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Protein structure
ABCB1
ATP binding cassette subfamily B member 1ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Top validated antibodies |
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| GeneTex |  GTX23364 |
24 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
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| Invitrogen Antibodies | MA5-13854 |
24 references | Monoclonal |
WB
ICC
FC
OA
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| Proteintech Group | 22336-1-AP |
86 references | Polyclonal |
WB
EL
IP
IHC
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| Boster Biological Technology | A00049-3 |
14 references | Polyclonal |
WB
EL
IHC
FC
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| antibodies-online | ABIN2673396 |
Monoclonal |
WB
ICC
IHC
FC
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