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Learn22336-1-AP
antibody from Proteintech Group
Targeting: ABCB1
ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [173]
- Comments [0]
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- Product number
- 22336-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- P glycoprotein antibody
- Antibody type
- Polyclonal
- Description
- P glycoprotein antibody (Cat. #22336-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting the OXNAD1-PTGS2 axis with resveratrol overcomes ferroptosis Inhibition and reverses 5-FU resistance in gastric cancer.
TMEM207-mediated the impairment of skin regeneration through YAP sequestration in an allergic contact dermatitis model.
Apatinib and silver nanoparticles synergize against gastric cancer through the PI3K/Akt signaling pathway-mediated ferroptosis.
USP9X promotes acute myeloid leukemia progression and adriamycin resistance by regulating METTL7A deubiquitination.
Rational discovery of novel phenylindole-bisamide derivatives as potent P-glycoprotein inhibitors for cancer multidrug resistance.
Bile Acid Metabolism Affects Muscle Regeneration in Aging Skeletal Muscle in a Manner Associated with Regulation of ABCB1 Expression.
The E3 ubiquitin ligase RNF180 modulates the EGFR/PI3K/AKT pathway to reduce cisplatin resistance in non-small cell lung cancer.
Multifunctional platinum(IV) complexes reverse cisplatin resistance in triple- negative breast cancer via ferroptosis and apoptosis.
Targeting serine synthesis pathway to reverse paclitaxel resistance in NSCLC with combination of paclitaxel and anlotinib.
A New Histology-Based Prognostic Index for Acute Lymphoblastic Leukemia: Preliminary Results of the "ALL Urayasu Classification".
Flavonoid-rich extracts of Nelumbo nucifera leaves alleviate obesity in HFD-fed mice via microbiota-dependent modulation of brown fat thermogenesis.
Asiatic acid reverses cisplatin resistance in A549/DDP cells by activating the P38 MAPK/Slug pathway.
Indole-3-Acetic Acid and Skatole Exert Opposing Effects on MDR1 Proteostasis in Human Colonic Epithelial Cells: A Molecular Basis for the Gut Microbial Metabolic Switch.
VDAC1 protein derived from extracellular vesicles promotes paclitaxel resistance in gastric cancer through autophagy and mitophagy.
AFP confers the resistance of lenvatinib in hepatocellular carcinoma by activating PI3K/AKT/LDHA signaling axis.
Lenvatinib-resistant liver cancer-derived HSP90α-containing extracellular vesicles enhance drug resistance via macrophage CXCL8 secretion.
Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4-Mediated Ferroptosis.
High viscosity microenvironment induces chemoresistance of cancer cells through upregulating P-gp.
HFD-induced Alterations in Renal Tubular Oatp4c1-P-gp Transport Systems in Mice: Impact on Digoxin Renal Excretion and Gadolinium-Enhanced Radiological Manifestations.
Chrysin sensitizes glioblastoma cells and spheroids to temozolomide treatment by reducing EMT and stemness phenotypes, as well as targeting multidrug resistance proteins.
Engineered NK92 cell-derived exosomes inhibit ovarian cancer progression by degrading GPRC5A.
A strategy for evaluating the impact of processing of Chinese meteria medica on meridian tropism: the influence of salt-water processing of phellodendri chinensis cortex on renal transport proteins.
Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment.
GDF15 promotes the resistance of epithelial ovarian cancer cells to gemcitabine via DHCR24-mediated cholesterol metabolism to elevate ABCB1 and ABCC1 levels in lipid rafts.
TMI, an isoflavone from the fruits of Ficus altissima Blume, overcomes K562/ADR leukemia cells resistance by targeting Nrf2.
Rational discovery of novel tetrahydroisoquinoline-indole derivatives as potent P-glycoprotein inhibitor against multidrug resistance in MCF-7/ADR cell.
Fusidic Acid Reverses Chemoresistance in Breast Cancer via Targeting DDX6 to Downregulate GSK-3β/β-Catenin Signaling.
Effect of fibrinogen like protein 1 on cisplatin-resistance in laryngeal carcinoma through targeting integrinβ1 in vivo and in vitro.
CDK11 Promotes Paclitaxel Resistance in Cervical Cancer by Regulating LATS1-Mediated Hippo Signaling Pathway Through Phosphorylation of NF2.
Pitavastatin overcomes multi-drug resistance in CRC and NSCLC by targeting the NRP1-ZFX axis.
Integrated pharmacokinetic properties and tissue distribution of Corydalis saxicola Bunting total alkaloids in HFHCD-induced mice: Implications for pharmacokinetic variability in MASH treatment.
Discovery of a novel Genipin derivative targeting YB-1 to enhance the P-glycoprotein-mediated paclitaxel sensitivity of paclitaxel-resistant non-small cell lung cancer.
USP30-AS1 Dictates Breast Cancer Cell Fate and Chemoresistance via a miR-3646/FZD7/Wnt/β-Catenin Circuit.
Targeting cancer stem-like cells via cholesterol modulation and ferroptosis induction using a multifunctional nanoplatform to overcome drug resistance.
Di-(2-ethylhexyl)-phthalate exposure impairs placental P-glycoprotein efflux function by reducing protein expression and ATP levels.
Tenacissoside G reverses paclitaxel resistance by inhibiting Src/PTN/P-gp signaling axis activation in ovarian cancer cells.
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells.
Three-Dimensional Dynamic Blood-Brain Barrier Model Incorporating Native Cell Culture Systems Based on Shape Memory Biomaterials.
Fluoxetine-Conjugated Platinum(IV) Prodrugs Targeting eEF2K and Conquering Multidrug Resistance against Triple-Negative Breast Cancer.
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
A New Histology-Based Prognostic Index for Acute Myeloid Leukemia: Preliminary Results for the "AML Urayasu Classification".
RBM10 deficiency promotes brain metastasis by modulating sphingolipid metabolism in a BBB model of EGFR mutant lung adenocarcinoma.
Blocking XIAP:CASP7-p19 selectively induces apoptosis of CASP3/DR malignancies by a novel reversible small molecule.
Screening a living biobank identifies cabazitaxel as a strategy to combat acquired taxol resistance in high-grade serous ovarian cancer.
Design, synthesis, and biological activity study of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives against multidrug resistance in Eca109/VCR cells.
Growth Hormone Signaling in Bladder Cancer: Transcriptomic Profiling of Patient Samples and In Vitro Evidence of Therapy Resistance via ABC Transporters and EMT Activation.
Glucosamine activates intestinal P-glycoprotein inhibiting drug absorption.
Wheat germ agglutinin modified mixed micelles overcome the dual barrier of mucus/enterocytes for effective oral absorption of shikonin and gefitinib.
Identifying ADME-related gene signature for immune landscape and prognosis in KIRC by single-cell and spatial transcriptome analysis.
Aging Reduces ATP-Binding Cassette Transporter Expression in Brain Microvessels of Mice.
The Unveiled Novel regulator of Adeno-associated virus production in HEK293 cells.
KSQ-4279, an Inhibitor of Ubiquitin Specific Peptidase 1, Enhanced the Chemotherapeutic Efficacy in ABCB1/ABCG2/ABCC1-Mediated Multidrug Resistant Cancers.
Exosomal microRNA-20b-5p contributes to cytarabine resistance in acute myeloid leukemia via the microtubule-associated serine/threonine kinase-like-phosphatidylinositol 3-kinase-protein kinase B signaling axis.
Plain DNA and cationic aromatics: a platform to simplify carrier-free delivery systems.
Discovery of a heterocyclic aromatic amide based P-gp inhibitor as coadjutant regulating autophagy against drug resistance in breast cancer.
Restoration of A2M reduces drug resistance and malignancy in paclitaxel-resistant lung cancer cells.
Limited predictive value of pretreatment P-glycoprotein immunostaining for chemotherapy efficacy and survival in long-follow-up osteosarcoma patients.
Gut-resident Phascolarctobacterium succinatutens decreases fat accumulation via MYC-driven epigenetic regulation of arginine biosynthesis.
Integrative analysis of taurine metabolism-related genes prognostic signature with immunotherapy and identification of ABCB1 and GORASP1 as key genes in nasopharyngeal carcinoma.
Long noncoding RNA UCA1 knockdown inhibits cisplatin-resistant cervical cancer tumorigenesis via the miR-195-5p/IKBKB axis.
Sucralose Promotes Benzo(a)Pyrene-Induced Renal Toxicity in Mice by Regulating P-glycoprotein.
Hybrid Liposome-MSN System with Co-Delivering Potential Effective Against Multidrug-Resistant Tumor Targets in Mice Model.
Lipid-Based Self-Microemulsion of Niclosamide Achieved Enhanced Oral Delivery and Anti-Tumor Efficacy in Orthotopic Patient-Derived Xenograft of Hepatocellular Carcinoma in Mice.
SiRNF8 Delivered by DNA Framework Nucleic Acid Effectively Sensitizes Chemotherapy in Colon Cancer.
Bisecting GlcNAc modification reverses the chemoresistance via attenuating the function of P-gp.
Intercellular adhesion molecule-1 suppresses TMZ chemosensitivity in acquired TMZ-resistant gliomas by increasing assembly of ABCB1 on the membrane.
Lansoprazole (LPZ) reverses multidrug resistance (MDR) in cancer through impeding ATP-binding cassette (ABC) transporter-mediated chemotherapeutic drug efflux and lysosomal sequestration.
Shikonin and chitosan-silver nanoparticles synergize against triple-negative breast cancer through RIPK3-triggered necroptotic immunogenic cell death.
P-glycoprotein-mediated herb-drug interaction evaluation between Tenacissoside G and paclitaxel.
Autocrine Motility Factor and Its Peptide Derivative Inhibit Triple-Negative Breast Cancer by Regulating Wound Repair, Survival, and Drug Efflux.
RGS5(+) lymphatic endothelial cells facilitate metastasis and acquired drug resistance of breast cancer through oxidative stress-sensing mechanism.
USP14 increases the sensitivity of retinoblastoma to cisplatin by mediating the ferroptosis.
Mitotic Arrest Deficient 2 Like 1 Contributes to Colorectal Cancer Cell Migration, Invasion, and Oxaliplatin Resistance Through the Wnt/β-Catenin Pathway.
Complex IIa formation and ABC transporters determine sensitivity of OSCC to Smac mimetics.
Targeted Elimination of the Oral Pathogen to Overcome Chemoresistance of Oral Squamous Cell Carcinoma by Biologically Derived Nanotherapeutics.
