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Protein structure
KLHL12
Kelch like family member 12C3IP1
This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Top validated antibodies |
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| Proteintech Group |  14883-1-AP |
2 references | Polyclonal |
WB
EL
ICC
IHC
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| LSBio | LS-C336809 |
Monoclonal |
WB
IHC
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| Invitrogen Antibodies | PA5-143992 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Biorbyt | orb2599855 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| GeneTex | GTX83228 |
1 references | Monoclonal |
WB
EL
ICC
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