Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
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- Product number
- 624901 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#624901, RRID:AB_315993
- Product name
- Purified anti-IkB-
- Antibody type
- Polyclonal
- Antigen
- Peptide mapping to the carboxy terminus of human IκB-α
- Description
- IκB-α is an inhibitory protein that binds the NFκB complex and retains this complex in the cytoplasm where it cannot activate transcription. Upon cellular stimulation, the IκB proteins are phosphorylated and degraded via the ubiquitin pathway allowing nuclear translocation of NFκB. The NFκB complex binds DNA to activate gene expression of a number of a variety of proteins involved in inflammation, cellular proliferation, differentiation, and apoptosis. Poly6249 recognizes the C-terminal region of human, mouse, rat IKB-α and has been shown to be useful for Western blotting, immunoprecipitation, and immunohistochemistry.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 50 µl
- Storage
- The antibody solution should be stored undiluted at 4°C. DO NOT FREEZE.
Submitted references Protein disulfide isomerase-like proteins play opposing roles during retrotranslocation.
Forster ML, Sivick K, Park YN, Arvan P, Lencer WI, Tsai B
The Journal of cell biology 2006 Jun 19;173(6):853-9
The Journal of cell biology 2006 Jun 19;173(6):853-9
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