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Learn22233-1-AP
antibody from Proteintech Group
Targeting: C4A
C4, C4A2, C4A3, C4A4, C4A6, C4B, C4S, CO4, CPAMD2, RG
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ELISAAntibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 22233-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- C4 Alpha Chain/C4b/C4d antibody
- Antibody type
- Polyclonal
- Description
- C4 Alpha Chain/C4b/C4d antibody (Cat. #22233-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Elevated N6-Methyladenosine (m6A)-RNA-Methylation During Oral Carcinogenesis.
Peripheral Complement C4 Protein in Schizophrenia: Association with Gene Copy Number and Immune Cell Subtypes.
Lactate metabolism orchestrates immune dysregulation in renal cancer: A multi-omics and causal inference study.
Rutin ameliorates sevoflurane-induced neurotoxicity by inhibiting microglial synaptic phagocytosis through the complement pathway.
Granzyme K activates the entire complement cascade.
Therapeutic potential of simvastatin in ALS: Enhanced axonal integrity and motor neuron survival through Apoa4 and Alb modulation.
Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies.
IGFBP2 and IGFBP4 interact to activate complement pathway in diabetic kidney disease.
Exploring the biological mechanisms of severe COVID-19 in the elderly: Insights from an aged mouse model.
Yuye Jinhua Qingre Tablets Attenuate Acute Pharyngitis by inhibiting the Complement Cascade and C5a/C5aR1 Axis.
Granzyme K drives a newly-intentified pathway of complement activation.
Extracellular vesicle biomarkers for complement dysfunction in schizophrenia.
Complement components regulates ferroptosis in CVB3 viral myocarditis by interatction with TFRC.
In silico analysis and verification of critical genes related to vascular calcification in multiple diseases.
Circulating Donor Heart Exosome Profiling Enables Noninvasive Detection of Antibody-mediated Rejection.
Inefficient and abortive classical complement pathway activation by the calcium inositol hexakisphosphate component of the Echinococcus granulosus laminated layer.
Qin Z, Chi Y, Wang X, Yan J, Zhang X, Li B
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2026 Jan;55(1):73-86
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2026 Jan;55(1):73-86
Peripheral Complement C4 Protein in Schizophrenia: Association with Gene Copy Number and Immune Cell Subtypes.
Kalinowski A, Macaubas C, Anker L, Wakeham DE, Ho M, Pattni R, Bayram B, Sharma S, Liliental J, Yoon JH, Mellins ED, Urban AE
bioRxiv : the preprint server for biology 2025 Sep 17;
bioRxiv : the preprint server for biology 2025 Sep 17;
Lactate metabolism orchestrates immune dysregulation in renal cancer: A multi-omics and causal inference study.
Li J, Liu C, Fu Z, He Q, Liu X, Sun Z
Science progress 2025 Oct-Dec;108(4):368504251408094
Science progress 2025 Oct-Dec;108(4):368504251408094
Rutin ameliorates sevoflurane-induced neurotoxicity by inhibiting microglial synaptic phagocytosis through the complement pathway.
Tian X, Xiong M, Jiang Z, Hong R, Wang H
Scientific reports 2025 Oct 30;15(1):38077
Scientific reports 2025 Oct 30;15(1):38077
Granzyme K activates the entire complement cascade.
Donado CA, Theisen E, Zhang F, Nathan A, Fairfield ML, Rupani KV, Jones D, Johannes KP, Accelerating Medicines Partnership RA/SLE Network, Raychaudhuri S, Dwyer DF, Jonsson AH, Brenner MB
Nature 2025 May;641(8061):211-221
Nature 2025 May;641(8061):211-221
Therapeutic potential of simvastatin in ALS: Enhanced axonal integrity and motor neuron survival through Apoa4 and Alb modulation.
