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LearnALX-801-002-C100
antibody from Enzo Life Sciences
Targeting: ABCB1
ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1
ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [39]
- Comments [0]
- Validations [0]
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- Product number
- ALX-801-002-C100 - Provider product page
- Provider
- Enzo Life Sciences
- Proper citation
- Enzo Life Sciences Cat#ALX-801-002-C100, RRID:AB_2052221
- Product name
- P-glycoprotein monoclonal antibody (C219)
- Antibody type
- Monoclonal
- Antigen
- Purified from natural sources
- Reactivity
- Human, Mouse, Rat, Canine, Simian
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- C219
- Vial size
- 1 ml
- Storage
- -20°C
- Handling
- Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20¡C.
Submitted references Selection of resistant acute myeloid leukemia SKM-1 and MOLM-13 cells by vincristine-, mitoxantrone- and lenalidomide-induced upregulation of P-glycoprotein activity and downregulation of CD33 cell surface exposure.
Inhibition of protein glycosylation reverses the MDR phenotype of cancer cell lines.
Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis.
St. John's Wort reduces beta-amyloid accumulation in a double transgenic Alzheimer's disease mouse model-role of P-glycoprotein.
Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability.
P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study.
Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice.
Effect of variations in the amounts of P-glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the human small intestine on PBPK models for predicting intestinal first pass.
Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier.
Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant to daunorubicin.
The P-glycoprotein inhibitor GF120918 modulates Ca2+-dependent processes and lipid metabolism in Toxoplasma gondii.
Expression and localization of P-glycoprotein in human heart: effects of cardiomyopathy.
Characterization of multidrug transporters in a normal renal tubular cell line resistant to doxorubicin. Multidrug transporters in the LLC-PK(1) cell line and its resistant counterpart.
Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone.
Cytofluorimetric analysis of a renal tubular cell line and its resistant counterpart.
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.
Expression of P-glycoprotein in hepatocellular carcinoma. A determinant of chemotherapy response.
Activation of the human P-glycoprotein ATPase by trypsin.
P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries.
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis.
Nucleotide-induced conformational changes in P-glycoprotein and in nucleotide binding site mutants monitored by trypsin sensitivity.
Clinical significance of P-glycoprotein (P-gp) expression in childhood acute lymphoblastic leukemia. Results of a 6-year prospective study.
Immunohistochemical evidence that P-glycoprotein in non-small cell lung cancers is associated with shorter survival.
Interferon alpha2b differentially affects proliferation of two human renal cell carcinoma cell lines differing in the P-glycoprotein-associated multidrug-resistant phenotype.
Kinetics of doxorubicin handling in the LLC-PK1 kidney epithelial cell line is mediated by both vesicle formation and P-glycoprotein drug transport.
Antibody C219 recognizes an alpha-helical epitope on P-glycoprotein.
Transport of doxorubicin in mast cell granules and the effect of the calcium antagonist verapamil.
Characterization of cyclosporin A transport in cultured rabbit corneal epithelial cells: P-glycoprotein transport activity and binding to cyclophilin.
Selectively induced high MRP gene expression in multidrug-resistant human HL60 leukemia cells.
A multidrug-resistant breast cancer cell line induced by weekly exposure to doxorubicin.
The effects of anticancer drugs in combination with nimodipine and verapamil on cultured cells of glioblastoma multiforme.
P-glycoprotein expression and prognostic value in acute myeloid leukemia.
MRP and MDR1 gene expression in primary breast carcinomas.
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations.
New immunohistochemical "sandwich" staining method for mdr1 P-glycoprotein detection with JSB-1 monoclonal antibody in formalin-fixed, paraffin-embedded human tissues.
Comparison of an immunoperoxidase "sandwich" staining method and western blot detection of P-glycoprotein in human cell lines and sarcomas.
Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies.
A sensitive method for immunocytochemical detection of P-glycoprotein in multidrug-resistant human ovarian carcinoma cell lines.
Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies.
Imrichova D, Messingerova L, Seres M, Kavcova H, Pavlikova L, Coculova M, Breier A, Sulova Z
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2015 Sep 18;77:29-39
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2015 Sep 18;77:29-39
Inhibition of protein glycosylation reverses the MDR phenotype of cancer cell lines.
