Antibody data
- Antibody Data
- Antigen structure
- References [34]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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Validation data
Reference
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- Product number
- 17617-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17617-1-AP, RRID:AB_1939430
- Product name
- CD3 antibody
- Antibody type
- Polyclonal
- Description
- CD3 antibody (Cat. #17617-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, pig, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Effect of miR-520b on Macrophage Polarization and T Cell Immunity by Targeting PTEN in Breast Cancer.
Paraspeckle Promotes Hepatocellular Carcinoma Immune Escape by Sequestering IFNGR1 mRNA.
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
M6A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma.
Inhibition of DCLK1 with DCLK1-IN-1 Suppresses Renal Cell Carcinoma Invasion and Stemness and Promotes Cytotoxic T-Cell-Mediated Anti-Tumor Immunity.
The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma.
The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer.
The impact of tobacco exposure on tumor microenvironment and prognosis in lung adenocarcinoma by integrative analysis of multi-omics data.
Dickkopf-related protein 3 alters aerobic glycolysis in pancreatic cancer BxPC-3 cells, promoting CD4+ T-cell activation and function.
The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Colon Adenocarcinoma Metastasis.
Overexpressed immunoglobulin-like transcript (ILT) 4 in lung adenocarcinoma is correlated with immunosuppressive T cell subset infiltration and poor patient outcomes.
Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.
sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells.
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway.
Indirubin alleviates bleomycin-induced pulmonary fibrosis in mice by suppressing fibroblast to myofibroblast differentiation.
Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration.
Majie cataplasm provides a shield against asthmatic punch from the neuroimmune system.
HIF1α/PLD2 axis linked to glycolysis induces T-cell immunity in oral lichen planus.
Collagen fiber structure guides 3D motility of cytotoxic T lymphocytes.
Autophagy plays a positive role in induction of epidermal proliferation.
The ACE2-deficient mouse: A model for a cytokine storm-driven inflammation.
IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma.
Fine-particulate matter aggravates cigarette smoke extract-induced airway inflammation via Wnt5a-ERK pathway in COPD.
Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56.
The preoperative neutrophil-to-lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving radical prostatectomy.
PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.
Clinical Impact of the Immune Microenvironment in Spinal Chordoma: Immunoscore as an Independent Favorable Prognostic Factor.
Curative effect of endostar combined with oxaliplatin in the treatment of primary hepatic carcinoma and its influence on immune cells.
A Novel Murine Chronic Obstructive Pulmonary Disease Model and the Pathogenic Role of MicroRNA-21.
Acacetin regulated the reciprocal differentiation of Th17 cells and Treg cells and mitigated the symptoms of collagen-induced arthritis in mice.
A self-organized actomyosin drives multiple intercellular junction disruption and directly promotes neutrophil recruitment in lipopolysaccharide-induced acute lung injury.
Flow Cytometric Immunophenotyping Is Sensitive for the Early Diagnosis of De Novo Aggressive Natural Killer Cell Leukemia (ANKL): A Multicenter Retrospective Analysis.
SNX17 affects T cell activation by regulating TCR and integrin recycling.
RAG1/2 knockout pigs with severe combined immunodeficiency.
Zhu Q, Yuan J, He Y, Hu Y
Journal of oncology 2021;2021:5170496
Journal of oncology 2021;2021:5170496
Paraspeckle Promotes Hepatocellular Carcinoma Immune Escape by Sequestering IFNGR1 mRNA.
Zan J, Zhao X, Deng X, Ding H, Wang B, Lu M, Wei Z, Huang Z, Wang S
Cellular and molecular gastroenterology and hepatology 2021;12(2):465-487
Cellular and molecular gastroenterology and hepatology 2021;12(2):465-487
c-Myb facilitates immune escape of esophageal adenocarcinoma cells through the miR-145-5p/SPOP/PD-L1 axis.
Zhang L, Wang X, Li Y, Han J, Gao X, Li S, Wang F
Clinical and translational medicine 2021 Sep;11(9):e464
Clinical and translational medicine 2021 Sep;11(9):e464
M6A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma.
Qiu X, Yang S, Wang S, Wu J, Zheng B, Wang K, Shen S, Jeong S, Li Z, Zhu Y, Wu T, Wu X, Wu R, Liu W, Wang HY, Chen L
Cancer research 2021 Sep 15;81(18):4778-4793
Cancer research 2021 Sep 15;81(18):4778-4793
Inhibition of DCLK1 with DCLK1-IN-1 Suppresses Renal Cell Carcinoma Invasion and Stemness and Promotes Cytotoxic T-Cell-Mediated Anti-Tumor Immunity.
Ding L, Yang Y, Ge Y, Lu Q, Yan Z, Chen X, Du J, Hafizi S, Xu X, Yao J, Liu J, Cao Z, Weygant N
Cancers 2021 Nov 16;13(22)
Cancers 2021 Nov 16;13(22)
The Role of IgM Antibodies in T Cell Lymphoma Protection in a Novel Model Resembling Anaplastic Large Cell Lymphoma.
