ACTG2

Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides. [provided by RefSeq, Dec 2010]

Description

Actin gamma 2, smooth muscle

Tissue specificity

Tissue enhanced (intestine, seminal vesicle, smooth muscle)

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (73892314 - 73919865)

Ensembl ID

ENSG00000163017  (ver. 103.38)

Orthologs

Mouse Actg2: ENSMUSG00000059430

UniProt

P63267

neXtProt

NX_P63267

Human splice variants
Mouse splice variants

Protein structure