22336-1-AP

antibody from Proteintech Group

Targeting: ABCB1 ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1

Provider product page for 22336-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [40]
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Product number: 22336-1-AP - Provider product page
Provider: Proteintech Group
Product name: P glycoprotein antibody
Antibody type: Polyclonal
Description: P glycoprotein antibody (Cat. #22336-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ABCB1 protein structure - 22336-1-AP shown in red.

Submitted references DNAzyme-Based nanoflowers for reversing P-glycoprotein-mediated multidrug resistance in breast cancer.

Liang L, Huo W, Wang B, Cao L, Huo H, Liu Y, Jin Y, Yang X
Journal of colloid and interface science 2022 Feb 15;608(Pt 3):2985-2993

Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.

Cao W, Li Y, Sun H, Yang C, Zhu J, Xie C, Li X, Wu J, Geng S, Wang L, Sun L, Geng G, Han H, Zhong C
Frontiers in cell and developmental biology 2021;9:679806

A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.

Wang T, Dong J, Yuan X, Wen H, Wu L, Liu J, Sui H, Deng W
Frontiers in pharmacology 2021;12:653306

Discovering and Characterizing of Survivin Dominant Negative Mutants With Stronger Pro-apoptotic Activity on Cancer Cells and CSCs.

Guo W, Ma X, Fu Y, Liu C, Liu Q, Hu F, Miao H, Zhang T, Liu Y, Han MH, You F, Yang Y, Zheng W
Frontiers in oncology 2021;11:635233

ZFX promotes tumorigenesis and confers chemotherapy resistance in esophageal squamous cell carcinoma.

Wu J, Zhou Y, Wang T, Jiang C, Gao Y, Wei B
Clinics and research in hepatology and gastroenterology 2021 Sep;45(5):101586

Rational design of phenyl thiophene (pyridine) derivatives that overcome P-glycoprotein mediated MDR in MCF-7/ADR cell.

Li YS, Mao S, Zhao DS, Wang CC, Zu D, Yang X, Liu GJ, Wang SJ, Zhang B, Bao XZ, Ye XY, Wei B, Cui ZN, Chen JW, Wang H
Bioorganic chemistry 2021 Sep;114:105075

Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation.

Wei L, Lin Q, Lu Y, Li G, Huang L, Fu Z, Chen R, Zhou Q
Cell death & disease 2021 Mar 29;12(4):334

The study of Raddeanin A cerebrovascular endothelial cell trafficking through P-glycoprotein.

Wang YY, Jiang CF, Liu X, Li JN, Cai GZ, Gong JY
Biochemical and biophysical research communications 2021 Jun 25;559:222-229

Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway.

Liu K, Song J, Yan Y, Zou K, Che Y, Wang B, Li Z, Yu W, Guo W, Zou L, Deng W, Sun X
Translational oncology 2021 Jan;14(1):100876

Polyphenol from millet bran increases the sensitivity of colorectal cancer cells to oxaliplatin by blocking the ganglioside GM3 catabolism.

Zhang X, Shan S, Shi J, Li H, Li Z
Food & function 2021 Jan 7;12(1):291-301

Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane.

Phatak V, von Grabowiecki Y, Janus J, Officer L, Behan C, Aschauer L, Pinon L, Mackay H, Zanivan S, Norman JC, Kelly M, Le Quesne J, Muller PAJ
Cell death & disease 2021 Feb 24;12(2):207

Acylglycerol kinase promotes paclitaxel resistance in nasopharyngeal carcinoma cells by regulating FOXM1 via the JAK2/STAT3 pathway.

Zhao C, Chen HY, Zhao F, Feng HJ, Su JP
Cytokine 2021 Dec;148:155595

Compound 968 reverses adriamycin resistance in breast cancer MCF-7^ADR cells via inhibiting P-glycoprotein function independently of glutaminase.

Yang R, Guo Z, Zhao Y, Ma L, Li B, Yang C
Cell death discovery 2021 Aug 5;7(1):204

TPGS-Galactose-Modified Polydopamine Co-delivery Nanoparticles of Nitric Oxide Donor and Doxorubicin for Targeted Chemo-Photothermal Therapy against Drug-Resistant Hepatocellular Carcinoma.

Du Z, Mao Y, Zhang P, Hu J, Fu J, You Q, Yin J
ACS applied materials & interfaces 2021 Aug 4;13(30):35518-35532

Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.

Li YS, Yang X, Zhao DS, Cai Y, Huang Z, Wu R, Wang SJ, Liu GJ, Wang J, Bao XZ, Ye XY, Wei B, Cui ZN, Wang H
European journal of medicinal chemistry 2021 Apr 15;216:113336

Circadian Clock Protein PERIOD2 Suppresses the PI3K/Akt Pathway and Promotes Cisplatin Sensitivity in Ovarian Cancer.

Wang Z, Li F, Wei M, Zhang S, Wang T
Cancer management and research 2020;12:11897-11908

Overexpression of close homolog of L1 enhances the chemosensitivity of lung cancer cells via inhibition of the Akt pathway.

Cai X, Hu B, Liu S, Liu M, Huang Y, Lei P, Zhang Z, He Z, Zhang L, Huang R
Oncology letters 2020 Oct;20(4):111

Cucurbitacin E Chemosensitizes Colorectal Cancer Cells via Mitigating TFAP4/Wnt/β-Catenin Signaling.

Yang P, Liu W, Fu R, Ding GB, Amin S, Li Z
Journal of agricultural and food chemistry 2020 Nov 18;

Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/AKT signalling pathway.

Mei Y, Liao X, Zhu L, Yang H
Journal of biochemistry 2020 Jun 1;167(6):603-611

LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.

