Antibody data
- Antibody Data
- Antigen structure
- References [38]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 60181-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60181-1-Ig, RRID:AB_10859262
- Product name
- CD3 antibody
- Antibody type
- Monoclonal
- Description
- CD3 antibody (Cat. #60181-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3F3A1
- Vial size
- 20ul, 150ul
Submitted references Mesothelin CAR-T cells expressing tumor-targeted immunocytokine IL-12 yield durable efficacy and fewer side effects.
Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies.
Endoplasmic reticulum aminopeptidase 2 regulates CD4(+) T cells pyroptosis in rheumatoid arthritis.
A novel lipid metabolism-based risk model associated with immunosuppressive mechanisms in diffuse large B-cell lymphoma.
ALOX5 drives the pyroptosis of CD4(+) T cells and tissue inflammation in rheumatoid arthritis.
Dclre1c-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research.
Engineered platelet-based immune engager for tumor post-surgery treatment.
Humanized single-domain antibody targeting HER2 enhances function of chimeric antigen receptor T cells.
Establishment and validation of an immune infiltration predictive model for ovarian cancer.
Combination of novel oncolytic herpesvirus with paclitaxel as an efficient strategy for breast cancer therapy.
Exploration of (68)Ga-labelled prostate-specific membrane antigen-11 PET/CT parameters for identifying PBRM1 status in primary clear cell renal cell carcinoma.
TRIM21 promotes inflammation by ubiquitylating NF-κB in T cells of oral lichen planus.
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation.
Effects of fermented Andrographis paniculata on growth performance, carcass traits, immune function, and intestinal health in Muscovy ducks.
Patient-derived melanoma organoid models facilitate the assessment of immunotherapies.
PYCR1 promotes the malignant progression of lung cancer through the JAK-STAT3 signaling pathway via PRODH-dependent glutamine synthesize.
Hydrogen Attenuates Inflammation by Inducing Early M2 Macrophage Polarization in Skin Wound Healing.
Autophagy loss impedes cancer-associated fibroblast activation via downregulating proline biosynthesis.
Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to promote liver fibrosis.
Role of TFRC as a Novel Prognostic Biomarker and in Immunotherapy for Pancreatic Carcinoma.
Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis.
The Proinflammatory Role of Guanylate-Binding Protein 5 in Inflammatory Bowel Diseases.
Clinical Impact of the Histopathological Index and Neuroimaging Features Status in Primary Central Nervous System Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Analysis of 51 Cases.
Scoring model based on the signature of non-m6A-related neoantigen-coding lncRNAs assists in immune microenvironment analysis and TCR-neoantigen pair selection in gliomas.
MutT Homolog 1 Inhibitor Karonudib Attenuates Autoimmune Hepatitis by Inhibiting DNA Repair in Activated T Cells.
CX-5461 is a potent immunosuppressant which inhibits T cell-mediated alloimmunity via p53-DUSP5.
Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression.
Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8(+) T cells.
Multifunctional chitin-based hollow nerve conduit for peripheral nerve regeneration and neuroma inhibition.
Construction and Biocompatibility Evaluation of Fibroin/Sericin-Based Scaffolds.
Clinical Relevance and Prognostic Value of the Neuronal Protein Neuroligin 2 in Breast Cancer.
Novel roles of VAT1 expression in the immunosuppressive action of diffuse gliomas.
B7-H5 blockade enhances CD8(+) T-cell-mediated antitumor immunity in colorectal cancer.
2-Deoxy-D-glucose impedes T cell-induced apoptosis of keratinocytes in oral lichen planus.
Regulatory T-cell expansion in oral and maxillofacial Langerhans cell histiocytosis.
T cell-derived exosomes induced macrophage inflammatory protein-1α/β drive the trafficking of CD8(+) T cells in oral lichen planus.
A PD-L2-based immune marker signature helps to predict survival in resected pancreatic ductal adenocarcinoma.
Intrarenal macrophage infiltration induced by T cells is associated with podocyte injury in lupus nephritis patients.
Zhu Y, Wang K, Yue L, Zuo D, Sheng J, Lan S, Zhao Z, Dong S, Hu S, Chen X, Feng M
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Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies.
Tang L, Zhang H, Zhou F, Wei Q, Du M, Wu J, Li C, Luo W, Zhou J, Wang X, Chen Z, Zhang Y, Huang Z, Wu Z, Wen Y, Jiang H, Liao D, Kou H, Xiong W, Mei H, Hu Y
Cancer communications (London, England) 2024 Mar;44(3):408-432
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Endoplasmic reticulum aminopeptidase 2 regulates CD4(+) T cells pyroptosis in rheumatoid arthritis.
Zhang J, Cai H, Sun W, Wu W, Nan Y, Ni Y, Wu X, Chen M, Xu H, Wang Y
Arthritis research & therapy 2024 Jan 25;26(1):36
Arthritis research & therapy 2024 Jan 25;26(1):36
A novel lipid metabolism-based risk model associated with immunosuppressive mechanisms in diffuse large B-cell lymphoma.
Zhang Z, Zhao C, Yang S, Lu W, Shi J
Lipids in health and disease 2024 Jan 22;23(1):20
Lipids in health and disease 2024 Jan 22;23(1):20
ALOX5 drives the pyroptosis of CD4(+) T cells and tissue inflammation in rheumatoid arthritis.
Cai H, Zhang J, Xu H, Sun W, Wu W, Dong C, Zhou P, Xue C, Nan Y, Ni Y, Wu X, Gu Z, Chen M, Wang Y
Science signaling 2024 Feb 27;17(825):eadh1178
Science signaling 2024 Feb 27;17(825):eadh1178
Dclre1c-Mutation-Induced Immunocompromised Mice Are a Novel Model for Human Xenograft Research.
Bin Y, Wei S, Chen R, Zhang H, Ren J, Liu P, Xin Z, Zhang T, Yang H, Wang K, Feng Z, Sun X, Chen Z, Zhang H
Biomolecules 2024 Feb 2;14(2)
Biomolecules 2024 Feb 2;14(2)
Engineered platelet-based immune engager for tumor post-surgery treatment.
Chen M, Zhang J, Li H, Deng Y, Huang Y, Shen W, Zeng Y, Ci T
Biomaterials advances 2024 Apr;158:213796
Biomaterials advances 2024 Apr;158:213796
Humanized single-domain antibody targeting HER2 enhances function of chimeric antigen receptor T cells.
Zheng R, Chen Y, Zhang Y, Liang S, Zhao X, Wang Y, Wang P, Meng R, Yang A, Yan B
Frontiers in immunology 2023;14:1258156
Frontiers in immunology 2023;14:1258156
Establishment and validation of an immune infiltration predictive model for ovarian cancer.
Song Z, Zhang J, Sun Y, Jiang Z, Liu X
BMC medical genomics 2023 Sep 28;16(1):227
BMC medical genomics 2023 Sep 28;16(1):227
Combination of novel oncolytic herpesvirus with paclitaxel as an efficient strategy for breast cancer therapy.
Deng X, Shen Y, Yi M, Zhang C, Zhao B, Zhong G, WeiyangLou, Xue D, Leng Q, Ding J, Zhao R, Jia W, Dong C, Dai Z
Journal of medical virology 2023 May;95(5):e28768
Journal of medical virology 2023 May;95(5):e28768
Exploration of (68)Ga-labelled prostate-specific membrane antigen-11 PET/CT parameters for identifying PBRM1 status in primary clear cell renal cell carcinoma.
Wang B, Deng Y, Xu Q, Gao J, Shen H, He X, Ding Q, Wang F, Guo H
Clinical radiology 2023 May;78(5):e417-e424
Clinical radiology 2023 May;78(5):e417-e424
TRIM21 promotes inflammation by ubiquitylating NF-κB in T cells of oral lichen planus.
Yao Y, Pan L, Wei Y, Feng M, Li X, Sun L, Tang G, Wang Y
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2023 May;52(5):448-455
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Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation.
Zhang HF, Liu HM, Xiang JY, Zhou XC, Wang D, Chen RY, Tan WL, Liang LQ, Liu LL, Shi MJ, Zhang F, Xiao Y, Zhou YX, Zhang T, Tang L, Guo B, Wang YY
Acta pharmacologica Sinica 2023 May;44(5):1051-1065
Acta pharmacologica Sinica 2023 May;44(5):1051-1065
Effects of fermented Andrographis paniculata on growth performance, carcass traits, immune function, and intestinal health in Muscovy ducks.
Liu Z, Lei X, Li J, Zhong Y, Tan D, Zhang Q, Kong Z
Poultry science 2023 Mar;102(3):102461
Poultry science 2023 Mar;102(3):102461
Patient-derived melanoma organoid models facilitate the assessment of immunotherapies.
