26223-1-AP

antibody from Proteintech Group

Targeting: ASPM ASP, Calmbp1, FLJ10517, FLJ10549, MCPH5

Provider product page for 26223-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [23]
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Product number: 26223-1-AP - Provider product page
Provider: Proteintech Group
Product name: ASPM antibody
Antibody type: Polyclonal
Description: KD/KO validated ASPM antibody (Cat. #26223-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ASPM protein structure - 26223-1-AP shown in red.

Submitted references ZBTB20 promotes malignancy and stemness in lung squamous cell carcinoma through the transcriptional repression of KCTD1 and activation of Hedgehog signaling.

Wang H, Tian X, Zhu W, Wang Y, Yang Y
Cancer letters 2026 Apr 10;643:218301

Assembly factor for spindle microtubules (ASPM) promotes osimertinib resistance in lung cancer by increasing EGFR stability.

Gui P, Han Z, Yin Z, Cao P, Zhou X, Li Y
Frontiers in genetics 2025;16:1593314

KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C.

Miao J, Hara M, Su KC, Keys HR, Kong W, Takenoshita Y, Cheeseman IM, Fukagawa T
Cell reports 2025 Nov 25;44(11):116515

ASPM mediates nuclear entrapment of FOXM1 via liquid-liquid phase separation to promote progression of hepatocarcinoma.

Jiang X, Liu J, Wang K, Sun J, Yin H, Jiang Y, Liu Y, Wang N, Ding X, Gao P, Li L, Zhang X, Li J, Zhang R
Genome biology 2025 Mar 23;26(1):68

ASPM Induces Radiotherapy Resistance by Disrupting Microtubule Stability Leading to Chromosome Malsegregation in Non-Small Cell Lung Cancer.

Zhong T, Liu N, Wang J, Xie S, Liu L, Wang M, Wu F, Chen X, Xiao C, Gongye X, Wu M, Wen L, Yu J, Chen D
Exploration (Beijing, China) 2025 Aug;5(4):e20230024

Identification of Key Immune and Cell Cycle Modules and Prognostic Genes for Glioma Patients through Transcriptome Analysis.

Guo K, Yang J, Jiang R, Ren X, Liu P, Wang W, Zhou S, Wang X, Ma L, Hu Y
Pharmaceuticals (Basel, Switzerland) 2024 Sep 28;17(10)

Nrf2/ASPM axis regulated vasculogenic mimicry formation in hepatocellular carcinoma under hypoxia.

Zhang Y, Che N, Wang S, Meng J, Zhao N, Han J, Dong X, Li Y, Mo J, Zhao X, Liu T
Journal of gastroenterology 2024 Oct;59(10):941-957

A transit-amplifying progenitor with biphasic behavior contributes to epidermal renewal.

Ghuwalewala S, Jiang K, Ragi S, Shalloway D, Tumbar T
Development (Cambridge, England) 2024 Jun 15;151(12)

The transcription factor NF-YA is crucial for neural progenitor maintenance during brain development.

Yamanaka T, Kurosawa M, Yoshida A, Shimogori T, Hiyama A, Maity SN, Hattori N, Matsui H, Nukina N
The Journal of biological chemistry 2024 Feb;300(2):105629

Promotion of hepatocellular carcinoma stemness and progression by abnormal spindle-like microcephaly-associated protein via the Wnt/β-catenin pathway.

Li GJ, Xiang Y, Yang JY, Weiskirchen R, Feng R, Zhai WL
Journal of gastrointestinal oncology 2024 Aug 31;15(4):1613-1626

ASPM promotes migration and invasion of anaplastic thyroid carcinoma by stabilizing KIF11.

Fang Q, Li Q, Qi Y, Pan Z, Feng T, Xin W
Cell biology international 2023 Jul;47(7):1209-1221

ASPM Promotes the Progression of Anaplastic Thyroid Carcinomas by Regulating the Wnt/β-Catenin Signaling Pathway.

Jiang L, Zhang S, An N, Chai G, Ye C
International journal of endocrinology 2022;2022:5316102

Binary organization of epidermal basal domains highlights robustness to environmental exposure.

Ghuwalewala S, Lee SA, Jiang K, Baidya J, Chovatiya G, Kaur P, Shalloway D, Tumbar T
The EMBO journal 2022 Sep 15;41(18):e110488

Proteomic analysis implicates that postovulatory aging leads to aberrant gene expression, biosynthesis, RNA metabolism and cell cycle in mouse oocytes.

Zhang C, Dong X, Yuan X, Song J, Wang J, Liu B, Wu K
Journal of ovarian research 2022 Oct 14;15(1):112

The mechanism of acentrosomal spindle assembly in human oocytes.

Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X, Sang Q, Wang L
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361

ASPM facilitates colorectal cancer cells migration and invasion by enhancing β-catenin expression and nuclear translocation.

Wang L, Hu XD, Li SY, Liang XY, Ren L, Lv SX
The Kaohsiung journal of medical sciences 2022 Feb;38(2):129-138

Identification of Novel Hub Genes Associated with Psoriasis Using Integrated Bioinformatics Analysis.

Yue Q, Li Z, Zhang Q, Jin Q, Zhang X, Jin G
International journal of molecular sciences 2022 Dec 4;23(23)

Abnormal spindle-like microcephaly-associated protein promotes proliferation by regulating cell cycle in epithelial ovarian cancer.

Wu Y, You Y, Chen L, Liu Y, Liu Y, Lou W, Fu F
Gland surgery 2022 Apr;11(4):687-701

Identifying and Validating Potential Biomarkers of Early Stage Lung Adenocarcinoma Diagnosis and Prognosis.

Chen Y, Jin L, Jiang Z, Liu S, Feng W
Frontiers in oncology 2021;11:644426

ASPM is a Novel Candidate Gene Associated with Colorectal Cancer Cell Growth.

Yang Q, Qi M, Chen Y, Tian S, Liao F, Dong W
DNA and cell biology 2021 Jul;40(7):921-935

Development and validation of a five-gene model to predict postoperative brain metastasis in operable lung adenocarcinoma.

Fu F, Zhang Y, Gao Z, Zhao Y, Wen Z, Han H, Li Y, Chen H
International journal of cancer 2020 Jul 15;147(2):584-592

Cancer-Testis Gene Expression in Hepatocellular Carcinoma: Identification of Prognostic Markers and Potential Targets for Immunotherapy.

Zhang YP, Bao ZW, Wu JB, Chen YH, Chen JR, Xie HY, Zhou L, Wu J, Zheng SS
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820944274

ASPM promotes glioblastoma growth by regulating G1 restriction point progression and Wnt-β-catenin signaling.

Chen X, Huang L, Yang Y, Chen S, Sun J, Ma C, Xie J, Song Y, Yang J
Aging 2020 Jan 6;12(1):224-241

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