310716

antibody from BioLegend

Targeting: CCR3 CC-CKR-3, CD193, CKR3, CMKBR3

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

310716

Provider

BioLegend

Proper citation

BioLegend Cat#310716, RRID:AB_2563831

Product name

Brilliant Violet 605™ anti-human CD193 (CCR3)

Antibody type

Monoclonal

Antigen

Other

Description

CD193, also known as CC-chemokine receptor 3 (CCR3), CC CKR3, MIP1-alpha receptor like-2, and eotaxin receptor, is a member of the G protein-coupled seven transmembrane receptors family. It binds to the CC chemokines eotaxin, eotaxin-2, and eotaxin-3 with high affinity. CCR3 has also been reported to bind RANTES, MCP-3, and MCP-4 with low affinity. CCR3 receptor is expressed on human eosinophils, basophils, mast cells, mononuclear phagocytes, platelets, CD34⁺ hematopoietic progenitor cells, Th2-like lymphocytes, and keratinocytes. CCR3 is thought to play a role in allergic diseases such as bronchial asthma and allergic rhinitis. CCR3 is a co-receptor for HIV-1 and HIV-2, and the binding of eotaxin with CCR3 has been shown to inhibit HIV infection in some cell types.

Reactivity

Human

Host

Mouse

Conjugate

Yellow dye

Antibody clone number

5.00E+08

Vial size

100 tests

Storage

2°C-8°C

Handling

Ambient RT

Flow cytometry

Supportive validation

Submitted by

BioLegend (provider)

Main image

Experimental details

Human peripheral blood leukocytes were stained with CD16 APC and CCR3 (clone 5E8) Brilliant Violet 605™ (top) or mouse IgG2b Brilliant Violet 605™ isotype control (bottom). Data shown was generated from granulocyte population gating.

Conjugate

Yellow dye