MGST3

This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides. [provided by RefSeq, May 2011]

Description

Microsomal glutathione S-transferase 3

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (165631213 - 165661796)

Ensembl ID

ENSG00000143198  (ver. 103.38)

Orthologs

Mouse Mgst3: ENSMUSG00000026688

UniProt

O14880

neXtProt

NX_O14880

Human splice variants
Mouse splice variants

Protein structure