Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- AF149 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal Presenilin-1 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects human PS-1 NTF in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) PS-1 CTF (aa 298-407) and rhPS-2 NTF (aa 1-80) is observed.
- Reactivity
- Human
- Host
- Goat
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.
Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.
Teranishi Y, Hur JY, Gu GJ, Kihara T, Ishikawa T, Nishimura T, Winblad B, Behbahani H, Kamali-Moghaddam M, Frykman S, Tjernberg LO
Biochemical and biophysical research communications 2012 Aug 3;424(3):476-81
Biochemical and biophysical research communications 2012 Aug 3;424(3):476-81
Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.
Cras-Méneur C, Li L, Kopan R, Permutt MA
Genes & development 2009 Sep 1;23(17):2088-101
Genes & development 2009 Sep 1;23(17):2088-101
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Presenilin-1 in Human Brain. Presenilin-1 was detected in immersion fixed paraffin-embedded sections of human brain (hippocampus) using 15 µg/mL Goat Anti-Human Presenilin-1 N-Terminal Frag-ment Antigen Affinity-purified Polyclonal Antibody (Catalog # AF149) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.