348604

antibody from BioLegend
Targeting: ABCB1 ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1
Provider product page for 348604
Immunoprecipitation
Immunohistochemistry
Flow cytometry
Blocking/Neutralizing

Antibody data

Product number
348604 - Provider product page
Provider
BioLegend
Product name
LEAF™ Purified anti-human CD243 (MDR-1) [UIC2]
Antibody type
Monoclonal
Antigen
NIH 3T3 cells transfected with human MDR-1 cDNA
Description
CD243 (MDR-1) belongs to the ATP binding cassette (ABC) transporter family. With an approximate molecular mass of 170 kD, it consists of two homologous halves. Each half contains two hydrophobic transmembrane domains (TMDs) and two hydrophilic nucleotide binding domains (NBDs). The TMDs span the membrane six times, forming a chamber with a 12 transmembrane α-helix structure. NBDs drive the transport process through ATP coupling and hydrolysis and are located at the cytoplasmic face of the membrane. CD243 transports various molecules across cellular membranes and is involved in multidrug resistance. MDR-1 is expressed on hematopoietic stem cells, T cells, B cells, and NK cells as well as on many multidrug resistant neoplastic cells. CD243 interacts with Caveolin, RING finger protein 1B, AAP1, p53, Orphan nuclear receptor PX, and cytochrome P450.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Vial size
500 µg
Concentration
1 mg/ml
Storage
The antibody solution should be stored undiluted at 4°C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
ABCB1 protein structure - 348604 shown in red.