Antibody data
- Antibody Data
- Antigen structure
- References [19]
- Comments [0]
- Validations
- Immunohistochemistry [3]
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- Product number
- 15954-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- Glucagon antibody
- Antibody type
- Polyclonal
- Description
- Glucagon antibody (Cat. #15954-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references JunD Regulates Pancreatic β-Cells Function by Altering Lipid Accumulation.
Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis.
HGF can reduce accumulation of inflammation and regulate glucose homeostasis in T2D mice.
Type IIB PKA is highly expressed in β cells and controls cell proliferation via regulating Cyclin D1 expression.
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Morphological and biochemical changes in the pancreas associated with acute systemic hypoxia.
Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states.
The active GLP-1 analogue liraglutide alleviates H9N2 influenza virus-induced acute lung injury in mice.
Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.
Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice.
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment.
Multifaceted secretion of htNSC-derived hypothalamic islets induces survival and antidiabetic effect via peripheral implantation in mice.
Mint3 is dispensable for pancreatic and kidney functions in mice.
aThe characteristics of glucose metabolism in the sulfonylurea receptor 1 knockout rat model.
Simultaneous Real-Time Measurement of the β-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on β-Cell Function.
TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.
SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.
TALK-1 channels control β cell endoplasmic reticulum Ca2+ homeostasis.
CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion.
Wang K, Cui Y, Lin P, Yao Z, Sun Y
Frontiers in endocrinology 2021;12:689845
Frontiers in endocrinology 2021;12:689845
Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis.
Zhang X, Tao J, Yu J, Hu N, Zhang X, Wang G, Feng J, Xiong X, Li M, Chai D, Li H, Rong Y, Tang Z, Wang W, Peng Z, Shi Q
Cell death & disease 2021 Sep 23;12(10):867
Cell death & disease 2021 Sep 23;12(10):867
HGF can reduce accumulation of inflammation and regulate glucose homeostasis in T2D mice.
Yan L, He X, Tang Y, Zhao X, Luo G, Wang X
Journal of physiology and biochemistry 2021 Nov;77(4):613-624
Journal of physiology and biochemistry 2021 Nov;77(4):613-624
Type IIB PKA is highly expressed in β cells and controls cell proliferation via regulating Cyclin D1 expression.
Jiang Y, Zhu L, Wu D, Ni Y, Huang C, Ye H, Yang Y, Liu R, Li Y
The FEBS journal 2021 Nov 28;
The FEBS journal 2021 Nov 28;
Mof acetyltransferase inhibition ameliorates glucose intolerance and islet dysfunction of type 2 diabetes via targeting pancreatic α-cells.
Guo X, Cui C, Song J, He Q, Zang N, Hu H, Wang X, Li D, Wang C, Hou X, Li X, Liang K, Yan F, Chen L
Molecular and cellular endocrinology 2021 Nov 1;537:111425
Molecular and cellular endocrinology 2021 Nov 1;537:111425
Morphological and biochemical changes in the pancreas associated with acute systemic hypoxia.
Morioka F, Tani N, Ikeda T, Hirokawa T, Ikeda K, Shida A, Aoki Y, Ishikawa T
Human cell 2021 Mar;34(2):400-418
Human cell 2021 Mar;34(2):400-418
Genetic activation of α-cell glucokinase in mice causes enhanced glucose-suppression of glucagon secretion during normal and diabetic states.
Bahl V, Lee May C, Perez A, Glaser B, Kaestner KH
Molecular metabolism 2021 Jul;49:101193
Molecular metabolism 2021 Jul;49:101193
The active GLP-1 analogue liraglutide alleviates H9N2 influenza virus-induced acute lung injury in mice.
Bai Y, Lian P, Li J, Zhang Z, Qiao J
Microbial pathogenesis 2021 Jan;150:104645
Microbial pathogenesis 2021 Jan;150:104645
Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model.