Luo S, Wang X, Ma B, Liu D, Li L, Wang L, Ding N, Zou L, Wang J, Pan J, Sang D, Zhou H, Qu H, Lu Y, Yang L
Biomolecules & biomedicine 2025 Jan 30;25(3):632-647
Biomolecules & biomedicine 2025 Jan 30;25(3):632-647
Complement classical and alternative pathway activation contributes to diabetic kidney disease progression: a glomerular proteomics on kidney biopsies.
Yang Y, Zhang Y, Li Y, Zhou X, Honda K, Kang D, Wang M, Yang JH, Xia Z, Wei Y, Liu L, Hu R, Takaki T, Xing G
Scientific reports 2025 Jan 2;15(1):495
Scientific reports 2025 Jan 2;15(1):495
IGFBP2 and IGFBP4 interact to activate complement pathway in diabetic kidney disease.
Liang J, Huang Y, Peng D, Xie Y, Liu Y, Lu X, Xu J
Renal failure 2025 Dec;47(1):2440528
Renal failure 2025 Dec;47(1):2440528
Exploring the biological mechanisms of severe COVID-19 in the elderly: Insights from an aged mouse model.
Ma L, Lin X, Xu M, Ke X, Liu D, Chen Q
Virulence 2025 Dec;16(1):2487671
Virulence 2025 Dec;16(1):2487671
Yuye Jinhua Qingre Tablets Attenuate Acute Pharyngitis by inhibiting the Complement Cascade and C5a/C5aR1 Axis.
Gao Y, You L, Zhou J, Tao X, Jin Z, Wu C, Zhang F, Guo S, Wang H, Guan Y, Luo H, Wu J
Chinese medicine 2025 Aug 25;20(1):134
Chinese medicine 2025 Aug 25;20(1):134
Granzyme K drives a newly-intentified pathway of complement activation.
Donado CA, Jonsson AH, Theisen E, Zhang F, Nathan A, Rupani KV, Jones D, Accelerating Medicines Partnership RA/SLE Network, Raychaudhuri S, Dwyer DF, Brenner MB
bioRxiv : the preprint server for biology 2024 May 26;
bioRxiv : the preprint server for biology 2024 May 26;
Extracellular vesicle biomarkers for complement dysfunction in schizophrenia.
Xue T, Liu W, Wang L, Shi Y, Hu Y, Yang J, Li G, Huang H, Cui D
Brain : a journal of neurology 2024 Mar 1;147(3):1075-1086
Brain : a journal of neurology 2024 Mar 1;147(3):1075-1086
Complement components regulates ferroptosis in CVB3 viral myocarditis by interatction with TFRC.
Yi L, Yang Y, Hu Y, Wu Z, Kong M, Zuoyuan B, Xin X, Yang Z
Free radical biology & medicine 2024 Feb 20;212:349-359
Free radical biology & medicine 2024 Feb 20;212:349-359
In silico analysis and verification of critical genes related to vascular calcification in multiple diseases.
Li S, Ruan J, Yang Z, Liu L, Jiang T
Cell biochemistry and function 2023 Dec;41(8):1242-1251
Cell biochemistry and function 2023 Dec;41(8):1242-1251
Circulating Donor Heart Exosome Profiling Enables Noninvasive Detection of Antibody-mediated Rejection.
Hu RW, Korutla L, Reddy S, Harmon J, Zielinski PD, Bueker A, Molina M, Romano C, Margulies K, McLean R, Lal P, Vallabhajosyula P
Transplantation direct 2020 Nov;6(11):e615
Transplantation direct 2020 Nov;6(11):e615
Inefficient and abortive classical complement pathway activation by the calcium inositol hexakisphosphate component of the Echinococcus granulosus laminated layer.
Barrios AA, Grezzi L, Miles S, Mariconti M, Mourglia-Ettlin G, Seoane PI, Díaz A
Immunobiology 2019 Sep;224(5):710-719
Immunobiology 2019 Sep;224(5):710-719
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The C4A antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human C4A. This antibody recognizes human antigen. The C4A antibody has been validated for the following applications: ELISA, WB analysis.
