orb131804

antibody from Biorbyt
Targeting: AIFM1 AIF, AUNX1, CMTX4, DFNX5, NAMSD, PDCD8
Provider product page for orb131804
Western blot

Antibody data

Product number
orb131804 - Provider product page
Provider
Biorbyt
Product name
AIFM1 antibody
Antibody type
Polyclonal
Description
Rabbit polyclonal to AIFM1. Apoptosis-inducing factor 1, mitochondrial (AIFM1) belongs to the FAD-dependent oxidoreductase family. AIFM1 is a probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. AIFM1 interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. AIFM1 also plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. AIFM1 binds to DNA in a sequence-independent manner.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Vial size
100 ul
Concentration
100 μg/ml BSA
Storage
-20°C
AIFM1 protein structure - orb131804 shown in red.