LRRN2

The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Description

Leucine rich repeat neuronal 2

Tissue specificity

Tissue enhanced (brain)

Subcell location

Endoplasmic reticulum

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

1 (204617170 - 204685738)

Ensembl ID

ENSG00000170382  (ver. 103.38)

Orthologs

Mouse Lrrn2: ENSMUSG00000026443

UniProt

O75325

neXtProt

NX_O75325

Human splice variants
Mouse splice variants

Protein structure