Quercetin improves the protection of hydroxysafflor yellow a against cerebral ischemic injury by modulating of blood-brain barrier and src-p-gp-mmp-9 signalling.
PARP1-DOT1L transcription axis drives acquired resistance to PARP inhibitor in ovarian cancer.
Enhanced Efficacy against Drug-Resistant Tumors Enabled by Redox-Responsive Mesoporous-Silica-Nanoparticle-Supported Lipid Bilayers as Targeted Delivery Vehicles.
Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.
Jianpi Jiedu decoction reverses 5-fluorouracil resistance in colorectal cancer by suppressing the xCT/GSH/GPX4 axis to induce ferroptosis.
A New Histology-Based Prognostic Index for Aggressive T-Cell lymphoma: Preliminary Results of the "TCL Urayasu Classification".
[Aqueous extract of Chuan Xiong Rhizoma enhances inhibitory effect of temozolomide against brain metastasis of melanoma in mice].
BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo.
The Anthraquinone Derivative C2 Enhances Oxaliplatin-Induced Cell Death and Triggers Autophagy via the PI3K/AKT/mTOR Pathway.
Lycorine attenuated proliferation and induced apoptosis on imatinib-resistant K562 cell by inhibiting autophagy.
QKL injection ameliorates Alzheimer's disease-like pathology by regulating expression of RAGE.
Overcoming flumatinib resistance in chronic myeloid leukaemia: Insights into cellular mechanisms and ivermectin's therapeutic potential.
Aronia Berry Extract Modulates MYD88/NF-kB/P-Glycoprotein Axis to Overcome Gemcitabine Resistance in Pancreatic Cancer.
tRNA-derived fragment 3'tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer.
Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.
Discovery of (quinazolin-6-yl)benzamide derivatives containing a 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety as potent reversal agents against P-glycoprotein-mediated multidrug resistance.
Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.
EGR1 mediates MDR1 transcriptional activity regulating gemcitabine resistance in pancreatic cancer.
Ivermectin Enhances Paclitaxel Efficacy by Overcoming Resistance Through Modulation of ABCB1 in Non-small Cell Lung Cancer.
Gastrodin reduces Aβ brain levels in an Alzheimer's disease mouse model by inhibiting P-glycoprotein ubiquitination.
EYA4 reduces chemosensitivity of osteosarcoma to doxorubicin through DNA damage repair.
mRNA-Lipid Nanoparticle-Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple-Negative Breast Cancer.
Lactate drives the ESM1-SCD1 axis to inhibit the antitumor CD8(+) T-cell response by activating the Wnt/β-catenin pathway in ovarian cancer cells and inducing cisplatin resistance.
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.
Possible New Histological Prognostic Index for Large B-Cell Lymphoma.
Multi-time point metabolomics reveals key metabolic features from the ultra-early stage of intracerebral hemorrhage in mice.
Fucoidan/chitosan layered PLGA nanoparticles with melatonin loading for inducing intestinal absorption and addressing triple-negative breast cancer progression.
Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer.
Enrofloxacin hydrochloride toxicological effects on crucian carp reflected by serological changes and neurotoxicity.
Enhancing Paclitaxel Efficacy with Piperine-Paclitaxel Albumin Nanoparticles in Multidrug-Resistant Triple-Negative Breast Cancer by Inhibiting P-Glycoprotein.
SORL1 stabilizes ABCB1 to promote cisplatin resistance in ovarian cancer.
Ribosome Biogenesis Regulator 1 Homolog (RRS1) Promotes Cisplatin Resistance by Regulating AEG-1 Abundance in Breast Cancer Cells.
ZYY-B-2, a novel ALK inhibitor, overcomes resistance to ceritinib by inhibiting P-gp function and induces apoptosis through mitochondrial pathway in ceritinib-resistant H2228 cells.
LncRNA BCAR4 promotes migration, invasion, and chemo-resistance by inhibiting miR-644a in breast cancer.
Self-intensified synergy of a versatile biomimetic nanozyme and doxorubicin on electrospun fibers to inhibit postsurgical tumor recurrence and metastasis.
Regulation of the ATP-binding cassette transporters ABCB1, ABCG2 and ABCC5 by nuclear receptors in porcine blood-brain barrier endothelial cells.
NIR-II Regulation of Mitochondrial Potassium Channel with Dual-Targeted Conjugated Oligomer Nanoparticles for Efficient Cancer Theranostics In Vivo.
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.
Novel Benzo Five-Membered Heterocycle Derivatives as P-Glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-Multidrug Resistance Activity.
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
ZIP1(+) fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn(2+) transfer.
Blood-brain barrier permeability to enrofloxacin in Pengze crucian carp (Carassius auratus var. Pengze).
Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer.
Myeloid ecotropic viral integration site-1 inhibition promotes apoptosis, suppresses proliferation of acute myeloid leukemia cells, accentuates the effects of anticancer drugs.
Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis.
Luteolin attenuates the chemoresistance of osteosarcoma through inhibiting the PTN/β-catenin/MDR1 signaling axis by upregulating miR-384.
Canthin-6-one (CO) from Picrasma quassioides (D.Don) Benn. ameliorates lipopolysaccharide (LPS)-induced astrocyte activation and associated brain endothelial disruption.
Murine Beta-Amyloid (1-42) Oligomers Disrupt Endothelial Barrier Integrity and VEGFR Signaling via Activating Astrocytes to Release Deleterious Soluble Factors.
S-20, a steroidal saponin from the berries of black nightshade, exerts anti-multidrug resistance activity in K562/ADR cells through autophagic cell death and ERK activation.
DNAzyme-Based nanoflowers for reversing P-glycoprotein-mediated multidrug resistance in breast cancer.
Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective Colon cancer therapy.
Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells through Lead Optimization.
Study of Drug Resistance in Chemotherapy Induced by Extracellular Vesicles on a Microchip.
Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium.
The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance.
Resveratrol-Loaded TPGS-Resveratrol-Solid Lipid Nanoparticles for Multidrug-Resistant Therapy of Breast Cancer: In Vivo and In Vitro Study.
Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.
Nucleolin Promotes Cisplatin Resistance in Cervical Cancer by the YB1-MDR1 Pathway.
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Hedgehog-Gli2 Signaling Promotes Chemoresistance in Ovarian Cancer Cells by Regulating MDR1.
Discovering and Characterizing of Survivin Dominant Negative Mutants With Stronger Pro-apoptotic Activity on Cancer Cells and CSCs.
ZFX promotes tumorigenesis and confers chemotherapy resistance in esophageal squamous cell carcinoma.
Rational design of phenyl thiophene (pyridine) derivatives that overcome P-glycoprotein mediated MDR in MCF-7/ADR cell.
Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation.
The study of Raddeanin A cerebrovascular endothelial cell trafficking through P-glycoprotein.
Knockdown of USP9X reverses cisplatin resistance by decreasing β-catenin expression in nasopharyngeal carcinoma cells.
Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway.
Polyphenol from millet bran increases the sensitivity of colorectal cancer cells to oxaliplatin by blocking the ganglioside GM3 catabolism.
Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane.
Acylglycerol kinase promotes paclitaxel resistance in nasopharyngeal carcinoma cells by regulating FOXM1 via the JAK2/STAT3 pathway.
Compound 968 reverses adriamycin resistance in breast cancer MCF-7(ADR) cells via inhibiting P-glycoprotein function independently of glutaminase.
TPGS-Galactose-Modified Polydopamine Co-delivery Nanoparticles of Nitric Oxide Donor and Doxorubicin for Targeted Chemo-Photothermal Therapy against Drug-Resistant Hepatocellular Carcinoma.
Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.
Circadian Clock Protein PERIOD2 Suppresses the PI3K/Akt Pathway and Promotes Cisplatin Sensitivity in Ovarian Cancer.
Overexpression of close homolog of L1 enhances the chemosensitivity of lung cancer cells via inhibition of the Akt pathway.
Cucurbitacin E Chemosensitizes Colorectal Cancer Cells via Mitigating TFAP4/Wnt/β-Catenin Signaling.
Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/AKT signalling pathway.
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
Total Saponins from Paris forrestii Reverse Multidrug Resistance of MCF-7/ADM Cells by Suppression of P-gp via ERK Signaling Pathway.
Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.
Novel Quinoline Compound Derivatives of NSC23925 as Potent Reversal Agents Against P-Glycoprotein-Mediated Multidrug Resistance.
Circadian sensitivity to the cardiac glycoside oleandrin is associated with diurnal intestinal P-glycoprotein expression.
Forkhead Box R2 Knockdown Decreases Chemoresistance to Cisplatin via MYC Pathway in Bladder Cancer.
Effect of Stereochemical Configuration on the Transport and Metabolism of Catechins from Green Tea across Caco-2 Monolayers.
Aptamer-Based Erythrocyte-Derived Mimic Vesicles Loaded with siRNA and Doxorubicin for the Targeted Treatment of Multidrug-Resistant Tumors.
LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR-184 in chronic myelogenous leukaemia cells.
Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases.
Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment.
RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.
Hierarchically Self-Assembled Supramolecular Host-Guest Delivery System for Drug Resistant Cancer Therapy.
Thermoresponsive Supramolecular Chemotherapy by "V"-Shaped Armed β-Cyclodextrin Star Polymer to Overcome Drug Resistance.
Long noncoding RNA MALAT1 knockdown reverses chemoresistance to temozolomide via promoting microRNA-101 in glioblastoma.
Pleiotrophin promotes chemoresistance to doxorubicin in osteosarcoma by upregulating P-glycoprotein.
PD-1/PD-L1 interaction up-regulates MDR1/P-gp expression in breast cancer cells via PI3K/AKT and MAPK/ERK pathways.
Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.
Exosomes play an important role in the process of psoralen reverse multidrug resistance of breast cancer.
Immunohistochemical analysis of transporters related to clearance of amyloid-β peptides through blood-cerebrospinal fluid barrier in human brain.
Wang J, Xu B, Lin X, Chen B, Liu X, Wu W
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2026 May;29(3):561-577
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2026 May;29(3):561-577
TMEM207-mediated the impairment of skin regeneration through YAP sequestration in an allergic contact dermatitis model.
Nomura S, Kito Y, Saigo C, Takeuchi T
Biochemistry and biophysics reports 2026 Mar;45:102409
Biochemistry and biophysics reports 2026 Mar;45:102409
Apatinib and silver nanoparticles synergize against gastric cancer through the PI3K/Akt signaling pathway-mediated ferroptosis.
