immune Evasion.
Xia X, Zhou W, Guo C, Fu Z, Zhu L, Li P, Xu Y, Zheng L, Zhang H, Shan C, Gao Y
Frontiers in oncology 2018;8:632
Frontiers in oncology 2018;8:632
Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells.
Wang J, Li M, Cui X, Lv D, Jin L, Khan M, Ma T
OncoTargets and therapy 2018;11:7031-7040
OncoTargets and therapy 2018;11:7031-7040
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
Du Y, Wang L, Chen S, Liu Y, Zhao Y
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
Alisol B-23-acetate, a tetracyclic triterpenoid isolated from Alisma orientale, induces apoptosis in human lung cancer cells via the mitochondrial pathway.
Wang J, Li H, Wang X, Shen T, Wang S, Ren D
Biochemical and biophysical research communications 2018 Nov 10;505(4):1015-1021
Biochemical and biophysical research communications 2018 Nov 10;505(4):1015-1021
Role of Daucosterol Linoleate on Breast Cancer: Studies on Apoptosis and Metastasis.
Han B, Jiang P, Liu W, Xu H, Li Y, Li Z, Ma H, Yu Y, Li X, Ye X
Journal of agricultural and food chemistry 2018 Jun 20;66(24):6031-6041
Journal of agricultural and food chemistry 2018 Jun 20;66(24):6031-6041
The role of the long non-coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR-93/RhoC pathway.
Chen S, Wang LL, Sun KX, Xiu YL, Zong ZH, Chen X, Zhao Y
Molecular carcinogenesis 2018 Feb;57(2):225-234
Molecular carcinogenesis 2018 Feb;57(2):225-234
Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.
Meng M, Chen Y, Jia J, Li L, Yang S
Biological research 2018 Aug 10;51(1):24
Biological research 2018 Aug 10;51(1):24
Silencing Lin28 promotes apoptosis in colorectal cancer cells by upregulating let‑7c targeting of antiapoptotic BCL2L1.
Zhang H, Zong Y, Qiu G, Jia R, Xu X, Wang F, Wu D
Molecular medicine reports 2018 Apr;17(4):5143-5149
Molecular medicine reports 2018 Apr;17(4):5143-5149
MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway.
Yin S, Du W, Wang F, Han B, Cui Y, Yang D, Chen H, Liu D, Liu X, Zhai X, Jiang C
Cancer biology & therapy 2018 Apr 3;19(4):260-270
Cancer biology & therapy 2018 Apr 3;19(4):260-270
Anticancer effect of PP31J isolated from Physalis pubescens L. in human cervical carcinoma cells.
Zeng W, Wang Q, Chen L, Huang L, Zhao X
American journal of translational research 2017;9(5):2466-2472
American journal of translational research 2017;9(5):2466-2472
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
Jiang Z, Song F, Li Y, Xue D, Zhao N, Zhang J, Deng G, Li M, Liu X, Wang Y
Oxidative medicine and cellular longevity 2017;2017:6175841
Oxidative medicine and cellular longevity 2017;2017:6175841
The role of long non-coding RNA PCA3 in epithelial ovarian carcinoma tumorigenesis and progression.
Liu Y, Zong ZH, Guan X, Wang LL, Zhao Y
Gene 2017 Oct 30;633:42-47
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DLEU1 contributes to ovarian carcinoma tumourigenesis and development by interacting with miR-490-3p and altering CDK1 expression.
Wang LL, Sun KX, Wu DD, Xiu YL, Chen X, Chen S, Zong ZH, Sang XB, Liu Y, Zhao Y
Journal of cellular and molecular medicine 2017 Nov;21(11):3055-3065
Journal of cellular and molecular medicine 2017 Nov;21(11):3055-3065
Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma.
Wang H, Zhu L, Feng X, Zhang H, Luo Q, Chen F
European journal of pharmacology 2017 Nov 15;815:282-289
European journal of pharmacology 2017 Nov 15;815:282-289
Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells.
