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- Antigen structure
- References [234]
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- Product number
- 17617-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17617-1-AP, RRID:AB_1939430
- Product name
- CD3 antibody
- Antibody type
- Polyclonal
- Description
- CD3 antibody (Cat. #17617-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, pig, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Blocking AREG-EGFR signaling attenuates pan-arterial fibrosis in chronic cardiac allograft rejection.
MIF-expressing tumor cells mediate immunotherapeutic resistance in esophageal squamous cell carcinoma.
Extracellular vesicles-derived hybrid biomimetic nanoplatforms camouflaged Golgi apparatus-targeted aggregation induced emission photosensitizer to elicit pyroptosis and immunogenic cell death for efficient antitumor photoimmunotherapy.
L-Arabinose attenuates loperamide-induced constipation through the regulation of gut microbiota in mice.
LIFUS-driven engineered bacteria reprogram immunosuppressive niches via mechano-NOTCH signaling.
Adhesion molecule with Ig-like domain 1 regulates stability of carotid plaque via TGFβ/Smad signaling pathway by interaction with TGFRII.
Deficiency of Med1 in keratinocytes augments dermal fibrosis and inflammation in scleroderma.
Pyoderma Gangrenosum Associated With Iatrogenic Interleukin 17A Blockade: A Report of Two Cases and a Review of the Literature.
Esaxerenone attenuates high salt-induced hypertension and renal damage via CD8(+)T cell- associated NCC activation in aldosterone treated rats.
Nanoparticle-Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy.
Duration of contact sports play associated with aberrant DNA methylation in human frontal cortex.
Mesenchymal stromal cells ameliorate systemic sclerosis-interstitial lung disease via PD-1/PD-L1 signalling axis.
Single-Cell Transcriptomic Characterization of DNCB-Induced Mouse Model Reveals Atopic Dermatitis-Associated Skin Lesions in Skin Microenvironment.
Engineering Drug-Eluting Ocular Bioadhesive "OcuTAPE" via Tannic Acid-Mediated Nanoparticle Bridging.
Apelin-13 alleviated ischemia reperfusion injury via KLF2/NF-κB signaling pathway after kidney transplantation.
Microfluidic-based patient-derived organoids recapitulate thyroid cancer heterogeneity and reveal NF-κB-driven maturation for precision therapy.
The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis.
Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome.
Single-cell transcriptome revealed the aberrant keratinocytes activation in antigen presentation in atopic dermatitis.
Inducible Nitric Oxide Deficiency Attenuates Necroptosis in Psoriasis-Like Dermatitis in Mice by Reducing Oxidative Stress.
PRMT5-Mediated Arginine Methylation of ACSL4 Attenuates Its Stability and Suppresses Ferroptosis in Renal Cancer.
Effects of Cacna1d D307G Mutation on Blood Pressure and Kidney Function in Rats with Salt Loading.
Targeting Smad3 Phosphorylation Attenuates Anastomotic Intimal Hyperplasia and Perigraft Fibrosis in Decellularized Tissue-Engineered Vascular Grafts.
Dot1l Regulates the Spontaneous Bone Regeneration of Periosteum-Derived Stem Cells by Regulating Chac1 Expression.
Iron-Oxide Labeled Stem Cells with Specific Magnetic Occurrence for Effective in Mouse Model of Cisplatin-Induced Acute Kidney Injury.
LOX1-mediated supramolecular self-assembly nanomedicine for microsatellite-stable colorectal cancer towards reactivating anti-tumor immunity.
Targeting PDPN enhances antitumor T-cell activity by disrupting β-catenin-mediated PD-L1 expression in melanoma.
Fibroblast-like synoviocytes mediate the generation of soluble PD-1 in an MMP-9-dependent manner: a novel target therapy for rheumatoid arthritis.
The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway.
LncRNA MIR31HG facilitates immune escape in head and neck squamous cell carcinoma by promoting heterotypic cell-in-cell formation.
PIGR predicts good clinical outcomes and plays a tumor suppressor role in the development of breast cancer.
Phospholipase A2 group IIA activates Indoleamine 2,3-dioxygenase 1 to drive the progression of pulmonary fibrosis.
Therapeutic Effect of a Composite Acellular Matrix/Hyaluronic Acid Thermosensitive Hydrogel for the Interstitial Cystitis/Bladder Pain Syndrome in a Rat Model.
Integrated spatial transcriptomic profiling to dissect the cellular characteristics of tumor-associated tertiary lymphoid structures.
Plasma exchange and intravenous immunoglobulin prolonged the survival of a porcine kidney xenograft in a sensitized, brain-dead human recipient.
Single-Cell Transcriptomics of Human Pericarotid Lymph Nodes Indicating Stability of Carotid Atherosclerotic Plaques.
Single-cell multi-omic and spatial profiling of esophageal squamous cell carcinoma reveals the immunosuppressive role of GPR116(+) pericytes in cancer metastasis.
Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti-PD-1 immunotherapy efficacy in colorectal cancer liver metastasis.
Engineered biomimetic vesicles induce cuproptosis and disrupt efferocytosis for metastatic adenoid cystic carcinoma immunotherapy.
Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer.
Exosome-like nanovesicles from Dunaliella salina efficient sequential Co-delivery of anti-PDL1 and miR-375 for enhancing gene/immune therapy.
Targeting Intratumoral Copper Inhibits Tumor Progression via p62-Mediated EZH2 Degradation and Potentiates Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinoma.
Enhanced FOS expression improves tumor clearance and resists exhaustion in NR4A3-deficient CAR T cells under chronic antigen exposure.
Disulfide-Appended siRNA Nanoeyedrops: Noninvasive Gene Therapy for Targeting Retinal Angiogenesis.
Sleep Deprivation Aggravates Periodontitis Through Trigeminal-Periodontal Neuroimmune Pathway Mediated by the AChE-ACh-α7nAChR Axis.
7,8-dihydroxyflavone attenuates NIH IIIA subtype chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) via TrkB/AKT/SIRT3 signaling activation.
Total tanshinones extract alleviates chronic prostatitis/chronic pelvic pain syndrome by modifying intestinal flora and suppressing the LPS-TLR4 axis.
The Immune Regulation of Melanin From Gallus gallus domesticus Brisson Against Cyclophosphamide-Induced Immunosuppression.
Quercetin down-regulates MCP-1 expression in autoimmune myocarditis via ERK1/2-C/EBPβ pathway: An integrative approach using network pharmacology and experimental models.
A single-cell atlas reveals immune heterogeneity in anti-PD-1-treated non-small cell lung cancer.
Excessive MYC Orchestrates Macrophages induced Chromatin Remodeling to Sustain Micropapillary-Patterned Malignancy in Lung Adenocarcinoma.
Bcl-xL overexpression in T cells preserves muscle mitochondrial structure and function and prevents frailty in old mice.
Loss of tricellular tight junction tricellulin leads to hyposalivation in Sjögren's syndrome.
Small extracellular vesicles from young adipose-derived stem cells ameliorate age-related changes in the heart of old mice.
Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice.
Cryo-trojan mesenchymal stem cells as non-living tumor-homing supercarriers for enhanced drug delivery and immune activation in prostate cancer.
Fufang-Biejia-Ruangan tablet targeting both cancer-associated fibroblasts and tumor cells by HIPPO-PI3K/AKT cascades in intrahepatic cholangiocarcinoma treatment.
Huang-Lian-Jie-Du decoction inhibits CD4+ T cell infiltration into CNS in MCAO rats by regulating BBB.
LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma.
Genetically-engineered Salmonella typhimurium expressing FGF21 promotes neurological recovery in ischemic stroke via FGFR1/AMPK/mTOR pathway.
Hypoxia upregulates the expression of PD-L1 via NPM1 in breast cancer.
The crosstalk between lung adenocarcinoma cells and M2 macrophages promotes cancer cell development via the SFRS1/miR-708-5p/PD-L1 axis.
ADRB2 inhibition suppresses cancer immune evasion by regulating tumor SOX10-PD-L1 axis and T cell function.
Notch signaling pathway regulates the progression of fetal growth restriction through mediating immune dysfunction.
Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for Cancer Immunotherapy.
Deficiency of inducible nitric oxide synthase (iNOS) enhances MC903-induced atopic dermatitis-like inflammation in mice.
Qingrehuoxue formula enhances anti-PD-1 immunotherapy in NSCLC by remodeling the tumor immune microenvironment via TREM2 signaling.
Immune profiling identifies CD161(+)CD127(+)CD8(+) T cells as a predictive biomarker for Anti-PD-L1 therapy response in the SCLC-I subtype.
Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor-Ligand Interactions That Instructs Intratumoral γδT-cell Activity.
Hyperactivity of the IL-33-ILC2s-IL-13-M-MDSCs axis promotes cervical cancer progression.
Escherichia coli combination with PD-1 blockade synergistically enhances immunotherapy in glioblastoma multiforme by regulating the immune cells.
ITIH5-mediated fibroblast/macrophage crosstalk exacerbates cardiac remodelling after myocardial infarction.
S1PR1-biased activation drives the resolution of endothelial dysfunction-associated inflammatory diseases by maintaining endothelial integrity.
Corydalis decumbens and tetrahydropalmatrubin inhibit macrophages inflammation to relieve rheumatoid arthritis by targeting Fosl2.
Loss of CDKN2A Enhances the Efficacy of Immunotherapy in EGFR-Mutant Non-Small Cell Lung Cancer.
CXCL11 as potential predictive biomarker and therapeutic target of acute rejection after kidney transplantation.
Nano MgO loaded thermosensitive HPCH@HA hydrogel accelerates in situ bone repair through osteoimmunomodulation while enhancing angiogenesis and osteogenesis.
From foe to friend: Rewiring oncogenic pathways through artificial selenoprotein to combat immune-resistant tumor.
VSIG2 as a novel immunosuppressive ligand interacts with Nectin-2 to regulate T cell responses.
KIAA1429 impairs anti-tumor immunity via regulation of PD-L1 and CD8(+) T cells in colorectal cancer.
Histone deacetylase HDAC7 restricts CD8 + T cell tumor infiltration and limits immunotherapy sensitivity in bladder cancer: reversal by pinocembrin.
Synergistic immunomodulatory effects of naringenin and photothermal therapy in triple-negative breast cancer.
Cathepsin C-driven enhancement of neutrophil extracellular trap formation contributes to acute lung injury.
Nerandomilast Improves Bleomycin-Induced Systemic Sclerosis-Associated Interstitial Lung Disease in Mice by Regulating the TGF-β1 Pathway.
A novel FTO-targeting nanodrug induces disulfidptosis and ameliorates the suppressive tumor immune environment to treat uveal melanoma.
Excessive ultra-processed foods exposure aggravates ulcerative colitis via macrophage ferroptosis.
Engineered MSC Aggregates with E/N-Cadherin and IL-6 Preconditioning for the Treatment of Systemic Sclerosis.
Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409-Ube2k-Foxp3 Axis in Regulatory T Cells.
Knockdown of the Clock gene in the liver aggravates MASLD in mice via inhibiting lipophagy.
Using Cancer-Associated Fibroblasts as a Shear-Wave Elastography Imaging Biomarker to Predict Anti-PD-1 Efficacy of Triple-Negative Breast Cancer.
Streptococcus mutans-derived extracellular vesicles promote skin wound healing via tRNA cargo.
Integrating bulk, single-cell, and spatial transcriptomics to identify and functionally validate novel targets to enhance immunotherapy in NSCLC.
HKDC1 promotes ovarian cancer progression through boosting lipid metabolism and immune escape by stabilizing G6PC/G6PC2.
Acidosis regulates immune progression in rheumatoid arthritis by promoting the expression of cytokines and co-stimulatory molecules in synovial fibroblasts.
Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups.
Single-Cell RNA Sequencing Revealed Functional Conjunctival Keratinocytes Loss via TGF-β-Wnt/β-Catenin Signaling in Sjögren's Syndrome Related Dry Eye.
The development and potent antitumor efficacy of CD44/CD133 dual-targeting IL7Rα-armored CAR-T cells against glioblastoma.
CCR7 and CD48 as Predicted Targets in Acute Rejection Related to M1 Macrophage after Pediatric Kidney Transplantation.
Salidroside may target PPARα to exert preventive and therapeutic activities on NASH.
Cardiac sympathetic overdrive, M2 macrophage activation and fibroblast heterogeneity are associated with cardiac remodeling in a chronic pressure overload rat model of HFpEF.
Platinum-based neoadjuvant chemotherapy upregulates STING/IFN pathway expression and promotes TILs infiltration in NSCLC.
CD161(+)CD127(+)CD8(+) T cell subsets can predict the efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer with diabetes mellitus.
Thirdhand smoke exposure promotes gastric tumor development in mouse and human.
Construction of a prognostic model with exosome biogenesis- and release-related genes and identification of RAB27B in immune infiltration of pancreatic cancer.
Brusatol improves the efficacy of an anti-mouse-PD-1 antibody via inhibiting programmed cell death 1 ligand 1 expression in a murine head and neck squamous cell carcinoma model.
Single-cell analysis reveals alternations between the aged and young mice prostates.
Astaxanthin Alleviates Chronic Prostatitis via the ERK1/2 Signaling Pathway: Evidence from Network Pharmacology and Experimental Validation.
Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment.
DNA-PKcs modulates mouse lung homeostasis via the regulation of mitochondrial fission.
Single-cell landscape identified SERPINB9 as a key player contributing to stemness and metastasis in non-seminomas.
Effective substances and molecular mechanisms guided by network pharmacology: An example study of Scrophulariae Radix treatment of hyperthyroidism and thyroid hormone-induced liver and kidney injuries.
Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota.
Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression.
Injectable ultrasonic sensor for wireless monitoring of intracranial signals.
Synergistic effects of Ω-3 polyunsaturated fatty acid supplementation and programmed cell death protein 1 blockade on tumor growth and immune modulation in a xenograft model of esophageal cancer.