Lin Z, Deng Z, Liang J, Chen B, Huang Y, Liu B, Zhao Y
Journal of pharmaceutical analysis 2026 Mar;16(3):101400
Journal of pharmaceutical analysis 2026 Mar;16(3):101400
USP9X promotes acute myeloid leukemia progression and adriamycin resistance by regulating METTL7A deubiquitination.
Yan Z, Siyi W, Siyu W, YuanYuan T, Jiajia L
Cellular signalling 2026 Mar;139:112314
Cellular signalling 2026 Mar;139:112314
Rational discovery of novel phenylindole-bisamide derivatives as potent P-glycoprotein inhibitors for cancer multidrug resistance.
Yang Z, Han J, Yang Y, Yang X, Du Y, Huang Z, Ying L, Yu X, Hua Y, Wu Q, Mou X, Wang H
RSC medicinal chemistry 2026 Mar 9;
RSC medicinal chemistry 2026 Mar 9;
Bile Acid Metabolism Affects Muscle Regeneration in Aging Skeletal Muscle in a Manner Associated with Regulation of ABCB1 Expression.
Wu X, Wei Y, Xue Q, Li X, Deng L, Li M, Liu Y, Wang J
International journal of molecular sciences 2026 Mar 13;27(6)
International journal of molecular sciences 2026 Mar 13;27(6)
The E3 ubiquitin ligase RNF180 modulates the EGFR/PI3K/AKT pathway to reduce cisplatin resistance in non-small cell lung cancer.
Song X, Jiang W, Wei H, Zhu Y, Shu J, Zhu C, Chen F
Scientific reports 2026 Mar 10;16(1)
Scientific reports 2026 Mar 10;16(1)
Multifunctional platinum(IV) complexes reverse cisplatin resistance in triple- negative breast cancer via ferroptosis and apoptosis.
Cao G, Zhou J, Qian Y, Yang Y, Hu W, Huang X, Liu Q, Liu Z
Journal of inorganic biochemistry 2026 Jul;280:113295
Journal of inorganic biochemistry 2026 Jul;280:113295
Targeting serine synthesis pathway to reverse paclitaxel resistance in NSCLC with combination of paclitaxel and anlotinib.
Yu M, Hong Y, Pan Q, Zheng P, He Y, Zhu W, Xu S, Lv Q
Journal of experimental & clinical cancer research : CR 2026 Jan 5;45(1):30
Journal of experimental & clinical cancer research : CR 2026 Jan 5;45(1):30
A New Histology-Based Prognostic Index for Acute Lymphoblastic Leukemia: Preliminary Results of the "ALL Urayasu Classification".
Mitsumori T, Nitta H, Takizawa H, Iizuka-Honma H, Furuya C, Maruo S, Fujishiro M, Tomita S, Hashizume A, Sawada T, Miyake K, Okubo M, Sekiguchi Y, Noguchi M
Journal of clinical medicine 2026 Jan 17;15(2)
Journal of clinical medicine 2026 Jan 17;15(2)
Flavonoid-rich extracts of Nelumbo nucifera leaves alleviate obesity in HFD-fed mice via microbiota-dependent modulation of brown fat thermogenesis.
Wang Z, Ren X, Peng Z, Zeng M, Wang Z, Chen Q, Chen J, Dai X, Christian M, Qie X, He Z
Journal of ethnopharmacology 2026 Jan 10;354:120513
Journal of ethnopharmacology 2026 Jan 10;354:120513
Asiatic acid reverses cisplatin resistance in A549/DDP cells by activating the P38 MAPK/Slug pathway.
Yu M, Zhang Q, Shang W, Wei S, Wen H, Huo S, Li X, Li X, Zhang H, Tian Y
Tissue & cell 2026 Feb;98:103145
Tissue & cell 2026 Feb;98:103145
Indole-3-Acetic Acid and Skatole Exert Opposing Effects on MDR1 Proteostasis in Human Colonic Epithelial Cells: A Molecular Basis for the Gut Microbial Metabolic Switch.
Naito K, Tomii A, Ishii K, Shimizu H
Journal of xenobiotics 2026 Feb 18;16(1)
Journal of xenobiotics 2026 Feb 18;16(1)
VDAC1 protein derived from extracellular vesicles promotes paclitaxel resistance in gastric cancer through autophagy and mitophagy.
Bi Y, Wei S, Zhang Z, Wang Y, Wen Y, Wang H, Li K, Zhang C, Wang Y, Zhao L, Sun G
Cancer biology & medicine 2026 Feb 17;23(2):252-75
Cancer biology & medicine 2026 Feb 17;23(2):252-75
AFP confers the resistance of lenvatinib in hepatocellular carcinoma by activating PI3K/AKT/LDHA signaling axis.
Xing W, Wang F, Feng S, Li X, Zhou Y, Wu H, Lin B, Dong X, Li M, Zhu M
Discover oncology 2026 Feb 16;17(1)
Discover oncology 2026 Feb 16;17(1)
Lenvatinib-resistant liver cancer-derived HSP90α-containing extracellular vesicles enhance drug resistance via macrophage CXCL8 secretion.
Xu XW, Zhang Y, Zhao CW, Wu H, Zhang MT, Ma YT, Yu Y, Zheng L, Gu F, Chen YQ
Immunology letters 2026 Apr;278:107122
Immunology letters 2026 Apr;278:107122
Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4-Mediated Ferroptosis.
Ren J, Wu S, Su T, Li H, Ding J, Chen F, Mo J, Li J, Wang Z, Han L, Wu Z
Small (Weinheim an der Bergstrasse, Germany) 2026 Apr;22(22):e14973
Small (Weinheim an der Bergstrasse, Germany) 2026 Apr;22(22):e14973
High viscosity microenvironment induces chemoresistance of cancer cells through upregulating P-gp.
Zhou G, Wu C, Zhang W
International journal of pharmaceutics 2026 Apr 10;694:126753
International journal of pharmaceutics 2026 Apr 10;694:126753
HFD-induced Alterations in Renal Tubular Oatp4c1-P-gp Transport Systems in Mice: Impact on Digoxin Renal Excretion and Gadolinium-Enhanced Radiological Manifestations.
Men J, Li J, Zhang T, Chen Y, Xu B, Hou H, Sun L, Yue H, Duan Z, Gui T, Gai Z
Current drug metabolism 2025;26(2):136-148
Current drug metabolism 2025;26(2):136-148
Chrysin sensitizes glioblastoma cells and spheroids to temozolomide treatment by reducing EMT and stemness phenotypes, as well as targeting multidrug resistance proteins.
Aksüt Y, Şengelen A, Gürsoy DM, Öğütcü İ, Kuvet Ö, Pekmez M
Frontiers in pharmacology 2025;16:1643186
Frontiers in pharmacology 2025;16:1643186
Engineered NK92 cell-derived exosomes inhibit ovarian cancer progression by degrading GPRC5A.
Si C, Wang Y, Li Y, Chen Y, Fan Y, Wang Y, Tian Y, Gao J, Ma X
Frontiers in immunology 2025;16:1613178
Frontiers in immunology 2025;16:1613178
A strategy for evaluating the impact of processing of Chinese meteria medica on meridian tropism: the influence of salt-water processing of phellodendri chinensis cortex on renal transport proteins.
Chen Y, Zhang F, Ren W, Zhou Y, Jiang S, Zhang S, Xu G, Ge X, Gao H
Frontiers in pharmacology 2025;16:1558298
Frontiers in pharmacology 2025;16:1558298
Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment.
Wei Z, Mu H, Qiu F, Zhao M, Zhang X, Li W, Jia H, Wang R
Frontiers in physiology 2025;16:1520246
Frontiers in physiology 2025;16:1520246
GDF15 promotes the resistance of epithelial ovarian cancer cells to gemcitabine via DHCR24-mediated cholesterol metabolism to elevate ABCB1 and ABCC1 levels in lipid rafts.
Guo L, He Y, Xin H
American journal of cancer research 2025;15(2):452-469
American journal of cancer research 2025;15(2):452-469
TMI, an isoflavone from the fruits of Ficus altissima Blume, overcomes K562/ADR leukemia cells resistance by targeting Nrf2.
Shen L, Xu J, Wang Y, Yao J, He X
Fitoterapia 2025 Sep;185:106688
Fitoterapia 2025 Sep;185:106688
Rational discovery of novel tetrahydroisoquinoline-indole derivatives as potent P-glycoprotein inhibitor against multidrug resistance in MCF-7/ADR cell.
Yang Z, Ying L, Yang N, Yang X, Yan H, Han J, Yang Y, Mou X, Wang H, Li Y
Bioorganic chemistry 2025 Sep;164:108854
Bioorganic chemistry 2025 Sep;164:108854
Fusidic Acid Reverses Chemoresistance in Breast Cancer via Targeting DDX6 to Downregulate GSK-3β/β-Catenin Signaling.
Fan X, Guo D, Li S, Tian J, Zhang C, Li Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e04680
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(39):e04680
Effect of fibrinogen like protein 1 on cisplatin-resistance in laryngeal carcinoma through targeting integrinβ1 in vivo and in vitro.
Li Z, Fang J, Ge H, Wang X, Dong H, Yu H, Liu Y, Li T
Discover oncology 2025 Oct 31;16(1):2000
Discover oncology 2025 Oct 31;16(1):2000
CDK11 Promotes Paclitaxel Resistance in Cervical Cancer by Regulating LATS1-Mediated Hippo Signaling Pathway Through Phosphorylation of NF2.
Zhang Y, Lu J, Qi M, Zhang X, Ou D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71085
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Oct 15;39(19):e71085
Pitavastatin overcomes multi-drug resistance in CRC and NSCLC by targeting the NRP1-ZFX axis.
Zhai YY, Wang Q, Nong QY, Gao MY, Zhang Y, Xiao QW, Tian Y, Zhang ZJ, Xu FG, Zhang P
Biochemical pharmacology 2025 Nov;241:117183
Biochemical pharmacology 2025 Nov;241:117183
Integrated pharmacokinetic properties and tissue distribution of Corydalis saxicola Bunting total alkaloids in HFHCD-induced mice: Implications for pharmacokinetic variability in MASH treatment.
Sun Q, Chen H, Lin Q, Wu Y, Lei Y, Luo X, Li N, Xu L, Zhou S, Cheng J, Huang F, Qiu Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Nov;192:118665
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Nov;192:118665
Discovery of a novel Genipin derivative targeting YB-1 to enhance the P-glycoprotein-mediated paclitaxel sensitivity of paclitaxel-resistant non-small cell lung cancer.