Wojtowicz K, Januchowski R, Nowicki M, Zabel M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Aug;74:49-56
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Aug;74:49-56
Plasma membrane phospholipase A2 controls hepatocellular fatty acid uptake and is responsive to pharmacological modulation: implications for nonalcoholic steatohepatitis.
Stremmel W, Staffer S, Wannhoff A, Pathil A, Chamulitrat W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jul;28(7):3159-70
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014 Jul;28(7):3159-70
St. John's Wort reduces beta-amyloid accumulation in a double transgenic Alzheimer's disease mouse model-role of P-glycoprotein.
Brenn A, Grube M, Jedlitschky G, Fischer A, Strohmeier B, Eiden M, Keller M, Groschup MH, Vogelgesang S
Brain pathology (Zurich, Switzerland) 2014 Jan;24(1):18-24
Brain pathology (Zurich, Switzerland) 2014 Jan;24(1):18-24
Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability.
O'Brien FE, Clarke G, Dinan TG, Cryan JF, Griffin BT
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2013 Nov;16(10):2259-72
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 2013 Nov;16(10):2259-72
P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study.
Feldmann M, Asselin MC, Liu J, Wang S, McMahon A, Anton-Rodriguez J, Walker M, Symms M, Brown G, Hinz R, Matthews J, Bauer M, Langer O, Thom M, Jones T, Vollmar C, Duncan JS, Sisodiya SM, Koepp MJ
The Lancet. Neurology 2013 Aug;12(8):777-85
The Lancet. Neurology 2013 Aug;12(8):777-85
Beta-Amyloid Downregulates MDR1-P-Glycoprotein (Abcb1) Expression at the Blood-Brain Barrier in Mice.
Brenn A, Grube M, Peters M, Fischer A, Jedlitschky G, Kroemer HK, Warzok RW, Vogelgesang S
International journal of Alzheimer's disease 2011;2011:690121
International journal of Alzheimer's disease 2011;2011:690121
Effect of variations in the amounts of P-glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the human small intestine on PBPK models for predicting intestinal first pass.
Bruyère A, Declèves X, Bouzom F, Ball K, Marques C, Treton X, Pocard M, Valleur P, Bouhnik Y, Panis Y, Scherrmann JM, Mouly S
Molecular pharmaceutics 2010 Oct 4;7(5):1596-607
Molecular pharmaceutics 2010 Oct 4;7(5):1596-607
Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier.
Poller B, Drewe J, Krähenbühl S, Huwyler J, Gutmann H
Cellular and molecular neurobiology 2010 Jan;30(1):63-70
Cellular and molecular neurobiology 2010 Jan;30(1):63-70
Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant to daunorubicin.
Borska S, Sopel M, Chmielewska M, Zabel M, Dziegiel P
Molecules (Basel, Switzerland) 2010 Feb 9;15(2):857-70
Molecules (Basel, Switzerland) 2010 Feb 9;15(2):857-70
The P-glycoprotein inhibitor GF120918 modulates Ca2+-dependent processes and lipid metabolism in Toxoplasma gondii.
Bottova I, Sauder U, Olivieri V, Hehl AB, Sonda S
PloS one 2010 Apr 8;5(4):e10062
PloS one 2010 Apr 8;5(4):e10062
Expression and localization of P-glycoprotein in human heart: effects of cardiomyopathy.
Meissner K, Sperker B, Karsten C, Meyer Zu Schwabedissen H, Seeland U, Böhm M, Bien S, Dazert P, Kunert-Keil C, Vogelgesang S, Warzok R, Siegmund W, Cascorbi I, Wendt M, Kroemer HK
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002 Oct;50(10):1351-6
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2002 Oct;50(10):1351-6
Characterization of multidrug transporters in a normal renal tubular cell line resistant to doxorubicin. Multidrug transporters in the LLC-PK(1) cell line and its resistant counterpart.
Decorti G, Rosati A, Candussio L, Giraldi T, Bartoli Klugmann F
Biochemical pharmacology 2001 Jan 1;61(1):61-6
Biochemical pharmacology 2001 Jan 1;61(1):61-6
Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone.