Investigation of the active ingredients and mechanism of Shuangling extract in dextran sulfate sodium salt induced ulcerative colitis mice based on network pharmacology and experimental verification.
cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity.
Brain Metastasis from EGFR-Mutated Non-Small Cell Lung Cancer: Secretion of IL11 from Astrocytes Up-Regulates PDL1 and Promotes Immune Escape.
Spatiotemporal single-cell analysis decodes cellular dynamics underlying different responses to immunotherapy in colorectal cancer.
HMGB1/TREM2 positive feedback loop drives the development of radioresistance and immune escape of glioblastoma by regulating TLR4/Akt signaling.
The recruitment of CD8(+) T cells through YBX1 stabilization abrogates tumor intrinsic oncogenic role of MIR155HG in lung adenocarcinoma.
CXC ligand 13 orchestrates an immunoactive microenvironment and enhances immunotherapy response in head and neck squamous cell carcinoma.
Cold atmospheric plasma sensitizes head and neck cancer to chemotherapy and immune checkpoint blockade therapy.
Calcitriol restrains microglial M1 polarization and alleviates dopaminergic degeneration in hemiparkinsonian mice by boosting regulatory T-cell expansion.
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma.
FGF18 alleviates sepsis-induced acute lung injury by inhibiting the NF-κB pathway.
Dickkopf-1 is an immune infiltration-related prognostic biomarker of head and neck squamous cell carcinoma.
PTPRZ1 dephosphorylates and stabilizes RNF26 to reduce the efficacy of TKIs and PD-1 blockade in ccRCC.
Bioactive sucralfate-based microneedles promote wound healing through reprogramming macrophages and protecting endogenous growth factors.
Simultaneous targeting of TGF-β1/PD-L1 via a hydrogel-nanoparticle system to remodel the ECM and immune microenvironment for limiting adhesion formation.
CRISPR/Cas9 Mediated Deletion of the Uox Gene Generates a Mouse Model of Hyperuricemia with Multiple Complications.
Turning attention to tumor-host interface and focus on the peritumoral heterogeneity of glioblastoma.
Intervention effect of regulating GABA-A receptor activity on the formation of experimental abdominal aortic aneurysm in rats.
Mechanistic Study of Purple Sweet Potato Anthocyanins: Multifaceted Anti-Fibrotic Effects and Targeting of PDGFRβ in Liver Fibrosis.
Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2.
Identification and Characterization of a Novel B Cell Epitope of ASFV Virulence Protein B125R Monoclonal Antibody.
The PP2A inhibitor LB-100 mitigates lupus nephritis by suppressing tertiary lymphoid structure formation.
SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia.
Single-Cell RNA Sequencing Identifies WARS1+ Mesenchymal Stem Cells with Enhanced Immunomodulatory Capacity and Improved Therapeutic Efficacy.
DPSCs regulate epithelial-T cell interactions in oral submucous fibrosis.
Diaphorobacter nitroreducens synergize with oxaliplatin to reduce tumor burden in mice with lung adenocarcinoma.
Accelerated Wound Healing in Diabetic Rat by miRNA-185-5p and Its Anti-Inflammatory Activity.
Clinical and Pathological Features of Hydroa Vacciniforme-Like Lymphoproliferative Disorder Along with Risk Factors Indicating Poor Prognosis.
Characterisation of macrophage infiltration and polarisation based on integrated transcriptomic and histological analyses in Primary Sjögren's syndrome.
Nanobody-derived bispecific CAR-T cell therapy enhances the anti-tumor efficacy of T cell lymphoma treatment.
A pan-cancer single-cell panorama of human natural killer cells.
Impact of chemotherapeutic agents on liver microenvironment: oxaliplatin create a pro-metastatic landscape.
Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer.
Ki67-targeted oncolytic adenovirus expressing IL-15 improves intratumoral T cell infiltration and PD-L1 expression in glioblastoma.
Heterogeneity of T cells in periapical lesions and in vitro validation of the proangiogenic effect of GZMA on HUVECs.
Zearalenone-14-glucoside specifically promotes dysplasia of Gut-Associated Lymphoid Tissue: A natural product for constructing intestinal nodular lymphatic hyperplasia model.
ARPC5 acts as a potential prognostic biomarker that is associated with cell proliferation, migration and immune infiltrate in gliomas.
Atractylodes lancea Rhizome Polysaccharide Alleviates Immunosuppression and Intestinal Mucosal Injury in Mice Treated with Cyclophosphamide.
Influence of PD-1/PD-L1 on immune microenvironment in oral leukoplakia and oral squamous cell carcinoma.
Therapeutic potential of Lianhua Qingke in airway mucus hypersecretion of acute exacerbation of chronic obstructive pulmonary disease.
Allogeneic T cells cause acute renal injury after hematopoietic cell transplantation.
Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A.
Effects of earthworm hydrolysate in production performance, serum biochemical parameters, antioxidant capacity and intestinal function of Muscovy ducks.
Guijiajiao (Colla Carapacis et Plastri, CCP) prevents male infertility via gut microbiota modulation.
An integrated bioinformatic investigation of focal adhesion-related genes in glioma followed by preliminary validation of COL1A2 in tumorigenesis.
Immune Enhancement of Clam Peptides on Immunosuppressed Mice Induced by Hydrocortisone.
Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer.
Novel RNA polymerase I inhibitor CX-5461 suppresses imiquimod-induced experimental psoriasis.
STAT6 suppression prevents bleomycin-induced dermal fibrosis.
The PD-L1 Expression and Tumor-Infiltrating Immune Cells Predict an Unfavorable Prognosis in Pancreatic Ductal Adenocarcinoma and Adenosquamous Carcinoma.
HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
C1Q labels a highly aggressive macrophage-like leukemia population indicating extramedullary infiltration and relapse.
Reduced Renal CSE/CBS/H2S Contributes to the Progress of Lupus Nephritis.
TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation.
Platycodon grandiflorus polysaccharide regulates colonic immunity through mesenteric lymphatic circulation to attenuate ulcerative colitis.
Ammonia-induced oxidative stress triggered proinflammatory response and apoptosis in pig lungs.
Senescence-Related lncRNA Signature Predicts Prognosis, Response to Immunotherapy and Chemotherapy in Skin Cutaneous Melanoma.
Dose-Dependent Effects in Plasma Oncotherapy: Critical In Vivo Immune Responses Missed by In Vitro Studies.
Tenascin C(+) papillary fibroblasts facilitate neuro-immune interaction in a mouse model of psoriasis.
Establishment of a New Abdominal Aortic Aneurysm Model in Rats by a Retroperitoneal Approach.
Asymptomatic Hyperuricemia Is Associated with Achilles Tendon Rupture through Disrupting the Normal Functions of Tendon Stem/Progenitor Cells.
Prognostic Lnc-S100B-2 Affects Cell Apoptosis and Microenvironment of Colorectal Cancer through MLLT10 Signaling.
Tissue Kallikrein Protects Rat Prostate against the Inflammatory Damage in a Chronic Autoimmune Prostatitis Model via Restoring Endothelial Function in a Bradykinin Receptor B2-Dependent Way.
Self-Assembly Catalase Nanocomplex Conveyed by Bacterial Vesicles for Oxygenated Photodynamic Therapy and Tumor Immunotherapy.
C-X-C-Chemokine-Receptor-Type-4 Inhibitor AMD3100 Attenuates Pulmonary Inflammation and Fibrosis in Silicotic Mice.
Mesalamine-Mediated Amelioration of Experimental Colitis in Piglets Involves Gut Microbiota Modulation and Intestinal Immune Cell Infiltration.
Single-cell RNA sequencing reveals TCR(+) macrophages in HPV-related head and neck squamous cell carcinoma.
Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockade in non-small cell lung cancer.
Ellagic acid prevents gut damage via ameliorating microbe-associated intestinal lymphocyte imbalance.
Angiotensin-converting enzyme 2 identifies immuno-hot tumors suggesting angiotensin-(1-7) as a sensitizer for chemotherapy and immunotherapy in breast cancer.
Traditional Chinese medicine CFF-1 exerts a potent anti-tumor immunity to hinder tumor growth and metastasis in prostate cancer through EGFR/JAK1/STAT3 pathway to inhibit PD-1/PD-L1 checkpoint signaling.
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
A novel TanCAR targeting IL13Rα2 and EphA2 for enhanced glioblastoma therapy.
Ras guanine nucleotide-releasing protein-4 promotes renal inflammatory injury in type 2 diabetes mellitus.
Photosynthetic microorganisms coupled photodynamic therapy for enhanced antitumor immune effect.
IQGAP1 is positively correlated with PD-L1 and regulates its expression via mediating STAT proteins phosphorylation.
Null Function of Npr1 Disturbs Immune Response in Colonic Inflammation During Early Postnatal Stage.
Intranasal bovine β-defensin-5 enhances antituberculosis immunity in a mouse model by a novel protein-based respiratory mucosal vaccine.
Single-Cell Sequencing Unveils the Heterogeneity of Nonimmune Cells in Chronic Apical Periodontitis.
The Effect of miR-520b on Macrophage Polarization and T Cell Immunity by Targeting PTEN in Breast Cancer.
Paraspeckle Promotes Hepatocellular Carcinoma Immune Escape by Sequestering IFNGR1 mRNA.
VISTA Blockade Aggravates Bone Loss in Experimental Murine Apical Periodontitis.
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
M(6)A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma.
Increased Expression of the lncRNA NRON Along With NFATc1/PIM-1 in Labial Salivary Glands of Sjögren's Syndrome Patients.
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes.
Inhibition of DCLK1 with DCLK1-IN-1 Suppresses Renal Cell Carcinoma Invasion and Stemness and Promotes Cytotoxic T-Cell-Mediated Anti-Tumor Immunity.
The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma.
The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer.
A multi-effective and long-acting immunotherapy through one single hydrogel based injection.
The impact of tobacco exposure on tumor microenvironment and prognosis in lung adenocarcinoma by integrative analysis of multi-omics data.
Dickkopf-related protein 3 alters aerobic glycolysis in pancreatic cancer BxPC-3 cells, promoting CD4(+) T-cell activation and function.
The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Colon Adenocarcinoma Metastasis.
Overexpressed immunoglobulin-like transcript (ILT) 4 in lung adenocarcinoma is correlated with immunosuppressive T cell subset infiltration and poor patient outcomes.
Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.
sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells.
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway.
Indirubin alleviates bleomycin-induced pulmonary fibrosis in mice by suppressing fibroblast to myofibroblast differentiation.
Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration.
Majie cataplasm provides a shield against asthmatic punch from the neuroimmune system.
HIF1α/PLD2 axis linked to glycolysis induces T-cell immunity in oral lichen planus.
Collagen fiber structure guides 3D motility of cytotoxic T lymphocytes.
Autophagy plays a positive role in induction of epidermal proliferation.
The ACE2-deficient mouse: A model for a cytokine storm-driven inflammation.
IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma.
Fine-particulate matter aggravates cigarette smoke extract-induced airway inflammation via Wnt5a-ERK pathway in COPD.
Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56.
The preoperative neutrophil-to-lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving radical prostatectomy.
PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.
Clinical Impact of the Immune Microenvironment in Spinal Chordoma: Immunoscore as an Independent Favorable Prognostic Factor.
Curative effect of endostar combined with oxaliplatin in the treatment of primary hepatic carcinoma and its influence on immune cells.
A Novel Murine Chronic Obstructive Pulmonary Disease Model and the Pathogenic Role of MicroRNA-21.
Acacetin regulated the reciprocal differentiation of Th17 cells and Treg cells and mitigated the symptoms of collagen-induced arthritis in mice.
A self-organized actomyosin drives multiple intercellular junction disruption and directly promotes neutrophil recruitment in lipopolysaccharide-induced acute lung injury.
Flow Cytometric Immunophenotyping Is Sensitive for the Early Diagnosis of De Novo Aggressive Natural Killer Cell Leukemia (ANKL): A Multicenter Retrospective Analysis.
SNX17 affects T cell activation by regulating TCR and integrin recycling.
RAG1/2 knockout pigs with severe combined immunodeficiency.
Xing K, Chang Y, An Y, Chen X, Zhu X, Huang J, Li P, Xu M, Sheng Y, Du X, Liu H, Song J
Theranostics 2026;16(9):4603-4618
Theranostics 2026;16(9):4603-4618
MIF-expressing tumor cells mediate immunotherapeutic resistance in esophageal squamous cell carcinoma.
Song J, Song X, Xie Y, Guo H, Cun Y
Theranostics 2026;16(3):1613-1629
Theranostics 2026;16(3):1613-1629
Extracellular vesicles-derived hybrid biomimetic nanoplatforms camouflaged Golgi apparatus-targeted aggregation induced emission photosensitizer to elicit pyroptosis and immunogenic cell death for efficient antitumor photoimmunotherapy.
Zhao X, Wu X, Shang R, Dou H, Chen H, Tan N
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1696-1716
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1696-1716
L-Arabinose attenuates loperamide-induced constipation through the regulation of gut microbiota in mice.
Zheng S, Zheng H, Huang Y, Liang B, Gong Y, Shen J, Liu W, Xu X, Ma Y, Liu Z, Wang Y
Food & function 2026 Mar 9;17(5):2327-2339
Food & function 2026 Mar 9;17(5):2327-2339
LIFUS-driven engineered bacteria reprogram immunosuppressive niches via mechano-NOTCH signaling.
Lin L, Li X, Guo W, Xie J, Li X, Guan X, Zhao C, Yin H, Xu H
Cell reports. Medicine 2026 Mar 17;7(3):102658
Cell reports. Medicine 2026 Mar 17;7(3):102658
Adhesion molecule with Ig-like domain 1 regulates stability of carotid plaque via TGFβ/Smad signaling pathway by interaction with TGFRII.
Hu X, Li X, Chen J, Li Y, Zhao Z, Yin X, Duan S, Wang B
Cellular signalling 2026 Jun;142:112412
Cellular signalling 2026 Jun;142:112412
Deficiency of Med1 in keratinocytes augments dermal fibrosis and inflammation in scleroderma.