Deng L, Zhang G, He M, Wang Y, Li J, Xu X, Hao X, Fan Y, Mu S
European journal of medicinal chemistry 2025 Nov 5;297:117910
European journal of medicinal chemistry 2025 Nov 5;297:117910
USP30-AS1 Dictates Breast Cancer Cell Fate and Chemoresistance via a miR-3646/FZD7/Wnt/β-Catenin Circuit.
He Q, Yang S, Xin Q, Jiang Y, Jiang L, Xu N
Current issues in molecular biology 2025 Nov 24;47(12)
Current issues in molecular biology 2025 Nov 24;47(12)
Targeting cancer stem-like cells via cholesterol modulation and ferroptosis induction using a multifunctional nanoplatform to overcome drug resistance.
Ye L, Zhu J, Wang X, Chen N, Sun Y, Zeng X, Liu S, Yan S
Journal of nanobiotechnology 2025 Nov 19;23(1):722
Journal of nanobiotechnology 2025 Nov 19;23(1):722
Di-(2-ethylhexyl)-phthalate exposure impairs placental P-glycoprotein efflux function by reducing protein expression and ATP levels.
Tang C, Ren K, Hou M, Liu Z, Zhang J, Qian G, Zuo M, Sun L, Lv H
Ecotoxicology and environmental safety 2025 Nov 15;307:119478
Ecotoxicology and environmental safety 2025 Nov 15;307:119478
Tenacissoside G reverses paclitaxel resistance by inhibiting Src/PTN/P-gp signaling axis activation in ovarian cancer cells.
Hu J, Hu Y, Zhang X, Zhang J, Zhou Y, Wang X, Wu W, Chen J, Han Y
Journal of natural medicines 2025 May;79(3):621-638
Journal of natural medicines 2025 May;79(3):621-638
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells.
Ou Y, Zhang K, Shuai Q, Wang C, Hu H, Cao L, Qi C, Guo M, Li Z, Shi J, Liu Y, Zuo S, Chen X, Wang Y, Feng M, Wang H, Sun P, Shi Y, Yang G, Yang S
Acta pharmaceutica Sinica. B 2025 May;15(5):2593-2611
Acta pharmaceutica Sinica. B 2025 May;15(5):2593-2611
Three-Dimensional Dynamic Blood-Brain Barrier Model Incorporating Native Cell Culture Systems Based on Shape Memory Biomaterials.
Ta W, Wang J, Zheng A, Jia Y, Liu J, Lu W, Zhang J
Advanced healthcare materials 2025 May;14(12):e2500066
Advanced healthcare materials 2025 May;14(12):e2500066
Fluoxetine-Conjugated Platinum(IV) Prodrugs Targeting eEF2K and Conquering Multidrug Resistance against Triple-Negative Breast Cancer.
Wang JQ, Liu XM, Zhu ZS, Li Z, Xie CZ, Qiao X, Feng YK, Xu JY
Journal of medicinal chemistry 2025 May 8;68(9):9661-9680
Journal of medicinal chemistry 2025 May 8;68(9):9661-9680
IGF2BP1-HAX-1 positive feedback loop-mediated HAX-1 overexpression blocks autophagic flux and promotes chemoresistance in nasopharyngeal carcinoma.
Zhang S, Gu M, Yin H, Pan S, Xie H, Chen W, Gul S, Zhao Y, Wang Z, Zheng W, You Y, You B
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
Cellular and molecular life sciences : CMLS 2025 Mar 7;82(1):105
A New Histology-Based Prognostic Index for Acute Myeloid Leukemia: Preliminary Results for the "AML Urayasu Classification".
Mitsumori T, Nitta H, Takizawa H, Iizuka-Honma H, Furuya C, Fujishiro M, Tomita S, Hashizume A, Sawada T, Miyake K, Okubo M, Sekiguchi Y, Ando M, Noguchi M
Journal of clinical medicine 2025 Mar 15;14(6)
Journal of clinical medicine 2025 Mar 15;14(6)
RBM10 deficiency promotes brain metastasis by modulating sphingolipid metabolism in a BBB model of EGFR mutant lung adenocarcinoma.
Xu G, An B, Wang R, Pan B, Hao H, Ren X, Jing Z, Gao W, Li Y, Jin Y, Lin E, Shang L, Jia D, Yu Y
Journal of experimental & clinical cancer research : CR 2025 Mar 11;44(1):95
Journal of experimental & clinical cancer research : CR 2025 Mar 11;44(1):95
Blocking XIAP:CASP7-p19 selectively induces apoptosis of CASP3/DR malignancies by a novel reversible small molecule.
Chen SH, Wu SY, Chang YX, Lui EN, Chang CK, Lin SW, Hsiao M, Yang JM, Liang PH
Cell death & disease 2025 Jun 18;16(1):459
Cell death & disease 2025 Jun 18;16(1):459
Screening a living biobank identifies cabazitaxel as a strategy to combat acquired taxol resistance in high-grade serous ovarian cancer.
Tighe A, Nelson L, Morgan RD, Barnes BM, Lin IH, Littler S, Altringham J, Tan JL, McGrail JC, Taylor SS
Cell reports. Medicine 2025 Jun 17;6(6):102160
Cell reports. Medicine 2025 Jun 17;6(6):102160
Design, synthesis, and biological activity study of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives against multidrug resistance in Eca109/VCR cells.
Xu B, Yu T, Liu HY, Liu H, Lai WJ, Guan Y, Gong L, Li YL, Zeng R, Ouyang Q
European journal of medicinal chemistry 2025 Jul 5;291:117542
European journal of medicinal chemistry 2025 Jul 5;291:117542
Growth Hormone Signaling in Bladder Cancer: Transcriptomic Profiling of Patient Samples and In Vitro Evidence of Therapy Resistance via ABC Transporters and EMT Activation.
Davis E, Caggiano LJ, Munholland H, Basu R, Berryman DE, Kopchick JJ
International journal of molecular sciences 2025 Jul 23;26(15)
International journal of molecular sciences 2025 Jul 23;26(15)
Glucosamine activates intestinal P-glycoprotein inhibiting drug absorption.
Wu Q, Wang Q, Luo X, Jin P, Jin M, Hussain S, Qi Y, Mo J, Yu Y, Shao H, Luo L
Nature communications 2025 Jul 2;16(1):6100
Nature communications 2025 Jul 2;16(1):6100
Wheat germ agglutinin modified mixed micelles overcome the dual barrier of mucus/enterocytes for effective oral absorption of shikonin and gefitinib.
Hou X, Ai X, Liu Z, Yang J, Wu Y, Zhang D, Feng N
Drug delivery and translational research 2025 Jan;15(1):325-342
Drug delivery and translational research 2025 Jan;15(1):325-342
Identifying ADME-related gene signature for immune landscape and prognosis in KIRC by single-cell and spatial transcriptome analysis.
Wang H, Li F, Wang Q, Guo X, Chen X, Zou X, Yuan J
Scientific reports 2025 Jan 8;15(1):1294
Scientific reports 2025 Jan 8;15(1):1294
Aging Reduces ATP-Binding Cassette Transporter Expression in Brain Microvessels of Mice.
Wada Y, Inoko M, Ishihara K, Fukumoto K, Tsurudome Y, Horiguchi M, Fujimura A, Ushijima K
Pharmaceuticals (Basel, Switzerland) 2025 Jan 30;18(2)
Pharmaceuticals (Basel, Switzerland) 2025 Jan 30;18(2)
The Unveiled Novel regulator of Adeno-associated virus production in HEK293 cells.
Yan J, Li Z, Shu Y, Chen H, Wang T, Li X, Zhang Y, Li L, Zhang Y
Gene 2025 Feb 20;938:149122
Gene 2025 Feb 20;938:149122
KSQ-4279, an Inhibitor of Ubiquitin Specific Peptidase 1, Enhanced the Chemotherapeutic Efficacy in ABCB1/ABCG2/ABCC1-Mediated Multidrug Resistant Cancers.
Yang Q, Luo K, To KKW, Pan C, Fu K, Zhu S, Li S, Wang F, Wu C, Fu L
MedComm 2025 Dec;6(12):e70517
MedComm 2025 Dec;6(12):e70517
Exosomal microRNA-20b-5p contributes to cytarabine resistance in acute myeloid leukemia via the microtubule-associated serine/threonine kinase-like-phosphatidylinositol 3-kinase-protein kinase B signaling axis.
Huang A, Wang L, Chen Y, Zhao Z, Cheng W, Cheng W, Cheng B, Guo H, Li Y, Cai J, Yang J, Zou X, Wang J
International journal of biological macromolecules 2025 Dec;333(Pt 2):148750
International journal of biological macromolecules 2025 Dec;333(Pt 2):148750
Plain DNA and cationic aromatics: a platform to simplify carrier-free delivery systems.
Fang S, Zhao Z, Li H, Li W, Ding Y, Meng Z, Wu F, Zheng L, Shu G, Chen M, Ye F, Liu Q, Zheng L, Ji J
Journal of nanobiotechnology 2025 Dec 28;24(1):98
Journal of nanobiotechnology 2025 Dec 28;24(1):98
Discovery of a heterocyclic aromatic amide based P-gp inhibitor as coadjutant regulating autophagy against drug resistance in breast cancer.
Xue WH, Zhang X, Guo S, Yu H, Man RY, Lu PF, Ge GH, Liu HY, Meng FH, Zhang TJ
European journal of medicinal chemistry 2025 Dec 15;300:118151
European journal of medicinal chemistry 2025 Dec 15;300:118151
Restoration of A2M reduces drug resistance and malignancy in paclitaxel-resistant lung cancer cells.
Fan X, Xue H, Liu Z, Zhou Y, Huang X, Dong X, Sun Q, Yao J, Liu J
The international journal of biochemistry & cell biology 2025 Aug;185:106789
The international journal of biochemistry & cell biology 2025 Aug;185:106789
Limited predictive value of pretreatment P-glycoprotein immunostaining for chemotherapy efficacy and survival in long-follow-up osteosarcoma patients.
Higuchi T, Igarashi K, Miwa S, Takeuchi A, Hayashi K, Demura S, Yamamoto N, Tsuchiya H
Medicine 2025 Aug 8;104(32):e43472
Medicine 2025 Aug 8;104(32):e43472
Gut-resident Phascolarctobacterium succinatutens decreases fat accumulation via MYC-driven epigenetic regulation of arginine biosynthesis.
