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LearnALX-801-004-C125
antibody from Enzo Life Sciences
Targeting: ABCB1
ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1
Immunocytochemistry
Immunohistochemistry
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [27]
- Comments [0]
- Validations
- Immunocytochemistry [1]
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- Product number
- ALX-801-004-C125 - Provider product page
- Provider
- Enzo Life Sciences
- Proper citation
- Enzo Life Sciences Cat#ALX-801-004-C125, RRID:AB_2052219
- Product name
- P-glycoprotein (human) monoclonal antibody (JSB-1)
- Antibody type
- Monoclonal
- Antigen
- Purified from natural sources
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- JSB-1
- Vial size
- 125 μg
- Storage
- -20°C
- Handling
- Avoid freeze/thaw cycles.
Submitted references P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study.
P-glycoprotein expression and multidrug resistance in cutaneous T-cell lymphoma.
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.
Incidence of P-glycoprotein overexpression and multidrug resistance (MDR) reversal in adult soft tissue sarcoma.
Assessment of P-glycoprotein expression by immunocytochemistry and flow cytometry using two different monoclonal antibodies coupled with functional efflux analysis in 34 patients with acute myeloid leukemia.
Expression of the multidrug-resistance P-glycoprotein (Pgp, MDR-1) by endothelial cells of the neovasculature in central nervous system tumors.
Interferon alpha2b differentially affects proliferation of two human renal cell carcinoma cell lines differing in the P-glycoprotein-associated multidrug-resistant phenotype.
Multidrug resistance phenotype in high grade soft tissue sarcoma: correlation of P-glycoprotein immunohistochemistry with pathologic response to chemotherapy.
Tc-99m MIBI SPECT is useful for noninvasively predicting the presence of MDR1 gene-encoded P-glycoprotein in patients with hepatocellular carcinoma.
The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein.
Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis.
Effect on cell kill of addition of multidrug resistance modifiers cyclosporin A and PSC 833 to cytotoxic agents in chronic lymphocytic leukaemia.
Overexpression of lung-resistance protein and increased P-glycoprotein function in acute myeloid leukaemia cells predict a poor response to chemotherapy and reduced patient survival.
Detection of P-glycoprotein in frozen and paraffin-embedded gastric adenocarcinoma tissues using a panel of monoclonal antibodies.
Co-expression of MDR-associated markers, including P-170, MRP and LRP and cytoskeletal proteins, in three resistant variants of the human ovarian carcinoma cell line, OAW42.
Sequential assessment of multidrug resistance phenotype and measurement of S-phase fraction as predictive markers of breast cancer response to neoadjuvant chemotherapy.
Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome.
Multidrug resistance P-glycoprotein monoclonal antibody JSB-1 crossreacts with pyruvate carboxylase.
Specificity and sensitivity of immunocytochemistry for detecting P-glycoprotein in haematological malignancies.
Immunohistochemical study of expression and cellular localization of the multidrug resistance gene product P-glycoprotein in primary liver carcinoma.
New immunohistochemical "sandwich" staining method for mdr1 P-glycoprotein detection with JSB-1 monoclonal antibody in formalin-fixed, paraffin-embedded human tissues.
Relationship of P-glycoprotein and carcinoembryonic antigen expression in human colon carcinoma to local invasion, DNA ploidy, and disease relapse.
P-glycoprotein expression in human plasma cell myeloma: correlation with prior chemotherapy.
Flow cytometric analysis of P-glycoprotein in normal and leukemic cells.
Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies.
Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.
Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.
Feldmann M, Asselin MC, Liu J, Wang S, McMahon A, Anton-Rodriguez J, Walker M, Symms M, Brown G, Hinz R, Matthews J, Bauer M, Langer O, Thom M, Jones T, Vollmar C, Duncan JS, Sisodiya SM, Koepp MJ
The Lancet. Neurology 2013 Aug;12(8):777-85
The Lancet. Neurology 2013 Aug;12(8):777-85
P-glycoprotein expression and multidrug resistance in cutaneous T-cell lymphoma.
Jillella AP, Murren JR, Hamid KK, Longley BJ, Edelson RL, Cooper DL
Cancer investigation 2000;18(7):609-13
Cancer investigation 2000;18(7):609-13
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.