Fujimoto BA, Young M, Nakamura N, Ha H, Carter L, Pitts MW, Torres D, Noh HL, Suk S, Kim JK, Polgar N
The Journal of biological chemistry 2021 Jan-Jun;296:100482
The Journal of biological chemistry 2021 Jan-Jun;296:100482
Nfe2l1 deficiency mitigates streptozotocin-induced pancreatic β-cell destruction and development of diabetes in male mice.
Bao S, Zheng H, Chen C, Zhang Y, Bao L, Yang B, Hou Y, Chen Y, Zhang Q, Pi J, Fu J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Dec;158:112633
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Dec;158:112633
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment.
Wu CT, Lidsky PV, Xiao Y, Lee IT, Cheng R, Nakayama T, Jiang S, Demeter J, Bevacqua RJ, Chang CA, Whitener RL, Stalder AK, Zhu B, Chen H, Goltsev Y, Tzankov A, Nayak JV, Nolan GP, Matter MS, Andino R, Jackson PK
Cell metabolism 2021 Aug 3;33(8):1565-1576.e5
Cell metabolism 2021 Aug 3;33(8):1565-1576.e5
Multifaceted secretion of htNSC-derived hypothalamic islets induces survival and antidiabetic effect via peripheral implantation in mice.
Tang Y, Zuniga-Hertz JP, Han C, Yu B, Cai D
eLife 2020 Feb 21;9
eLife 2020 Feb 21;9
Mint3 is dispensable for pancreatic and kidney functions in mice.
Chung Y, Saitoh Y, Hayashi T, Fukui Y, Terada N, Seiki M, Murakami Y, Sakamoto T
Biochemistry and biophysics reports 2020 Dec;24:100872
Biochemistry and biophysics reports 2020 Dec;24:100872
aThe characteristics of glucose metabolism in the sulfonylurea receptor 1 knockout rat model.
Zhou X, Xu C, Zou Z, Shen X, Xie T, Zhang R, Liao L, Dong J
Molecular medicine (Cambridge, Mass.) 2019 Jan 7;25(1):2
Molecular medicine (Cambridge, Mass.) 2019 Jan 7;25(1):2
Simultaneous Real-Time Measurement of the β-Cell Membrane Potential and Ca2+ Influx to Assess the Role of Potassium Channels on β-Cell Function.
Vierra NC, Dickerson MT, Philipson LH, Jacobson DA
Methods in molecular biology (Clifton, N.J.) 2018;1684:73-84
Methods in molecular biology (Clifton, N.J.) 2018;1684:73-84
TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin secretion.
Vierra NC, Dickerson MT, Jordan KL, Dadi PK, Katdare KA, Altman MK, Milian SC, Jacobson DA
Molecular metabolism 2018 Mar;9:84-97
Molecular metabolism 2018 Mar;9:84-97
SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice.
Qin K, Zhang N, Zhang Z, Nipper M, Zhu Z, Leighton J, Xu K, Musi N, Wang P
Diabetologia 2018 Apr;61(4):906-918
Diabetologia 2018 Apr;61(4):906-918
TALK-1 channels control β cell endoplasmic reticulum Ca2+ homeostasis.
Vierra NC, Dadi PK, Milian SC, Dickerson MT, Jordan KL, Gilon P, Jacobson DA
Science signaling 2017 Sep 19;10(497)
Science signaling 2017 Sep 19;10(497)
CNC-bZIP protein Nrf1-dependent regulation of glucose-stimulated insulin secretion.
Zheng H, Fu J, Xue P, Zhao R, Dong J, Liu D, Yamamoto M, Tong Q, Teng W, Qu W, Zhang Q, Andersen ME, Pi J
Antioxidants & redox signaling 2015 Apr 1;22(10):819-31
Antioxidants & redox signaling 2015 Apr 1;22(10):819-31
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas using 15954-1-AP(GCG antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas using 15954-1-AP(GCG antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Glucagon antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Glucagon. This antibody recognizes human,mouse,rat antigen. The Glucagon antibody has been validated for the following applications: ELISA, IHC analysis.