NPL

This gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Description

N-acetylneuraminate pyruvate lyase

Tissue specificity

Tissue enhanced (kidney, placenta)

Subcell location

Vesicles, Plasma membrane

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (182789293 - 182830384)

Ensembl ID

ENSG00000135838  (ver. 103.38)

Orthologs

Mouse Npl: ENSMUSG00000042684

UniProt

Q9BXD5

neXtProt

NX_Q9BXD5

Human splice variants
Mouse splice variants

Protein structure