Huang Z, Yang G, Shen T, Wang X, Li H, Ren D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 May;89:623-631
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 May;89:623-631
SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways.
Tang F, Hu P, Yang Z, Xue C, Gong J, Sun S, Shi L, Zhang S, Li Z, Yang C, Zhang J, Xie C
Oncology reports 2017 Jun;37(6):3449-3458
Oncology reports 2017 Jun;37(6):3449-3458
Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
Ning C, Liang M, Liu S, Wang G, Edwards H, Xia Y, Polin L, Dyson G, Taub JW, Mohammad RM, Azmi AS, Zhao L, Ge Y
Oncotarget 2017 Jul 4;8(27):44295-44311
Oncotarget 2017 Jul 4;8(27):44295-44311
Inhibition of store-operated Ca(2+) entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.
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Oncology letters 2017 Feb;13(2):921-929
Oncology letters 2017 Feb;13(2):921-929
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
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International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
MicroRNA-490 inhibits tumorigenesis and progression in breast cancer.
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OncoTargets and therapy 2016;9:4505-16
OncoTargets and therapy 2016;9:4505-16
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Drug design, development and therapy 2016;10:1225-32
Drug design, development and therapy 2016;10:1225-32
Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats.
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Molecular nutrition & food research 2016 Sep;60(9):1902-11
Molecular nutrition & food research 2016 Sep;60(9):1902-11
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
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Oncology reports 2016 Sep;36(3):1576-84
Oncology reports 2016 Sep;36(3):1576-84
Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction.
Mu Y, Yan WJ, Yin TL, Yang J
Molecular medicine reports 2016 Oct;14(4):3588-94
Molecular medicine reports 2016 Oct;14(4):3588-94
Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma.
Ye M, Wu Q, Zhang M, Huang J
Molecular medicine reports 2016 Oct;14(4):2953-8
Molecular medicine reports 2016 Oct;14(4):2953-8
Persistent Cytomegalovirus Infection in Amniotic Membranes of the Human Placenta.
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The American journal of pathology 2016 Nov;186(11):2970-2986
The American journal of pathology 2016 Nov;186(11):2970-2986
MicroRNA-184 Modulates Doxorubicin Resistance in Osteosarcoma Cells by Targeting BCL2L1.
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Medical science monitor : international medical journal of experimental and clinical research 2016 May 25;22:1761-5
Medical science monitor : international medical journal of experimental and clinical research 2016 May 25;22:1761-5
Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.
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Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7599-613
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7599-613
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
Zhao X, Tao X, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2016 Jun 4;21(6)
Molecules (Basel, Switzerland) 2016 Jun 4;21(6)
HIF-1α inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute myeloid leukemia.
Zhe N, Chen S, Zhou Z, Liu P, Lin X, Yu M, Cheng B, Zhang Y, Wang J
Cancer biology & therapy 2016 Jun 2;17(6):625-34
Cancer biology & therapy 2016 Jun 2;17(6):625-34
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
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Oncology reports 2016 Jul;36(1):589-97
Oncology reports 2016 Jul;36(1):589-97
Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer.
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Oncotarget 2016 Jan 26;7(4):4226-40
Oncotarget 2016 Jan 26;7(4):4226-40
Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway.
Zhao L, Wen Q, Yang G, Huang Z, Shen T, Li H, Ren D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Feb 15;23(2):114-22
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Feb 15;23(2):114-22
β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.
Li X, Lin Z, Zhang B, Guo L, Liu S, Li H, Zhang J, Ye Q
Scientific reports 2016 Feb 12;6:21010
Scientific reports 2016 Feb 12;6:21010
Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells.
Zhang G, Xu M, Zhang H, Song Y, Wang J, Zhang C
Toxicology and applied pharmacology 2016 Dec 15;313:1-9
Toxicology and applied pharmacology 2016 Dec 15;313:1-9
EGCG induces lung cancer A549 cell apoptosis by regulating Ku70 acetylation.
