GTF2A1L

The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Mar 2014]

Description

General transcription factor IIA subunit 1 like

Tissue specificity

Tissue enriched (testis)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

2 (48617798 - 48733148)

Ensembl ID

ENSG00000242441  (ver. 103.38)

Orthologs

Mouse Gtf2a1l: ENSMUSG00000024154

UniProt

Q9UNN4

neXtProt

NX_Q9UNN4

Human splice variants
Mouse splice variants

Protein structure