Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 17-1939-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD193 (CCR3) Monoclonal Antibody (eBio5E8-G9-B4 (5E8-G9-B4)), APC, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The eBio5E8-G9-B4 monoclonal antibody reacts with human CD193 (CCR3, CKR3). CD193 is a member of the seven transmembrane G-protein coupled receptor (GPCR) family, and is a high affinity chemokine receptor for the chemokines eotaxin-1 (CCL11), eotaxin-2 (CCL24), eotaxin-3 (CCL26) and MCP-4 (CCL13), but has also been reported to bind RANTES, MCP-3 and MCP-4. CD193 is highly expressed on the surface of eosinophils, and is the key eosinophil chemokine receptor responsible for the regulation of eosinophil migration and function. In addition to eosinophils, CD193 is also expressed on CD4+ TH2 cells, basophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitors and airway epithelial cells. CD193 likely plays an important role in the migration of eosinophils in allergic airway inflammation and asthma. CD193 can also serve as a receptor for HIV-1 cell entry.
- Antibody clone number
- eBio5E8-G9-B4 (5E8-G9-B4)
- Concentration
- 5 µL/Test
Submitted references Inhibition of TLR ligand- and interferon gamma-induced murine microglial activation by Panax notoginseng.
Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells.
Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes.
Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.
Beamer CA, Shepherd DM
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012 Jun;7(2):465-76
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012 Jun;7(2):465-76
Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells.
Sallusto F, Mackay CR, Lanzavecchia A
Science (New York, N.Y.) 1997 Sep 26;277(5334):2005-7
Science (New York, N.Y.) 1997 Sep 26;277(5334):2005-7
Eotaxin-2, a novel CC chemokine that is selective for the chemokine receptor CCR3, and acts like eotaxin on human eosinophil and basophil leukocytes.
Forssmann U, Uguccioni M, Loetscher P, Dahinden CA, Langen H, Thelen M, Baggiolini M
The Journal of experimental medicine 1997 Jun 16;185(12):2171-6
The Journal of experimental medicine 1997 Jun 16;185(12):2171-6
Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody.
Heath H, Qin S, Rao P, Wu L, LaRosa G, Kassam N, Ponath PD, Mackay CR
The Journal of clinical investigation 1997 Jan 15;99(2):178-84
The Journal of clinical investigation 1997 Jan 15;99(2):178-84
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.
Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J
Cell 1996 Jun 28;85(7):1135-48
Cell 1996 Jun 28;85(7):1135-48
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Anti-Human CD16 PE (Product # 12-0168-42) and Mouse IgG2b K Isotype Control APC (Product # 17-4732-81) (left) or Anti-Human CD193 (CCR3) APC (right). Cells in the large scatter population were used for analysis.