Tissue expression
Cell line expression

C4B

gene product
C4B1, C4B3, C4F, CH, CO4, CPAMD3 
This gene encodes the basic form of complement factor 4, and together with the C4A gene, is part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, May 2020]
More gene data

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330 antibodies from 21 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
74 antibodies
GeneTex
7 antibodies
Invitrogen Antibodies
21 antibodies
antibodies-online
83 antibodies
LifeSpan BioSciences, Inc.
56 antibodies
Abnova Corporation
6 antibodies
Acris Antibodies GmbH
2 antibodies
Aviva Systems Biology
2 antibodies
Cusabio Biotech Co., Ltd
4 antibodies
Abgent
1 antibody
Proteintech Group
1 antibody
Biorbyt
7 antibodies
Arigo
4 antibodies
Creative Diagnostics
19 antibodies
OriGene
5 antibodies
Creative Biolabs
14 antibodies
Abbexa
7 antibodies
MyBioSource
12 antibodies
ProSci
2 antibodies
United States Biological
1 antibody
MilliporeSigma / Merck KGaA
2 antibodies