NBP2-34503JF646

antibody from Novus Biologicals

Targeting: TYMS HsT422, TMS, TS, Tsase

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NBP2-34503JF646

Provider

Novus Biologicals

Product name

Mouse Monoclonal Thymidylate Synthase Antibody

Antibody type

Monoclonal

Description

Protein A purified. It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

Reactivity

Human

Host

Mouse

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark.