Antibody data

Product number
NBP2-45325 - Provider product page
Provider
Novus Biologicals
Product name
Mouse Monoclonal CD8 Antibody
Antibody type
Monoclonal
Description
Protein A or G purified. CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
Reactivity
Human
Host
Mouse
Isotype
IgG
Vial size
7 ml
Storage
Store at 4C.
CD8A protein structure - NBP2-45325 shown in red.