PSEN1

gene product
AD3, FAD, PS1, S182
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
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689 antibodies from 40 providers.

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AntibodyRefsTypeAVIWBELICCIPIHCFC
Novus Biologicals
47 antibodies
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8 antibodies
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antibodies-online
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St John's Laboratory
5 antibodies
R&D Systems
6 antibodies
Enzo Life Sciences
2 antibodies
LifeSpan BioSciences, Inc.
93 antibodies
Proteintech Group
2 antibodies
Rockland Immunochemicals, Inc.
1 antibody
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Affinity Biosciences
3 antibodies
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21 antibodies
ProSci
2 antibodies
Bioworld Technology, Inc
2 antibodies
RabMAbs
8 antibodies
Cell Signaling Technology, Inc
2 antibodies
MyBioSource
16 antibodies
Creative Biolabs
9 antibodies
FabGennix
6 antibodies
Abbkine Scientific Co.Ltd.
3 antibodies
Arigo
2 antibodies
Atlas Antibodies
2 antibodies
EMD Millipore
8 antibodies
Creative Diagnostics
5 antibodies
Abbiotec
4 antibodies
Spring Bioscience
4 antibodies
GenWay
7 antibodies
United States Biological
67 antibodies
BioLegend (formerly Covance Antibody Products)
6 antibodies
Sigma-Aldrich
3 antibodies
RayBiotech, Inc.
2 antibodies
Abbexa
3 antibodies