Ou L, Liu S, Wang H, Guo Y, Guan L, Shen L, Luo R, Elder DE, Huang AC, Karakousis G, Miura J, Mitchell T, Schuchter L, Amaravadi R, Flowers A, Mou H, Yi F, Guo W, Ko J, Chen Q, Tian B, Herlyn M, Xu X
EBioMedicine 2023 Jun;92:104614
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PYCR1 promotes the malignant progression of lung cancer through the JAK-STAT3 signaling pathway via PRODH-dependent glutamine synthesize.
Zhang L, Zhao X, Wang E, Yang Y, Hu L, Xu H, Zhang B
Translational oncology 2023 Jun;32:101667
Translational oncology 2023 Jun;32:101667
Hydrogen Attenuates Inflammation by Inducing Early M2 Macrophage Polarization in Skin Wound Healing.
Zhao P, Cai Z, Zhang X, Liu M, Xie F, Liu Z, Lu S, Ma X
Pharmaceuticals (Basel, Switzerland) 2023 Jun 15;16(6)
Pharmaceuticals (Basel, Switzerland) 2023 Jun 15;16(6)
Autophagy loss impedes cancer-associated fibroblast activation via downregulating proline biosynthesis.
Bai J, Liu T, Tu B, Yuan M, Shu Z, Fan M, Huo S, Guo Y, Wang L, Wang H, Zhao Y
Autophagy 2023 Feb;19(2):632-643
Autophagy 2023 Feb;19(2):632-643
Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to promote liver fibrosis.
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Hepatology (Baltimore, Md.) 2023 Apr 1;77(4):1181-1197
Hepatology (Baltimore, Md.) 2023 Apr 1;77(4):1181-1197
Role of TFRC as a Novel Prognostic Biomarker and in Immunotherapy for Pancreatic Carcinoma.
Yang C, Li J, Guo Y, Gan D, Zhang C, Wang R, Hua L, Zhu L, Ma P, Shi J, Li S, Su H
Frontiers in molecular biosciences 2022;9:756895
Frontiers in molecular biosciences 2022;9:756895
Targeting Ferroptosis Attenuates Inflammation, Fibrosis, and Mast Cell Activation in Chronic Prostatitis.
Lin D, Zhang M, Luo C, Wei P, Cui K, Chen Z
Journal of immunology research 2022;2022:6833867
Journal of immunology research 2022;2022:6833867
The Proinflammatory Role of Guanylate-Binding Protein 5 in Inflammatory Bowel Diseases.
Li Y, Lin X, Wang W, Wang W, Cheng S, Huang Y, Zou Y, Ke J, Zhu L
Frontiers in microbiology 2022;13:926915
Frontiers in microbiology 2022;13:926915
Clinical Impact of the Histopathological Index and Neuroimaging Features Status in Primary Central Nervous System Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Analysis of 51 Cases.
Qi Z, Duan L, Yuan G, Liu J, Li J, Li G, Yu Y, Xu Y, Ma S, Pan Y, Zhang Y
Frontiers in oncology 2022;12:769895
Frontiers in oncology 2022;12:769895
Scoring model based on the signature of non-m6A-related neoantigen-coding lncRNAs assists in immune microenvironment analysis and TCR-neoantigen pair selection in gliomas.
Zhao W, Wu Y, Zhao F, Xue Z, Liu W, Cao Z, Zhao Z, Huang B, Han M, Li X
Journal of translational medicine 2022 Oct 29;20(1):494
Journal of translational medicine 2022 Oct 29;20(1):494
MutT Homolog 1 Inhibitor Karonudib Attenuates Autoimmune Hepatitis by Inhibiting DNA Repair in Activated T Cells.
Chen Y, Hua X, Huang B, Karsten S, You Z, Li B, Li Y, Li Y, Liang J, Zhang J, Wei Y, Chen R, Lyu Z, Xiao X, Lian M, Wei J, Fang J, Miao Q, Wang Q, Berglung UW, Tang R, Helleday T, Ma X
Hepatology communications 2022 May;6(5):1016-1031
Hepatology communications 2022 May;6(5):1016-1031
CX-5461 is a potent immunosuppressant which inhibits T cell-mediated alloimmunity via p53-DUSP5.
Pan G, Zhang J, Han Y, Chen Y, Guo X, Cui X, Cheng M, Gao H, Wang J, Jiang F
Pharmacological research 2022 Mar;177:106120
Pharmacological research 2022 Mar;177:106120
Bacteria-mediated tumor immunotherapy via photothermally-programmed PD1 expression.
