Tissue expression
Cell line expression

C4A

gene product
C4, C4A2, C4A3, C4A4, C4A6, C4B, C4S, CO4, CPAMD2, RG 
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain is cleaved to release C4 anaphylatoxin, an antimicrobial peptide and a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
More gene data

Antibodies

 

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679 antibodies from 37 providers.

Antibody properties

Applications

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AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
2 antibodies
OriGene
21 antibodies
Novus Biologicals
8 antibodies
Boster Biological Technology
4 antibodies
antibodies-online
284 antibodies
Wuhan Fine Biotech Co., Ltd.
2 antibodies
GeneTex
3 antibodies
Cusabio Biotech Co., Ltd
5 antibodies
HUABIO Research
3 antibodies
LifeSpan BioSciences, Inc.
53 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Biorbyt
46 antibodies
NSJ Bioreagents
9 antibodies
NovoPro Bioscience Inc.
2 antibodies
FabGennix
3 antibodies
Abgent
5 antibodies
Acris Antibodies GmbH
36 antibodies
ProSci
3 antibodies
Abnova Corporation
11 antibodies
Atlas Antibodies
3 antibodies
Aviva Systems Biology
7 antibodies
Invitrogen Antibodies
4 antibodies
Creative Diagnostics
8 antibodies
Bioworld Technology, Inc
1 antibody
Spring Bioscience
8 antibodies
Creative Biolabs
54 antibodies
Abbexa
11 antibodies
RabMAbs
2 antibodies
RayBiotech, Inc.
2 antibodies
Cell Signaling Technology, Inc
1 antibody
DB Biotech
1 antibody
United States Biological
27 antibodies
MyBioSource
5 antibodies
Abbiotec
3 antibodies
Enzo Life Sciences
2 antibodies
St John's Laboratory
3 antibodies