Lan Q, Liufu S, Chen B, Wang K, Chen W, Xiao L, Liu X, Yi L, Liu J, Xu X, Liu C, Liu M, Yin Y, Ma H
NPJ biofilms and microbiomes 2025 Aug 2;11(1):150
NPJ biofilms and microbiomes 2025 Aug 2;11(1):150
Integrative analysis of taurine metabolism-related genes prognostic signature with immunotherapy and identification of ABCB1 and GORASP1 as key genes in nasopharyngeal carcinoma.
Feng Z, Yang Y, Luo W, Li J, Xie Z, Zuo L, Duan M, Zuo D, Mo R, Tang X, Yi S, He X, Liu F, Ma N, He F
Amino acids 2025 Apr 24;57(1):21
Amino acids 2025 Apr 24;57(1):21
Long noncoding RNA UCA1 knockdown inhibits cisplatin-resistant cervical cancer tumorigenesis via the miR-195-5p/IKBKB axis.
Wang B, Li L, Wu Z, Qian X, Yu W, Huang Z
Acta biochimica et biophysica Sinica 2025 Apr 22;57(9):1492-1506
Acta biochimica et biophysica Sinica 2025 Apr 22;57(9):1492-1506
Sucralose Promotes Benzo(a)Pyrene-Induced Renal Toxicity in Mice by Regulating P-glycoprotein.
Hu J, Feng J, Bai Y, Yao ZS, Wu XY, Hong XY, Lu GD, Xue K
Antioxidants (Basel, Switzerland) 2025 Apr 16;14(4)
Antioxidants (Basel, Switzerland) 2025 Apr 16;14(4)
Hybrid Liposome-MSN System with Co-Delivering Potential Effective Against Multidrug-Resistant Tumor Targets in Mice Model.
Yang Y, Yang S, Zhang B, Wang J, Meng D, Cui L, Zhang L
International journal of nanomedicine 2024;19:8949-8970
International journal of nanomedicine 2024;19:8949-8970
Lipid-Based Self-Microemulsion of Niclosamide Achieved Enhanced Oral Delivery and Anti-Tumor Efficacy in Orthotopic Patient-Derived Xenograft of Hepatocellular Carcinoma in Mice.
Liu Y, Guerrero DQ, Lechuga-Ballesteros D, Tan M, Ahmad F, Aleiwi B, Ellsworth EL, Chen B, Chua MS, So S
International journal of nanomedicine 2024;19:2639-2653
International journal of nanomedicine 2024;19:2639-2653
SiRNF8 Delivered by DNA Framework Nucleic Acid Effectively Sensitizes Chemotherapy in Colon Cancer.
Guo Z, Song H, Tian Y, Xu J, Zhang G, Guo Y, Shen R, Wang D
International journal of nanomedicine 2024;19:171-188
International journal of nanomedicine 2024;19:171-188
Bisecting GlcNAc modification reverses the chemoresistance via attenuating the function of P-gp.
Tan Z, Ning L, Cao L, Zhou Y, Li J, Yang Y, Lin S, Ren X, Xue X, Kang H, Li X, Guan F
Theranostics 2024;14(13):5184-5199
Theranostics 2024;14(13):5184-5199
Intercellular adhesion molecule-1 suppresses TMZ chemosensitivity in acquired TMZ-resistant gliomas by increasing assembly of ABCB1 on the membrane.
Zhang X, Tan Y, Li T, Tan D, Fu B, Yang M, Chen Y, Cao M, Xuan C, Du Q, Hu R, Wang Q
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Sep;76:101112
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Sep;76:101112
Lansoprazole (LPZ) reverses multidrug resistance (MDR) in cancer through impeding ATP-binding cassette (ABC) transporter-mediated chemotherapeutic drug efflux and lysosomal sequestration.
Ji N, Li H, Zhang Y, Li Y, Wang P, Chen X, Liu YN, Wang JQ, Yang Y, Chen ZS, Li Y, Wang R, Kong D
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Sep;76:101100
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Sep;76:101100
Shikonin and chitosan-silver nanoparticles synergize against triple-negative breast cancer through RIPK3-triggered necroptotic immunogenic cell death.
Liang J, Tian X, Zhou M, Yan F, Fan J, Qin Y, Chen B, Huo X, Yu Z, Tian Y, Deng S, Peng Y, Wang Y, Liu B, Ma X
Biomaterials 2024 Sep;309:122608
Biomaterials 2024 Sep;309:122608
P-glycoprotein-mediated herb-drug interaction evaluation between Tenacissoside G and paclitaxel.
Hu J, Hu Y, Xu L, Chen J, Shi M, Wu W, Yang J, Han Y
Biomedical chromatography : BMC 2024 Oct;38(10):e5984
Biomedical chromatography : BMC 2024 Oct;38(10):e5984
Autocrine Motility Factor and Its Peptide Derivative Inhibit Triple-Negative Breast Cancer by Regulating Wound Repair, Survival, and Drug Efflux.
Kim SG, Kim SJ, Duong TV, Cho Y, Park B, Kadam US, Park HS, Hong JC
International journal of molecular sciences 2024 Oct 31;25(21)
International journal of molecular sciences 2024 Oct 31;25(21)
RGS5(+) lymphatic endothelial cells facilitate metastasis and acquired drug resistance of breast cancer through oxidative stress-sensing mechanism.
Qiu C, Tang C, Tang Y, Su K, Chai X, Zhan Z, Niu X, Li J
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Nov;77:101149
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Nov;77:101149
USP14 increases the sensitivity of retinoblastoma to cisplatin by mediating the ferroptosis.
Liu H, Gan Q, Lai Y, Pan Z, Jin Q, Li J, Wang N, Jiao S, Chai Y
Naunyn-Schmiedeberg's archives of pharmacology 2024 Nov;397(11):8671-8680
Naunyn-Schmiedeberg's archives of pharmacology 2024 Nov;397(11):8671-8680
Mitotic Arrest Deficient 2 Like 1 Contributes to Colorectal Cancer Cell Migration, Invasion, and Oxaliplatin Resistance Through the Wnt/β-Catenin Pathway.
Ding X, Zhou Y, He L, Kang H, Wen Y, Xu J, Zhu C, Luo L, Zeng Q
Chemical biology & drug design 2024 Nov;104(5):e70012
Chemical biology & drug design 2024 Nov;104(5):e70012
Complex IIa formation and ABC transporters determine sensitivity of OSCC to Smac mimetics.
Wang Y, Liu Z, Si Q, Lu W, Song Y, Jin W, Yang X, Li Z, Hu X, Ding L, Jing Y, Weng P, Yu Q, O'Reilly LA, Silke J, Zhang X, Hu Q, Ni Y
Cell death & disease 2024 Nov 22;15(11):855
Cell death & disease 2024 Nov 22;15(11):855
Targeted Elimination of the Oral Pathogen to Overcome Chemoresistance of Oral Squamous Cell Carcinoma by Biologically Derived Nanotherapeutics.
Pang X, Li J, Liu Z, Chen Q, Chen WH, Zhang XZ, Luo GF, Shang Z
ACS nano 2024 Nov 19;18(46):31794-31808
ACS nano 2024 Nov 19;18(46):31794-31808
Quercetin improves the protection of hydroxysafflor yellow a against cerebral ischemic injury by modulating of blood-brain barrier and src-p-gp-mmp-9 signalling.
Li X, Yang Y, Feng P, Wang H, Zheng M, Zhu Y, Zhong K, Hu J, Ye Y, Lu L, Zhao Q
Heliyon 2024 May 30;10(10):e31002
Heliyon 2024 May 30;10(10):e31002
PARP1-DOT1L transcription axis drives acquired resistance to PARP inhibitor in ovarian cancer.
Liu C, Li J, Xu F, Chen L, Ni M, Wu J, Zhao H, Wu Y, Li J, Wu X, Chen X
Molecular cancer 2024 May 22;23(1):111
Molecular cancer 2024 May 22;23(1):111
Enhanced Efficacy against Drug-Resistant Tumors Enabled by Redox-Responsive Mesoporous-Silica-Nanoparticle-Supported Lipid Bilayers as Targeted Delivery Vehicles.
Yang S, Zhang B, Zhao X, Zhang M, Zhang M, Cui L, Zhang L
International journal of molecular sciences 2024 May 20;25(10)
International journal of molecular sciences 2024 May 20;25(10)
Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.
Li R, Xiong Z, Ma Y, Li Y, Yang Y, Ma S, Ha C
World journal of surgical oncology 2024 Mar 21;22(1):81
World journal of surgical oncology 2024 Mar 21;22(1):81
Jianpi Jiedu decoction reverses 5-fluorouracil resistance in colorectal cancer by suppressing the xCT/GSH/GPX4 axis to induce ferroptosis.
Ou QL, Cheng L, Chang YL, Liu JH, Zhang SF
Heliyon 2024 Mar 15;10(5):e27082
Heliyon 2024 Mar 15;10(5):e27082
A New Histology-Based Prognostic Index for Aggressive T-Cell lymphoma: Preliminary Results of the "TCL Urayasu Classification".
Nitta H, Takizawa H, Mitsumori T, Iizuka-Honma H, Ochiai T, Furuya C, Araki Y, Fujishiro M, Tomita S, Hashizume A, Sawada T, Miyake K, Okubo M, Sekiguchi Y, Ando M, Noguchi M
Journal of clinical medicine 2024 Jun 30;13(13)
Journal of clinical medicine 2024 Jun 30;13(13)
[Aqueous extract of Chuan Xiong Rhizoma enhances inhibitory effect of temozolomide against brain metastasis of melanoma in mice].
Zhao Q, Zhang Z, Zhou X, Rong X, Liu X, Zhao X, Wang H, Pang J, Li S, Li X
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Jun 20;44(6):1088-1097
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Jun 20;44(6):1088-1097
BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo.
Yang Q, To KKW, Hu G, Fu K, Yang C, Zhu S, Pan C, Wang F, Luo K, Fu L
Cell communication and signaling : CCS 2024 Jun 13;22(1):325
Cell communication and signaling : CCS 2024 Jun 13;22(1):325
The Anthraquinone Derivative C2 Enhances Oxaliplatin-Induced Cell Death and Triggers Autophagy via the PI3K/AKT/mTOR Pathway.
Li Y, Yan W, Qin Y, Zhang L, Xiao S
International journal of molecular sciences 2024 Jun 12;25(12)
International journal of molecular sciences 2024 Jun 12;25(12)
Lycorine attenuated proliferation and induced apoptosis on imatinib-resistant K562 cell by inhibiting autophagy.
