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LearnALX-801-008-C150
antibody from Enzo Life Sciences
Targeting: ABCB1
ABC20, CD243, CLCS, GP170, MDR1, P-gp, PGY1
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [24]
- Comments [0]
- Validations [0]
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- Product number
- ALX-801-008-C150 - Provider product page
- Provider
- Enzo Life Sciences
- Proper citation
- Enzo Life Sciences Cat#ALX-801-008-C150, RRID:AB_2052220
- Product name
- P-glycoprotein (human) monoclonal antibody (MRK16)
- Antibody type
- Monoclonal
- Antigen
- Purified from natural sources
- Description
- Protein A affinity purified.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- MRK16
- Vial size
- 150 μg
- Storage
- -20°C
- Handling
- Avoid freeze/thaw cycles.
Submitted references Conformational heterogeneity of P-glycoprotein.
Human placental transport of vinblastine, vincristine, digoxin and progesterone: contribution of P-glycoprotein.
Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system.
Modulation of multidrug resistance in human leukemia cells with mdr1-targeted antisense oligonucleotides using variable treatment schedules.
Discordance of P-glycoprotein expression and function in acute leukemia.
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier.
P-glycoprotein expression on normal and abnormally expanded natural killer cells and inhibition of P-glycoprotein function by cyclosporin A and its analogue, PSC833.
The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis.
Reference method for detection of Pgp mediated multidrug resistance in human hematological malignancies: a method validated by the laboratories of the French Drug Resistance Network.
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations.
In vivo imaging and specific targeting of P-glycoprotein expression in multidrug resistant nude mice xenografts with [125I]MRK-16 monoclonal antibody.
Cystic fibrosis-type mutational analysis in the ATP-binding cassette transporter signature of human P-glycoprotein MDR1.
Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein.
Specific targeting and killing activities of anti-P-glycoprotein monoclonal antibody MRK16 directed against intrinsically multidrug-resistant human colorectal carcinoma cell lines in the nude mouse model.
Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators.
Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibody.
Decreased P-glycoprotein expression in multidrug-sensitive and -resistant human myeloma cells induced by the cytokine leukoregulin.
Detection of multidrug-resistant protein, P-glycoprotein in childhood leukaemia and lymphoma.
Immunohistochemical detection of multidrug resistance associated P-glycoprotein in tumour and stromal cells of human cancers.
Multidrug resistance in cultured human leukemia and lymphoma cell lines detected by a monoclonal antibody, MRK16.
Further characterization of the human adrenal-derived P-glycoprotein recognized by monoclonal antibody MRK 16 reacting with only human P-glycoprotein.
Mechanisms of multidrug resistance and implications for therapy.
A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.
Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.
Goda K, Nagy H, Bene L, Balázs M, Arceci R, Mechetner E, Szabó G
Cancer detection and prevention 2000;24(5):415-21
Cancer detection and prevention 2000;24(5):415-21
Human placental transport of vinblastine, vincristine, digoxin and progesterone: contribution of P-glycoprotein.
Ushigome F, Takanaga H, Matsuo H, Yanai S, Tsukimori K, Nakano H, Uchiumi T, Nakamura T, Kuwano M, Ohtani H, Sawada Y
European journal of pharmacology 2000 Nov 10;408(1):1-10
European journal of pharmacology 2000 Nov 10;408(1):1-10
Functional characterization of glycosylation-deficient human P-glycoprotein using a vaccinia virus expression system.
Gribar JJ, Ramachandra M, Hrycyna CA, Dey S, Ambudkar SV
The Journal of membrane biology 2000 Feb 1;173(3):203-14
The Journal of membrane biology 2000 Feb 1;173(3):203-14
Modulation of multidrug resistance in human leukemia cells with mdr1-targeted antisense oligonucleotides using variable treatment schedules.
Dassow H, Lassner D, Remke H, Preiss R
International journal of clinical pharmacology and therapeutics 2000 Apr;38(4):209-16
International journal of clinical pharmacology and therapeutics 2000 Apr;38(4):209-16
Discordance of P-glycoprotein expression and function in acute leukemia.
De Moerloose B, Dhooge C, Philippé J
Advances in experimental medicine and biology 1999;457:107-18
Advances in experimental medicine and biology 1999;457:107-18
Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier.
Rao VV, Dahlheimer JL, Bardgett ME, Snyder AZ, Finch RA, Sartorelli AC, Piwnica-Worms D
Proceedings of the National Academy of Sciences of the United States of America 1999 Mar 30;96(7):3900-5
Proceedings of the National Academy of Sciences of the United States of America 1999 Mar 30;96(7):3900-5
P-glycoprotein expression on normal and abnormally expanded natural killer cells and inhibition of P-glycoprotein function by cyclosporin A and its analogue, PSC833.
Egashira M, Kawamata N, Sugimoto K, Kaneko T, Oshimi K
Blood 1999 Jan 15;93(2):599-606
Blood 1999 Jan 15;93(2):599-606
The drug efflux protein, P-glycoprotein, additionally protects drug-resistant tumor cells from multiple forms of caspase-dependent apoptosis.
Smyth MJ, Krasovskis E, Sutton VR, Johnstone RW
Proceedings of the National Academy of Sciences of the United States of America 1998 Jun 9;95(12):7024-9
Proceedings of the National Academy of Sciences of the United States of America 1998 Jun 9;95(12):7024-9
Reference method for detection of Pgp mediated multidrug resistance in human hematological malignancies: a method validated by the laboratories of the French Drug Resistance Network.
