COG2

This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

Description

Component of oligomeric golgi complex 2

Tissue specificity

Tissue enhanced (parathyroid gland)

Subcell location

Golgi apparatus

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (230642481 - 230693982)

Ensembl ID

ENSG00000135775  (ver. 103.38)

Orthologs

Mouse Cog2: ENSMUSG00000031979

UniProt

Q14746

neXtProt

NX_Q14746

Human splice variants
Mouse splice variants

Protein structure