ABCB1

gene product
ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
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1369 antibodies from 45 providers.

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GeneTex
8 antibodies
Atlas Antibodies
1 antibody
Enzo Life Sciences
5 antibodies
antibodies-online
351 antibodies
Novus Biologicals
108 antibodies
Invitrogen Antibodies
16 antibodies
Biorbyt
55 antibodies
OriGene
266 antibodies
LifeSpan BioSciences, Inc.
244 antibodies
Antibodies.com
3 antibodies
Boster Biological Technology
7 antibodies
Cell Signaling Technology, Inc
3 antibodies
Abnova Corporation
11 antibodies
NovoPro Bioscience Inc.
4 antibodies
Abgent
5 antibodies
Abbiotec
2 antibodies
Affinity Biosciences
1 antibody
Rockland Immunochemicals, Inc.
3 antibodies
Aviva Systems Biology
9 antibodies
BioLegend
22 antibodies
Acris Antibodies GmbH
17 antibodies
St John's Laboratory
5 antibodies
Bethyl Laboratories
1 antibody
Creative Biolabs
70 antibodies
ProSci
6 antibodies
Sigma-Aldrich
4 antibodies
NSJ Bioreagents
5 antibodies
EMD Millipore
10 antibodies
Creative Diagnostics
14 antibodies
BioLegend (formerly Covance Antibody Products)
3 antibodies
Miltenyi Biotec
12 antibodies
Molecular Depot LLC
5 antibodies
Abbexa
6 antibodies
MyBioSource
13 antibodies
Absolute Antibody
2 antibodies
United States Biological
33 antibodies
RabMAbs
3 antibodies
RayBiotech, Inc.
4 antibodies
GenWay
6 antibodies
Abiocode, Inc.
1 antibody
Bioworld Technology, Inc
1 antibody
eBioscience, An Affymetrix Company
10 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Exalpha Biologicals, Inc.
1 antibody