Tissue expression
Cell line expression
Protein structure
CD3E
CD3e moleculeThe protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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Proteintech Group | ![]() |
106 references | Polyclonal |
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GeneTex | ![]() |
2 references | Monoclonal |
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NSJ Bioreagents | ![]() |
23 references | Monoclonal |
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R&D Systems | ![]() |
18 references | Monoclonal |
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LSBio | ![]() |
Polyclonal |
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