Scheffer GL, Kool M, Heijn M, de Haas M, Pijnenborg AC, Wijnholds J, van Helvoort A, de Jong MC, Hooijberg JH, Mol CA, van der Linden M, de Vree JM, van der Valk P, Elferink RP, Borst P, Scheper RJ
Cancer research 2000 Sep 15;60(18):5269-77
Cancer research 2000 Sep 15;60(18):5269-77
Incidence of P-glycoprotein overexpression and multidrug resistance (MDR) reversal in adult soft tissue sarcoma.
Coley HM, Verrill MW, Gregson SE, Odell DE, Fisher C, Judson IR
European journal of cancer (Oxford, England : 1990) 2000 May;36(7):881-8
European journal of cancer (Oxford, England : 1990) 2000 May;36(7):881-8
Assessment of P-glycoprotein expression by immunocytochemistry and flow cytometry using two different monoclonal antibodies coupled with functional efflux analysis in 34 patients with acute myeloid leukemia.
Poulain S, Lepelley P, Cambier N, Cosson A, Fenaux P, Wattel E
Advances in experimental medicine and biology 1999;457:57-63
Advances in experimental medicine and biology 1999;457:57-63
Expression of the multidrug-resistance P-glycoprotein (Pgp, MDR-1) by endothelial cells of the neovasculature in central nervous system tumors.
Sawada T, Kato Y, Sakayori N, Takekawa Y, Kobayashi M
Brain tumor pathology 1999;16(1):23-7
Brain tumor pathology 1999;16(1):23-7
Interferon alpha2b differentially affects proliferation of two human renal cell carcinoma cell lines differing in the P-glycoprotein-associated multidrug-resistant phenotype.
Frank MH, Pomer S
Journal of cancer research and clinical oncology 1999;125(2):117-20
Journal of cancer research and clinical oncology 1999;125(2):117-20
Multidrug resistance phenotype in high grade soft tissue sarcoma: correlation of P-glycoprotein immunohistochemistry with pathologic response to chemotherapy.
Jimenez RE, Zalupski MM, Frank JJ, Du W, Ryan JR, Lucas DR
Cancer 1999 Sep 15;86(6):976-81
Cancer 1999 Sep 15;86(6):976-81
Tc-99m MIBI SPECT is useful for noninvasively predicting the presence of MDR1 gene-encoded P-glycoprotein in patients with hepatocellular carcinoma.
Kim YS, Cho SW, Lee KJ, Hahm KB, Wang HJ, Yim H, Jin YM, Park CH
Clinical nuclear medicine 1999 Nov;24(11):874-9
Clinical nuclear medicine 1999 Nov;24(11):874-9
The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein.
Barg S, Renström E, Berggren PO, Bertorello A, Bokvist K, Braun M, Eliasson L, Holmes WE, Köhler M, Rorsman P, Thévenod F
Proceedings of the National Academy of Sciences of the United States of America 1999 May 11;96(10):5539-44
Proceedings of the National Academy of Sciences of the United States of America 1999 May 11;96(10):5539-44
Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis.
Meijer GA, Schroeijers AB, Flens MJ, Meuwissen SG, van der Valk P, Baak JP, Scheper RJ
Journal of clinical pathology 1999 Jun;52(6):450-4
Journal of clinical pathology 1999 Jun;52(6):450-4
Effect on cell kill of addition of multidrug resistance modifiers cyclosporin A and PSC 833 to cytotoxic agents in chronic lymphocytic leukaemia.
Grey MR, Burgess R, Fisher A, Yin JA
Leukemia research 1999 Jan;23(1):29-35
Leukemia research 1999 Jan;23(1):29-35
Overexpression of lung-resistance protein and increased P-glycoprotein function in acute myeloid leukaemia cells predict a poor response to chemotherapy and reduced patient survival.
Borg AG, Burgess R, Green LM, Scheper RJ, Yin JA
British journal of haematology 1998 Dec;103(4):1083-91
British journal of haematology 1998 Dec;103(4):1083-91
Detection of P-glycoprotein in frozen and paraffin-embedded gastric adenocarcinoma tissues using a panel of monoclonal antibodies.
Lacueva FJ, Teruel A, Calpena R, Medrano J, Mayol MJ, Perez-Vazquez MT, Rufete C, Camarasa MV, Ferragut JA
Histopathology 1998 Apr;32(4):328-34
Histopathology 1998 Apr;32(4):328-34
Co-expression of MDR-associated markers, including P-170, MRP and LRP and cytoskeletal proteins, in three resistant variants of the human ovarian carcinoma cell line, OAW42.
