Antibody data

Product number
Ab123023 - Provider product page
Provider
Aladdin Scientific
Product name
Recombinant Presenilin 1/PS-1 Antibody
Antibody type
Recombinant
Description
Rabbit anti Human Presenilin 1/PS-1 Antibody, Recombinant, could be used for WB, IF, ICC and so on.Application:WB: 1/500-1/1000ICC/IF: 1/50-1/200Protein functionProbable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 346-361
Vial size
100_l,10_l,1ml,50_l
Concentration
0,2 mg/ml
Storage
Store at 4¡C short term (1-2 weeks). Store at -20¡C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
PSEN1 protein structure - Ab123023 shown in red.