Bai J, Feng Z, Chen Y, Li Y, Zhang L, Li L
Discover oncology 2024 Jun 10;15(1):217
Discover oncology 2024 Jun 10;15(1):217
QKL injection ameliorates Alzheimer's disease-like pathology by regulating expression of RAGE.
Dou J, Zhang X, Hu C, Gao Y, Zhao Y, Hei M, Wang Z, Guo N, Zhu H
Experimental gerontology 2024 Jun 1;190:112422
Experimental gerontology 2024 Jun 1;190:112422
Overcoming flumatinib resistance in chronic myeloid leukaemia: Insights into cellular mechanisms and ivermectin's therapeutic potential.
Huang J, Xiao J, He L, Dai W, Xiao J, Li Y, He Y, Yu L
Journal of cellular and molecular medicine 2024 Jul;28(14):e18539
Journal of cellular and molecular medicine 2024 Jul;28(14):e18539
Aronia Berry Extract Modulates MYD88/NF-kB/P-Glycoprotein Axis to Overcome Gemcitabine Resistance in Pancreatic Cancer.
Li Y, Xu C, Han H, Pascual-Sabater S, Fillat C, Goel A
Pharmaceuticals (Basel, Switzerland) 2024 Jul 9;17(7)
Pharmaceuticals (Basel, Switzerland) 2024 Jul 9;17(7)
tRNA-derived fragment 3'tRF-AlaAGC modulates cell chemoresistance and M2 macrophage polarization via binding to TRADD in breast cancer.
Mo D, Tang X, Ma Y, Chen D, Xu W, Jiang N, Zheng J, Yan F
Journal of translational medicine 2024 Jul 30;22(1):706
Journal of translational medicine 2024 Jul 30;22(1):706
Sestrin 2 protects human lens epithelial cells from oxidative stress and apoptosis induced by hydrogen peroxide by regulating the mTOR/Nrf2 pathway.
Tian X, Wei J
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241234741
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241234741
Discovery of (quinazolin-6-yl)benzamide derivatives containing a 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety as potent reversal agents against P-glycoprotein-mediated multidrug resistance.
Xue WH, Liu KL, Zhang TJ, Dong G, Wang JH, Wang J, Guo S, Hu J, Zhang QY, Li XY, Meng FH
European journal of medicinal chemistry 2024 Jan 15;264:116039
European journal of medicinal chemistry 2024 Jan 15;264:116039
Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.
Huang Y, Chan S, Chen S, Liu X, Li M, Zheng L, Dong Z, Yang Z, Liu Z, Zhou D, Zhang X, Zhang B
Journal of translational medicine 2024 Feb 3;22(1):133
Journal of translational medicine 2024 Feb 3;22(1):133
EGR1 mediates MDR1 transcriptional activity regulating gemcitabine resistance in pancreatic cancer.
Yang Z, Chen F, Wei D, Chen F, Jiang H, Qin S
BMC cancer 2024 Feb 26;24(1):268
BMC cancer 2024 Feb 26;24(1):268
Ivermectin Enhances Paclitaxel Efficacy by Overcoming Resistance Through Modulation of ABCB1 in Non-small Cell Lung Cancer.
Hayashi A, Kamio K, Miyanaga A, Yoshida K, Noro R, Matsuda K, Tozuka T, Omori M, Hirao M, Fukuizumi A, Hisakane K, Takeuchi S, Matsumoto M, Kasahara K, Amano T, Honda K, Seike M
Anticancer research 2024 Dec;44(12):5271-5282
Anticancer research 2024 Dec;44(12):5271-5282
Gastrodin reduces Aβ brain levels in an Alzheimer's disease mouse model by inhibiting P-glycoprotein ubiquitination.
Zhu C, Wang S, Ma S, Zhang S, Wang Y, Li B, Zhang W, Sun Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156229
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156229
EYA4 reduces chemosensitivity of osteosarcoma to doxorubicin through DNA damage repair.
Heng W, Wang T, Wei F, Yang F, Chen C, Yu Z, Du M, Qian J, Zhou C
Biochemical pharmacology 2024 Aug;226:116366
Biochemical pharmacology 2024 Aug;226:116366
mRNA-Lipid Nanoparticle-Mediated Restoration of PTPN14 Exhibits Antitumor Effects by Overcoming Anoikis Resistance in Triple-Negative Breast Cancer.
Li W, Huang M, Wu Z, Zhang Y, Cai Y, Su J, Xia J, Yang F, Xiao D, Yang W, Xu Y, Liu Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2309988
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(32):e2309988
Lactate drives the ESM1-SCD1 axis to inhibit the antitumor CD8(+) T-cell response by activating the Wnt/β-catenin pathway in ovarian cancer cells and inducing cisplatin resistance.
Fan Z, Ye M, Liu D, Zhou W, Zeng T, He S, Li Y
International immunopharmacology 2024 Aug 20;137:112461
International immunopharmacology 2024 Aug 20;137:112461
Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis.
Fu Y, Li L, Zhang X, Deng Z, Wu Y, Chen W, Liu Y, He S, Wang J, Xie Y, Tu Z, Lyu Y, Wei Y, Wang S, Cui CP, Liu CH, Zhang L
Nature communications 2024 Apr 6;15(1):2974
Nature communications 2024 Apr 6;15(1):2974
Possible New Histological Prognostic Index for Large B-Cell Lymphoma.
Nitta H, Takizawa H, Mitsumori T, Iizuka-Honma H, Araki Y, Fujishiro M, Tomita S, Kishikawa S, Hashizume A, Sawada T, Okubo M, Sekiguchi Y, Ando M, Noguchi M
Journal of clinical medicine 2023 Sep 30;12(19)
Journal of clinical medicine 2023 Sep 30;12(19)
Multi-time point metabolomics reveals key metabolic features from the ultra-early stage of intracerebral hemorrhage in mice.
Xiao Z, Li P, Shen Y, Manaenko A, Yang W, Wang P, Li X, Liu F, Xie P, Li Q
Experimental neurology 2023 Oct;368:114507
Experimental neurology 2023 Oct;368:114507
Fucoidan/chitosan layered PLGA nanoparticles with melatonin loading for inducing intestinal absorption and addressing triple-negative breast cancer progression.
Yen YW, Lee YL, Yu LY, Li CE, Shueng PW, Chiu HC, Lo CL
International journal of biological macromolecules 2023 Oct 1;250:126211
International journal of biological macromolecules 2023 Oct 1;250:126211
Cell membrane-camouflaged bufalin targets NOD2 and overcomes multidrug resistance in pancreatic cancer.
Zhang W, Fan Y, Zhang J, Shi D, Yuan J, Ashrafizadeh M, Li W, Hu M, Abd El-Aty AM, Hacimuftuoglu A, Linnebacher M, Cheng Y, Li W, Fang S, Gong P, Zhang X
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2023 Nov;71:101005
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2023 Nov;71:101005
Enrofloxacin hydrochloride toxicological effects on crucian carp reflected by serological changes and neurotoxicity.
Wan G, Huang J, Wang R, Liu H, Wei L, Liang X, Li F, Wang Z, Gu X, Ruan J
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2023 Nov;273:109737
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2023 Nov;273:109737
Enhancing Paclitaxel Efficacy with Piperine-Paclitaxel Albumin Nanoparticles in Multidrug-Resistant Triple-Negative Breast Cancer by Inhibiting P-Glycoprotein.
Xu W, Xiao Y, Zheng L, Xu M, Jiang X, Wang L
Pharmaceutics 2023 Nov 30;15(12)
Pharmaceutics 2023 Nov 30;15(12)
SORL1 stabilizes ABCB1 to promote cisplatin resistance in ovarian cancer.
Zheng Z, Li X, Yang B, Xu Q, Zhu X, Hu L, Teng Y
Functional & integrative genomics 2023 May 5;23(2):147
Functional & integrative genomics 2023 May 5;23(2):147
Ribosome Biogenesis Regulator 1 Homolog (RRS1) Promotes Cisplatin Resistance by Regulating AEG-1 Abundance in Breast Cancer Cells.
Song J, Peng C, Wang R, Hua Y, Wu Q, Deng L, Cao Y, Zhang L, Hou L
Molecules (Basel, Switzerland) 2023 Mar 25;28(7)
Molecules (Basel, Switzerland) 2023 Mar 25;28(7)
ZYY-B-2, a novel ALK inhibitor, overcomes resistance to ceritinib by inhibiting P-gp function and induces apoptosis through mitochondrial pathway in ceritinib-resistant H2228 cells.
Gao Y, Liu T, Liu J, Yang Y, Sun K, Li Z, Zhai X, Zuo D
Chemico-biological interactions 2023 Jul 1;379:110516
Chemico-biological interactions 2023 Jul 1;379:110516
LncRNA BCAR4 promotes migration, invasion, and chemo-resistance by inhibiting miR-644a in breast cancer.
Wu T, Li X, Yan G, Tan Z, Zhao D, Liu S, Wang H, Xiang Y, Chen W, Lu H, Liao X, Li Y, Lu Z
Journal of experimental & clinical cancer research : CR 2023 Jan 10;42(1):14
Journal of experimental & clinical cancer research : CR 2023 Jan 10;42(1):14
Self-intensified synergy of a versatile biomimetic nanozyme and doxorubicin on electrospun fibers to inhibit postsurgical tumor recurrence and metastasis.
Hu Y, Xu Y, Mintz RL, Luo X, Fang Y, Lao YH, Chan HF, Li K, Lv S, Chen G, Tao Y, Luo Y, Li M
Biomaterials 2023 Feb;293:121942
Biomaterials 2023 Feb;293:121942
Regulation of the ATP-binding cassette transporters ABCB1, ABCG2 and ABCC5 by nuclear receptors in porcine blood-brain barrier endothelial cells.
Ho YS, Torres-Vergara P, Penny J
British journal of pharmacology 2023 Dec;180(23):3092-3109
British journal of pharmacology 2023 Dec;180(23):3092-3109
NIR-II Regulation of Mitochondrial Potassium Channel with Dual-Targeted Conjugated Oligomer Nanoparticles for Efficient Cancer Theranostics In Vivo.
Li C, Gao D, Gao Y, Zhang R, Qu X, Li S, Xing C
Advanced healthcare materials 2023 Dec;12(31):e2301954
Advanced healthcare materials 2023 Dec;12(31):e2301954
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.
