FMO4

Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes fish odor syndrome (Trimethylaminuria). Three forms of the enzyme are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Jan 2015]

Description

Flavin containing dimethylaniline monoxygenase 4

Tissue specificity

Group enriched (kidney, liver)

Subcell location

Vesicles, Cytosol

Predicted location

Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

1 (171314183 - 171342084)

Ensembl ID

ENSG00000076258  (ver. 103.38)

Orthologs

Mouse Fmo4: ENSMUSG00000026692

UniProt

P31512

neXtProt

NX_P31512

Human splice variants
Mouse splice variants

Protein structure