Luo J, Kang Y, Zhang Z, Zhang E, Huang J, Zhu Q, Guo Q, Song S, Wang B, Li M, Yuan Q, Li H, Zhao D, Chen H, Wang S, Li Y, Zhang B, He J, Hu L
International immunopharmacology 2026 Jul 15;181:116667
International immunopharmacology 2026 Jul 15;181:116667
Pyoderma Gangrenosum Associated With Iatrogenic Interleukin 17A Blockade: A Report of Two Cases and a Review of the Literature.
Magro CM, Crowson N, Kalomeris T, Nuovo G
Journal of cutaneous pathology 2026 Jan;53(1):112-120
Journal of cutaneous pathology 2026 Jan;53(1):112-120
Esaxerenone attenuates high salt-induced hypertension and renal damage via CD8(+)T cell- associated NCC activation in aldosterone treated rats.
Xu C, Zhai N, Wang H, Fang F, An J, Liu F, Zhong Y, Wang Z, Wang X
The Journal of steroid biochemistry and molecular biology 2026 Jan;255:106884
The Journal of steroid biochemistry and molecular biology 2026 Jan;255:106884
Nanoparticle-Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy.
Li M, Li R, Xu B, Lian Y, Yang C, Li J, Liang J, Ding L, Zhang D, Guo J, Fu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e08753
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e08753
Duration of contact sports play associated with aberrant DNA methylation in human frontal cortex.
Breen KA, Aytan N, Hawkins S, Nicks R, Alvarez VE, Mez J, Blusztajn JK, Cherry JD, McKee AC, Lin H, Stein TD
Research square 2026 Jan 7;
Research square 2026 Jan 7;
Mesenchymal stromal cells ameliorate systemic sclerosis-interstitial lung disease via PD-1/PD-L1 signalling axis.
Chen Y, Zhu H, Zhang Y, Liu M, Wu Y, Ding S, Wang D, Sun L
RMD open 2026 Jan 6;12(1)
RMD open 2026 Jan 6;12(1)
Single-Cell Transcriptomic Characterization of DNCB-Induced Mouse Model Reveals Atopic Dermatitis-Associated Skin Lesions in Skin Microenvironment.
Liu W, Qiu Z, Fu J, Hou L, Ding X, Du H, Zhai Y, Cao Z, Wang P, Wang C
Inflammation 2026 Jan 24;49(1):63
Inflammation 2026 Jan 24;49(1):63
Engineering Drug-Eluting Ocular Bioadhesive "OcuTAPE" via Tannic Acid-Mediated Nanoparticle Bridging.
Zheng Y, Monu M, Vo S, Gupta S, Kumar LK, Kumar P, Nassiri N, Singh PK, Annabi N
Advanced functional materials 2026 Jan 15;36(5)
Advanced functional materials 2026 Jan 15;36(5)
Apelin-13 alleviated ischemia reperfusion injury via KLF2/NF-κB signaling pathway after kidney transplantation.
Zhang J, Yu C, Wang H, Xiao H, Wen S, Hua Y, Wei G
International immunopharmacology 2026 Jan 1;168(Pt 1):115802
International immunopharmacology 2026 Jan 1;168(Pt 1):115802
Microfluidic-based patient-derived organoids recapitulate thyroid cancer heterogeneity and reveal NF-κB-driven maturation for precision therapy.
Gao H, Lin J, Chen X, Su Y, Huang Y, Zhang Y, Zhang J, Xu N, Dai X
Journal of translational medicine 2026 Feb 27;24(1)
Journal of translational medicine 2026 Feb 27;24(1)
The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis.
Liu Y, Yan S, Wang J, Dong D, Yan S, Yin H, Liu K, Liu M, Liu H, Li D, Gao J, Xie W, Zhou J
Cell death and differentiation 2026 Feb 27;
Cell death and differentiation 2026 Feb 27;
Hepatocyte PLAGL2 deficiency alleviates MASH through MYD88-licensed inactivation of inflammasome.
Duan R, Wang X, Wang Q, Zhou X, Gao S, Sun Y, Feng Q, Li Z, Yang Z, Ding J, Chen Z, Duan J, Yang Y
Cell reports 2026 Feb 24;45(2):116942
Cell reports 2026 Feb 24;45(2):116942
Single-cell transcriptome revealed the aberrant keratinocytes activation in antigen presentation in atopic dermatitis.
Liu WX, Cao Y, Chen YF, Lu YF, Xu CY, Zhai YH, Wang C, Cao Z
Annals of medicine 2026 Dec;58(1):2627742
Annals of medicine 2026 Dec;58(1):2627742
Inducible Nitric Oxide Deficiency Attenuates Necroptosis in Psoriasis-Like Dermatitis in Mice by Reducing Oxidative Stress.
Sun M, Guo P, Guo Q, Li H, Huang J, Luo J, Zhu Q, Zhu Y, Yuan Q, Song S, He J, Su L, Xing W, Hu L
The Journal of investigative dermatology 2026 Apr;146(4):986-997.e12
The Journal of investigative dermatology 2026 Apr;146(4):986-997.e12
PRMT5-Mediated Arginine Methylation of ACSL4 Attenuates Its Stability and Suppresses Ferroptosis in Renal Cancer.
Zhang M, Liu H, Yin R, Xu J, Fan S, Qian X, Cao M, Li S, Zhang A, Chen G, Yong H, Li Z, Bai J
Research (Washington, D.C.) 2025;8:0789
Research (Washington, D.C.) 2025;8:0789
Effects of Cacna1d D307G Mutation on Blood Pressure and Kidney Function in Rats with Salt Loading.
Cheng L, Chen H, Maboh RN, Wang H
Kidney & blood pressure research 2025;50(1):46-60
Kidney & blood pressure research 2025;50(1):46-60
Targeting Smad3 Phosphorylation Attenuates Anastomotic Intimal Hyperplasia and Perigraft Fibrosis in Decellularized Tissue-Engineered Vascular Grafts.
Lu P, Wang T, Liao S, He Z, Cheng S, Wang T, Cheng Z, An Y, Zhou S, Wang M, Zhang Q, Shu C
Biomaterials research 2025;29:0241
Biomaterials research 2025;29:0241
Dot1l Regulates the Spontaneous Bone Regeneration of Periosteum-Derived Stem Cells by Regulating Chac1 Expression.
Jiang T, Fang B, Yu Z, Cao D
Stem cells international 2025;2025:1508850
Stem cells international 2025;2025:1508850
Iron-Oxide Labeled Stem Cells with Specific Magnetic Occurrence for Effective in Mouse Model of Cisplatin-Induced Acute Kidney Injury.
Wang K, Zhao Y, Lv H, Li X
International journal of nanomedicine 2025;20:11435-11449
International journal of nanomedicine 2025;20:11435-11449
LOX1-mediated supramolecular self-assembly nanomedicine for microsatellite-stable colorectal cancer towards reactivating anti-tumor immunity.
Wei X, Guo Y, Lei J, Chen N
Frontiers in immunology 2025;16:1737031
Frontiers in immunology 2025;16:1737031
Targeting PDPN enhances antitumor T-cell activity by disrupting β-catenin-mediated PD-L1 expression in melanoma.
Feng C, Liu Y, Zhong X, Wei Z, Cui H, Yi J
Frontiers in immunology 2025;16:1692864
Frontiers in immunology 2025;16:1692864
Fibroblast-like synoviocytes mediate the generation of soluble PD-1 in an MMP-9-dependent manner: a novel target therapy for rheumatoid arthritis.
Yang C, Ma M, Yu K, Wang Y, Zhang Y, Shen Y, Wang J, Wang X, Luo L, Zhao Y
Frontiers in immunology 2025;16:1665078
Frontiers in immunology 2025;16:1665078
The ultrafine powder of atractylodis macrocephalae rhizoma improves immune function in naturally aging rats by regulating the PI3K/Akt/NF-κB signaling pathway.
Yu W, Jie S, Su G, Zhuangwei N, Yiqing Z, Suhong C, Guiyuan L
Frontiers in pharmacology 2025;16:1550357
Frontiers in pharmacology 2025;16:1550357
LncRNA MIR31HG facilitates immune escape in head and neck squamous cell carcinoma by promoting heterotypic cell-in-cell formation.
Fang Q, Yuan J, Zhang X, Lin L
American journal of cancer research 2025;15(8):3395-3416
American journal of cancer research 2025;15(8):3395-3416
PIGR predicts good clinical outcomes and plays a tumor suppressor role in the development of breast cancer.
Jiang T, Sun Z, Dong K, Pu Q, Gao H, Lv Y, Li P, Zhao G
Frontiers in oncology 2025;15:1439120
Frontiers in oncology 2025;15:1439120
Phospholipase A2 group IIA activates Indoleamine 2,3-dioxygenase 1 to drive the progression of pulmonary fibrosis.
Wang L, Lv W, Mao H, Chen Q, Ma Y, Zhang L, Ruan Y, Zhang C
Free radical biology & medicine 2025 Sep;237:251-269
Free radical biology & medicine 2025 Sep;237:251-269
Therapeutic Effect of a Composite Acellular Matrix/Hyaluronic Acid Thermosensitive Hydrogel for the Interstitial Cystitis/Bladder Pain Syndrome in a Rat Model.
Liu H, Guo W, Zhang J, Tang W, Wang F, Zhang J, Zhang P
Journal of biomedical materials research. Part A 2025 Sep;113(9):e37973
Journal of biomedical materials research. Part A 2025 Sep;113(9):e37973
Integrated spatial transcriptomic profiling to dissect the cellular characteristics of tumor-associated tertiary lymphoid structures.
Li X, Chu X, Xu W, Yang Y, Wei T, Bo Y, Miao Y, Zhang Y, Wang J, Wang T, Dang G, Qi L, Tong D, Zhu L, Zhao H, Zhang Z, Cheng S
Cell reports 2025 Sep 23;44(9):116250
Cell reports 2025 Sep 23;44(9):116250
Plasma exchange and intravenous immunoglobulin prolonged the survival of a porcine kidney xenograft in a sensitized, brain-dead human recipient.
Ma S, Qi R, Han S, Li Z, Zhang X, Wang G, Liu K, Xu T, Zhang Y, Han D, Zhang J, Wei D, Fan X, Pan D, Jia Y, Li J, Wang Z, Zhang X, Yang Z, Tao K, Yang X, Dou K, Qin W
Chinese medical journal 2025 Sep 20;138(18):2293-2307
Chinese medical journal 2025 Sep 20;138(18):2293-2307
Single-Cell Transcriptomics of Human Pericarotid Lymph Nodes Indicating Stability of Carotid Atherosclerotic Plaques.
Sun T, Wu Y, Liu G, Xue Z, Yu M, Mao B, Han M, Liang X, Ling L, You N, Ji L, Liu H, Xu C, Qin Z, Zhao P, Wang D
Journal of the American Heart Association 2025 Sep 16;14(18):e039777
Journal of the American Heart Association 2025 Sep 16;14(18):e039777
Single-cell multi-omic and spatial profiling of esophageal squamous cell carcinoma reveals the immunosuppressive role of GPR116(+) pericytes in cancer metastasis.
Pei X, Liu Z, Tang L, Zhang J, He Y, Zhuang X, Song Y, Peng S, He Y, Zhao Y, Huang X, Xu Y, Li J, Peng L, Shi X, Zhang F, Liu C, He M, Dai W, Wu L, Law S, Liu J, Wang Z, Li Z, Xu W, Liu Z, Li B
Nature genetics 2025 Oct;57(10):2494-2508
Nature genetics 2025 Oct;57(10):2494-2508
Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti-PD-1 immunotherapy efficacy in colorectal cancer liver metastasis.
Zhan Y, Xu J, Zhang Z, Hu Y, Li Y, Qian J, Ling Y, Wu D, Deng H, Li G, Shen Z, Fang Y
Cancer communications (London, England) 2025 Oct;45(10):1203-1228
Cancer communications (London, England) 2025 Oct;45(10):1203-1228
Engineered biomimetic vesicles induce cuproptosis and disrupt efferocytosis for metastatic adenoid cystic carcinoma immunotherapy.
Li M, Dong W, Cui Y, Li J, Yang C, Zhang D, Fu X
Materials today. Bio 2025 Oct;34:102233
Materials today. Bio 2025 Oct;34:102233
Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer.
McDonald HG, Reagan AM, Bailey CJ, Gao M, Gao M, Solomon AL, Cavnar MJ, Pandalai PK, Barry-Hundeyin MT, Harper MM, Rueckert JA, Turrero Á, Tobio A, Vidal A, Roca-Lema D, Álvarez-Coiradas E, Garrido P, Simón L, Kim J
Molecular oncology 2025 Oct;19(10):2978-2988
Molecular oncology 2025 Oct;19(10):2978-2988
Exosome-like nanovesicles from Dunaliella salina efficient sequential Co-delivery of anti-PDL1 and miR-375 for enhancing gene/immune therapy.
Wei Z, Zhu M, Li S, An J, Liu Y, Feng S, Yang T, Gao S, Liang G
Non-coding RNA research 2025 Oct;14:191-203
Non-coding RNA research 2025 Oct;14:191-203
Targeting Intratumoral Copper Inhibits Tumor Progression via p62-Mediated EZH2 Degradation and Potentiates Anti-PD-1 Immunotherapy in Oral Squamous Cell Carcinoma.
Lin X, Chen W, Li B, Zhao Z, Yu Z, Zhao XY, Zhou X, Feng Z, Lin C, Cao W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e17795
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(40):e17795
Enhanced FOS expression improves tumor clearance and resists exhaustion in NR4A3-deficient CAR T cells under chronic antigen exposure.
Yin P, Yang J, Jiang Y, Han L, Xiong T, Liu H, Fang Y, Ruan W, Wu J, Chen L, Tan L, Zuo Y, Wu X, Mao F, Huang R, Liu X, Bian XW
Science advances 2025 Oct 17;11(42):eadw3571
Science advances 2025 Oct 17;11(42):eadw3571
Disulfide-Appended siRNA Nanoeyedrops: Noninvasive Gene Therapy for Targeting Retinal Angiogenesis.
