Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- ABIN500539 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Presenilin 1 (PSEN1) antibody
- Antibody type
- Polyclonal
- Antigen
- Presenilin1 antibody was raised against a 23 amino acid peptide from near the carboxyterminus of human presenilin1.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
- Storage
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeatedfreezing and thawing. Shelf life: one year from despatch.
Submitted references Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides.
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.
Periz G, Fortini ME
Journal of neuroscience research 2004 Aug 1;77(3):309-22
Journal of neuroscience research 2004 Aug 1;77(3):309-22
Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides.
Weihofen A, Martoglio B
Trends in cell biology 2003 Feb;13(2):71-8
Trends in cell biology 2003 Feb;13(2):71-8
The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.
Selkoe DJ
Trends in cell biology 1998 Nov;8(11):447-53
Trends in cell biology 1998 Nov;8(11):447-53
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH
Nature 1995 Jun 29;375(6534):754-60
Nature 1995 Jun 29;375(6534):754-60
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of presenilin1 in human brain lysate with AP30692PU-N at (A) 0.5, (B) 1, and (C) 2 ?g/ml.
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Immunohistochemistry of Presenilin1 in human brain tissue with AP30692PU-N at 2.5 ?g/ml.