Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS6227 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IkB Ï«/NFKBIA polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human IkB-Ï«/NFKBIA.
- Description
- Activation of NF°ÙB requires that I°ÙB be phosphorylated on specific serine residues, which results in targeted degradation of I°ÙB. I°ÙB kinase Ï« (IKKÏ«), previously designated CHUK, interacts with I°ÙB-Ï« and specifically phosphorylates I°ÙB-Ï« on the sites that trigger its degradation Serines 32 and 36. IKKÏ« appears to be critical for NF°ÙB activation in response to proinflammatory cytokines. Phosphorylation of I°ÙB by IKKÏ« is stimulated by the NF°ÙB inducing kinase (NIK), which itself is a central regulator for NF°ÙB activation in response to TNF and IL-1.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of IkB-¦Á pAb in extracts from HL60 cells.