Liu S, Wang D, Ye S, Zhang J, Du B, Lian Z, Yang W, Zhou J, Chen Q, Li J, Li J, Yang H
ACS nano 2025 Oct 14;19(40):35333-35347
ACS nano 2025 Oct 14;19(40):35333-35347
Sleep Deprivation Aggravates Periodontitis Through Trigeminal-Periodontal Neuroimmune Pathway Mediated by the AChE-ACh-α7nAChR Axis.
Liu K, Huang Q, Yang M, Huang Z, Tuerhong K, Zu Y, Xie Y, Hu X, Zhang Q, He P, Huang N, Zhang R, Li Y, Yang S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e00945
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(43):e00945
7,8-dihydroxyflavone attenuates NIH IIIA subtype chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) via TrkB/AKT/SIRT3 signaling activation.
Li W, Zhao P, Shen C, Song Y, Shen B, He Y, Jin J, He Z, Gao J
Translational andrology and urology 2025 Nov 30;14(11):3613-3626
Translational andrology and urology 2025 Nov 30;14(11):3613-3626
Total tanshinones extract alleviates chronic prostatitis/chronic pelvic pain syndrome by modifying intestinal flora and suppressing the LPS-TLR4 axis.
Ning F, Luo S, Nong T, Lu L, Yin Z, Qin Z, Huang M, Jin J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157458
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157458
The Immune Regulation of Melanin From Gallus gallus domesticus Brisson Against Cyclophosphamide-Induced Immunosuppression.
Liu J, Gao H, Liu T, Zhang T, Nan T, Li H, Li H, Li J, Yuan Y
Food science & nutrition 2025 May;13(5):e70253
Food science & nutrition 2025 May;13(5):e70253
Quercetin down-regulates MCP-1 expression in autoimmune myocarditis via ERK1/2-C/EBPβ pathway: An integrative approach using network pharmacology and experimental models.
Liu J, Li Z, Liu W, Jiang Z, Zhang X, Yuan Y, Shen Y
International immunopharmacology 2025 May 8;154:114559
International immunopharmacology 2025 May 8;154:114559
A single-cell atlas reveals immune heterogeneity in anti-PD-1-treated non-small cell lung cancer.
Liu Z, Yang Z, Wu J, Zhang W, Sun Y, Zhang C, Bai G, Yang L, Fan H, Chen Y, Zhang L, Jiang B, Liu X, Ma X, Tang W, Liu C, Qu Y, Yan L, Zhao D, Wu Y, He S, Xu L, Peng L, Chen X, Zhou B, Zhao L, Zhao Z, Tan F, Zhang W, Yi D, Li X, Gao Q, Zhang G, Wang Y, Yang M, Fu H, Guo Y, Hu X, Cai Q, Qi L, Bo Y, Peng H, Tian Z, She Y, Zou C, Zhu L, Cheng S, Zhang Y, Zhong W, Chen C, Gao S, Zhang Z
Cell 2025 May 29;188(11):3081-3096.e19
Cell 2025 May 29;188(11):3081-3096.e19
Excessive MYC Orchestrates Macrophages induced Chromatin Remodeling to Sustain Micropapillary-Patterned Malignancy in Lung Adenocarcinoma.
Song X, Pan Z, Zhang Y, Yang W, Zhang T, Wang H, Chen Y, Yu X, Ding H, Li R, Ge P, Xu L, Dong G, Jiang F
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2403851
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2403851
Bcl-xL overexpression in T cells preserves muscle mitochondrial structure and function and prevents frailty in old mice.
Mas-Bargues C, Román-Domínguez A, Sanz-Ros J, Romero-García N, Huete-Acevedo J, Dromant M, Cuervo AM, Borrás C, Viña J
Science advances 2025 Mar 21;11(12):eadr1378
Science advances 2025 Mar 21;11(12):eadr1378
Loss of tricellular tight junction tricellulin leads to hyposalivation in Sjögren's syndrome.
Mao X, Li H, Min S, Su J, Wei P, Zhang Y, He Q, Wu L, Yu G, Cong X
International journal of oral science 2025 Mar 19;17(1):22
International journal of oral science 2025 Mar 19;17(1):22
Small extracellular vesicles from young adipose-derived stem cells ameliorate age-related changes in the heart of old mice.
Sanz-Ros J, Huete-Acevedo J, Mas-Bargues C, Romero-García N, Dromant M, van Weeghel M, Janssens GE, Borrás C
Stem cell research & therapy 2025 Mar 13;16(1):138
Stem cell research & therapy 2025 Mar 13;16(1):138
Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice.
Isola JVV, Biswas S, Jayarathne H, Hubbart CR, Hense JD, Matsuzaki S, Kinter MT, Humphries KM, Ocañas SR, Sadagurski M, Stout MB
GeroScience 2025 Jun;47(3):3061-3076
GeroScience 2025 Jun;47(3):3061-3076
Cryo-trojan mesenchymal stem cells as non-living tumor-homing supercarriers for enhanced drug delivery and immune activation in prostate cancer.
Wang C, Rong X, Zhang F, Mu X, Jiang J
Materials today. Bio 2025 Jun;32:101650
Materials today. Bio 2025 Jun;32:101650
Fufang-Biejia-Ruangan tablet targeting both cancer-associated fibroblasts and tumor cells by HIPPO-PI3K/AKT cascades in intrahepatic cholangiocarcinoma treatment.
Xu Y, Li X, Cui M, Pan T, Zheng S, Shang Z, Yin D, Xu Y, Yang Z, Wang J, Song X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156690
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156690
Huang-Lian-Jie-Du decoction inhibits CD4+ T cell infiltration into CNS in MCAO rats by regulating BBB.
Chen C, Li C, Lan X, Ren Z, Zheng Y, Chen D, Xu W, Cui Y, Wang X, Cheng F, Wang Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156607
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156607
LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma.
Li Y, Zhu J, Zhai F, Ge Y, Zhan Z, Wang S, Kong L, Zhao J, Hu L, Wang S, Shi J, Mao J, Yu Z, Wang H, Jin J, Zhao M, Li H, Jin X
Cell death discovery 2025 Jun 7;11(1):269
Cell death discovery 2025 Jun 7;11(1):269
Genetically-engineered Salmonella typhimurium expressing FGF21 promotes neurological recovery in ischemic stroke via FGFR1/AMPK/mTOR pathway.
Xu D, Wen M, Lebohang Anesu B, Chen X, Chen Y, Qian W, Yang C, Zheng JH, Zhou Y, Ni H, Jin K, Zhuge Q, Yang S
Journal of neuroinflammation 2025 Jun 28;22(1):170
Journal of neuroinflammation 2025 Jun 28;22(1):170
Hypoxia upregulates the expression of PD-L1 via NPM1 in breast cancer.
Yu Y, Sun R, Hu F, Ding Z, Li X, Han J, Liang L, Wang T, Xi G, Dong X, Li Y, Zhao X, Zhang D
Journal for immunotherapy of cancer 2025 Jun 23;13(6)
Journal for immunotherapy of cancer 2025 Jun 23;13(6)
The crosstalk between lung adenocarcinoma cells and M2 macrophages promotes cancer cell development via the SFRS1/miR-708-5p/PD-L1 axis.
Xu L, Li K, Li J, Xu F, Liang S, Kong Y, Chen B
Life sciences 2025 Jun 15;371:123599
Life sciences 2025 Jun 15;371:123599
ADRB2 inhibition suppresses cancer immune evasion by regulating tumor SOX10-PD-L1 axis and T cell function.
Zhang Y, Yu F, Ouyang J, Liu P, Dai Y, Wang Y, Yi H, Wang S, Liu D, Song K, Pei W, Hong Z, Zhang W, Huang W, Zhou G, Cao S, McLeod H, Peng C, Chen L, He Y
Journal for immunotherapy of cancer 2025 Jun 12;13(6)
Journal for immunotherapy of cancer 2025 Jun 12;13(6)
Notch signaling pathway regulates the progression of fetal growth restriction through mediating immune dysfunction.
Ye L, Zheng X, Yang Y, Lyu Y
Biomedical reports 2025 Jul;23(1):111
Biomedical reports 2025 Jul;23(1):111
Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for Cancer Immunotherapy.
Lin S, Xiang N, Liu W, Wu D, Chen Y, Xiong T, Ge J, Zhou W, Tian H, Zhang K, Sheng L, Jin J, Wang H, Xu H
Journal of medicinal chemistry 2025 Jul 24;68(14):14859-14881
Journal of medicinal chemistry 2025 Jul 24;68(14):14859-14881
Deficiency of inducible nitric oxide synthase (iNOS) enhances MC903-induced atopic dermatitis-like inflammation in mice.
Luo J, Li C, Zhu Y, Guo R, Huang J, Yu H, Sun M, Zhu Q, Guo Q, Li Y, Guo P, Su L, Hu L
Biochemical and biophysical research communications 2025 Jul 22;771:152028
Biochemical and biophysical research communications 2025 Jul 22;771:152028
Qingrehuoxue formula enhances anti-PD-1 immunotherapy in NSCLC by remodeling the tumor immune microenvironment via TREM2 signaling.
Li BB, Jiang YY, Li X, Yu MM, Meng Q, Wang DN, Zang JM, Xu F
BMC complementary medicine and therapies 2025 Jul 16;25(1):270
BMC complementary medicine and therapies 2025 Jul 16;25(1):270
Immune profiling identifies CD161(+)CD127(+)CD8(+) T cells as a predictive biomarker for Anti-PD-L1 therapy response in the SCLC-I subtype.
Qu J, Sun W, Li Y, Cai Z, Wu B, Shen Q, Chen L, Wang B, Ying L, Xie C, Zheng J, Zhou J, Zhou J
Journal of translational medicine 2025 Jul 1;23(1):711
Journal of translational medicine 2025 Jul 1;23(1):711
Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor-Ligand Interactions That Instructs Intratumoral γδT-cell Activity.
Wang X, Wang H, Lu Z, Liu X, Chai W, Wang W, Feng J, Yang S, Yang W, Cheng H, Chen C, Zhang S, Sun N, Liu Q, Li Q, Song W, Jin F, Zeng Q, Wang S, Su Y, Wang H, Ni X, Gui J
Cancer research 2025 Jan 15;85(2):277-298
Cancer research 2025 Jan 15;85(2):277-298
Hyperactivity of the IL-33-ILC2s-IL-13-M-MDSCs axis promotes cervical cancer progression.
Wang B, Zhu Y, Zhang Y, Ru Z, Chen L, Zhang M, Wu Y, Ding J, Chen Z
International immunopharmacology 2025 Jan 10;144:113693
International immunopharmacology 2025 Jan 10;144:113693
Escherichia coli combination with PD-1 blockade synergistically enhances immunotherapy in glioblastoma multiforme by regulating the immune cells.
Li G, Yang H, Ke T, Tan N, Du X, Duan X, Zhou X, Zheng G, Liao C
Journal of translational medicine 2025 Feb 7;23(1):164
Journal of translational medicine 2025 Feb 7;23(1):164
ITIH5-mediated fibroblast/macrophage crosstalk exacerbates cardiac remodelling after myocardial infarction.
Wu Y, Meng L, Zhan S, Li M, Huang J, Chen X, Chen L, Gao X, Chen H, Chen H, Zhong Y, Xu L, Xu Y
Journal of translational medicine 2025 Feb 24;23(1):224
Journal of translational medicine 2025 Feb 24;23(1):224
S1PR1-biased activation drives the resolution of endothelial dysfunction-associated inflammatory diseases by maintaining endothelial integrity.
Zheng H, Yu J, Gao L, Wang K, Xu Z, Zeng Z, Zheng K, Tang X, Tian X, Zhao Q, Zhao J, Wan H, Cao Z, Zhang K, Cheng J, Brosius J, Zhang H, Li W, Yan W, Shao Z, Luo F, Deng C
Nature communications 2025 Feb 20;16(1):1826
Nature communications 2025 Feb 20;16(1):1826
Corydalis decumbens and tetrahydropalmatrubin inhibit macrophages inflammation to relieve rheumatoid arthritis by targeting Fosl2.
Gao P, Yuan S, Wang Y, Wang Y, Li X, Liu T, Zheng Y, Wang J, Liu D, Xu L, Jiang Y, Zeng K, Tu P
Journal of ethnopharmacology 2025 Feb 11;341:119348
Journal of ethnopharmacology 2025 Feb 11;341:119348
Loss of CDKN2A Enhances the Efficacy of Immunotherapy in EGFR-Mutant Non-Small Cell Lung Cancer.
Wang S, Lai JC, Li Y, Tang C, Lu J, Han M, Ye X, Jia L, Cui W, Yang J, Wu C, Wang L
Cancer research 2025 Feb 1;85(3):585-601
Cancer research 2025 Feb 1;85(3):585-601
CXCL11 as potential predictive biomarker and therapeutic target of acute rejection after kidney transplantation.
Zhang J, Yu C, Wang H, Xiao H, Wen S, Hua Y, Wei G
Transplant immunology 2025 Dec;93:102306
Transplant immunology 2025 Dec;93:102306
Nano MgO loaded thermosensitive HPCH@HA hydrogel accelerates in situ bone repair through osteoimmunomodulation while enhancing angiogenesis and osteogenesis.
Ni F, Chang L, Peng Y, Li D, Wu D, Li K, Zhang X, Jiang X, Shao Z, Chen Y, Wang H
Bioactive materials 2025 Dec;54:248-272
Bioactive materials 2025 Dec;54:248-272
From foe to friend: Rewiring oncogenic pathways through artificial selenoprotein to combat immune-resistant tumor.
