CD8A

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein. [provided by RefSeq, May 2020]

Description

CD8a molecule

Tissue specificity

Tissue enriched (lymphoid tissue)

Subcell location

Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

CD markers
Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (86784610 - 86808396)

Ensembl ID

ENSG00000153563  (ver. 103.38)

Orthologs

Mouse Cd8a: ENSMUSG00000053977

UniProt

P01732

neXtProt

NX_P01732

Human splice variants
Mouse splice variants

Protein structure