Yumoto R, Murakami T, Sanemasa M, Nasu R, Nagai J, Takano M
Drug metabolism and disposition: the biological fate of chemicals 2001 Feb;29(2):145-51
Drug metabolism and disposition: the biological fate of chemicals 2001 Feb;29(2):145-51
Cytofluorimetric analysis of a renal tubular cell line and its resistant counterpart.
Rosati A, Decorti G, Klugmann FB, Candussio L, Granzotto M, Melato M, Giraldi T
Anticancer research 2000 Sep- Oct;20(5B):3403-10
Anticancer research 2000 Sep- Oct;20(5B):3403-10
Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.
Scheffer GL, Kool M, Heijn M, de Haas M, Pijnenborg AC, Wijnholds J, van Helvoort A, de Jong MC, Hooijberg JH, Mol CA, van der Linden M, de Vree JM, van der Valk P, Elferink RP, Borst P, Scheper RJ
Cancer research 2000 Sep 15;60(18):5269-77
Cancer research 2000 Sep 15;60(18):5269-77
Expression of P-glycoprotein in hepatocellular carcinoma. A determinant of chemotherapy response.
Ng IO, Liu CL, Fan ST, Ng M
American journal of clinical pathology 2000 Mar;113(3):355-63
American journal of clinical pathology 2000 Mar;113(3):355-63
Activation of the human P-glycoprotein ATPase by trypsin.
Nuti SL, Mehdi A, Rao US
Biochemistry 2000 Mar 28;39(12):3424-32
Biochemistry 2000 Mar 28;39(12):3424-32
P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries.
Demeule M, Jodoin J, Gingras D, Béliveau R
FEBS letters 2000 Jan 28;466(2-3):219-24
FEBS letters 2000 Jan 28;466(2-3):219-24
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis.
Thévenod F, Friedmann JM, Katsen AD, Hauser IA
The Journal of biological chemistry 2000 Jan 21;275(3):1887-96
The Journal of biological chemistry 2000 Jan 21;275(3):1887-96
Nucleotide-induced conformational changes in P-glycoprotein and in nucleotide binding site mutants monitored by trypsin sensitivity.
Julien M, Gros P
Biochemistry 2000 Apr 18;39(15):4559-68
Biochemistry 2000 Apr 18;39(15):4559-68
Clinical significance of P-glycoprotein (P-gp) expression in childhood acute lymphoblastic leukemia. Results of a 6-year prospective study.
Dhooge C, De Moerloose B
Advances in experimental medicine and biology 1999;457:11-9
Advances in experimental medicine and biology 1999;457:11-9
Immunohistochemical evidence that P-glycoprotein in non-small cell lung cancers is associated with shorter survival.
Yokoyama H, Ishida T, Sugio K, Inoue T, Sugimachi K
Surgery today 1999;29(11):1141-7
Surgery today 1999;29(11):1141-7
Interferon alpha2b differentially affects proliferation of two human renal cell carcinoma cell lines differing in the P-glycoprotein-associated multidrug-resistant phenotype.
Frank MH, Pomer S
Journal of cancer research and clinical oncology 1999;125(2):117-20
Journal of cancer research and clinical oncology 1999;125(2):117-20
Kinetics of doxorubicin handling in the LLC-PK1 kidney epithelial cell line is mediated by both vesicle formation and P-glycoprotein drug transport.
Crivellato E, Candussio L, Rosati AM, Decorti G, Klugmann FB, Mallardi F
The Histochemical journal 1999 Oct;31(10):635-43
The Histochemical journal 1999 Oct;31(10):635-43
Antibody C219 recognizes an alpha-helical epitope on P-glycoprotein.
van Den Elsen JM, Kuntz DA, Hoedemaeker FJ, Rose DR
Proceedings of the National Academy of Sciences of the United States of America 1999 Nov 23;96(24):13679-84
Proceedings of the National Academy of Sciences of the United States of America 1999 Nov 23;96(24):13679-84
Transport of doxorubicin in mast cell granules and the effect of the calcium antagonist verapamil.
Candussio L, Decorti G, Crivellato E, Rosati AM, Traversa U, Klugmann FB
Anticancer research 1999 Mar-Apr;19(2A):1101-8
Anticancer research 1999 Mar-Apr;19(2A):1101-8
Characterization of cyclosporin A transport in cultured rabbit corneal epithelial cells: P-glycoprotein transport activity and binding to cyclophilin.
