CD3E

gene product
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
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Proteintech Group
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ProSci
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RabMAbs
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MyBioSource
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Absolute Antibody
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Abiocode, Inc.
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DB Biotech
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Sigma-Aldrich
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BioLegend (formerly Covance Antibody Products)
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Nordic BioSite
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