Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations [0]
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- Product number
- ABIN358721 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Presenilin 1 (PSEN1) (C-Term) antibody
- Antibody type
- Polyclonal
- Description
- Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- C-Term
- Vial size
- 0.4 mL
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease.
Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations.
Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein.
Surface plasmon resonance studies of wild-type and AV77 tryptophan repressor resolve ambiguities in super-repressor activity.
Miklossy J, Taddei K, Suva D, Verdile G, Fonte J, Fisher C, Gnjec A, Ghika J, Suard F, Mehta PD, McLean CA, Masters CL, Brooks WS, Martins RN
Neurobiology of aging 2003 Sep;24(5):655-62
Neurobiology of aging 2003 Sep;24(5):655-62
Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.
Kim SH, Ikeuchi T, Yu C, Sisodia SS
The Journal of biological chemistry 2003 Sep 5;278(36):33992-4002
The Journal of biological chemistry 2003 Sep 5;278(36):33992-4002
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations.
Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK
Cell 2003 Sep 5;114(5):635-45
Cell 2003 Sep 5;114(5):635-45
Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein.
Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H
The Journal of biological chemistry 2003 Jan 31;278(5):3446-54
The Journal of biological chemistry 2003 Jan 31;278(5):3446-54
Surface plasmon resonance studies of wild-type and AV77 tryptophan repressor resolve ambiguities in super-repressor activity.
Finucane MD, Jardetzky O
Protein science : a publication of the Protein Society 2003 Aug;12(8):1613-20
Protein science : a publication of the Protein Society 2003 Aug;12(8):1613-20
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