Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS60515 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- RAMP1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- A synthetic peptide corresponding to residues in Human RAMP1.
- Description
- Receptor activity-modifying proteins (RAMPs) are transmembrane accessory proteins that influence the pharmacological profiles of the calcitonin receptor-like receptors (CRLR) . RAMPs associate with CRLR in the endoplasmic reticulum and facilitate the glycosylation and transport of CRLR to the cell surface, where the mature protein then operates as a receptor for two structurally related vasodilatory peptides, calcitonin-gene-related peptide (CGRP) or adrenomedullin (ADM). RAMP-1 associating with CRLR confers a CGRP receptor, while RAMP-2 and RAMP-3 preferentially induce a responsiveness to ADM . RAMP proteins, including RAMP-1, RAMP-2 and RAMP-3, are structurally similar as they are type I receptors, which have a single extracellular N-terminus and a cytoplasmic C-terminus, and they share approximately 55% sequence similarity. RAMP-1 expression is highest in the uterus, brain and gastrointestinal tract, whereas RAMP-2 and RAMP-3 are highest in lung, breast and fetal tissues.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of RAMP1 pAb at 1:500 dilutionLane1:Hela whole cell lysateLane2:NIH-3T3 whole cell lysate Lane3:H9C2 whole cell lysate