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Oncology reports 2016 Apr;35(4):2339-47
Oncology reports 2016 Apr;35(4):2339-47
By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice.
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Oncotarget 2015 May 30;6(15):13703-17
Oncotarget 2015 May 30;6(15):13703-17
Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells.
Wu P, Zhu X, Jin W, Hao S, Liu Q, Zhang L
Biochemical and biophysical research communications 2015 May 1;460(2):183-90
Biochemical and biophysical research communications 2015 May 1;460(2):183-90
An ESRG-interacting protein, COXII, is involved in pro-apoptosis of human embryonic stem cells.
Shi J, Ren C, Liu H, Wang L, Zhu B, Huang W, Liu W, Liu J, Liu Y, Xia X, Xu R, Jiang X
Biochemical and biophysical research communications 2015 May 1;460(2):130-5
Biochemical and biophysical research communications 2015 May 1;460(2):130-5
Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling.
Xiang M, Su H, Hong Z, Yang T, Shu G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jun;80:62-71
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2015 Jun;80:62-71
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Liu J, Huang W, Ren C, Wen Q, Liu W, Yang X, Wang L, Zhu B, Zeng L, Feng X, Zhang C, Chen H, Jia W, Zhang L, Xia X, Chen Y
Scientific reports 2015 Jul 24;5:11614
Scientific reports 2015 Jul 24;5:11614
Protective efficacy of carnosic acid against hydrogen peroxide induced oxidative injury in HepG2 cells through the SIRT1 pathway.
Hu Y, Zhang N, Fan Q, Lin M, Zhang C, Fan G, Zhai X, Zhang F, Chen Z, Yao J
Canadian journal of physiology and pharmacology 2015 Aug;93(8):625-31
Canadian journal of physiology and pharmacology 2015 Aug;93(8):625-31
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Huang W, Liu J, Feng X, Chen H, Zeng L, Huang G, Liu W, Wang L, Jia W, Chen J, Ren C
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells.
Sun S, Han Y, Liu J, Fang Y, Tian Y, Zhou J, Ma D, Wu P
PloS one 2014;9(3):e91610
PloS one 2014;9(3):e91610
PNMA1 promotes cell growth in human pancreatic ductal adenocarcinoma.
Jiang SH, He P, Ma MZ, Wang Y, Li RK, Fang F, Fu Y, Tian GA, Qin WX, Zhang ZG
International journal of clinical and experimental pathology 2014;7(7):3827-35
International journal of clinical and experimental pathology 2014;7(7):3827-35
Serine threonine kinase Pim-3 regulates STAT3 pathway to inhibit proliferation of human liver cancers.
Wang J, Lao L, Zhao H, Huang Y
International journal of clinical and experimental medicine 2014;7(2):348-55
International journal of clinical and experimental medicine 2014;7(2):348-55
Modulating the p66shc signaling pathway with protocatechuic acid protects the intestine from ischemia-reperfusion injury and alleviates secondary liver damage.
Ma L, Wang G, Chen Z, Li Z, Yao J, Zhao H, Wang S, Ma Z, Chang H, Tian X
TheScientificWorldJournal 2014;2014:387640
TheScientificWorldJournal 2014;2014:387640
The mitochondrial thioredoxin is required for liver development in zebrafish.
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Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Tao X, Wan X, Xu Y, Xu L, Qi Y, Yin L, Han X, Lin Y, Peng J
Transplantation 2014 Sep 27;98(6):604-11
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Pao Pereira Extract Suppresses Castration-Resistant Prostate Cancer Cell Growth, Survival, and Invasion Through Inhibition of NFκB Signaling.
