GCG

The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008]

Description

Glucagon

Tissue specificity

Tissue enriched (pancreas)

Subcell location

Endoplasmic reticulum, Vesicles

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (162142882 - 162152404)

Ensembl ID

ENSG00000115263  (ver. 103.38)

Orthologs

Mouse Gcg: ENSMUSG00000000394

UniProt

P01275

neXtProt

NX_P01275

Human splice variants
Mouse splice variants

Protein structure