Moran E, Cleary I, Larkin AM, Amhlaoibh RN, Masterson A, Scheper RJ, Izquierdo MA, Center M, O'Sullivan F, Clynes M
European journal of cancer (Oxford, England : 1990) 1997 Apr;33(4):652-60
European journal of cancer (Oxford, England : 1990) 1997 Apr;33(4):652-60
Sequential assessment of multidrug resistance phenotype and measurement of S-phase fraction as predictive markers of breast cancer response to neoadjuvant chemotherapy.
Chevillard S, Pouillart P, Beldjord C, Asselain B, Beuzeboc P, Magdelénat H, Vielh P
Cancer 1996 Jan 15;77(2):292-300
Cancer 1996 Jan 15;77(2):292-300
Expression of P-glycoprotein in high-grade osteosarcomas in relation to clinical outcome.
Baldini N, Scotlandi K, Barbanti-Bròdano G, Manara MC, Maurici D, Bacci G, Bertoni F, Picci P, Sottili S, Campanacci M
The New England journal of medicine 1995 Nov 23;333(21):1380-5
The New England journal of medicine 1995 Nov 23;333(21):1380-5
Multidrug resistance P-glycoprotein monoclonal antibody JSB-1 crossreacts with pyruvate carboxylase.
Rao VV, Anthony DC, Piwnica-Worms D
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995 Dec;43(12):1187-92
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1995 Dec;43(12):1187-92
Specificity and sensitivity of immunocytochemistry for detecting P-glycoprotein in haematological malignancies.
Gala JL, McLachlan JM, Bell DR, Michaux JL, Ma DD
Journal of clinical pathology 1994 Jul;47(7):619-24
Journal of clinical pathology 1994 Jul;47(7):619-24
Immunohistochemical study of expression and cellular localization of the multidrug resistance gene product P-glycoprotein in primary liver carcinoma.
Itsubo M, Ishikawa T, Toda G, Tanaka M
Cancer 1994 Jan 15;73(2):298-303
Cancer 1994 Jan 15;73(2):298-303
New immunohistochemical "sandwich" staining method for mdr1 P-glycoprotein detection with JSB-1 monoclonal antibody in formalin-fixed, paraffin-embedded human tissues.
Tóth K, Vaughan MM, Slocum HK, Arredondo MA, Takita H, Baker RM, Rustum YM
The American journal of pathology 1994 Feb;144(2):227-36
The American journal of pathology 1994 Feb;144(2):227-36
Relationship of P-glycoprotein and carcinoembryonic antigen expression in human colon carcinoma to local invasion, DNA ploidy, and disease relapse.
Sinicrope FA, Hart J, Brasitus TA, Michelassi F, Lee JJ, Safa AR
Cancer 1994 Dec 1;74(11):2908-17
Cancer 1994 Dec 1;74(11):2908-17
P-glycoprotein expression in human plasma cell myeloma: correlation with prior chemotherapy.
Grogan TM, Spier CM, Salmon SE, Matzner M, Rybski J, Weinstein RS, Scheper RJ, Dalton WS
Blood 1993 Jan 15;81(2):490-5
Blood 1993 Jan 15;81(2):490-5
Flow cytometric analysis of P-glycoprotein in normal and leukemic cells.
Tiirikainen MI, Syrjälä MT, Jansson SE, Krusius T
Annals of hematology 1992 Sep;65(3):124-30
Annals of hematology 1992 Sep;65(3):124-30
Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies.
Schinkel AH, Roelofs EM, Borst P
Cancer research 1991 May 15;51(10):2628-35
Cancer research 1991 May 15;51(10):2628-35
Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.
Dalton WS, Grogan TM, Meltzer PS, Scheper RJ, Durie BG, Taylor CW, Miller TP, Salmon SE
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989 Apr;7(4):415-24
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1989 Apr;7(4):415-24
Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.
Hamada H, Tsuruo T
Proceedings of the National Academy of Sciences of the United States of America 1986 Oct;83(20):7785-9
Proceedings of the National Academy of Sciences of the United States of America 1986 Oct;83(20):7785-9
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Supportive validation
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- Enzo Life Sciences (provider)
- Main image
- Experimental details
- Liver cells stained with JSB-1 (ALX-801-004).