You W, Zhou Z, Li Z, Yan J, Wang Y
Journal of pharmaceutical analysis 2025 Dec;15(12):101322
Journal of pharmaceutical analysis 2025 Dec;15(12):101322
VSIG2 as a novel immunosuppressive ligand interacts with Nectin-2 to regulate T cell responses.
Wang X, Hu R, Chen K, He K, Li Y, Gao J, Tian Y, Du G, Wang Z, Zhao Y, Lai L, Su M
Journal of neuroinflammation 2025 Dec 5;23(1):11
Journal of neuroinflammation 2025 Dec 5;23(1):11
KIAA1429 impairs anti-tumor immunity via regulation of PD-L1 and CD8(+) T cells in colorectal cancer.
Du Y, Liu Y, Wang M, Wang Y, Lin M
Scientific reports 2025 Dec 4;15(1):43619
Scientific reports 2025 Dec 4;15(1):43619
Histone deacetylase HDAC7 restricts CD8 + T cell tumor infiltration and limits immunotherapy sensitivity in bladder cancer: reversal by pinocembrin.
Lv J, Li K, Zhou J, Yu R, Lu Q, Liu B
Journal of experimental & clinical cancer research : CR 2025 Dec 24;44(1):324
Journal of experimental & clinical cancer research : CR 2025 Dec 24;44(1):324
Synergistic immunomodulatory effects of naringenin and photothermal therapy in triple-negative breast cancer.
Lei C, Yao Y, Xie Q, Li N, Zhu C, Lan H, Yang S, Wang G, Peng X, Zheng D, Wang H, Zhu K, Zhu Z, Shao F
iScience 2025 Dec 19;28(12):114124
iScience 2025 Dec 19;28(12):114124
Cathepsin C-driven enhancement of neutrophil extracellular trap formation contributes to acute lung injury.
Wu X, Liu H, Qin Q, Yuan L, Yao Y, Du X, Qin Q, Wang L, Zhao Q, Qin L, Xiang Y, Yang M, Qin X, Liu C
iScience 2025 Dec 19;28(12):113928
iScience 2025 Dec 19;28(12):113928
Nerandomilast Improves Bleomycin-Induced Systemic Sclerosis-Associated Interstitial Lung Disease in Mice by Regulating the TGF-β1 Pathway.
Liu Y, Liu Z, Li X, Li W, Yang Z, Jiao R, Wang Q, Meng L, Zhang T, Liu J, Chai D, Zhang N, Peng S, Zhou H, Yang C
Inflammation 2025 Aug;48(4):1760-1774
Inflammation 2025 Aug;48(4):1760-1774
A novel FTO-targeting nanodrug induces disulfidptosis and ameliorates the suppressive tumor immune environment to treat uveal melanoma.
Tian H, Deng H, Liu X, Liu C, Zhang C, Leong KW, Fan X, Ruan J
Biomaterials 2025 Aug;319:123168
Biomaterials 2025 Aug;319:123168
Excessive ultra-processed foods exposure aggravates ulcerative colitis via macrophage ferroptosis.
Pang X, Yan J, Lv X, Wang J, Chen Q, Qi Y, Xu X, Wang B, Cao H
Environment international 2025 Aug;202:109706
Environment international 2025 Aug;202:109706
Engineered MSC Aggregates with E/N-Cadherin and IL-6 Preconditioning for the Treatment of Systemic Sclerosis.
Zhang Y, Qian M, Shi Y, Cao J, Xu M, Wen X, Yan Y, Liu S, Chen H, Liu S, Yang J, Sun L
Advanced healthcare materials 2025 Aug;14(20):e2500663
Advanced healthcare materials 2025 Aug;14(20):e2500663
Akkermansia Muciniphila Alleviates Severe Acute Pancreatitis via Amuc1409-Ube2k-Foxp3 Axis in Regulatory T Cells.
Xie J, Du L, Lu Y, Guo X, Zhou X, Tong Y, Shen B, Yu X, Guo F, Yu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e04214
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(30):e04214
Knockdown of the Clock gene in the liver aggravates MASLD in mice via inhibiting lipophagy.
Yang S, Ren X, Liu J, Lei Y, Li M, Wang F, Cheng S, Ying J, Ding J, Chen X
Molecular and cellular biochemistry 2025 Apr;480(4):2455-2469
Molecular and cellular biochemistry 2025 Apr;480(4):2455-2469
Using Cancer-Associated Fibroblasts as a Shear-Wave Elastography Imaging Biomarker to Predict Anti-PD-1 Efficacy of Triple-Negative Breast Cancer.
Zhang Z, Liang S, Zheng D, Wang S, Zhou J, Wang Z, Huang Y, Chang C, Wang Y, Guo Y, Zhou S
International journal of molecular sciences 2025 Apr 9;26(8)
International journal of molecular sciences 2025 Apr 9;26(8)
Streptococcus mutans-derived extracellular vesicles promote skin wound healing via tRNA cargo.
Oh SY, Kim DY, Lee KY, Ha DL, Kim TL, Kwon TG, Kim JW, Lee HJ, Choi SY, Hong SH
Journal of nanobiotechnology 2025 Apr 28;23(1):322
Journal of nanobiotechnology 2025 Apr 28;23(1):322
Integrating bulk, single-cell, and spatial transcriptomics to identify and functionally validate novel targets to enhance immunotherapy in NSCLC.
Cao K, Wei S, Ma T, Yang X, Wang Y, He X, Lu M, Bai Y, Qi C, Zhang L, Li L, Meng H, Ma J, Zhu J
NPJ precision oncology 2025 Apr 16;9(1):112
NPJ precision oncology 2025 Apr 16;9(1):112
HKDC1 promotes ovarian cancer progression through boosting lipid metabolism and immune escape by stabilizing G6PC/G6PC2.
Wang Y, Chen J, Wang Z, Luo X, Wu N, Wang J
Communications biology 2025 Apr 16;8(1):615
Communications biology 2025 Apr 16;8(1):615
Acidosis regulates immune progression in rheumatoid arthritis by promoting the expression of cytokines and co-stimulatory molecules in synovial fibroblasts.
Qian X, Zai Z, Tao Y, Lv H, Hao M, Zhang L, Zhang X, Xu Y, Zhang Y, Chen F
Molecular medicine (Cambridge, Mass.) 2025 Apr 15;31(1):136
Molecular medicine (Cambridge, Mass.) 2025 Apr 15;31(1):136
Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups.
Ji S, Cao L, Gao J, Du Y, Ye Z, Lou X, Liu F, Zhang Y, Xu J, Shi X, Wang H, Li P, Li Y, Chen H, Yang Z, Gao S, Zhang W, Huang D, Ni S, Wei M, Wang F, Wang Y, Ding T, Jing D, Fan G, Gong Z, Lu R, Qin Y, Chen J, Xu X, Wang P, Zhang B, Ding L, Robles AI, Rodriguez H, Chang DK, Hruban RH, Gao D, Gao D, Jin G, Zhou H, Wu J, Yu X
Cancer cell 2025 Apr 14;43(4):776-796.e14
Cancer cell 2025 Apr 14;43(4):776-796.e14
Single-Cell RNA Sequencing Revealed Functional Conjunctival Keratinocytes Loss via TGF-β-Wnt/β-Catenin Signaling in Sjögren's Syndrome Related Dry Eye.
Wang B, Liang L, Zeng H, Yang X, Zhang R, Deng W, Wang X, Yuan J
Investigative ophthalmology & visual science 2025 Apr 1;66(4):43
Investigative ophthalmology & visual science 2025 Apr 1;66(4):43
The development and potent antitumor efficacy of CD44/CD133 dual-targeting IL7Rα-armored CAR-T cells against glioblastoma.
Zhai Y, Li G, Pan C, Yu M, Hu H, Wang D, Shi Z, Jiang T, Zhang W
Cancer letters 2025 Apr 1;614:217541
Cancer letters 2025 Apr 1;614:217541
CCR7 and CD48 as Predicted Targets in Acute Rejection Related to M1 Macrophage after Pediatric Kidney Transplantation.
Zhang J, Pei J, Yu C, Luo J, Hong Y, Hua Y, Wei G
Journal of immunology research 2024;2024:6908968
Journal of immunology research 2024;2024:6908968
Salidroside may target PPARα to exert preventive and therapeutic activities on NASH.
Chu X, Liu S, Qu B, Xin Y, Lu L
Frontiers in pharmacology 2024;15:1433076
Frontiers in pharmacology 2024;15:1433076
Cardiac sympathetic overdrive, M2 macrophage activation and fibroblast heterogeneity are associated with cardiac remodeling in a chronic pressure overload rat model of HFpEF.
Sun F, Yuan L, Wang Z, Cui X, Lv N, Zhang T, Zhang Y, Cai J
Frontiers in pharmacology 2024;15:1364758
Frontiers in pharmacology 2024;15:1364758
Platinum-based neoadjuvant chemotherapy upregulates STING/IFN pathway expression and promotes TILs infiltration in NSCLC.
Gao H, Zhang X, Ren M, Jiang A, Liu N, Wang J, Zheng X, Liang X, Ruan Z, Tian T, Fu X, Yao Y
Frontiers in oncology 2024;14:1346225
Frontiers in oncology 2024;14:1346225
CD161(+)CD127(+)CD8(+) T cell subsets can predict the efficacy of anti-PD-1 immunotherapy in non-small cell lung cancer with diabetes mellitus.
Qu J, Li Y, Wu B, Shen Q, Chen L, Sun W, Wang B, Ying L, Wu L, Zhou H, Zhou J, Zhou J
Oncoimmunology 2024;13(1):2371575
Oncoimmunology 2024;13(1):2371575
Thirdhand smoke exposure promotes gastric tumor development in mouse and human.
Jiang C, Chen L, Ye C, Schick SF, Jacob P 3rd, Zhuang Y, Inman JL, Chen C, Gundel LA, Chang H, Snijders AM, Zou X, Mao JH, Hang B, Wang P
Environment international 2024 Sep;191:108986
Environment international 2024 Sep;191:108986
Construction of a prognostic model with exosome biogenesis- and release-related genes and identification of RAB27B in immune infiltration of pancreatic cancer.
Li TY, Qin C, Zhao BB, Li ZR, Wang YY, Zhao YT, Wang WB
Translational cancer research 2024 Sep 30;13(9):4846-4865
Translational cancer research 2024 Sep 30;13(9):4846-4865
Brusatol improves the efficacy of an anti-mouse-PD-1 antibody via inhibiting programmed cell death 1 ligand 1 expression in a murine head and neck squamous cell carcinoma model.
Wu Y, Zhang G, Yin P, Wen J, Su Y, Zhang X
Archives of oral biology 2024 Oct;166:106043
Archives of oral biology 2024 Oct;166:106043
Single-cell analysis reveals alternations between the aged and young mice prostates.
Li Y, Ding Y, Hou Y, Liu L, Liu Z, Yao Z, Shi P, Li J, Chen K, Hu J
Biomarker research 2024 Oct 9;12(1):117
Biomarker research 2024 Oct 9;12(1):117
Astaxanthin Alleviates Chronic Prostatitis via the ERK1/2 Signaling Pathway: Evidence from Network Pharmacology and Experimental Validation.
Liu Y, Huang L, Zhang Z, Zhu Q, Xi P, Sun T, Gong B
Combinatorial chemistry & high throughput screening 2024 Oct 9;
Combinatorial chemistry & high throughput screening 2024 Oct 9;
Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment.
Wu T, Wu S, Gao H, Liu H, Feng J, Yin G
European journal of histochemistry : EJH 2024 Oct 23;68(4)
European journal of histochemistry : EJH 2024 Oct 23;68(4)
DNA-PKcs modulates mouse lung homeostasis via the regulation of mitochondrial fission.
Xiao Y, Zhang J, Li X, Liu P, Gou B, Gao Z, Song M
Life sciences 2024 Nov 15;357:123078
Life sciences 2024 Nov 15;357:123078
Single-cell landscape identified SERPINB9 as a key player contributing to stemness and metastasis in non-seminomas.
Bian Z, Chen B, Shi G, Yuan H, Zhou Y, Jiang B, Li L, Su H, Zhang Y
Cell death & disease 2024 Nov 11;15(11):812
Cell death & disease 2024 Nov 11;15(11):812
Effective substances and molecular mechanisms guided by network pharmacology: An example study of Scrophulariae Radix treatment of hyperthyroidism and thyroid hormone-induced liver and kidney injuries.
Sheng MY, Peng DW, Peng HM, Zhang YL, Xiao L, Zhang MR, Wang SY, Zhao CP, Zhu SY, Lu JK, Lin L, Huang R, Nie J, Fang JB
Journal of ethnopharmacology 2024 May 23;326:117965
Journal of ethnopharmacology 2024 May 23;326:117965
Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota.
Xu J, Lu L, Jiang S, Qin Z, Huang J, Huang M, Jin J
European journal of pharmacology 2024 May 15;971:176516
European journal of pharmacology 2024 May 15;971:176516
Multi-omic profiling of clear cell renal cell carcinoma identifies metabolic reprogramming associated with disease progression.
Hu J, Wang SG, Hou Y, Chen Z, Liu L, Li R, Li N, Zhou L, Yang Y, Wang L, Wang L, Yang X, Lei Y, Deng C, Li Y, Deng Z, Ding Y, Kuang Y, Yao Z, Xun Y, Li F, Li H, Hu J, Liu Z, Wang T, Hao Y, Jiao X, Guan W, Tao Z, Ren S, Chen K
Nature genetics 2024 Mar;56(3):442-457
Nature genetics 2024 Mar;56(3):442-457
Injectable ultrasonic sensor for wireless monitoring of intracranial signals.
Tang H, Yang Y, Liu Z, Li W, Zhang Y, Huang Y, Kang T, Yu Y, Li N, Tian Y, Liu X, Cheng Y, Yin Z, Jiang X, Chen X, Zang J
Nature 2024 Jun;630(8015):84-90
Nature 2024 Jun;630(8015):84-90
Synergistic effects of Ω-3 polyunsaturated fatty acid supplementation and programmed cell death protein 1 blockade on tumor growth and immune modulation in a xenograft model of esophageal cancer.
