15954-1-AP

antibody from Proteintech Group

Targeting: GCG GLP-1, GLP1, GLP2, GRPP

Provider product page for 15954-1-AP

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [36]
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Validations
Immunohistochemistry [3]

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Product number: 15954-1-AP - Provider product page
Provider: Proteintech Group
Product name: Glucagon antibody
Antibody type: Polyclonal
Description: Glucagon antibody (Cat. #15954-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GCG protein structure - 15954-1-AP shown in red.

Submitted references Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis.

Lu P, Xu J, Shen X, Sun J, Liu M, Niu N, Wang Q, Xue J
Cell reports 2024 Feb 27;43(2):113703

Generation of rat forebrain tissues in mice.

Huang J, He B, Yang X, Long X, Wei Y, Li L, Tang M, Gao Y, Fang Y, Ying W, Wang Z, Li C, Zhou Y, Li S, Shi L, Choi S, Zhou H, Guo F, Yang H, Wu J
Cell 2024 Apr 25;187(9):2129-2142.e17

Berberine enhances the function of db/db mice islet β cell through GLP-1/GLP-1R/PKA signaling pathway in intestinal L cell and islet α cell.

Wu W, Xia Q, Guo Y, Wang H, Dong H, Lu F, Yuan F
Frontiers in pharmacology 2023;14:1228722

FTZ promotes islet β-cell regeneration in T1DM mice via the regulation of nuclear proliferation factors.

Zhong Q, Yin J, Wang K, Chen X, Wang H, Hu X, Wang W, Wang L, Bei W, Guo J
Journal of ethnopharmacology 2023 Oct 28;315:116564

Thyroid hormone treatment counteracts cellular phenotypical remodeling in diabetic organs.

Lavecchia AM, Mantzouratou P, Cerullo D, Locatelli M, Conti S, Tironi M, Sangalli F, Corna D, Zoja C, Remuzzi G, Xinaris C
iScience 2023 Oct 20;26(10):107826

Paternal sleep deprivation induces metabolic perturbations in male offspring via altered LRP5 DNA methylation of pancreatic islets.

Zeng Y, Zhang Z, Liang S, Chang X, Qin R, Chen H, Guo L
Journal of pineal research 2023 May;74(4):e12863

Selenium Nanodots (SENDs) as Antioxidants and Antioxidant-Prodrugs to Rescue Islet β Cells in Type 2 Diabetes Mellitus by Restoring Mitophagy and Alleviating Endoplasmic Reticulum Stress.

Huang Q, Liu Z, Yang Y, Yang Y, Huang T, Hong Y, Zhang J, Chen Q, Zhao T, Xiao Z, Gong X, Jiang Y, Peng J, Nan Y, Ai K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(19):e2300880

Fufang-zhenzhu-tiaozhi formula protects islet against injury and promotes β cell regeneration in diabetic mice.

Chen X, Yin J, Zhong Q, Wang K, Zhang X, Liang M, Lin Q, Wang H, Wang W, Wang L, Hu X, Bei W, Guo J
Journal of ethnopharmacology 2023 Jan 30;301:115791

Combined therapy of GABA and sitagliptin prevents high-fat diet impairment of beta-cell function.

Wang Z, Fan L, Ni Y, Wu D, Ma A, Zhao Y, Li J, Cui Q, Zhou Y, Zhang L, Lou YR, Prud'homme GJ, Wang Q
Molecular and cellular endocrinology 2023 Jan 1;559:111755

An Association between Decreased Small Intestinal RNA Modification and Disturbed Glucagon-like Peptide-1 Secretion under High-Fat Diet Stress.

Chen J, Deng LL, Xiao XL, Long SY, Deng Y, Peng T, Xie J, Zhang XY
Nutrients 2023 Aug 24;15(17)

The potential mechanism of Liu-Wei-Di-Huang Pills in treatment of type 2 diabetic mellitus: from gut microbiota to short-chain fatty acids metabolism.

Yi ZY, Chen L, Wang Y, He D, Zhao D, Zhang SH, Yu R, Huang JH
Acta diabetologica 2022 Oct;59(10):1295-1308

VAMP4 regulates insulin levels by targeting secretory granules to lysosomes.

Li M, Feng F, Feng H, Hu P, Xue Y, Xu T, Song E
The Journal of cell biology 2022 Oct 3;221(10)

A Chinese medical nutrition therapy diet accompanied by intermittent energy restriction alleviates type 2 diabetes by enhancing pancreatic islet function and regulating gut microbiota composition.

Luo W, Zhou J, Yang X, Wu R, Liu H, Shao H, Huang B, Kang X, Yang L, Liu D
Food research international (Ottawa, Ont.) 2022 Nov;161:111744

cGAS-STING mediates cytoplasmic mitochondrial-DNA-induced inflammatory signal transduction during accelerated senescence of pancreatic β-cells induced by metabolic stress.

Hu H, Zhao R, He Q, Cui C, Song J, Guo X, Zang N, Yang M, Zou Y, Yang J, Li J, Wang L, Xia L, Wang L, He F, Hou X, Yan F, Chen L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 May;36(5):e22266

Type IIB PKA is highly expressed in β cells and controls cell proliferation via regulating Cyclin D1 expression.

Jiang Y, Zhu L, Wu D, Ni Y, Huang C, Ye H, Yang Y, Liu R, Li Y
The FEBS journal 2022 May;289(10):2865-2876

Long-Term High-Fat High-Fructose Diet Induces Type 2 Diabetes in Rats through Oxidative Stress.

