17-2439-42

antibody from Invitrogen Antibodies
Targeting: ABCB1 ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1
Provider product page for 17-2439-42

Antibody data

Product number
17-2439-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD243 (ABCB1) Monoclonal Antibody (UIC2), APC, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This monoclonal antibody reacts with human Multidrug Resistant (MDR)-1, which is also known as P-glycoprotein (Pgp) and CD243. A 170-kDa transmembrane protein, MDR-1 is an ATP-dependent efflux pump for lipophilic compounds, including anti-cancer drugs. Expression of MDR-1 has been shown to correlate with multidrug resistance. In fact, tumor resistance to chemotherapy has been linked to MDR-1 expression in many cancers. MDR-1 is expressed in a variety of tissues, including the brain, kidney, liver, pancreas, and testes. Within the immune system, this molecule can be found on normal T, B, and natural killer cells, but not on monocytes. This antibody has been reported to inhibit MDR1-mediated efflux. Applications Reported: This UIC2 antibody has been reported for use in flow cytometric analysis. Applications Tested: This UIC2 antibody has been pre-titrated and tested This UIC2 antibody has been pre-titrated and tested by flow cytometric analysis on the multidrug resistant cell line 8226 DOX40 and its parent line 8226/S. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 µm post-manufacturing filtered.
Reactivity
Human
Host
Mouse
Isotype
IgG
Antibody clone number
UIC2
Vial size
100 Tests
Concentration
5 µL/Test
Storage
4° C, store in dark, DO NOT FREEZE!
ABCB1 protein structure - 17-2439-42 shown in red.