NFKBIA

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]

Description

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Protein family

Cancer-related genes, Disease related genes, Mapped to UniProt SWISS-PROT, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014), Transcription factors

Chromosome

14:q13.2 (35401511 - 35404749)

Ensembl ID

ENSG00000100906  (ver. 84.38)

Orthologs

Mouse Nfkbia: ENSMUSG00000021025

UniProt

P25963

neXtProt

NX_P25963

Human splice variants
Mouse splice variants