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Integrative cancer therapies 2014 May;13(3):249-58
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Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Dong D, Xu L, Han X, Qi Y, Xu Y, Yin L, Liu K, Peng J
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
KLF9, a transcription factor induced in flutamide-caused cell apoptosis, inhibits AKT activation and suppresses tumor growth of prostate cancer cells.
Shen P, Sun J, Xu G, Zhang L, Yang Z, Xia S, Wang Y, Liu Y, Shi G
The Prostate 2014 Jun;74(9):946-58
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ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21((CIP1/WAF1)) in human cancer cells.
Li J, Chen Y, Wan J, Liu X, Yu C, Li W
British journal of pharmacology 2014 Jul;171(13):3182-95
British journal of pharmacology 2014 Jul;171(13):3182-95
Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats.
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Toxicology letters 2014 Jul 15;228(2):67-74
Toxicology letters 2014 Jul 15;228(2):67-74
Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo.
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Chemico-biological interactions 2014 Dec 5;224:149-56
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Liu M, Xu Y, Han X, Liang C, Yin L, Xu L, Qi Y, Zhao Y, Peng J, Sun C
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Sine oculis homeobox homolog 1 promotes α5β1-mediated invasive migration and metastasis of cervical cancer cells.
Liu D, Zhang XX, Wan DY, Xi BX, Ma D, Wang H, Gao QL
Biochemical and biophysical research communications 2014 Apr 4;446(2):549-54
Biochemical and biophysical research communications 2014 Apr 4;446(2):549-54
Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway.
Wei Y, Xu Y, Han X, Qi Y, Xu L, Xu Y, Yin L, Sun H, Liu K, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Sep;59:118-28
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Synergistic anti-glioma effect of Hydroxygenkwanin and Apigenin in vitro.
Wang Y, Xu YS, Yin LH, Xu LN, Peng JY, Zhou H, Kang W
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Synergistic antitumour activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species (ROS)/Akt signaling.
Wan J, Liu T, Mei L, Li J, Gong K, Yu C, Li W
British journal of cancer 2013 Jul 23;109(2):342-50
British journal of cancer 2013 Jul 23;109(2):342-50
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Li JJ, Gu QH, Li M, Yang HP, Cao LM, Hu CP
Oncology letters 2013 Jan;5(1):101-106
Oncology letters 2013 Jan;5(1):101-106
Chemical composition of total flavonoids from Salvia chinensia Benth and their pro-apoptotic effect on hepatocellular carcinoma cells: potential roles of suppressing cellular NF-κB signaling.
Xiang M, Su H, Hu Y, Hu Y, Yang T, Shu G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:420-6
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:420-6
Suppression of the p66shc adapter protein by protocatechuic acid prevents the development of lung injury induced by intestinal ischemia reperfusion in mice.
Wang GZ, Yao JH, Jing HR, Zhang F, Lin MS, Shi L, Wu H, Gao DY, Liu KX, Tian XF
The journal of trauma and acute care surgery 2012 Nov;73(5):1130-7
The journal of trauma and acute care surgery 2012 Nov;73(5):1130-7
CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.
Gong K, Xie J, Yi H, Li W
The Biochemical journal 2012 May 1;443(3):735-46
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Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma.
Liu C, Gong K, Mao X, Li W
International journal of cancer 2011 Sep 15;129(6):1519-31
International journal of cancer 2011 Sep 15;129(6):1519-31
Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma.
Gong K, Li W
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Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling.
Lin C, Jiang X, Dai Z, Guo X, Weng T, Wang J, Li Y, Feng G, Gao X, He L
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Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009 Oct;24(10):1651-61
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 10783-1-AP(Bcl-xL antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BCL2L1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BCL2L1. This antibody recognizes human,mouse,rat antigen. The BCL2L1 antibody has been validated for the following applications: ELISA, IHC, IP, WB, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-Bcl-xL (IP:10783-1-AP, 3ug; Detection:10783-1-AP 1:500) with K-562 cells lysate 8000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 10783-1-AP(Bcl-xL antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