Xiao X, Luo S, Huang J, Wan B, Bi N, Wang J
Clinical nutrition ESPEN 2024 Jun;61:308-315
Clinical nutrition ESPEN 2024 Jun;61:308-315
Investigation of the active ingredients and mechanism of Shuangling extract in dextran sulfate sodium salt induced ulcerative colitis mice based on network pharmacology and experimental verification.
Mengzhen C, Yu W, Zhijian L, Jintao L, Xiaomeng Z, Bing Z
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Jun;44(3):478-488
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Jun;44(3):478-488
cGAS suppresses hepatocellular carcinoma independent of its cGAMP synthase activity.
Ma D, Yang M, Sun C, Cui X, Xiong G, Wang Q, Jing W, Chen H, Lv X, Liu S, Li T, Zhao Y, Han L
Cell death and differentiation 2024 Jun;31(6):722-737
Cell death and differentiation 2024 Jun;31(6):722-737
Brain Metastasis from EGFR-Mutated Non-Small Cell Lung Cancer: Secretion of IL11 from Astrocytes Up-Regulates PDL1 and Promotes Immune Escape.
Tang M, Xu M, Wang J, Liu Y, Liang K, Jin Y, Duan W, Xia S, Li G, Chu H, Liu W, Wang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(26):e2306348
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(26):e2306348
Spatiotemporal single-cell analysis decodes cellular dynamics underlying different responses to immunotherapy in colorectal cancer.
Chen Y, Wang D, Li Y, Qi L, Si W, Bo Y, Chen X, Ye Z, Fan H, Liu B, Liu C, Zhang L, Zhang X, Li Z, Zhu L, Wu A, Zhang Z
Cancer cell 2024 Jul 8;42(7):1268-1285.e7
Cancer cell 2024 Jul 8;42(7):1268-1285.e7
HMGB1/TREM2 positive feedback loop drives the development of radioresistance and immune escape of glioblastoma by regulating TLR4/Akt signaling.
Qiu H, Shao Z, Wen X, Qu D, Liu Z, Chen Z, Zhang X, Ding X, Zhang L
Journal of translational medicine 2024 Jul 29;22(1):688
Journal of translational medicine 2024 Jul 29;22(1):688
The recruitment of CD8(+) T cells through YBX1 stabilization abrogates tumor intrinsic oncogenic role of MIR155HG in lung adenocarcinoma.
Li R, Zhang Y, Wang A, Feng Y, Zhang T, Wang H, Chen Y, Yu X, Song X, Ding H, Xu L, Dong G, Jiang F
Cell death discovery 2024 Jul 23;10(1):334
Cell death discovery 2024 Jul 23;10(1):334
CXC ligand 13 orchestrates an immunoactive microenvironment and enhances immunotherapy response in head and neck squamous cell carcinoma.
Lin X, Zhao X, Chen Y, Yang R, Dai Z, Li W, Lin C, Cao W
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241227312
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241227312
Cold atmospheric plasma sensitizes head and neck cancer to chemotherapy and immune checkpoint blockade therapy.
Wang Y, Mang X, Li D, Wang Z, Chen Y, Cai Z, Tan F
Redox biology 2024 Feb;69:102991
Redox biology 2024 Feb;69:102991
Calcitriol restrains microglial M1 polarization and alleviates dopaminergic degeneration in hemiparkinsonian mice by boosting regulatory T-cell expansion.
Xie Y, Chen L, Chen J, Chen Y
Brain and behavior 2024 Feb;14(2):e3373
Brain and behavior 2024 Feb;14(2):e3373
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
Luan X, Lei T, Fang J, Liu X, Fu H, Li Y, Chu W, Jiang P, Tong C, Qi H, Fu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma.
Xiong G, Xie N, Nie M, Ling R, Yun B, Xie J, Ren L, Huang Y, Wang W, Yi C, Zhang M, Xu X, Zhang C, Zou B, Zhang L, Liu X, Huang H, Chen D, Cao W, Wang C
International journal of oral science 2024 Feb 29;16(1):21
International journal of oral science 2024 Feb 29;16(1):21
FGF18 alleviates sepsis-induced acute lung injury by inhibiting the NF-κB pathway.
Hu Z, Dai J, Xu T, Chen H, Shen G, Zhou J, Ma H, Wang Y, Jin L
Respiratory research 2024 Feb 28;25(1):108
Respiratory research 2024 Feb 28;25(1):108
Dickkopf-1 is an immune infiltration-related prognostic biomarker of head and neck squamous cell carcinoma.
Zhao C, Liu L, He Q, Li Y, Feng J, Chen Y, Li Y, Xu X, Zhu S, Ye Y, Wen Y, Zeng Z, Zhou D, Jin F
Aging 2024 Feb 19;16(4):3837-3855
Aging 2024 Feb 19;16(4):3837-3855
PTPRZ1 dephosphorylates and stabilizes RNF26 to reduce the efficacy of TKIs and PD-1 blockade in ccRCC.
Ma Y, Li W, Liu X, Peng W, Qing B, Ren S, Liu W, Chen X
Oncogene 2024 Dec;43(50):3633-3644
Oncogene 2024 Dec;43(50):3633-3644
Bioactive sucralfate-based microneedles promote wound healing through reprogramming macrophages and protecting endogenous growth factors.
Le Z, Ramos MC, Shou Y, Li RR, Cheng HS, Jang CJ, Liu L, Xue C, Li X, Liu H, Lim CT, Tan NS, White AD, Charles CJ, Chen Y, Liu Z, Tay A
Biomaterials 2024 Dec;311:122700
Biomaterials 2024 Dec;311:122700
Simultaneous targeting of TGF-β1/PD-L1 via a hydrogel-nanoparticle system to remodel the ECM and immune microenvironment for limiting adhesion formation.
Yang QQ, Jin J, Sun J, Zhang L, Tang JB, Zhou YL
Acta biomaterialia 2024 Dec;190:447-462
Acta biomaterialia 2024 Dec;190:447-462
CRISPR/Cas9 Mediated Deletion of the Uox Gene Generates a Mouse Model of Hyperuricemia with Multiple Complications.
Zeng L, Shali S, Gao Y, Du X, Zhu X, Li L, Dai Y, Zhou P
Journal of cardiovascular translational research 2024 Dec;17(6):1455-1465
Journal of cardiovascular translational research 2024 Dec;17(6):1455-1465
Turning attention to tumor-host interface and focus on the peritumoral heterogeneity of glioblastoma.
Wang F, Dong J, Xu Y, Jin J, Xu Y, Yan X, Liu Z, Zhao H, Zhang J, Wang N, Hu X, Gao X, Xu L, Yang C, Ma S, Du J, Hu Y, Ji H, Hu S
Nature communications 2024 Dec 30;15(1):10885
Nature communications 2024 Dec 30;15(1):10885
Intervention effect of regulating GABA-A receptor activity on the formation of experimental abdominal aortic aneurysm in rats.
Zhu JX, Zhou C, Huang LZ, Guo JW, Yin NP, Yang F, Zhang YD, Yang Y
Scientific reports 2024 Dec 28;14(1):31388
Scientific reports 2024 Dec 28;14(1):31388
Mechanistic Study of Purple Sweet Potato Anthocyanins: Multifaceted Anti-Fibrotic Effects and Targeting of PDGFRβ in Liver Fibrosis.
Dai J, Li H, Gou L, Tian Y, Cheng C, Yuan F, Xie J, Zhang L, Ji J, Zhang L, Wang X
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27861-27875
Journal of agricultural and food chemistry 2024 Dec 18;72(50):27861-27875
Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2.
Vogt M, Dudvarski Stankovic N, Cruz Garcia Y, Hofstetter J, Schneider K, Kuybu F, Hauck T, Adhikari B, Hamann A, Rocca Y, Grysczyk L, Martin B, Gebhardt-Wolf A, Wiegering A, Diefenbacher M, Gasteiger G, Knapp S, Saur D, Eilers M, Rosenfeldt M, Erhard F, Vos SM, Wolf E
Gut 2024 Aug 8;73(9):1509-1528
Gut 2024 Aug 8;73(9):1509-1528
Identification and Characterization of a Novel B Cell Epitope of ASFV Virulence Protein B125R Monoclonal Antibody.
Zhao Y, Ren H, Lin Z, Shi S, Zhang B, Zhang Y, Han S, He WR, Wan B, Hu M, Zhang GP
Viruses 2024 Aug 5;16(8)
Viruses 2024 Aug 5;16(8)
The PP2A inhibitor LB-100 mitigates lupus nephritis by suppressing tertiary lymphoid structure formation.
Yang H, Luo X, Wang X, Peng Y, Li Z, He Y, Cong J, Xie T, Zhang W
European journal of pharmacology 2024 Aug 15;977:176703
European journal of pharmacology 2024 Aug 15;977:176703
SARS-CoV-2 N protein-induced Dicer, XPO5, SRSF3, and hnRNPA3 downregulation causes pneumonia.
Luo YW, Zhou JP, Ji H, Xu D, Zheng A, Wang X, Dai Z, Luo Z, Cao F, Wang XY, Bai Y, Chen D, Chen Y, Wang Q, Yang Y, Zhang X, Chiu S, Peng X, Huang AL, Tang KF
Nature communications 2024 Aug 13;15(1):6964
Nature communications 2024 Aug 13;15(1):6964
Single-Cell RNA Sequencing Identifies WARS1+ Mesenchymal Stem Cells with Enhanced Immunomodulatory Capacity and Improved Therapeutic Efficacy.
Li X, Zhang F, Sun L, Cai X, Lou F, Sun Y, Gao M, Wang Z, Tang S, Fan L, Wu Y, Jin X, Deng S, Xu Z, Sun X, Li Q, Wang H
Journal of immunology (Baltimore, Md. : 1950) 2024 Aug 1;213(3):257-267
Journal of immunology (Baltimore, Md. : 1950) 2024 Aug 1;213(3):257-267
DPSCs regulate epithelial-T cell interactions in oral submucous fibrosis.
Wang SY, Zhang SJ, Meng HF, Xu HQ, Guo ZX, Yan JF, Gao JL, Niu LN, Wang SL, Jiao K
Stem cell research & therapy 2024 Apr 23;15(1):113
Stem cell research & therapy 2024 Apr 23;15(1):113
Diaphorobacter nitroreducens synergize with oxaliplatin to reduce tumor burden in mice with lung adenocarcinoma.
Ni Y, Li R, Shen X, Yi D, Ren Y, Wang F, Geng Y, You Q
mSystems 2024 Apr 16;9(4):e0132323
mSystems 2024 Apr 16;9(4):e0132323
Accelerated Wound Healing in Diabetic Rat by miRNA-185-5p and Its Anti-Inflammatory Activity.
Wang KX, Zhao LL, Zheng LT, Meng LB, Jin L, Zhang LJ, Kong FL, Liang F
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:1657-1667
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:1657-1667
Clinical and Pathological Features of Hydroa Vacciniforme-Like Lymphoproliferative Disorder Along with Risk Factors Indicating Poor Prognosis.
Chang L, Zhang C, Lu J, Shen J, Hamal K, Liu D
Infection and drug resistance 2023;16:1545-1559
Infection and drug resistance 2023;16:1545-1559
Characterisation of macrophage infiltration and polarisation based on integrated transcriptomic and histological analyses in Primary Sjögren's syndrome.
Zong Y, Yang Y, Zhao J, Li L, Luo D, Hu J, Gao Y, Wei L, Li N, Jiang L
Frontiers in immunology 2023;14:1292146
Frontiers in immunology 2023;14:1292146
Nanobody-derived bispecific CAR-T cell therapy enhances the anti-tumor efficacy of T cell lymphoma treatment.
Xia B, Lin K, Wang X, Chen F, Zhou M, Li Y, Lin Y, Qiao Y, Li R, Zhang W, He X, Zou F, Li L, Lu L, Chen C, Li W, Zhang H, Liu B
Molecular therapy oncolytics 2023 Sep 21;30:86-102
Molecular therapy oncolytics 2023 Sep 21;30:86-102
A pan-cancer single-cell panorama of human natural killer cells.
Tang F, Li J, Qi L, Liu D, Bo Y, Qin S, Miao Y, Yu K, Hou W, Li J, Peng J, Tian Z, Zhu L, Peng H, Wang D, Zhang Z
Cell 2023 Sep 14;186(19):4235-4251.e20
Cell 2023 Sep 14;186(19):4235-4251.e20
Impact of chemotherapeutic agents on liver microenvironment: oxaliplatin create a pro-metastatic landscape.
Ma Y, Guo C, Wang X, Wei X, Ma J
Journal of experimental & clinical cancer research : CR 2023 Sep 11;42(1):237
Journal of experimental & clinical cancer research : CR 2023 Sep 11;42(1):237
Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer.
Sun H, Zhang L, Wang Z, Gu D, Zhu M, Cai Y, Li L, Tang J, Huang B, Bosco B, Li N, Wu L, Wu W, Li L, Liang Y, Luo L, Liu Q, Zhu Y, Sun J, Shi L, Xia T, Yang C, Xu Q, Han X, Zhang W, Liu J, Meng D, Shao H, Zheng X, Li S, Pan H, Ke J, Jiang W, Zhang X, Han X, Chu J, An H, Ge J, Pan C, Wang X, Li K, Wang Q, Ding Q
Nature communications 2023 Sep 11;14(1):5590
Nature communications 2023 Sep 11;14(1):5590
Ki67-targeted oncolytic adenovirus expressing IL-15 improves intratumoral T cell infiltration and PD-L1 expression in glioblastoma.
Zhang Q, Zhang J, Tian Y, Wang J, Jin G, Liu F
Virology 2023 Oct;587:109885
Virology 2023 Oct;587:109885
Heterogeneity of T cells in periapical lesions and in vitro validation of the proangiogenic effect of GZMA on HUVECs.