Huet S, Marie JP, Gualde N, Robert J
Cytometry 1998 Dec 15;34(6):248-56
Cytometry 1998 Dec 15;34(6):248-56
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations.
Beck WT, Grogan TM, Willman CL, Cordon-Cardo C, Parham DM, Kuttesch JF, Andreeff M, Bates SE, Berard CW, Boyett JM, Brophy NA, Broxterman HJ, Chan HS, Dalton WS, Dietel M, Fojo AT, Gascoyne RD, Head D, Houghton PJ, Srivastava DK, Lehnert M, Leith CP, Paietta E, Pavelic ZP, Weinstein R
Cancer research 1996 Jul 1;56(13):3010-20
Cancer research 1996 Jul 1;56(13):3010-20
In vivo imaging and specific targeting of P-glycoprotein expression in multidrug resistant nude mice xenografts with [125I]MRK-16 monoclonal antibody.
Scott AM, Rosa E, Mehta BM, Divgi CR, Finn RD, Biedler JL, Tsuruo T, Kalaigian H, Larson SM
Nuclear medicine and biology 1995 May;22(4):497-504
Nuclear medicine and biology 1995 May;22(4):497-504
Cystic fibrosis-type mutational analysis in the ATP-binding cassette transporter signature of human P-glycoprotein MDR1.
Hoof T, Demmer A, Hadam MR, Riordan JR, Tümmler B
The Journal of biological chemistry 1994 Aug 12;269(32):20575-83
The Journal of biological chemistry 1994 Aug 12;269(32):20575-83
Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein.
Schinkel AH, Arceci RJ, Smit JJ, Wagenaar E, Baas F, Dollé M, Tsuruo T, Mechetner EB, Roninson IB, Borst P
International journal of cancer 1993 Sep 30;55(3):478-84
International journal of cancer 1993 Sep 30;55(3):478-84
Specific targeting and killing activities of anti-P-glycoprotein monoclonal antibody MRK16 directed against intrinsically multidrug-resistant human colorectal carcinoma cell lines in the nude mouse model.
Iwahashi T, Okochi E, Ariyoshi K, Watabe H, Amann E, Mori S, Tsuruo T, Ono K
Cancer research 1993 Nov 15;53(22):5475-82
Cancer research 1993 Nov 15;53(22):5475-82
Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators.
Hunter J, Jepson MA, Tsuruo T, Simmons NL, Hirst BH
The Journal of biological chemistry 1993 Jul 15;268(20):14991-7
The Journal of biological chemistry 1993 Jul 15;268(20):14991-7
Topology of P-glycoprotein as determined by epitope mapping of MRK-16 monoclonal antibody.
Georges E, Tsuruo T, Ling V
The Journal of biological chemistry 1993 Jan 25;268(3):1792-8
The Journal of biological chemistry 1993 Jan 25;268(3):1792-8
Decreased P-glycoprotein expression in multidrug-sensitive and -resistant human myeloma cells induced by the cytokine leukoregulin.
Evans CH, Baker PD
Cancer research 1992 Nov 1;52(21):5893-9
Cancer research 1992 Nov 1;52(21):5893-9
Detection of multidrug-resistant protein, P-glycoprotein in childhood leukaemia and lymphoma.
Mizuno Y, Hara T, Nagata M, Tawa A, Tsuruo T, Ueda K
European journal of pediatrics 1991 Apr;150(6):416-8
European journal of pediatrics 1991 Apr;150(6):416-8
Immunohistochemical detection of multidrug resistance associated P-glycoprotein in tumour and stromal cells of human cancers.
Schlaifer D, Laurent G, Chittal S, Tsuruo T, Soues S, Muller C, Charcosset JY, Alard C, Brousset P, Mazerrolles C
British journal of cancer 1990 Aug;62(2):177-82
British journal of cancer 1990 Aug;62(2):177-82
Multidrug resistance in cultured human leukemia and lymphoma cell lines detected by a monoclonal antibody, MRK16.
Ishida Y, Ohtsu T, Hamada H, Sugimoto Y, Tobinai K, Minato K, Tsuruo T, Shimoyama M
Japanese journal of cancer research : Gann 1989 Oct;80(10):1006-13
Japanese journal of cancer research : Gann 1989 Oct;80(10):1006-13
Further characterization of the human adrenal-derived P-glycoprotein recognized by monoclonal antibody MRK 16 reacting with only human P-glycoprotein.
Sugawara I, Hamada H, Nakahama M, Okamoto S, Tsuruo T, Mori S
Japanese journal of cancer research : Gann 1989 Dec;80(12):1199-205
Japanese journal of cancer research : Gann 1989 Dec;80(12):1199-205
Mechanisms of multidrug resistance and implications for therapy.
Tsuruo T
Japanese journal of cancer research : Gann 1988 Mar;79(3):285-96
Japanese journal of cancer research : Gann 1988 Mar;79(3):285-96
A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.
FitzGerald DJ, Willingham MC, Cardarelli CO, Hamada H, Tsuruo T, Gottesman MM, Pastan I
Proceedings of the National Academy of Sciences of the United States of America 1987 Jun;84(12):4288-92
Proceedings of the National Academy of Sciences of the United States of America 1987 Jun;84(12):4288-92
Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.
Hamada H, Tsuruo T
Proceedings of the National Academy of Sciences of the United States of America 1986 Oct;83(20):7785-9
Proceedings of the National Academy of Sciences of the United States of America 1986 Oct;83(20):7785-9
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