orb385751

antibody from Biorbyt

Targeting: TYMS HsT422, TMS, TS, Tsase

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb385751

Provider

Biorbyt

Product name

Thymidylate Synthase Antibody Cocktail

Antibody type

Monoclonal

Description

It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

TS106 + TMS715

Vial size

20 ug

Storage

Store the Thymidylate Synthase antibody cocktail at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).