HTT

gene product
HD, IT15
Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
738 antibodies from 35 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
15 antibodies
Novus Biologicals
27 antibodies
GeneTex
11 antibodies
LifeSpan BioSciences, Inc.
116 antibodies
antibodies-online
168 antibodies
NovoPro Bioscience Inc.
5 antibodies
Acris Antibodies GmbH
16 antibodies
Boster Biological Technology
4 antibodies
Cell Signaling Technology, Inc
2 antibodies
Abnova Corporation
17 antibodies
OriGene
9 antibodies
Atlas Antibodies
1 antibody
Biorbyt
24 antibodies
Abgent
6 antibodies
Affinity Biosciences
2 antibodies
St John's Laboratory
4 antibodies
Rockland Immunochemicals, Inc.
7 antibodies
SICGEN
1 antibody
Enzo Life Sciences
2 antibodies
Creative Biolabs
102 antibodies
RabMAbs
4 antibodies
Bethyl Laboratories
2 antibodies
Aviva Systems Biology
4 antibodies
Creative Diagnostics
11 antibodies
EMD Millipore
11 antibodies
ProSci
3 antibodies
NSJ Bioreagents
1 antibody
GenWay
8 antibodies
RayBiotech, Inc.
3 antibodies
MyBioSource
8 antibodies
United States Biological
124 antibodies
Sigma-Aldrich
5 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
Absolute Antibody
1 antibody