Lin X, Lv X, Li B, Meng Q, Lai H, Gong Q, Tong Z
International endodontic journal 2023 Oct;56(10):1254-1269
International endodontic journal 2023 Oct;56(10):1254-1269
Zearalenone-14-glucoside specifically promotes dysplasia of Gut-Associated Lymphoid Tissue: A natural product for constructing intestinal nodular lymphatic hyperplasia model.
Ruan H, Wang Y, Zhang J, Huang Y, Yang Y, Wu C, Guo M, Luo J, Yang M
Journal of advanced research 2023 Oct;52:135-150
Journal of advanced research 2023 Oct;52:135-150
ARPC5 acts as a potential prognostic biomarker that is associated with cell proliferation, migration and immune infiltrate in gliomas.
Ming Y, Luo C, Ji B, Cheng J
BMC cancer 2023 Oct 3;23(1):937
BMC cancer 2023 Oct 3;23(1):937
Atractylodes lancea Rhizome Polysaccharide Alleviates Immunosuppression and Intestinal Mucosal Injury in Mice Treated with Cyclophosphamide.
Wang D, Dong Y, Xie Y, Xiao Y, Ke C, Shi K, Zhou Z, Tu J, Qu L, Liu Y
Journal of agricultural and food chemistry 2023 Oct 20;
Journal of agricultural and food chemistry 2023 Oct 20;
Influence of PD-1/PD-L1 on immune microenvironment in oral leukoplakia and oral squamous cell carcinoma.
Xu SB, Wang MY, Shi XZ, Wang Q, Yu M, Zhang W, Xu XH, Liu LK
Oral diseases 2023 Nov;29(8):3268-3277
Oral diseases 2023 Nov;29(8):3268-3277
Therapeutic potential of Lianhua Qingke in airway mucus hypersecretion of acute exacerbation of chronic obstructive pulmonary disease.
Hao Y, Wang T, Hou Y, Wang X, Yin Y, Liu Y, Han N, Ma Y, Li Z, Wei Y, Feng W, Jia Z, Qi H
Chinese medicine 2023 Nov 3;18(1):145
Chinese medicine 2023 Nov 3;18(1):145
Allogeneic T cells cause acute renal injury after hematopoietic cell transplantation.
Miyata M, Matsuki E, Ichikawa K, Takehara T, Hosokawa Y, Sekiguchi E, Peltier D, Reddy P, Ishizawa K, Watanabe M, Toubai T
Blood advances 2023 Nov 28;7(22):6936-6948
Blood advances 2023 Nov 28;7(22):6936-6948
Allicin ameliorates imiquimod-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A.
Zhang L, Ma X, Shi R, Zhang L, Zhao R, Duan R, Qin Y, Gao S, Li X, Duan J, Li J
British journal of pharmacology 2023 Mar;180(5):628-646
British journal of pharmacology 2023 Mar;180(5):628-646
Effects of earthworm hydrolysate in production performance, serum biochemical parameters, antioxidant capacity and intestinal function of Muscovy ducks.
Liu Z, Chen Q, Zhong Y, Wu Y, Li J, Kong Z, Zhang Q, Lei X
Poultry science 2023 Mar;102(3):102409
Poultry science 2023 Mar;102(3):102409
Guijiajiao (Colla Carapacis et Plastri, CCP) prevents male infertility via gut microbiota modulation.
Sheng W, Xu W, Ding J, Lu B, Liu L, He Q, Zhou Q
Chinese journal of natural medicines 2023 Jun;21(6):403-410
Chinese journal of natural medicines 2023 Jun;21(6):403-410
An integrated bioinformatic investigation of focal adhesion-related genes in glioma followed by preliminary validation of COL1A2 in tumorigenesis.
Yao G, Deng L, Long X, Zhou Y, Zhou X
Aging 2023 Jun 22;15(13):6225-6254
Aging 2023 Jun 22;15(13):6225-6254
Immune Enhancement of Clam Peptides on Immunosuppressed Mice Induced by Hydrocortisone.
Lv M, Liu M, Zou S, Yin D, Lv C, Li F, Wei Y
Molecules (Basel, Switzerland) 2023 Jul 28;28(15)
Molecules (Basel, Switzerland) 2023 Jul 28;28(15)
Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer.
Yu D, Yang P, Lu X, Huang S, Liu L, Fan X
Cell communication and signaling : CCS 2023 Jul 10;21(1):169
Cell communication and signaling : CCS 2023 Jul 10;21(1):169
Novel RNA polymerase I inhibitor CX-5461 suppresses imiquimod-induced experimental psoriasis.
Wu X, Yin Q, Wang J, Dai C, Wang J, Guo X, Jiang F
Experimental dermatology 2023 Jan;32(1):91-99
Experimental dermatology 2023 Jan;32(1):91-99
STAT6 suppression prevents bleomycin-induced dermal fibrosis.
Huang J, Puente H, Wareing NE, Wu M, Mayes MD, Karmouty-Quintana H, Assassi S, Mills TW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22761
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22761
The PD-L1 Expression and Tumor-Infiltrating Immune Cells Predict an Unfavorable Prognosis in Pancreatic Ductal Adenocarcinoma and Adenosquamous Carcinoma.
Zhang Z, Xiong Q, Xu Y, Cai X, Zhang L, Zhu Q
Journal of clinical medicine 2023 Feb 9;12(4)
Journal of clinical medicine 2023 Feb 9;12(4)
HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
Lv J, Li K, Yu H, Han J, Zhuang J, Yu R, Cheng Y, Song Q, Bai K, Cao Q, Yang H, Yang X, Lu Q
Journal of experimental & clinical cancer research : CR 2023 Feb 6;42(1):41
Journal of experimental & clinical cancer research : CR 2023 Feb 6;42(1):41
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
Jing B, Guo F, An R, Gao Y, Li Y, Xie Y, Wang J, Chen Y, Li H, Gao T, Jin Q, Zhang L, Xie M
Journal of nanobiotechnology 2023 Feb 2;21(1):37
Journal of nanobiotechnology 2023 Feb 2;21(1):37
C1Q labels a highly aggressive macrophage-like leukemia population indicating extramedullary infiltration and relapse.
Yang LX, Zhang CT, Yang MY, Zhang XH, Liu HC, Luo CH, Jiang Y, Wang ZM, Yang ZY, Shi ZP, Yang YC, Wei RQ, Zhou L, Mi J, Zhou AW, Yao ZR, Xia L, Yan JS, Lu Y
Blood 2023 Feb 16;141(7):766-786
Blood 2023 Feb 16;141(7):766-786
Reduced Renal CSE/CBS/H2S Contributes to the Progress of Lupus Nephritis.
Wang X, Lin T, He Y, Zhou Y, Peng Y, Zhang W, Ni X
Biology 2023 Feb 16;12(2)
Biology 2023 Feb 16;12(2)
TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation.
Wu Y, Zhan S, Chen L, Sun M, Li M, Mou X, Zhang Z, Xu L, Xu Y
Journal of translational medicine 2023 Aug 14;21(1):544
Journal of translational medicine 2023 Aug 14;21(1):544
Platycodon grandiflorus polysaccharide regulates colonic immunity through mesenteric lymphatic circulation to attenuate ulcerative colitis.
Liu Y, Dong Y, Shen W, DU J, Sun Q, Yang Y, Yin D
Chinese journal of natural medicines 2023 Apr;21(4):263-278
Chinese journal of natural medicines 2023 Apr;21(4):263-278
Ammonia-induced oxidative stress triggered proinflammatory response and apoptosis in pig lungs.
Li D, Shen L, Zhang D, Wang X, Wang Q, Qin W, Gao Y, Li X
Journal of environmental sciences (China) 2023 Apr;126:683-696
Journal of environmental sciences (China) 2023 Apr;126:683-696
Senescence-Related lncRNA Signature Predicts Prognosis, Response to Immunotherapy and Chemotherapy in Skin Cutaneous Melanoma.
Lin K, Zhou Y, Lin Y, Feng Y, Chen Y, Cai L
Biomolecules 2023 Apr 9;13(4)
Biomolecules 2023 Apr 9;13(4)
Dose-Dependent Effects in Plasma Oncotherapy: Critical In Vivo Immune Responses Missed by In Vitro Studies.
He Y, Gong F, Jin T, Liu Q, Fang H, Chen Y, Wang G, Chu PK, Wu Z, Ostrikov KK
Biomolecules 2023 Apr 21;13(4)
Biomolecules 2023 Apr 21;13(4)
Tenascin C(+) papillary fibroblasts facilitate neuro-immune interaction in a mouse model of psoriasis.
Cai X, Han M, Lou F, Sun Y, Yin Q, Sun L, Wang Z, Li X, Zhou H, Xu Z, Wang H, Deng S, Zheng X, Zhang T, Li Q, Zhou B, Wang H
Nature communications 2023 Apr 10;14(1):2004
Nature communications 2023 Apr 10;14(1):2004
Establishment of a New Abdominal Aortic Aneurysm Model in Rats by a Retroperitoneal Approach.
Zhu JX, Tang QQ, Zhou C, Shi XC, Yi SY, Yang Y
Frontiers in cardiovascular medicine 2022;9:808732
Frontiers in cardiovascular medicine 2022;9:808732
Asymptomatic Hyperuricemia Is Associated with Achilles Tendon Rupture through Disrupting the Normal Functions of Tendon Stem/Progenitor Cells.
Liang J, Chen B, Li Y, Nie D, Lei C, Yang Q, Zhou Y, Li S, Chen S, Li B, Shu L, Chen L, Wang W
Stem cells international 2022;2022:6795573
Stem cells international 2022;2022:6795573
Prognostic Lnc-S100B-2 Affects Cell Apoptosis and Microenvironment of Colorectal Cancer through MLLT10 Signaling.
Yi J, Peng F, Zhao J, Gong X
Journal of oncology 2022;2022:3565118
Journal of oncology 2022;2022:3565118
Tissue Kallikrein Protects Rat Prostate against the Inflammatory Damage in a Chronic Autoimmune Prostatitis Model via Restoring Endothelial Function in a Bradykinin Receptor B2-Dependent Way.
Zhang M, Lin D, Luo C, Wei P, Cui K, Chen Z
Oxidative medicine and cellular longevity 2022;2022:1247806
Oxidative medicine and cellular longevity 2022;2022:1247806
Self-Assembly Catalase Nanocomplex Conveyed by Bacterial Vesicles for Oxygenated Photodynamic Therapy and Tumor Immunotherapy.
Zhang J, Li Z, Liu L, Li L, Zhang L, Wang Y, Zhao J
International journal of nanomedicine 2022;17:1971-1985
International journal of nanomedicine 2022;17:1971-1985
C-X-C-Chemokine-Receptor-Type-4 Inhibitor AMD3100 Attenuates Pulmonary Inflammation and Fibrosis in Silicotic Mice.
Sun Q, Tao X, Li B, Cao H, Chen H, Zou Y, Tao H, Mu M, Wang W, Xu K
Journal of inflammation research 2022;15:5827-5843
Journal of inflammation research 2022;15:5827-5843
Mesalamine-Mediated Amelioration of Experimental Colitis in Piglets Involves Gut Microbiota Modulation and Intestinal Immune Cell Infiltration.
Huang Y, Wu M, Xiao H, Liu H, Yang G
Frontiers in immunology 2022;13:883682
Frontiers in immunology 2022;13:883682
Single-cell RNA sequencing reveals TCR(+) macrophages in HPV-related head and neck squamous cell carcinoma.
Jiang Y, Zhang S, Tang L, Li R, Zhai J, Luo S, Peng Y, Chen X, Wei L
Frontiers in immunology 2022;13:1030222
Frontiers in immunology 2022;13:1030222
Statin shapes inflamed tumor microenvironment and enhances immune checkpoint blockade in non-small cell lung cancer.
Mao W, Cai Y, Chen D, Jiang G, Xu Y, Chen R, Wang F, Wang X, Zheng M, Zhao X, Mei J
JCI insight 2022 Sep 22;7(18)
JCI insight 2022 Sep 22;7(18)
Ellagic acid prevents gut damage via ameliorating microbe-associated intestinal lymphocyte imbalance.
Jin H, Che S, Wu K, Wu M
Food & function 2022 Oct 3;13(19):9822-9831
Food & function 2022 Oct 3;13(19):9822-9831
Angiotensin-converting enzyme 2 identifies immuno-hot tumors suggesting angiotensin-(1-7) as a sensitizer for chemotherapy and immunotherapy in breast cancer.
Mei J, Cai Y, Xu R, Yu X, Han X, Weng M, Chen L, Ma T, Gao T, Gao F, Xia T, Zhu Y, Zhang Y
Biological procedures online 2022 Oct 25;24(1):15
Biological procedures online 2022 Oct 25;24(1):15
Traditional Chinese medicine CFF-1 exerts a potent anti-tumor immunity to hinder tumor growth and metastasis in prostate cancer through EGFR/JAK1/STAT3 pathway to inhibit PD-1/PD-L1 checkpoint signaling.
Zhang Y, Wei Y, Jiang S, Dang Y, Yang Y, Zuo W, Zhu Q, Liu P, Gao Y, Lu S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153939
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153939
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
Tian H, Wang G, Wang Q, Zhang B, Jiang G, Li H, Chai D, Fang L, Wang M, Zheng J
Cancer science 2022 Mar;113(3):875-890
Cancer science 2022 Mar;113(3):875-890
A novel TanCAR targeting IL13Rα2 and EphA2 for enhanced glioblastoma therapy.
Muhammad N, Wang R, Li W, Zhang Z, Chang Y, Hu Y, Zhao J, Zheng X, Mao Q, Xia H
Molecular therapy oncolytics 2022 Mar 17;24:729-741
Molecular therapy oncolytics 2022 Mar 17;24:729-741
Ras guanine nucleotide-releasing protein-4 promotes renal inflammatory injury in type 2 diabetes mellitus.