Zhou C, Yi C, Yi Y, Qin W, Yan Y, Dong X, Zhang X, Huang Y, Zhang R, Wei J, Ali DW, Michalak M, Chen XZ, Tang J
Molecular cancer 2020 Jul 29;19(1):118

Total Saponins from Paris forrestii Reverse Multidrug Resistance of MCF-7/ADM Cells by Suppression of P-gp via ERK Signaling Pathway.

Chai D, Yuan J, Zhu X, Zeng Y, Yang R, Chen Y, Wang Y, Zhou Y
Biological & pharmaceutical bulletin 2020 Dec 1;43(12):1823-1830

Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.

Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S, Shan C
Biochemical pharmacology 2020 Aug;178:114092

1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.

Jia Z, Zhang Y, Yan A, Wang M, Han Q, Wang K, Wang J, Qiao C, Pan Z, Chen C, Hu D, Ding X
Cell death & disease 2020 Aug 20;11(8):670

Novel Quinoline Compound Derivatives of NSC23925 as Potent Reversal Agents Against P-Glycoprotein-Mediated Multidrug Resistance.

Quan X, Du H, Xu J, Hou X, Gong X, Wu Y, Zhou Y, Jiang J, Lu L, Yuan S, Yang X, Shi L, Sun L
Frontiers in chemistry 2019;7:820

Circadian sensitivity to the cardiac glycoside oleandrin is associated with diurnal intestinal P-glycoprotein expression.

Zhou C, Yu F, Zeng P, Zhang T, Huang H, Chen W, Wu B
Biochemical pharmacology 2019 Nov;169:113622

Forkhead Box R2 Knockdown Decreases Chemoresistance to Cisplatin via MYC Pathway in Bladder Cancer.

Li Y, Zu X, Hu X, Wang L, He W
Medical science monitor : international medical journal of experimental and clinical research 2019 Nov 25;25:8928-8939

Effect of Stereochemical Configuration on the Transport and Metabolism of Catechins from Green Tea across Caco-2 Monolayers.

Ai Z, Liu S, Qu F, Zhang H, Chen Y, Ni D
Molecules (Basel, Switzerland) 2019 Mar 26;24(6)

Aptamer-Based Erythrocyte-Derived Mimic Vesicles Loaded with siRNA and Doxorubicin for the Targeted Treatment of Multidrug-Resistant Tumors.

Wang T, Luo Y, Lv H, Wang J, Zhang Y, Pei R
ACS applied materials & interfaces 2019 Dec 11;11(49):45455-45466

LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR-184 in chronic myelogenous leukaemia cells.

Zhang F, Ni H, Li X, Liu H, Xi T, Zheng L
FEBS letters 2019 Aug;593(15):1993-2007

Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases.

Guo HH, Feng CL, Zhang WX, Luo ZG, Zhang HJ, Zhang TT, Ma C, Zhan Y, Li R, Wu S, Abliz Z, Li C, Li XL, Ma XL, Wang LL, Zheng WS, Han YX, Jiang JD
Nature communications 2019 Apr 30;10(1):1981

Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment.

Wang D, Xu X, Zhang K, Sun B, Wang L, Meng L, Liu Q, Zheng C, Yang B, Sun H
International journal of nanomedicine 2018;13:187-198

RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.

Wang X, Liu W, Wang P, Li S
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2018 Nov;47(10):930-937

Hierarchically Self-Assembled Supramolecular Host-Guest Delivery System for Drug Resistant Cancer Therapy.

Cheng H, Fan X, Wang X, Ye E, Loh XJ, Li Z, Wu YL
Biomacromolecules 2018 Jun 11;19(6):1926-1938

Thermoresponsive Supramolecular Chemotherapy by "V"-Shaped Armed β-Cyclodextrin Star Polymer to Overcome Drug Resistance.

Fan X, Cheng H, Wang X, Ye E, Loh XJ, Wu YL, Li Z
Advanced healthcare materials 2018 Apr;7(7):e1701143

Long noncoding RNA MALAT1 knockdown reverses chemoresistance to temozolomide via promoting microRNA-101 in glioblastoma.

Cai T, Liu Y, Xiao J
Cancer medicine 2018 Apr;7(4):1404-1415

Pleiotrophin promotes chemoresistance to doxorubicin in osteosarcoma by upregulating P-glycoprotein.

Wu D, Liu L, Yan X, Wang C, Wang Y, Han K, Lin S, Gan Z, Min D
Oncotarget 2017 Sep 8;8(38):63857-63870

PD-1/PD-L1 interaction up-regulates MDR1/P-gp expression in breast cancer cells via PI3K/AKT and MAPK/ERK pathways.

Liu S, Chen S, Yuan W, Wang H, Chen K, Li D, Li D
Oncotarget 2017 Nov 21;8(59):99901-99912

Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.

Jiang YQ, Xu XP, Guo QM, Xu XC, Liu QY, An SH, Xu JL, Su F, Tai JB
Genetics and molecular research : GMR 2016 Sep 2;15(3)

Exosomes play an important role in the process of psoralen reverse multidrug resistance of breast cancer.

Wang X, Xu C, Hua Y, Sun L, Cheng K, Jia Z, Han Y, Dong J, Cui Y, Yang Z
Journal of experimental & clinical cancer research : CR 2016 Dec 1;35(1):186

Immunohistochemical analysis of transporters related to clearance of amyloid-β peptides through blood-cerebrospinal fluid barrier in human brain.

Matsumoto K, Chiba Y, Fujihara R, Kubo H, Sakamoto H, Ueno M
Histochemistry and cell biology 2015 Dec;144(6):597-611

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