FMOD

Fibromodulin belongs to the family of small interstitial proteoglycans. The encoded protein possesses a central region containing leucine-rich repeats with 4 keratan sulfate chains, flanked by terminal domains containing disulphide bonds. Owing to the interaction with type I and type II collagen fibrils and in vitro inhibition of fibrillogenesis, the encoded protein may play a role in the assembly of extracellular matrix. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. Sequence variations in this gene may be associated with the pathogenesis of high myopia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Description

fibromodulin

Protein family

Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Predicted secreted proteins, Protein evidence (Peptideatlas)

Chromosome

1:q32.1 (203340628 - 203351758)

Ensembl ID

ENSG00000122176  (ver. 99.38)

Orthologs

Mouse Fmod: ENSMUSG00000041559

UniProt

Q06828

neXtProt

NX_Q06828

Human splice variants
Mouse splice variants