Jiang C, Zhao ML, Ramos L, Dobaczewska K, Herbert R, Hobbie K, Mikulski Z, Verkoczy L, Diaz M
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2468-2477
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2468-2477
The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer.
Xia Z, Wang C, Zhang H
World journal of surgical oncology 2021 Jun 14;19(1):177
World journal of surgical oncology 2021 Jun 14;19(1):177
The impact of tobacco exposure on tumor microenvironment and prognosis in lung adenocarcinoma by integrative analysis of multi-omics data.
Lu X, Ma L, Yin X, Ji H, Qian Y, Zhong S, Yan A, Zhang Y
International immunopharmacology 2021 Dec;101(Pt B):108253
International immunopharmacology 2021 Dec;101(Pt B):108253
Dickkopf-related protein 3 alters aerobic glycolysis in pancreatic cancer BxPC-3 cells, promoting CD4+ T-cell activation and function.
Guo Q, Chu Y, Li H, Shi D, Lin L, Lan W, Wu D
European journal of medical research 2021 Aug 14;26(1):93
European journal of medical research 2021 Aug 14;26(1):93
The Construction and Analysis of ceRNA Network and Patterns of Immune Infiltration in Colon Adenocarcinoma Metastasis.
Chang Z, Huang R, Fu W, Li J, Ji G, Huang J, Shi W, Yin H, Wang W, Meng T, Huang Z, Wei Q, Qin H
Frontiers in cell and developmental biology 2020;8:688
Frontiers in cell and developmental biology 2020;8:688
Overexpressed immunoglobulin-like transcript (ILT) 4 in lung adenocarcinoma is correlated with immunosuppressive T cell subset infiltration and poor patient outcomes.
Li Q, Li J, Wang S, Wang J, Chen X, Zhou D, Fang Y, Gao A, Sun Y
Biomarker research 2020;8:11
Biomarker research 2020;8:11
Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.
Yu Y, Wu DM, Li J, Deng SH, Liu T, Zhang T, He M, Zhao YY, Xu Y
Frontiers in immunology 2020;11:593368
Frontiers in immunology 2020;11:593368
sATP‑binding cassette subfamily G member 2 enhances the multidrug resistance properties of human nasal natural killer/T cell lymphoma side population cells.
Wu S, Zhang X, Dong M, Yang Z, Zhang M, Chen Q
Oncology reports 2020 Oct;44(4):1467-1478
Oncology reports 2020 Oct;44(4):1467-1478
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway.
Deng R, Zuo C, Li Y, Xue B, Xun Z, Guo Y, Wang X, Xu Y, Tian R, Chen S, Liu Q, Chen J, Wang J, Huang X, Li H, Guo M, Wang X, Yang M, Wu Z, Wang J, Ma J, Hu J, Li G, Tang S, Tu Z, Ji H, Zhu H
Cellular & molecular immunology 2020 Nov;17(11):1163-1179
Cellular & molecular immunology 2020 Nov;17(11):1163-1179
Indirubin alleviates bleomycin-induced pulmonary fibrosis in mice by suppressing fibroblast to myofibroblast differentiation.
Wang Q, Yu J, Hu Y, Chen X, Zhang L, Pan T, Miao K, Mou Y, Xu Y, Xiong W, Wang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110715
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110715
Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration.
Luo B, Zhan Y, Luo M, Dong H, Liu J, Lin Y, Zhang J, Wang G, Verhoeyen E, Zhang Y, Zhang H
Cell death & disease 2020 Nov 12;11(11):973
Cell death & disease 2020 Nov 12;11(11):973
Majie cataplasm provides a shield against asthmatic punch from the neuroimmune system.
Ji W, Yu X, Gao Y, Ren B, Zhang S, Wang Q, Wang X
Heliyon 2020 May;6(5):e03896
Heliyon 2020 May;6(5):e03896
HIF1α/PLD2 axis linked to glycolysis induces T-cell immunity in oral lichen planus.
Wang F, Zhang J, Zhou G
Biochimica et biophysica acta. General subjects 2020 Jul;1864(7):129602
Biochimica et biophysica acta. General subjects 2020 Jul;1864(7):129602
Collagen fiber structure guides 3D motility of cytotoxic T lymphocytes.
Pruitt HC, Lewis D, Ciccaglione M, Connor S, Smith Q, Hickey JW, Schneck JP, Gerecht S
Matrix biology : journal of the International Society for Matrix Biology 2020 Jan;85-86:147-159
Matrix biology : journal of the International Society for Matrix Biology 2020 Jan;85-86:147-159
Autophagy plays a positive role in induction of epidermal proliferation.
Wang J, Kaplan N, Wang S, Yang W, Wang L, He C, Peng H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Aug;34(8):10657-10667
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Aug;34(8):10657-10667
The ACE2-deficient mouse: A model for a cytokine storm-driven inflammation.