Huang S, Wang J, Zhang L, Tian S, Wang Y, Shao X, Zhou S, Yu P
Metabolism: clinical and experimental 2022 Jun;131:155177
Metabolism: clinical and experimental 2022 Jun;131:155177
Photosynthetic microorganisms coupled photodynamic therapy for enhanced antitumor immune effect.
Wang H, Liu H, Guo Y, Zai W, Li X, Xiong W, Zhao X, Yao Y, Hu Y, Zou Z, Wu J
Bioactive materials 2022 Jun;12:97-106
Bioactive materials 2022 Jun;12:97-106
IQGAP1 is positively correlated with PD-L1 and regulates its expression via mediating STAT proteins phosphorylation.
Chen Y, Mei J, Zhang P, Liu J, Chen L, Wu L, Zhang Y
International immunopharmacology 2022 Jul;108:108897
International immunopharmacology 2022 Jul;108:108897
Null Function of Npr1 Disturbs Immune Response in Colonic Inflammation During Early Postnatal Stage.
Long C, Liu H, Zhan W, Chen L, Wu A, Yang L, Chen S
Inflammation 2022 Dec;45(6):2419-2432
Inflammation 2022 Dec;45(6):2419-2432
Intranasal bovine β-defensin-5 enhances antituberculosis immunity in a mouse model by a novel protein-based respiratory mucosal vaccine.
Liang Z, Li H, Qu M, Liu Y, Wang Y, Wang H, Dong Y, Chen Y, Ge X, Zhou X
Virulence 2022 Dec;13(1):949-962
Virulence 2022 Dec;13(1):949-962
Single-Cell Sequencing Unveils the Heterogeneity of Nonimmune Cells in Chronic Apical Periodontitis.
Lin X, Chi D, Meng Q, Gong Q, Tong Z
Frontiers in cell and developmental biology 2021;9:820274
Frontiers in cell and developmental biology 2021;9:820274
The Effect of miR-520b on Macrophage Polarization and T Cell Immunity by Targeting PTEN in Breast Cancer.
Zhu Q, Yuan J, He Y, Hu Y
Journal of oncology 2021;2021:5170496
Journal of oncology 2021;2021:5170496
Paraspeckle Promotes Hepatocellular Carcinoma Immune Escape by Sequestering IFNGR1 mRNA.
Zan J, Zhao X, Deng X, Ding H, Wang B, Lu M, Wei Z, Huang Z, Wang S
Cellular and molecular gastroenterology and hepatology 2021;12(2):465-487
Cellular and molecular gastroenterology and hepatology 2021;12(2):465-487
VISTA Blockade Aggravates Bone Loss in Experimental Murine Apical Periodontitis.
Yang F, Zhang Y, Chen Z, Zhang L
Frontiers in immunology 2021;12:738586
Frontiers in immunology 2021;12:738586
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
Zhang L, Wang X, Li Y, Han J, Gao X, Li S, Wang F
Clinical and translational medicine 2021 Sep;11(9):e464
Clinical and translational medicine 2021 Sep;11(9):e464
M(6)A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma.
Qiu X, Yang S, Wang S, Wu J, Zheng B, Wang K, Shen S, Jeong S, Li Z, Zhu Y, Wu T, Wu X, Wu R, Liu W, Wang HY, Chen L
Cancer research 2021 Sep 15;81(18):4778-4793
Cancer research 2021 Sep 15;81(18):4778-4793
Increased Expression of the lncRNA NRON Along With NFATc1/PIM-1 in Labial Salivary Glands of Sjögren's Syndrome Patients.
Horai Y, Nakamura H, Shimizu T, Nishihata S, Iwamoto N, Kuroki T, Okano S, Kawakami A
Applied immunohistochemistry & molecular morphology : AIMM 2021 Nov-Dec 01;29(10):734-740
Applied immunohistochemistry & molecular morphology : AIMM 2021 Nov-Dec 01;29(10):734-740
Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes.
Petrigliano FA, Liu NQ, Lee S, Tassey J, Sarkar A, Lin Y, Li L, Yu Y, Geng D, Zhang J, Shkhyan R, Bogdanov J, Van Handel B, Ferguson GB, Lee Y, Hinderer S, Tseng KC, Kavanaugh A, Crump JG, Pyle AD, Schenke-Layland K, Billi F, Wang L, Lieberman J, Hurtig M, Evseenko D
NPJ Regenerative medicine 2021 Nov 23;6(1):77
NPJ Regenerative medicine 2021 Nov 23;6(1):77
Inhibition of DCLK1 with DCLK1-IN-1 Suppresses Renal Cell Carcinoma Invasion and Stemness and Promotes Cytotoxic T-Cell-Mediated Anti-Tumor Immunity.
Ding L, Yang Y, Ge Y, Lu Q, Yan Z, Chen X, Du J, Hafizi S, Xu X, Yao J, Liu J, Cao Z, Weygant N
Cancers 2021 Nov 16;13(22)
Cancers 2021 Nov 16;13(22)
The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma.
Jiang C, Zhao ML, Ramos L, Dobaczewska K, Herbert R, Hobbie K, Mikulski Z, Verkoczy L, Diaz M
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2468-2477
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2468-2477
The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer.
Xia Z, Wang C, Zhang H
World journal of surgical oncology 2021 Jun 14;19(1):177
World journal of surgical oncology 2021 Jun 14;19(1):177
A multi-effective and long-acting immunotherapy through one single hydrogel based injection.
Wang M, Cheng X, Luo L, Liu Y, Cao F, Zhao S, Peng H, Hong C, Jin L, Deng L, Xin H, Wang X
Biomaterials science 2021 Feb 21;9(4):1374-1380
Biomaterials science 2021 Feb 21;9(4):1374-1380
The impact of tobacco exposure on tumor microenvironment and prognosis in lung adenocarcinoma by integrative analysis of multi-omics data.
Lu X, Ma L, Yin X, Ji H, Qian Y, Zhong S, Yan A, Zhang Y
International immunopharmacology 2021 Dec;101(Pt B):108253
International immunopharmacology 2021 Dec;101(Pt B):108253
Dickkopf-related protein 3 alters aerobic glycolysis in pancreatic cancer BxPC-3 cells, promoting CD4(+) T-cell activation and function.
Guo Q, Chu Y, Li H, Shi D, Lin L, Lan W, Wu D
European journal of medical research 2021 Aug 14;26(1):93
European journal of medical research 2021 Aug 14;26(1):93
The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Colon Adenocarcinoma Metastasis.
Chang Z, Huang R, Fu W, Li J, Ji G, Huang J, Shi W, Yin H, Wang W, Meng T, Huang Z, Wei Q, Qin H
Frontiers in cell and developmental biology 2020;8:688
Frontiers in cell and developmental biology 2020;8:688
Overexpressed immunoglobulin-like transcript (ILT) 4 in lung adenocarcinoma is correlated with immunosuppressive T cell subset infiltration and poor patient outcomes.
Li Q, Li J, Wang S, Wang J, Chen X, Zhou D, Fang Y, Gao A, Sun Y
Biomarker research 2020;8:11
Biomarker research 2020;8:11
Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.
Yu Y, Wu DM, Li J, Deng SH, Liu T, Zhang T, He M, Zhao YY, Xu Y
Frontiers in immunology 2020;11:593368
Frontiers in immunology 2020;11:593368
sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells.
Wu S, Zhang X, Dong M, Yang Z, Zhang M, Chen Q
Oncology reports 2020 Oct;44(4):1467-1478
Oncology reports 2020 Oct;44(4):1467-1478
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway.
Deng R, Zuo C, Li Y, Xue B, Xun Z, Guo Y, Wang X, Xu Y, Tian R, Chen S, Liu Q, Chen J, Wang J, Huang X, Li H, Guo M, Wang X, Yang M, Wu Z, Wang J, Ma J, Hu J, Li G, Tang S, Tu Z, Ji H, Zhu H
Cellular & molecular immunology 2020 Nov;17(11):1163-1179
Cellular & molecular immunology 2020 Nov;17(11):1163-1179
Indirubin alleviates bleomycin-induced pulmonary fibrosis in mice by suppressing fibroblast to myofibroblast differentiation.
Wang Q, Yu J, Hu Y, Chen X, Zhang L, Pan T, Miao K, Mou Y, Xu Y, Xiong W, Wang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110715
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110715
Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration.
Luo B, Zhan Y, Luo M, Dong H, Liu J, Lin Y, Zhang J, Wang G, Verhoeyen E, Zhang Y, Zhang H
Cell death & disease 2020 Nov 12;11(11):973
Cell death & disease 2020 Nov 12;11(11):973
Majie cataplasm provides a shield against asthmatic punch from the neuroimmune system.
Ji W, Yu X, Gao Y, Ren B, Zhang S, Wang Q, Wang X
Heliyon 2020 May;6(5):e03896
Heliyon 2020 May;6(5):e03896
HIF1α/PLD2 axis linked to glycolysis induces T-cell immunity in oral lichen planus.
Wang F, Zhang J, Zhou G
Biochimica et biophysica acta. General subjects 2020 Jul;1864(7):129602
Biochimica et biophysica acta. General subjects 2020 Jul;1864(7):129602
Collagen fiber structure guides 3D motility of cytotoxic T lymphocytes.
Pruitt HC, Lewis D, Ciccaglione M, Connor S, Smith Q, Hickey JW, Schneck JP, Gerecht S
Matrix biology : journal of the International Society for Matrix Biology 2020 Jan;85-86:147-159
Matrix biology : journal of the International Society for Matrix Biology 2020 Jan;85-86:147-159
Autophagy plays a positive role in induction of epidermal proliferation.
Wang J, Kaplan N, Wang S, Yang W, Wang L, He C, Peng H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Aug;34(8):10657-10667
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Aug;34(8):10657-10667
The ACE2-deficient mouse: A model for a cytokine storm-driven inflammation.
Wang J, Kaplan N, Wysocki J, Yang W, Lu K, Peng H, Batlle D, Lavker RM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Aug;34(8):10505-10515
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Aug;34(8):10505-10515
IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma.
Gao Y, Lu J, Zeng C, Yang J, Huang B, Zhang N, Li L, Fu X
Clinical and experimental medicine 2020 Aug;20(3):449-459
Clinical and experimental medicine 2020 Aug;20(3):449-459
Fine-particulate matter aggravates cigarette smoke extract-induced airway inflammation via Wnt5a-ERK pathway in COPD.
Wang Z, Zhao J, Wang T, Du X, Xie J
International journal of chronic obstructive pulmonary disease 2019;14:979-994
International journal of chronic obstructive pulmonary disease 2019;14:979-994
Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56.
Zou F, Lu L, Liu J, Xia B, Zhang W, Hu Q, Liu W, Zhang Y, Lin Y, Jing S, Huang M, Huang B, Liu B, Zhang H
Nature communications 2019 Sep 11;10(1):4109
Nature communications 2019 Sep 11;10(1):4109
The preoperative neutrophil-to-lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving radical prostatectomy.
Cao Z, Ji J, Zhang C, Wang F, Xu H, Yu Y, Sun Y
Cancer medicine 2019 Mar;8(3):1004-1012
Cancer medicine 2019 Mar;8(3):1004-1012
PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.
Li Y, Zhou H, Li Y, Han L, Song M, Chen F, Shang G, Wang D, Wang Z, Zhang W, Zhong M
Journal of cellular and molecular medicine 2019 Jun;23(6):4179-4195
Journal of cellular and molecular medicine 2019 Jun;23(6):4179-4195
Clinical Impact of the Immune Microenvironment in Spinal Chordoma: Immunoscore as an Independent Favorable Prognostic Factor.
Zou MX, Lv GH, Wang XB, Huang W, Li J, Jiang Y, She XL
Neurosurgery 2019 Jun 1;84(6):E318-E333
Neurosurgery 2019 Jun 1;84(6):E318-E333
Curative effect of endostar combined with oxaliplatin in the treatment of primary hepatic carcinoma and its influence on immune cells.
Lei C, Ren D, Fu M, Sun C, Ren H, Pan Q, Li Y
Oncology letters 2019 Apr;17(4):3665-3670
Oncology letters 2019 Apr;17(4):3665-3670
A Novel Murine Chronic Obstructive Pulmonary Disease Model and the Pathogenic Role of MicroRNA-21.
He S, Li L, Sun S, Zeng Z, Lu J, Xie L
Frontiers in physiology 2018;9:503
Frontiers in physiology 2018;9:503
Acacetin regulated the reciprocal differentiation of Th17 cells and Treg cells and mitigated the symptoms of collagen-induced arthritis in mice.
Liu L, Yang J, Zu B, Wang J, Sheng K, Zhao L, Xu W
Scandinavian journal of immunology 2018 Oct;88(4):e12712
Scandinavian journal of immunology 2018 Oct;88(4):e12712
A self-organized actomyosin drives multiple intercellular junction disruption and directly promotes neutrophil recruitment in lipopolysaccharide-induced acute lung injury.
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 7;:fj201701506RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 7;:fj201701506RR
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Li Y, Wei J, Mao X, Gao Q, Liu L, Cheng P, Liu L, Zhang X, Zhang K, Wang J, Zhu L, Zhou J, Zhang Y, Meng L, Sun H, Li D, Huang M, Huang W, Deng J, Zhang D
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PloS one 2016;11(8):e0158827
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Journal of immunology (Baltimore, Md. : 1950) 2015 May 1;194(9):4555-66
Journal of immunology (Baltimore, Md. : 1950) 2015 May 1;194(9):4555-66
RAG1/2 knockout pigs with severe combined immunodeficiency.
Huang J, Guo X, Fan N, Song J, Zhao B, Ouyang Z, Liu Z, Zhao Y, Yan Q, Yi X, Schambach A, Frampton J, Esteban MA, Yang D, Yang H, Lai L
Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 1;193(3):1496-503
Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 1;193(3):1496-503
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 17617-1-AP(CD3E antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 17617-1-AP(CD3E antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 17617-1-AP(CD3E antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CD3 epsilon antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CD3 epsilon. This antibody recognizes human antigen. The CD3 epsilon antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.