Liang X, Yang Y, Huang C, Ye Z, Lai W, Luo J, Li X, Yi X, Fan JB, Wang Y, Wang Y
Journal of controlled release : official journal of the Controlled Release Society 2023 Apr;356:691-701
Journal of controlled release : official journal of the Controlled Release Society 2023 Apr;356:691-701
Novel Benzo Five-Membered Heterocycle Derivatives as P-Glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-Multidrug Resistance Activity.
Yang Z, Cai Y, Yang X, Li Y, Wu Q, Yu Y, Chen Z, Wei B, Tian JM, Bao X, Ye X, Chen J, Zhang H, Mou X, Sun X, Wang H
Journal of medicinal chemistry 2023 Apr 27;66(8):5550-5566
Journal of medicinal chemistry 2023 Apr 27;66(8):5550-5566
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
Xin M, Gao Q, Xiang X, Xu J, Jiao Y, Li X, Zhang X, Jia X
Frontiers in pharmacology 2022;13:890974
Frontiers in pharmacology 2022;13:890974
ZIP1(+) fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn(2+) transfer.
Ni C, Lou X, Yao X, Wang L, Wan J, Duan X, Liang J, Zhang K, Yang Y, Zhang L, Sun C, Li Z, Wang M, Zhu L, Lv D, Qin Z
Nature communications 2022 Oct 7;13(1):5919
Nature communications 2022 Oct 7;13(1):5919
Blood-brain barrier permeability to enrofloxacin in Pengze crucian carp (Carassius auratus var. Pengze).
Zhang F, Wang R, Huang J, Zhang H, Wang L, Zhong Z, Ruan J, Liu H
Veterinary medicine and science 2022 Nov;8(6):2404-2410
Veterinary medicine and science 2022 Nov;8(6):2404-2410
Hsa-miR-3178/RhoB/PI3K/Akt, a novel signaling pathway regulates ABC transporters to reverse gemcitabine resistance in pancreatic cancer.
Gu J, Huang W, Wang X, Zhang J, Tao T, Zheng Y, Liu S, Yang J, Chen ZS, Cai CY, Li J, Wang H, Fan Y
Molecular cancer 2022 May 10;21(1):112
Molecular cancer 2022 May 10;21(1):112
Myeloid ecotropic viral integration site-1 inhibition promotes apoptosis, suppresses proliferation of acute myeloid leukemia cells, accentuates the effects of anticancer drugs.
Jin Y, Wang J, Zhao M, Lin J, Hong L
Bioengineered 2022 Mar;13(3):5700-5708
Bioengineered 2022 Mar;13(3):5700-5708
Kaempferol Can Reverse the 5-Fu Resistance of Colorectal Cancer Cells by Inhibiting PKM2-Mediated Glycolysis.
Wu H, Du J, Li C, Li H, Guo H, Li Z
International journal of molecular sciences 2022 Mar 24;23(7)
International journal of molecular sciences 2022 Mar 24;23(7)
Luteolin attenuates the chemoresistance of osteosarcoma through inhibiting the PTN/β-catenin/MDR1 signaling axis by upregulating miR-384.
Qin T, Zhu W, Kan X, Li L, Wu D
Journal of bone oncology 2022 Jun;34:100429
Journal of bone oncology 2022 Jun;34:100429
Canthin-6-one (CO) from Picrasma quassioides (D.Don) Benn. ameliorates lipopolysaccharide (LPS)-induced astrocyte activation and associated brain endothelial disruption.
Yue Q, Xu Y, Lin L, Hoi MPM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154108
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul;101:154108
Murine Beta-Amyloid (1-42) Oligomers Disrupt Endothelial Barrier Integrity and VEGFR Signaling via Activating Astrocytes to Release Deleterious Soluble Factors.
Yue Q, Zhou X, Zhang Z, Hoi MPM
International journal of molecular sciences 2022 Feb 7;23(3)
International journal of molecular sciences 2022 Feb 7;23(3)
S-20, a steroidal saponin from the berries of black nightshade, exerts anti-multidrug resistance activity in K562/ADR cells through autophagic cell death and ERK activation.
Wang Y, Xu J, Wang Y, Xiang L, He X
Food & function 2022 Feb 21;13(4):2200-2215
Food & function 2022 Feb 21;13(4):2200-2215
DNAzyme-Based nanoflowers for reversing P-glycoprotein-mediated multidrug resistance in breast cancer.
Liang L, Huo W, Wang B, Cao L, Huo H, Liu Y, Jin Y, Yang X
Journal of colloid and interface science 2022 Feb 15;608(Pt 3):2985-2993
Journal of colloid and interface science 2022 Feb 15;608(Pt 3):2985-2993
Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective Colon cancer therapy.
Almoshari Y, Iqbal H, Razzaq A, Ali Ahmad K, Khan MK, Saeed Alqahtani S, Hadi Sultan M, Ali Khan B
Drug delivery 2022 Dec;29(1):2633-2643
Drug delivery 2022 Dec;29(1):2633-2643
Identification of a Novel Potent CYP4Z1 Inhibitor Attenuating the Stemness of Breast Cancer Cells through Lead Optimization.
Yuan Y, Yao H, Zhou M, Ma X, Zhou Y, Xu J, Niu M, Yin J, Zheng L, Xu S
Journal of medicinal chemistry 2022 Dec 8;65(23):15749-15769
Journal of medicinal chemistry 2022 Dec 8;65(23):15749-15769
Study of Drug Resistance in Chemotherapy Induced by Extracellular Vesicles on a Microchip.
Fang T, Lu W, Zhang J, Ge K, Chen Z, Wang M, Yao B
Analytical chemistry 2022 Dec 6;94(48):16919-16926
Analytical chemistry 2022 Dec 6;94(48):16919-16926
Biotransformation of graphene oxide within lung fluids could intensify its synergistic biotoxicity effect with cadmium by inhibiting cellular efflux of cadmium.
Zhu J, Liu L, Ma J, Fu Q, Zheng Z, Du E, Xu Y, Zhang Z
Environmental pollution (Barking, Essex : 1987) 2022 Aug 1;306:119421
Environmental pollution (Barking, Essex : 1987) 2022 Aug 1;306:119421
The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance.
Deng C, Hu F, Zhao Z, Zhou Y, Liu Y, Zhang T, Li S, Zheng W, Zhang W, Wang T, Ma X
Frontiers in cell and developmental biology 2021;9:797005
Frontiers in cell and developmental biology 2021;9:797005
Resveratrol-Loaded TPGS-Resveratrol-Solid Lipid Nanoparticles for Multidrug-Resistant Therapy of Breast Cancer: In Vivo and In Vitro Study.
Wang W, Zhou M, Xu Y, Peng W, Zhang S, Li R, Zhang H, Zhang H, Cheng S, Wang Y, Wei X, Yue C, Yang Q, Chen C
Frontiers in bioengineering and biotechnology 2021;9:762489
Frontiers in bioengineering and biotechnology 2021;9:762489
Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.
Cao W, Li Y, Sun H, Yang C, Zhu J, Xie C, Li X, Wu J, Geng S, Wang L, Sun L, Geng G, Han H, Zhong C
Frontiers in cell and developmental biology 2021;9:679806
Frontiers in cell and developmental biology 2021;9:679806
Nucleolin Promotes Cisplatin Resistance in Cervical Cancer by the YB1-MDR1 Pathway.
Ke J, Gu C, Zhang H, Liu Y, Zhang W, Rao H, Li S, Wu F
Journal of oncology 2021;2021:9992218
Journal of oncology 2021;2021:9992218
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Wang T, Dong J, Yuan X, Wen H, Wu L, Liu J, Sui H, Deng W
Frontiers in pharmacology 2021;12:653306
Frontiers in pharmacology 2021;12:653306
Hedgehog-Gli2 Signaling Promotes Chemoresistance in Ovarian Cancer Cells by Regulating MDR1.
Wang Q, Wei X, Hu L, Zhuang L, Zhang H, Chen Q
Frontiers in oncology 2021;11:794959
Frontiers in oncology 2021;11:794959
Discovering and Characterizing of Survivin Dominant Negative Mutants With Stronger Pro-apoptotic Activity on Cancer Cells and CSCs.
Guo W, Ma X, Fu Y, Liu C, Liu Q, Hu F, Miao H, Zhang T, Liu Y, Han MH, You F, Yang Y, Zheng W
Frontiers in oncology 2021;11:635233
Frontiers in oncology 2021;11:635233
ZFX promotes tumorigenesis and confers chemotherapy resistance in esophageal squamous cell carcinoma.
Wu J, Zhou Y, Wang T, Jiang C, Gao Y, Wei B
Clinics and research in hepatology and gastroenterology 2021 Sep;45(5):101586
Clinics and research in hepatology and gastroenterology 2021 Sep;45(5):101586
Rational design of phenyl thiophene (pyridine) derivatives that overcome P-glycoprotein mediated MDR in MCF-7/ADR cell.
Li YS, Mao S, Zhao DS, Wang CC, Zu D, Yang X, Liu GJ, Wang SJ, Zhang B, Bao XZ, Ye XY, Wei B, Cui ZN, Chen JW, Wang H
Bioorganic chemistry 2021 Sep;114:105075
Bioorganic chemistry 2021 Sep;114:105075
Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation.
Wei L, Lin Q, Lu Y, Li G, Huang L, Fu Z, Chen R, Zhou Q
Cell death & disease 2021 Mar 29;12(4):334
Cell death & disease 2021 Mar 29;12(4):334
The study of Raddeanin A cerebrovascular endothelial cell trafficking through P-glycoprotein.
Wang YY, Jiang CF, Liu X, Li JN, Cai GZ, Gong JY
Biochemical and biophysical research communications 2021 Jun 25;559:222-229
Biochemical and biophysical research communications 2021 Jun 25;559:222-229
Knockdown of USP9X reverses cisplatin resistance by decreasing β-catenin expression in nasopharyngeal carcinoma cells.
Lu WX, Gan GS, Yang B
Neoplasma 2021 Jul;68(4):810-822
Neoplasma 2021 Jul;68(4):810-822
Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway.
Liu K, Song J, Yan Y, Zou K, Che Y, Wang B, Li Z, Yu W, Guo W, Zou L, Deng W, Sun X
Translational oncology 2021 Jan;14(1):100876
Translational oncology 2021 Jan;14(1):100876
Polyphenol from millet bran increases the sensitivity of colorectal cancer cells to oxaliplatin by blocking the ganglioside GM3 catabolism.
