SMG7

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]

Description

SMG7 nonsense mediated mRNA decay factor

Tissue specificity

Low tissue specificity

Subcell location

Intermediate filaments, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (183472216 - 183598246)

Ensembl ID

ENSG00000116698  (ver. 103.38)

Orthologs

Mouse Smg7: ENSMUSG00000042772

UniProt

Q92540

neXtProt

NX_Q92540

Human splice variants
Mouse splice variants

Protein structure