Kawazu K, Yamada K, Nakamura M, Ota A
Investigative ophthalmology & visual science 1999 Jul;40(8):1738-44
Investigative ophthalmology & visual science 1999 Jul;40(8):1738-44
Selectively induced high MRP gene expression in multidrug-resistant human HL60 leukemia cells.
Wada H, Saikawa Y, Niida Y, Nishimura R, Noguchi T, Matsukawa H, Ichihara T, Koizumi S
Experimental hematology 1999 Jan;27(1):99-109
Experimental hematology 1999 Jan;27(1):99-109
A multidrug-resistant breast cancer cell line induced by weekly exposure to doxorubicin.
Hahn SM, Russo A, Cook JA, Mitchell JB
International journal of oncology 1999 Feb;14(2):273-9
International journal of oncology 1999 Feb;14(2):273-9
The effects of anticancer drugs in combination with nimodipine and verapamil on cultured cells of glioblastoma multiforme.
Durmaz R, Deliorman S, Uyar R, Işiksoy S, Erol K, Tel E
Clinical neurology and neurosurgery 1999 Dec;101(4):238-44
Clinical neurology and neurosurgery 1999 Dec;101(4):238-44
P-glycoprotein expression and prognostic value in acute myeloid leukemia.
Senent L, Jarque I, Martín G, Sempere A, González-García Y, Gomis F, Pérez-Sirvent M, De La Rubia J, Sanz MA
Haematologica 1998 Sep;83(9):783-7
Haematologica 1998 Sep;83(9):783-7
MRP and MDR1 gene expression in primary breast carcinomas.
Filipits M, Suchomel RW, Dekan G, Haider K, Valdimarsson G, Depisch D, Pirker R
Clinical cancer research : an official journal of the American Association for Cancer Research 1996 Jul;2(7):1231-7
Clinical cancer research : an official journal of the American Association for Cancer Research 1996 Jul;2(7):1231-7
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations.
Beck WT, Grogan TM, Willman CL, Cordon-Cardo C, Parham DM, Kuttesch JF, Andreeff M, Bates SE, Berard CW, Boyett JM, Brophy NA, Broxterman HJ, Chan HS, Dalton WS, Dietel M, Fojo AT, Gascoyne RD, Head D, Houghton PJ, Srivastava DK, Lehnert M, Leith CP, Paietta E, Pavelic ZP, Weinstein R
Cancer research 1996 Jul 1;56(13):3010-20
Cancer research 1996 Jul 1;56(13):3010-20
New immunohistochemical "sandwich" staining method for mdr1 P-glycoprotein detection with JSB-1 monoclonal antibody in formalin-fixed, paraffin-embedded human tissues.
Tóth K, Vaughan MM, Slocum HK, Arredondo MA, Takita H, Baker RM, Rustum YM
The American journal of pathology 1994 Feb;144(2):227-36
The American journal of pathology 1994 Feb;144(2):227-36
Comparison of an immunoperoxidase "sandwich" staining method and western blot detection of P-glycoprotein in human cell lines and sarcomas.
Tóth K, Vaughan MM, Slocum HK, Fredericks WJ, Chen YF, Arredondo MA, Harstrick A, Karakousis C, Baker RM, Rustum YM
The American journal of pathology 1992 May;140(5):1009-16
The American journal of pathology 1992 May;140(5):1009-16
Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies.
Schinkel AH, Roelofs EM, Borst P
Cancer research 1991 May 15;51(10):2628-35
Cancer research 1991 May 15;51(10):2628-35
A sensitive method for immunocytochemical detection of P-glycoprotein in multidrug-resistant human ovarian carcinoma cell lines.
Chan HS, Bradley G, Thorner P, Haddad G, Gallie BL, Ling V
Laboratory investigation; a journal of technical methods and pathology 1988 Dec;59(6):870-5
Laboratory investigation; a journal of technical methods and pathology 1988 Dec;59(6):870-5
Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies.
Kartner N, Evernden-Porelle D, Bradley G, Ling V
Nature 1985 Aug 29-Sep 4;316(6031):820-3
Nature 1985 Aug 29-Sep 4;316(6031):820-3
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