Xu W, Ren D, Yu Z, Hou J, Huang F, Gan T, Ji P, Zhang C, Ma L, Hu Y
Nanoscale advances 2022 Mar 15;4(6):1577-1586
Nanoscale advances 2022 Mar 15;4(6):1577-1586
Ferroptosis participates in neuron damage in experimental cerebral malaria and is partially induced by activated CD8(+) T cells.
Liang J, Shen Y, Wang Y, Huang Y, Wang J, Zhu Q, Tong G, Yu K, Cao W, Wang Q, Li Y, Zhao Y
Molecular brain 2022 Jun 20;15(1):57
Molecular brain 2022 Jun 20;15(1):57
Multifunctional chitin-based hollow nerve conduit for peripheral nerve regeneration and neuroma inhibition.
Yang X, Huang L, Yi X, Huang S, Duan B, Yu A
Carbohydrate polymers 2022 Aug 1;289:119443
Carbohydrate polymers 2022 Aug 1;289:119443
Construction and Biocompatibility Evaluation of Fibroin/Sericin-Based Scaffolds.
Fu Z, Li W, Wei J, Yao K, Wang Y, Yang P, Li G, Yang Y, Zhang L
ACS biomaterials science & engineering 2022 Apr 11;8(4):1494-1505
ACS biomaterials science & engineering 2022 Apr 11;8(4):1494-1505
Clinical Relevance and Prognostic Value of the Neuronal Protein Neuroligin 2 in Breast Cancer.
Zhang G, Sun Y, Wu ZS, Huang X
Frontiers in oncology 2021;11:630257
Frontiers in oncology 2021;11:630257
Novel roles of VAT1 expression in the immunosuppressive action of diffuse gliomas.
Yang P, Wang K, Zhang C, Wang Z, Liu Q, Wang J, Jiang T, Shan X
Cancer immunology, immunotherapy : CII 2021 Sep;70(9):2589-2600
Cancer immunology, immunotherapy : CII 2021 Sep;70(9):2589-2600
B7-H5 blockade enhances CD8(+) T-cell-mediated antitumor immunity in colorectal cancer.
Wang J, Wu H, Chen Y, Zhu J, Sun L, Li J, Yao Z, Chen Y, Zhang X, Xia S, Chen W, Shi T
Cell death discovery 2021 Sep 18;7(1):248
Cell death discovery 2021 Sep 18;7(1):248
2-Deoxy-D-glucose impedes T cell-induced apoptosis of keratinocytes in oral lichen planus.
Wang F, Zhang J, Zhou G
Journal of cellular and molecular medicine 2021 Nov;25(21):10257-10267
Journal of cellular and molecular medicine 2021 Nov;25(21):10257-10267
Regulatory T-cell expansion in oral and maxillofacial Langerhans cell histiocytosis.
Zhang C, Gao J, He J, Liu C, Lv X, Yin X, Deng Y, Lu Z, Tian Z
Oral surgery, oral medicine, oral pathology and oral radiology 2020 Nov;130(5):547-556
Oral surgery, oral medicine, oral pathology and oral radiology 2020 Nov;130(5):547-556
T cell-derived exosomes induced macrophage inflammatory protein-1α/β drive the trafficking of CD8(+) T cells in oral lichen planus.
Yang JY, Zhang J, Lu R, Tan YQ, Du GF, Zhou G
Journal of cellular and molecular medicine 2020 Dec;24(23):14086-14098
Journal of cellular and molecular medicine 2020 Dec;24(23):14086-14098
A PD-L2-based immune marker signature helps to predict survival in resected pancreatic ductal adenocarcinoma.
Zhang Y, Xu J, Hua J, Liu J, Liang C, Meng Q, Wei M, Zhang B, Yu X, Shi S
Journal for immunotherapy of cancer 2019 Aug 29;7(1):233
Journal for immunotherapy of cancer 2019 Aug 29;7(1):233
Intrarenal macrophage infiltration induced by T cells is associated with podocyte injury in lupus nephritis patients.
Ma R, Jiang W, Li Z, Sun Y, Wei Z
Lupus 2016 Dec;25(14):1577-1586
Lupus 2016 Dec;25(14):1577-1586
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 60181-1-Ig(CD3E antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human tonsillitis using 60181-1-Ig(CD3E antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CD3 epsilon antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human CD3 epsilon. This antibody recognizes human antigen. The CD3 epsilon antibody has been validated for the following applications: ELISA, WB, IHC analysis.