MA1-058

antibody from Invitrogen Antibodies
Targeting: HTT HD, IT15
Provider product page for MA1-058
Western blot
Immunohistochemistry

Antibody data

Product number
MA1-058 - Provider product page
Provider
Invitrogen Antibodies
Product name
Huntingtin Monoclonal Antibody (4-13)
Antibody type
Monoclonal
Antigen
Synthetic peptide
Description
MA1-058 has been successfully used in Western blot, immunofluorescence, and immunohistochemistry on human and mouse samples. Neoepitope antibodies distinguish smaller cleaved fragments or processed forms of proteins versus the intact full-length or precursor by using a designed peptide purification process to maximize immunoreactivity to a specific cleavage site. Human HTT caspase cleavage sites generate fragment-specific forms of the protein. Caspase-3/7 has been shown to generate cleavage sites at animo acids 513 and 552. Caspase-2 cleaves at amino acid 552 and caspase-6 at amino acid 586. Neo-specific antibody MA1-058 recognizes the 552 cleaved fragment without detecting the full-length form.
Reactivity
Human, Mouse
Host
Mouse
Isotype
IgG
Antibody clone number
13-Apr
Vial size
100 µg
Concentration
1 mg/mL
Storage
-20°C
HTT protein structure - MA1-058 shown in red.