Zhang X, Shan S, Shi J, Li H, Li Z
Food & function 2021 Jan 7;12(1):291-301
Food & function 2021 Jan 7;12(1):291-301
Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane.
Phatak V, von Grabowiecki Y, Janus J, Officer L, Behan C, Aschauer L, Pinon L, Mackay H, Zanivan S, Norman JC, Kelly M, Le Quesne J, Muller PAJ
Cell death & disease 2021 Feb 24;12(2):207
Cell death & disease 2021 Feb 24;12(2):207
Acylglycerol kinase promotes paclitaxel resistance in nasopharyngeal carcinoma cells by regulating FOXM1 via the JAK2/STAT3 pathway.
Zhao C, Chen HY, Zhao F, Feng HJ, Su JP
Cytokine 2021 Dec;148:155595
Cytokine 2021 Dec;148:155595
Compound 968 reverses adriamycin resistance in breast cancer MCF-7(ADR) cells via inhibiting P-glycoprotein function independently of glutaminase.
Yang R, Guo Z, Zhao Y, Ma L, Li B, Yang C
Cell death discovery 2021 Aug 5;7(1):204
Cell death discovery 2021 Aug 5;7(1):204
TPGS-Galactose-Modified Polydopamine Co-delivery Nanoparticles of Nitric Oxide Donor and Doxorubicin for Targeted Chemo-Photothermal Therapy against Drug-Resistant Hepatocellular Carcinoma.
Du Z, Mao Y, Zhang P, Hu J, Fu J, You Q, Yin J
ACS applied materials & interfaces 2021 Aug 4;13(30):35518-35532
ACS applied materials & interfaces 2021 Aug 4;13(30):35518-35532
Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.
Li YS, Yang X, Zhao DS, Cai Y, Huang Z, Wu R, Wang SJ, Liu GJ, Wang J, Bao XZ, Ye XY, Wei B, Cui ZN, Wang H
European journal of medicinal chemistry 2021 Apr 15;216:113336
European journal of medicinal chemistry 2021 Apr 15;216:113336
Circadian Clock Protein PERIOD2 Suppresses the PI3K/Akt Pathway and Promotes Cisplatin Sensitivity in Ovarian Cancer.
Wang Z, Li F, Wei M, Zhang S, Wang T
Cancer management and research 2020;12:11897-11908
Cancer management and research 2020;12:11897-11908
Overexpression of close homolog of L1 enhances the chemosensitivity of lung cancer cells via inhibition of the Akt pathway.
Cai X, Hu B, Liu S, Liu M, Huang Y, Lei P, Zhang Z, He Z, Zhang L, Huang R
Oncology letters 2020 Oct;20(4):111
Oncology letters 2020 Oct;20(4):111
Cucurbitacin E Chemosensitizes Colorectal Cancer Cells via Mitigating TFAP4/Wnt/β-Catenin Signaling.
Yang P, Liu W, Fu R, Ding GB, Amin S, Li Z
Journal of agricultural and food chemistry 2020 Nov 18;
Journal of agricultural and food chemistry 2020 Nov 18;
Overexpression of RSK4 reverses doxorubicin resistance in human breast cancer cells via PI3K/AKT signalling pathway.
Mei Y, Liao X, Zhu L, Yang H
Journal of biochemistry 2020 Jun 1;167(6):603-611
Journal of biochemistry 2020 Jun 1;167(6):603-611
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
Zhou C, Yi C, Yi Y, Qin W, Yan Y, Dong X, Zhang X, Huang Y, Zhang R, Wei J, Ali DW, Michalak M, Chen XZ, Tang J
Molecular cancer 2020 Jul 29;19(1):118
Molecular cancer 2020 Jul 29;19(1):118
Total Saponins from Paris forrestii Reverse Multidrug Resistance of MCF-7/ADM Cells by Suppression of P-gp via ERK Signaling Pathway.
Chai D, Yuan J, Zhu X, Zeng Y, Yang R, Chen Y, Wang Y, Zhou Y
Biological & pharmaceutical bulletin 2020 Dec 1;43(12):1823-1830
Biological & pharmaceutical bulletin 2020 Dec 1;43(12):1823-1830
Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.
Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S, Shan C
Biochemical pharmacology 2020 Aug;178:114092
Biochemical pharmacology 2020 Aug;178:114092
1,25-dihydroxyvitamin D3 signaling-induced decreases in IRX4 inhibits NANOG-mediated cancer stem-like properties and gefitinib resistance in NSCLC cells.
Jia Z, Zhang Y, Yan A, Wang M, Han Q, Wang K, Wang J, Qiao C, Pan Z, Chen C, Hu D, Ding X
Cell death & disease 2020 Aug 20;11(8):670
Cell death & disease 2020 Aug 20;11(8):670
Novel Quinoline Compound Derivatives of NSC23925 as Potent Reversal Agents Against P-Glycoprotein-Mediated Multidrug Resistance.
Quan X, Du H, Xu J, Hou X, Gong X, Wu Y, Zhou Y, Jiang J, Lu L, Yuan S, Yang X, Shi L, Sun L
Frontiers in chemistry 2019;7:820
Frontiers in chemistry 2019;7:820
Circadian sensitivity to the cardiac glycoside oleandrin is associated with diurnal intestinal P-glycoprotein expression.
Zhou C, Yu F, Zeng P, Zhang T, Huang H, Chen W, Wu B
Biochemical pharmacology 2019 Nov;169:113622
Biochemical pharmacology 2019 Nov;169:113622
Forkhead Box R2 Knockdown Decreases Chemoresistance to Cisplatin via MYC Pathway in Bladder Cancer.
Li Y, Zu X, Hu X, Wang L, He W
Medical science monitor : international medical journal of experimental and clinical research 2019 Nov 25;25:8928-8939
Medical science monitor : international medical journal of experimental and clinical research 2019 Nov 25;25:8928-8939
Effect of Stereochemical Configuration on the Transport and Metabolism of Catechins from Green Tea across Caco-2 Monolayers.
Ai Z, Liu S, Qu F, Zhang H, Chen Y, Ni D
Molecules (Basel, Switzerland) 2019 Mar 26;24(6)
Molecules (Basel, Switzerland) 2019 Mar 26;24(6)
Aptamer-Based Erythrocyte-Derived Mimic Vesicles Loaded with siRNA and Doxorubicin for the Targeted Treatment of Multidrug-Resistant Tumors.
Wang T, Luo Y, Lv H, Wang J, Zhang Y, Pei R
ACS applied materials & interfaces 2019 Dec 11;11(49):45455-45466
ACS applied materials & interfaces 2019 Dec 11;11(49):45455-45466
LncRNA FENDRR attenuates adriamycin resistance via suppressing MDR1 expression through sponging HuR and miR-184 in chronic myelogenous leukaemia cells.
Zhang F, Ni H, Li X, Liu H, Xi T, Zheng L
FEBS letters 2019 Aug;593(15):1993-2007
FEBS letters 2019 Aug;593(15):1993-2007
Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases.
Guo HH, Feng CL, Zhang WX, Luo ZG, Zhang HJ, Zhang TT, Ma C, Zhan Y, Li R, Wu S, Abliz Z, Li C, Li XL, Ma XL, Wang LL, Zheng WS, Han YX, Jiang JD
Nature communications 2019 Apr 30;10(1):1981
Nature communications 2019 Apr 30;10(1):1981
Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment.
Wang D, Xu X, Zhang K, Sun B, Wang L, Meng L, Liu Q, Zheng C, Yang B, Sun H
International journal of nanomedicine 2018;13:187-198
International journal of nanomedicine 2018;13:187-198
RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.
Wang X, Liu W, Wang P, Li S
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2018 Nov;47(10):930-937
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2018 Nov;47(10):930-937
Hierarchically Self-Assembled Supramolecular Host-Guest Delivery System for Drug Resistant Cancer Therapy.
Cheng H, Fan X, Wang X, Ye E, Loh XJ, Li Z, Wu YL
Biomacromolecules 2018 Jun 11;19(6):1926-1938
Biomacromolecules 2018 Jun 11;19(6):1926-1938
Thermoresponsive Supramolecular Chemotherapy by "V"-Shaped Armed β-Cyclodextrin Star Polymer to Overcome Drug Resistance.
Fan X, Cheng H, Wang X, Ye E, Loh XJ, Wu YL, Li Z
Advanced healthcare materials 2018 Apr;7(7):e1701143
Advanced healthcare materials 2018 Apr;7(7):e1701143
Long noncoding RNA MALAT1 knockdown reverses chemoresistance to temozolomide via promoting microRNA-101 in glioblastoma.
Cai T, Liu Y, Xiao J
Cancer medicine 2018 Apr;7(4):1404-1415
Cancer medicine 2018 Apr;7(4):1404-1415
Pleiotrophin promotes chemoresistance to doxorubicin in osteosarcoma by upregulating P-glycoprotein.
Wu D, Liu L, Yan X, Wang C, Wang Y, Han K, Lin S, Gan Z, Min D
Oncotarget 2017 Sep 8;8(38):63857-63870
Oncotarget 2017 Sep 8;8(38):63857-63870
PD-1/PD-L1 interaction up-regulates MDR1/P-gp expression in breast cancer cells via PI3K/AKT and MAPK/ERK pathways.
Liu S, Chen S, Yuan W, Wang H, Chen K, Li D, Li D
Oncotarget 2017 Nov 21;8(59):99901-99912
Oncotarget 2017 Nov 21;8(59):99901-99912
Reversal of cisplatin resistance in non-small cell lung cancer stem cells by Taxus chinensis var.
Jiang YQ, Xu XP, Guo QM, Xu XC, Liu QY, An SH, Xu JL, Su F, Tai JB
Genetics and molecular research : GMR 2016 Sep 2;15(3)
Genetics and molecular research : GMR 2016 Sep 2;15(3)
Exosomes play an important role in the process of psoralen reverse multidrug resistance of breast cancer.
Wang X, Xu C, Hua Y, Sun L, Cheng K, Jia Z, Han Y, Dong J, Cui Y, Yang Z
Journal of experimental & clinical cancer research : CR 2016 Dec 1;35(1):186
Journal of experimental & clinical cancer research : CR 2016 Dec 1;35(1):186
Immunohistochemical analysis of transporters related to clearance of amyloid-β peptides through blood-cerebrospinal fluid barrier in human brain.
Matsumoto K, Chiba Y, Fujihara R, Kubo H, Sakamoto H, Ueno M
Histochemistry and cell biology 2015 Dec;144(6):597-611
Histochemistry and cell biology 2015 Dec;144(6):597-611
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