Zhao Y, Wang QY, Zeng LT, Wang JJ, Liu Z, Fan GQ, Li J, Cai JP
Nutrients 2022 May 24;14(11)

Small Hepatitis B Virus Surface Antigen Promotes Hepatic Gluconeogenesis via Enhancing Glucagon/cAMP/Protein Kinase A/CREB Signaling.

Chen Y, Wang B, Ou X, Wu Y, He Y, Lin X, Lin X
Journal of virology 2022 Dec 14;96(23):e0102022

JunD Regulates Pancreatic β-Cells Function by Altering Lipid Accumulation.

Wang K, Cui Y, Lin P, Yao Z, Sun Y
Frontiers in endocrinology 2021;12:689845

Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis.

Zhang X, Tao J, Yu J, Hu N, Zhang X, Wang G, Feng J, Xiong X, Li M, Chai D, Li H, Rong Y, Tang Z, Wang W, Peng Z, Shi Q
Cell death & disease 2021 Sep 23;12(10):867

HGF can reduce accumulation of inflammation and regulate glucose homeostasis in T2D mice.

Yan L, He X, Tang Y, Zhao X, Luo G, Wang X
Journal of physiology and biochemistry 2021 Nov;77(4):613-624

Mesenchymal stem cell-conditioned medium alleviates high fat-induced hyperglucagonemia via miR-181a-5p and its target PTEN/AKT signaling.

Song J, He Q, Guo X, Wang L, Wang J, Cui C, Hu H, Yang M, Cui Y, Zang N, Yan F, Liu F, Sun Y, Liang K, Qin J, Zhao R, Wang C, Sun Z, Hou X, Li W, Chen L
Molecular and cellular endocrinology 2021 Nov 1;537:111445

Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.

Guo X, Cui C, Song J, He Q, Zang N, Hu H, Wang X, Li D, Wang C, Hou X, Li X, Liang K, Yan F, Chen L
Molecular and cellular endocrinology 2021 Nov 1;537:111425

Morphological and biochemical changes in the pancreas associated with acute systemic hypoxia.

Morioka F, Tani N, Ikeda T, Hirokawa T, Ikeda K, Shida A, Aoki Y, Ishikawa T
Human cell 2021 Mar;34(2):400-418

Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states.

Bahl V, Lee May C, Perez A, Glaser B, Kaestner KH
Molecular metabolism 2021 Jul;49:101193

The active GLP-1 analogue liraglutide alleviates H9N2 influenza virus-induced acute lung injury in mice.

Bai Y, Lian P, Li J, Zhang Z, Qiao J
Microbial pathogenesis 2021 Jan;150:104645

Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.

Fujimoto BA, Young M, Nakamura N, Ha H, Carter L, Pitts MW, Torres D, Noh HL, Suk S, Kim JK, Polgar N
The Journal of biological chemistry 2021 Jan-Jun;296:100482

Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice.

Bao S, Zheng H, Chen C, Zhang Y, Bao L, Yang B, Hou Y, Chen Y, Zhang Q, Pi J, Fu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Dec;158:112633

SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment.

Wu CT, Lidsky PV, Xiao Y, Lee IT, Cheng R, Nakayama T, Jiang S, Demeter J, Bevacqua RJ, Chang CA, Whitener RL, Stalder AK, Zhu B, Chen H, Goltsev Y, Tzankov A, Nayak JV, Nolan GP, Matter MS, Andino R, Jackson PK
Cell metabolism 2021 Aug 3;33(8):1565-1576.e5

Multifaceted secretion of htNSC-derived hypothalamic islets induces survival and antidiabetic effect via peripheral implantation in mice.

Tang Y, Zuniga-Hertz JP, Han C, Yu B, Cai D
eLife 2020 Feb 21;9

Mint3 is dispensable for pancreatic and kidney functions in mice.

Chung Y, Saitoh Y, Hayashi T, Fukui Y, Terada N, Seiki M, Murakami Y, Sakamoto T
Biochemistry and biophysics reports 2020 Dec;24:100872

aThe characteristics of glucose metabolism in the sulfonylurea receptor 1 knockout rat model.

Zhou X, Xu C, Zou Z, Shen X, Xie T, Zhang R, Liao L, Dong J
Molecular medicine (Cambridge, Mass.) 2019 Jan 7;25(1):2

Simultaneous Real-Time Measurement of the β-Cell Membrane Potential and Ca(2+) Influx to Assess the Role of Potassium Channels on β-Cell Function.

Vierra NC, Dickerson MT, Philipson LH, Jacobson DA
Methods in molecular biology (Clifton, N.J.) 2018;1684:73-84

TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.

Vierra NC, Dickerson MT, Jordan KL, Dadi PK, Katdare KA, Altman MK, Milian SC, Jacobson DA
Molecular metabolism 2018 Mar;9:84-97

SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.

Qin K, Zhang N, Zhang Z, Nipper M, Zhu Z, Leighton J, Xu K, Musi N, Wang P
Diabetologia 2018 Apr;61(4):906-918

TALK-1 channels control β cell endoplasmic reticulum Ca(2+) homeostasis.

Vierra NC, Dadi PK, Milian SC, Dickerson MT, Jordan KL, Gilon P, Jacobson DA
Science signaling 2017 Sep 19;10(497)

CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion.

Zheng H, Fu J, Xue P, Zhao R, Dong J, Liu D, Yamamoto M, Tong Q, Teng W, Qu W, Zhang Q, Andersen ME, Pi J
Antioxidants & redox signaling 2015 Apr 1;22(10):819-31

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human pancreas using 15954-1-AP(GCG antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human pancreas using 15954-1-AP(GCG antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Glucagon antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Glucagon. This antibody recognizes human,mouse,rat antigen. The Glucagon antibody has been validated for the following applications: ELISA, IHC analysis.
Appendix: 15954-1-AP.pdf

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