UGT1A9

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq, Jul 2008]

Description

UDP glucuronosyltransferase family 1 member A9

Tissue specificity

Group enriched (kidney, liver)

Predicted location

Membrane

Protein family

Cancer-related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

2 (233671898 - 233773300)

Ensembl ID

ENSG00000241119  (ver. 103.38)

Orthologs

-

UniProt

O60656

neXtProt

NX_O60656

Human splice variants

Protein structure