Wang J, Kaplan N, Wysocki J, Yang W, Lu K, Peng H, Batlle D, Lavker RM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Aug;34(8):10505-10515
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Aug;34(8):10505-10515
IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma.
Gao Y, Lu J, Zeng C, Yang J, Huang B, Zhang N, Li L, Fu X
Clinical and experimental medicine 2020 Aug;20(3):449-459
Clinical and experimental medicine 2020 Aug;20(3):449-459
Fine-particulate matter aggravates cigarette smoke extract-induced airway inflammation via Wnt5a-ERK pathway in COPD.
Wang Z, Zhao J, Wang T, Du X, Xie J
International journal of chronic obstructive pulmonary disease 2019;14:979-994
International journal of chronic obstructive pulmonary disease 2019;14:979-994
Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56.
Zou F, Lu L, Liu J, Xia B, Zhang W, Hu Q, Liu W, Zhang Y, Lin Y, Jing S, Huang M, Huang B, Liu B, Zhang H
Nature communications 2019 Sep 11;10(1):4109
Nature communications 2019 Sep 11;10(1):4109
The preoperative neutrophil-to-lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving radical prostatectomy.
Cao Z, Ji J, Zhang C, Wang F, Xu H, Yu Y, Sun Y
Cancer medicine 2019 Mar;8(3):1004-1012
Cancer medicine 2019 Mar;8(3):1004-1012
PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.
Li Y, Zhou H, Li Y, Han L, Song M, Chen F, Shang G, Wang D, Wang Z, Zhang W, Zhong M
Journal of cellular and molecular medicine 2019 Jun;23(6):4179-4195
Journal of cellular and molecular medicine 2019 Jun;23(6):4179-4195
Clinical Impact of the Immune Microenvironment in Spinal Chordoma: Immunoscore as an Independent Favorable Prognostic Factor.
Zou MX, Lv GH, Wang XB, Huang W, Li J, Jiang Y, She XL
Neurosurgery 2019 Jun 1;84(6):E318-E333
Neurosurgery 2019 Jun 1;84(6):E318-E333
Curative effect of endostar combined with oxaliplatin in the treatment of primary hepatic carcinoma and its influence on immune cells.
Lei C, Ren D, Fu M, Sun C, Ren H, Pan Q, Li Y
Oncology letters 2019 Apr;17(4):3665-3670
Oncology letters 2019 Apr;17(4):3665-3670
A Novel Murine Chronic Obstructive Pulmonary Disease Model and the Pathogenic Role of MicroRNA-21.
He S, Li L, Sun S, Zeng Z, Lu J, Xie L
Frontiers in physiology 2018;9:503
Frontiers in physiology 2018;9:503
Acacetin regulated the reciprocal differentiation of Th17 cells and Treg cells and mitigated the symptoms of collagen-induced arthritis in mice.
Liu L, Yang J, Zu B, Wang J, Sheng K, Zhao L, Xu W
Scandinavian journal of immunology 2018 Oct;88(4):e12712
Scandinavian journal of immunology 2018 Oct;88(4):e12712
A self-organized actomyosin drives multiple intercellular junction disruption and directly promotes neutrophil recruitment in lipopolysaccharide-induced acute lung injury.
Chen B, Yang Z, Yang C, Qin W, Gu J, Hu C, Chen A, Ning J, Yi B, Lu K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 7;:fj201701506RR
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 7;:fj201701506RR
Flow Cytometric Immunophenotyping Is Sensitive for the Early Diagnosis of De Novo Aggressive Natural Killer Cell Leukemia (ANKL): A Multicenter Retrospective Analysis.
Li Y, Wei J, Mao X, Gao Q, Liu L, Cheng P, Liu L, Zhang X, Zhang K, Wang J, Zhu L, Zhou J, Zhang Y, Meng L, Sun H, Li D, Huang M, Huang W, Deng J, Zhang D
PloS one 2016;11(8):e0158827
PloS one 2016;11(8):e0158827
SNX17 affects T cell activation by regulating TCR and integrin recycling.
Osborne DG, Piotrowski JT, Dick CJ, Zhang JS, Billadeau DD
Journal of immunology (Baltimore, Md. : 1950) 2015 May 1;194(9):4555-66
Journal of immunology (Baltimore, Md. : 1950) 2015 May 1;194(9):4555-66
RAG1/2 knockout pigs with severe combined immunodeficiency.
Huang J, Guo X, Fan N, Song J, Zhao B, Ouyang Z, Liu Z, Zhao Y, Yan Q, Yi X, Schambach A, Frampton J, Esteban MA, Yang D, Yang H, Lai L
Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 1;193(3):1496-503
Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 1;193(3):1496-503
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 17617-1-AP(CD3E antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 17617-1-AP(CD3E antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human spleen using 17617-1-AP(CD3E antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CD3 epsilon antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CD3 epsilon. This antibody recognizes human antigen. The CD3 epsilon antibody has been validated for the following applications: ELISA, WB, IHC, FC analysis.